LOCUS       NM_001348800           27503 bp    mRNA    linear   PRI 12-OCT-2024
DEFINITION  Homo sapiens zinc finger and BTB domain containing 20 (ZBTB20),
            transcript variant 9, mRNA.
ACCESSION   NM_001348800
VERSION     NM_001348800.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 27503)
  AUTHORS   Wang,Q., Zhang,G., Zhang,M., Zhang,Y., Ruan,L. and Hao,H.
  TITLE     [Le miR-224-5p regule sert de biomarqueur pour l'insuffisance
            hepatique aigue pediatrique et regule l'inflammation en modulant
            ZBTB20]
  JOURNAL   Ann Biol Clin (Paris) 82 (1), 70-80 (2024)
   PUBMED   38638020
  REMARK    GeneRIF: [Le miR-224-5p regule sert de biomarqueur pour
            l'insuffisance hepatique aigue pediatrique et regule l'inflammation
            en modulant ZBTB20].
REFERENCE   2  (bases 1 to 27503)
  AUTHORS   Liu,J. and Zhang,H.
  TITLE     Zinc Finger and BTB Domain-Containing 20: A Newly Emerging Player
            in Pathogenesis and Development of Human Cancers
  JOURNAL   Biomolecules 14 (2), 192 (2024)
   PUBMED   38397429
  REMARK    GeneRIF: Zinc Finger and BTB Domain-Containing 20: A Newly Emerging
            Player in Pathogenesis and Development of Human Cancers.
            Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 27503)
  AUTHORS   Wu,W., Deng,J., Chen,C., Ma,X., Yu,L. and Chen,L.
  TITLE     Circ_0001602 aggravates the progression of acute myeloid leukemia
            by regulating the miR-192-5p/ZBTB20 axis
  JOURNAL   Hematology 28 (1), 2240133 (2023)
   PUBMED   37585722
  REMARK    GeneRIF: Circ_0001602 aggravates the progression of acute myeloid
            leukemia by regulating the miR-192-5p/ZBTB20 axis.
REFERENCE   4  (bases 1 to 27503)
  AUTHORS   Stoyanov,D., Stoyanov,G.S., Ivanov,M.N., Spasov,R.H. and
            Tonchev,A.B.
  TITLE     Transcription Factor Zbtb20 as a Regulator of Malignancy and Its
            Practical Applications
  JOURNAL   Int J Mol Sci 24 (18), 13763 (2023)
   PUBMED   37762065
  REMARK    GeneRIF: Transcription Factor Zbtb20 as a Regulator of Malignancy
            and Its Practical Applications.
            Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 27503)
  AUTHORS   Chen,S., Zhuang,Q., Li,P., Zeng,J., Peng,Y., Ding,Z., Cao,H.,
            Zheng,R. and Wang,W.
  TITLE     The long non-coding RNA KLF3-AS1/miR-10a-3p/ZBTB20 axis improves
            the degenerative changes in human nucleus pulposus cells
  JOURNAL   Cell Tissue Res 393 (1), 97-109 (2023)
   PUBMED   37052702
  REMARK    GeneRIF: The long non-coding RNA KLF3-AS1/miR-10a-3p/ZBTB20 axis
            improves the degenerative changes in human nucleus pulposus cells.
REFERENCE   6  (bases 1 to 27503)
  AUTHORS   Nielsen,J.V., Blom,J.B., Noraberg,J. and Jensen,N.A.
  TITLE     Zbtb20-induced CA1 pyramidal neuron development and area
            enlargement in the cerebral midline cortex of mice
  JOURNAL   Cereb Cortex 20 (8), 1904-1914 (2010)
   PUBMED   19955470
  REMARK    GeneRIF: Misexpression of Zbtb20 in transgenic mice converts the
            normal cytoarchitectonic organization of the subiculum,
            postsubiculum, and granular retrosplenial cortex to a CA1-like
            stratum pyramidale.
REFERENCE   7  (bases 1 to 27503)
  AUTHORS   Wang,A.G., Yoon,S.Y., Oh,J.H., Jeon,Y.J., Kim,M., Kim,J.M.,
            Byun,S.S., Yang,J.O., Kim,J.H., Kim,D.G., Yeom,Y.I., Yoo,H.S.,
            Kim,Y.S. and Kim,N.S.
