LOCUS       NM_005453               2660 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens zinc finger and BTB domain containing 22 (ZBTB22),
            transcript variant 1, mRNA.
ACCESSION   NM_005453
VERSION     NM_005453.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2660)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2660)
  AUTHORS   Yin,Y., Morgunova,E., Jolma,A., Kaasinen,E., Sahu,B.,
            Khund-Sayeed,S., Das,P.K., Kivioja,T., Dave,K., Zhong,F.,
            Nitta,K.R., Taipale,M., Popov,A., Ginno,P.A., Domcke,S., Yan,J.,
            Schubeler,D., Vinson,C. and Taipale,J.
  TITLE     Impact of cytosine methylation on DNA binding specificities of
            human transcription factors
  JOURNAL   Science 356 (6337) (2017)
   PUBMED   28473536
REFERENCE   3  (bases 1 to 2660)
  AUTHORS   Zhong,Q., Pevzner,S.J., Hao,T., Wang,Y., Mosca,R., Menche,J.,
            Taipale,M., Tasan,M., Fan,C., Yang,X., Haley,P., Murray,R.R.,
            Mer,F., Gebreab,F., Tam,S., MacWilliams,A., Dricot,A., Reichert,P.,
            Santhanam,B., Ghamsari,L., Calderwood,M.A., Rolland,T.,
            Charloteaux,B., Lindquist,S., Barabasi,A.L., Hill,D.E., Aloy,P.,
            Cusick,M.E., Xia,Y., Roth,F.P. and Vidal,M.
  TITLE     An inter-species protein-protein interaction network across vast
            evolutionary distance
  JOURNAL   Mol Syst Biol 12 (4), 865 (2016)
   PUBMED   27107014
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2660)
  AUTHORS   Barcellos,L.F., May,S.L., Ramsay,P.P., Quach,H.L., Lane,J.A.,
            Nititham,J., Noble,J.A., Taylor,K.E., Quach,D.L., Chung,S.A.,
            Kelly,J.A., Moser,K.L., Behrens,T.W., Seldin,M.F., Thomson,G.,
            Harley,J.B., Gaffney,P.M. and Criswell,L.A.
  TITLE     High-density SNP screening of the major histocompatibility complex
            in systemic lupus erythematosus demonstrates strong evidence for
            independent susceptibility regions
  JOURNAL   PLoS Genet 5 (10), e1000696 (2009)
   PUBMED   19851445
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   5  (bases 1 to 2660)
  AUTHORS   Mungall,A.J., Palmer,S.A., Sims,S.K., Edwards,C.A., Ashurst,J.L.,
            Wilming,L., Jones,M.C., Horton,R., Hunt,S.E., Scott,C.E.,
            Gilbert,J.G., Clamp,M.E., Bethel,G., Milne,S., Ainscough,R.,
            Almeida,J.P., Ambrose,K.D., Andrews,T.D., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Barker,D.J.,
            Barlow,K.F., Bates,K., Beare,D.M., Beasley,H., Beasley,O.,
            Bird,C.P., Blakey,S., Bray-Allen,S., Brook,J., Brown,A.J.,
            Brown,J.Y., Burford,D.C., Burrill,W., Burton,J., Carder,C.,
            Carter,N.P., Chapman,J.C., Clark,S.Y., Clark,G., Clee,C.M.,
            Clegg,S., Cobley,V., Collier,R.E., Collins,J.E., Colman,L.K.,
            Corby,N.R., Coville,G.J., Culley,K.M., Dhami,P., Davies,J.,
            Dunn,M., Earthrowl,M.E., Ellington,A.E., Evans,K.A., Faulkner,L.,
            Francis,M.D., Frankish,A., Frankland,J., French,L., Garner,P.,
            Garnett,J., Ghori,M.J., Gilby,L.M., Gillson,C.J., Glithero,R.J.,
            Grafham,D.V., Grant,M., Gribble,S., Griffiths,C., Griffiths,M.,
            Hall,R., Halls,K.S., Hammond,S., Harley,J.L., Hart,E.A.,
            Heath,P.D., Heathcott,R., Holmes,S.J., Howden,P.J., Howe,K.L.,
            Howell,G.R., Huckle,E., Humphray,S.J., Humphries,M.D., Hunt,A.R.,
            Johnson,C.M., Joy,A.A., Kay,M., Keenan,S.J., Kimberley,A.M.,
            King,A., Laird,G.K., Langford,C., Lawlor,S., Leongamornlert,D.A.,
            Leversha,M., Lloyd,C.R., Lloyd,D.M., Loveland,J.E., Lovell,J.,
            Martin,S., Mashreghi-Mohammadi,M., Maslen,G.L., Matthews,L.,
            McCann,O.T., McLaren,S.J., McLay,K., McMurray,A., Moore,M.J.,
            Mullikin,J.C., Niblett,D., Nickerson,T., Novik,K.L., Oliver,K.,
            Overton-Larty,E.K., Parker,A., Patel,R., Pearce,A.V., Peck,A.I.,
            Phillimore,B., Phillips,S., Plumb,R.W., Porter,K.M., Ramsey,Y.,
            Ranby,S.A., Rice,C.M., Ross,M.T., Searle,S.M., Sehra,H.K.,
            Sheridan,E., Skuce,C.D., Smith,S., Smith,M., Spraggon,L.,
            Squares,S.L., Steward,C.A., Sycamore,N., Tamlyn-Hall,G., Tester,J.,
            Theaker,A.J., Thomas,D.W., Thorpe,A., Tracey,A., Tromans,A.,
            Tubby,B., Wall,M., Wallis,J.M., West,A.P., White,S.S.,
            Whitehead,S.L., Whittaker,H., Wild,A., Willey,D.J., Wilmer,T.E.,
            Wood,J.M., Wray,P.W., Wyatt,J.C., Young,L., Younger,R.M.,
            Bentley,D.R., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E.,
            Dunham,I., Rogers,J. and Beck,S.
  TITLE     The DNA sequence and analysis of human chromosome 6
  JOURNAL   Nature 425 (6960), 805-811 (2003)
   PUBMED   14574404
REFERENCE   6  (bases 1 to 2660)
  AUTHORS   Herberg,J.A., Beck,S. and Trowsdale,J.
  TITLE     TAPASIN, DAXX, RGL2, HKE2 and four new genes (BING 1, 3 to 5) form
            a dense cluster at the centromeric end of the MHC
  JOURNAL   J Mol Biol 277 (4), 839-857 (1998)
   PUBMED   9545376
REFERENCE   7  (bases 1 to 2660)
  AUTHORS   Herberg,J.A., Sgouros,J., Jones,T., Copeman,J., Humphray,S.J.,
            Sheer,D., Cresswell,P., Beck,S. and Trowsdale,J.
  TITLE     Genomic analysis of the Tapasin gene, located close to the TAP loci
            in the MHC
  JOURNAL   Eur J Immunol 28 (2), 459-467 (1998)
   PUBMED   9521053
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL662820.6, BX459194.2, DA777388.1, BC018541.1, DA625357.1 and
            BQ002626.1.