  TITLE     Identification of intrahepatic cholangiocarcinoma related genes by
            comparison with normal liver tissues using expressed sequence tags
  JOURNAL   Biochem Biophys Res Commun 345 (3), 1022-1032 (2006)
   PUBMED   16712791
REFERENCE   8  (bases 1 to 27503)
  AUTHORS   Zhang,W., Mi,J., Li,N., Sui,L., Wan,T., Zhang,J., Chen,T. and
            Cao,X.
  TITLE     Identification and characterization of DPZF, a novel human BTB/POZ
            zinc finger protein sharing homology to BCL-6
  JOURNAL   Biochem Biophys Res Commun 282 (4), 1067-1073 (2001)
   PUBMED   11352661
REFERENCE   9  (bases 1 to 27503)
  AUTHORS   Harboe,T.L., Tumer,Z., Hansen,C., Jensen,N.A. and Tommerup,N.
  TITLE     Assignment of the human zinc finger gene, ZNF288, to chromosome 3
            band q13.2 by radiation hybrid mapping and fluorescence in situ
            hybridisation
  JOURNAL   Cytogenet Cell Genet 89 (3-4), 156-157 (2000)
   PUBMED   10965110
REFERENCE   10 (bases 1 to 27503)
  AUTHORS   Arora,V., Ferreira,C.R., Dua Puri,R. and Verma,I.C.
  TITLE     Primrose Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   33956417
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC069063.22, AC092915.7,
            AC069506.14, AC078986.20, AC055739.23, AC083886.19, AC131152.3 and
            AC093010.7.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jan 7, 2020 this sequence version replaced NM_001348800.2.
            
            Summary: This gene, which was initially designated as dendritic
            cell-derived BTB/POZ zinc finger (DPZF), belongs to a family of
            transcription factors with an N-terminal BTB/POZ domain and a
            C-terminal DNA-bindng zinc finger domain. The BTB/POZ domain is a
            hydrophobic region of approximately 120 aa which mediates
            association with other BTB/POZ domain-containing proteins. This
            gene acts as a transcriptional repressor and plays a role in many
            processes including neurogenesis, glucose homeostasis, and
            postnatal growth. Mutations in this gene have been associated with
            Primrose syndrome as well as the 3q13.31 microdeletion syndrome.
            Alternative splicing results in multiple transcript variants
            encoding distinct isoforms. [provided by RefSeq, Feb 2017].
            
            Transcript Variant: This variant (9) differs in the 5' UTR compared
            to variant 1 and, like variant 1, encodes isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853566.19925.1,
                                           SRR18074967.3469669.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1968189 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000675478.1/ ENSP00000501561.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-70                AC069063.22        59995-60064         c
            71-266              AC092915.7         17815-18010
            267-317             AC092915.7         114813-114863
            318-356             AC069506.14        1676-1714
            357-430             AC069506.14        100844-100917
            431-478             AC078986.20        79174-79221
            479-518             AC055739.23        28144-28183         c
            519-619             AC083886.19        9329-9429           c
            620-783             AC131152.3         737-900
            784-971             AC131152.3         1273-1460
            972-2576            AC131152.3         29799-31403
            2577-8040           AC131152.3         42251-47714
            8041-27503          AC093010.7         141615-161077       c
FEATURES             Location/Qualifiers
     source          1..27503
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q13.31"
     gene            1..27503
                     /gene="ZBTB20"