            
            On Nov 23, 2018 this sequence version replaced NM_005453.4.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.168801.1, BX442464.2
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000431845.3/ ENSP00000407545.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 AL662820.6         46740-46748         c
            10-10               BX459194.2         1-1
            11-211              DA777388.1         1-201
            212-1088            BC018541.1         185-1061
            1089-1089           DA625357.1         518-518
            1090-2226           BC018541.1         1063-2199
            2227-2660           BQ002626.1         18-451              c
FEATURES             Location/Qualifiers
     source          1..2660
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.32"
     gene            1..2660
                     /gene="ZBTB22"
                     /gene_synonym="BING1; fru; fruitless; ZBTB22A; ZNF297;
                     ZNF297A"
                     /note="zinc finger and BTB domain containing 22"
                     /db_xref="GeneID:9278"
                     /db_xref="HGNC:HGNC:13085"
                     /db_xref="MIM:611439"
     exon            1..92
                     /gene="ZBTB22"
                     /gene_synonym="BING1; fru; fruitless; ZBTB22A; ZNF297;
                     ZNF297A"
                     /inference="alignment:Splign:2.1.0"
     exon            93..2660
                     /gene="ZBTB22"
                     /gene_synonym="BING1; fru; fruitless; ZBTB22A; ZNF297;
                     ZNF297A"
                     /inference="alignment:Splign:2.1.0"
     CDS             162..2066
                     /gene="ZBTB22"
                     /gene_synonym="BING1; fru; fruitless; ZBTB22A; ZNF297;
                     ZNF297A"
                     /note="zinc finger protein 297; zinc finger and BTB
                     domain-containing protein 22A"
                     /codon_start=1
                     /product="zinc finger and BTB domain-containing protein
                     22"
                     /protein_id="NP_005444.4"
                     /db_xref="CCDS:CCDS4775.1"
                     /db_xref="GeneID:9278"
                     /db_xref="HGNC:HGNC:13085"
                     /db_xref="MIM:611439"
                     /translation="MEPSPLSPSGAALPLPLSLAPPPLPLPAAAVVHVSFPEVTSALL
                     ESLNQQRLQGQLCDVSIRVQGREFRAHRAVLAASSPYFHDQVLLKGMTSISLPSVMDP
                     GAFETVLASAYTGRLSMAAADIVNFLTVGSVLQMWHIVDKCTELLREGRASATTTITT
                     AAATSVTVPGAGVPSGSGGTVAPATMGSARSHASSRASENQSPSSSNYFSPRESTDFS
                     SSSQEAFAASAVGSGERRGGGPVFPAPVVGSGGATSGKLLLEADELCDDGGDGRGAVV
                     PGAGLRRPTYTPPSIMPQKHWVYVKRGGNCPAPTPLVPQDPDLEEEEEEEDLVLTCED
                     DEDEELGGSSRVPVGGGPEATLSISDVRTLSEPPDKGEEQVNFCESSNDFGPYEGGGP
                     VAGLDDSGGPTPSSYAPSHPPRPLLPLDMQGNQILVFPSSSSSSSSQAPGQPPGNQAE
                     HGAVTVGGTSVGSLGVPGSVGGVPGGTGSGDGNKIFLCHCGKAFSHKSMRDRHVNMHL
                     NLRPFDCPVCNKKFKMKHHLTEHMKTHTGLKPYECGVCAKKFMWRDSFMRHRGHCERR
                     HRLGGVGAVPGPGTPTGPSLPSKRESPGVGGGSGDEASAATPPSSRRVWSPPRVHKVE
                     MGFGGGGGAN"
     regulatory      2637..2642
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZBTB22"
                     /gene_synonym="BING1; fru; fruitless; ZBTB22A; ZNF297;
                     ZNF297A"
                     /note="hexamer: ATTAAA"
     polyA_site      2660
                     /gene="ZBTB22"
                     /gene_synonym="BING1; fru; fruitless; ZBTB22A; ZNF297;
                     ZNF297A"
                     /note="major polyA site"
ORIGIN      
        1 gggagtcggc gcaagatggc ggcgggaggg gcccaggttg ctgctctggc cgccgagtga
       61 ggggcggggg gggcccgggg gcgcgcggcc cgagaccccc ccggccgccc tcctcctttc
      121 tttgttcctg tggctggggg ggtatcccct ccctccacaa catggagcca tctcctctgt
      181 ctcccagtgg ggcagcactt cccctgccgc tgtcgctggc tccgccccca ctacccctgc
      241 cagcagctgc agtggtacat gtgtccttcc ctgaggtgac cagtgccctc ttggagtccc
      301 tcaatcagca gcgtctgcag ggccagctct gcgatgtatc tatcagagtg cagggccggg
      361 agttccgggc tcatcgggct gtcctggctg cctcctcccc ttacttccat gatcaggtcc
      421 tactcaaagg catgacctcc atctcgctgc ccagtgtcat ggacccaggc gcctttgaga
      481 ctgtcctagc ctccgcttac actggccgcc tcagcatggc tgctgctgac attgtcaact
      541 tccttacagt ggggtctgtg ctccaaatgt ggcacattgt ggacaagtgc actgaactac
      601 tccgagaagg ccgggcctca gctaccacca ccatcactac tgctgcagcc acctctgtca
      661 ctgtccctgg tgctggggtg ccatccggga gtgggggcac tgtggcccct gctaccatgg
      721 gctctgcgcg ctcccatgcc tccagccggg ccagtgagaa tcaatctccc agcagcagca
      781 actacttcag ccccagggag tccactgatt tctcatcttc ctcccaagag gcatttgcag
      841 cttctgcagt gggcagtggg gagcgtcgag gaggtggccc tgtattccca gcccctgtcg
      901 ttggcagtgg aggggccaca tctggaaagc tgctgctgga ggcagatgag ctgtgcgatg
      961 atggtgggga tgggaggggg gcagtggttc ctggggctgg gctccggaga cccacctaca
     1021 caccccctag catcatgcca cagaaacact gggtatacgt gaagcgaggt ggtaattgcc
     1081 cagcgccaac acccctggtt ccccaagacc cagatctgga ggaggaagag gaggaggaag
     1141 atctggtgtt gacctgtgag gatgatgaag atgaagaact agggggtagc tccagggttc
     1201 cagtgggggg agggcctgag gctaccctca gcataagtga tgtccgtacc ctgagtgagc
     1261 ccccagacaa gggggaggag caggtcaact tctgtgagtc ctccaatgac tttggcccat
     1321 atgagggtgg gggtcctgtg gcaggtcttg atgactcagg ggggccaact ccctcttcct
     1381 atgccccctc ccaccctcct cgaccgctcc ttcccttgga catgcagggc aaccagatcc
     1441 tggtcttccc gtcgtcgtct tcatcctcat cctcacaggc tcctggccaa ccaccaggga
     1501 accaagcaga acacggggca gtgaccgtgg ggggcacgtc ggtggggagc ctgggtgtgc
     1561 cgggtagcgt tggtggggtc cctggaggga ctggcagtgg ggacgggaat aagatctttc
     1621 tgtgccattg tgggaaggcc ttctcccaca agagcatgcg ggaccggcac gtgaacatgc
     1681 acctcaatct gcggccgttt gactgccccg tgtgcaacaa aaagttcaag atgaagcacc
     1741 atctgactga gcacatgaag acgcacacag gtctcaagcc ctacgagtgc ggagtctgcg
     1801 ccaagaagtt catgtggcga gacagcttca tgcgccaccg aggacactgt gagcgccggc
     1861 accgcctggg cggggtcggg gccgtacctg ggcctgggac tcccacgggg ccatccttgc
     1921 cgtccaagag agagtctccc ggagtgggcg ggggcagcgg cgacgaagcg agtgcggcca
     1981 cgcccccgtc cagcagacgt gtctggtccc cacccagagt ccacaaggtg gagatgggct
     2041 tcggtggagg tggaggagca aactgaaggg gcaggctact ggggtggggt agctttcggg
     2101 aaagggaata aggagcacga tgcaagggcg ctgtggcccc cgggtgatct cccaccacac
     2161 ttactgtctt cctttatctc tgtggacttg tatatattct ggaaggggaa ccacagtttc
     2221 accatcgccc gcccattcta ctactcaacc cctccccccc aaggtatttc cagaactaaa
     2281 cccttccttt ccctctgatg ggtacactga agcccctgct ccacagagta gattgcacat
     2341 ggagggaggg agagggggcg tgttgaacat cctgcagtca cagggtcagg ggtcaggtgg
     2401 ttgtagtctg tgcctgaagt ctgtgtttgt gttgtcgtgg agacaaggcc tttgagcccc
     2461 acccttgtcc tagaacctac cccctctcaa ggatgcgctc tttatttcta ccctgtctct
     2521 ccccgccacc cccgacttcc cgtggaaatt cccaactcgg ttctcatgga ggagtgggtg
     2581 gagacaagga gggagtaagt cgtaggagta caaggttttt atttttttta acagtgatta
     2641 aaatatttat tggtcattta
//