                     /gene_synonym="DPZF; HOF; ODA-8S; PRIMS; ZNF288"
                     /note="zinc finger and BTB domain containing 20"
                     /db_xref="GeneID:26137"
                     /db_xref="HGNC:HGNC:13503"
                     /db_xref="MIM:606025"
     exon            1..70
                     /gene="ZBTB20"
                     /gene_synonym="DPZF; HOF; ODA-8S; PRIMS; ZNF288"
                     /inference="alignment:Splign:2.1.0"
     exon            71..266
                     /gene="ZBTB20"
                     /gene_synonym="DPZF; HOF; ODA-8S; PRIMS; ZNF288"
                     /inference="alignment:Splign:2.1.0"
     exon            267..317
                     /gene="ZBTB20"
                     /gene_synonym="DPZF; HOF; ODA-8S; PRIMS; ZNF288"
                     /inference="alignment:Splign:2.1.0"
     exon            318..356
                     /gene="ZBTB20"
                     /gene_synonym="DPZF; HOF; ODA-8S; PRIMS; ZNF288"
                     /inference="alignment:Splign:2.1.0"
     exon            357..430
                     /gene="ZBTB20"
                     /gene_synonym="DPZF; HOF; ODA-8S; PRIMS; ZNF288"
                     /inference="alignment:Splign:2.1.0"
     exon            431..478
                     /gene="ZBTB20"
                     /gene_synonym="DPZF; HOF; ODA-8S; PRIMS; ZNF288"
                     /inference="alignment:Splign:2.1.0"
     exon            479..518
                     /gene="ZBTB20"
                     /gene_synonym="DPZF; HOF; ODA-8S; PRIMS; ZNF288"
                     /inference="alignment:Splign:2.1.0"
     exon            519..619
                     /gene="ZBTB20"
                     /gene_synonym="DPZF; HOF; ODA-8S; PRIMS; ZNF288"
                     /inference="alignment:Splign:2.1.0"
     exon            620..783
                     /gene="ZBTB20"
                     /gene_synonym="DPZF; HOF; ODA-8S; PRIMS; ZNF288"
                     /inference="alignment:Splign:2.1.0"
     CDS             773..2998
                     /gene="ZBTB20"
                     /gene_synonym="DPZF; HOF; ODA-8S; PRIMS; ZNF288"
                     /note="isoform 1 is encoded by transcript variant 9; zinc
                     finger protein 288; BTB/POZ zinc finger protein DPZF;
                     dendritic cell-derived BTB/POZ zinc finger"
                     /codon_start=1
                     /product="zinc finger and BTB domain-containing protein 20
                     isoform 1"
                     /protein_id="NP_001335729.1"
                     /db_xref="CCDS:CCDS54626.1"
                     /db_xref="GeneID:26137"
                     /db_xref="HGNC:HGNC:13503"
                     /db_xref="MIM:606025"
                     /translation="MLERKKPKTAENQKASEENEITQPGGSSAKPGLPCLNFEAVLSP
                     DPALIHSTHSLTNSHAHTGSSDCDISCKGMTERIHSINLHNFSNSVLETLNEQRNRGH
                     FCDVTVRIHGSMLRAHRCVLAAGSPFFQDKLLLGYSDIEIPSVVSVQSVQKLIDFMYS
                     GVLRVSQSEALQILTAASILQIKTVIDECTRIVSQNVGDVFPGIQDSGQDTPRGTPES
                     GTSGQSSDTESGYLQSHPQHSVDRIYSALYACSMQNGSGERSFYSGAVVSHHETALGL
                     PRDHHMEDPSWITRIHERSQQMERYLSTTPETTHCRKQPRPVRIQTLVGNIHIKQEME
                     DDYDYYGQQRVQILERNESEECTEDTDQAEGTESEPKGESFDSGVSSSIGTEPDSVEQ
                     QFGPGAARDSQAEPTQPEQAAEAPAEGGPQTNQLETGASSPERSNEVEMDSTVITVSN
                     SSDKSVLQQPSVNTSIGQPLPSTQLYLRQTETLTSNLRMPLTLTSNTQVIGTAGNTYL
                     PALFTTQPAGSGPKPFLFSLPQPLAGQQTQFVTVSQPGLSTFTAQLPAPQPLASSAGH
                     STASGQGEKKPYECTLCNKTFTAKQNYVKHMFVHTGEKPHQCSICWRSFSLKDYLIKH
                     MVTHTGVRAYQCSICNKRFTQKSSLNVHMRLHRGEKSYECYICKKKFSHKTLLERHVA
                     LHSASNGTPPAGTPPGARAGPPGVVACTEGTTYVCSVCPAKFDQIEQFNDHMRMHVSD
                     G"
     exon            784..971
                     /gene="ZBTB20"
                     /gene_synonym="DPZF; HOF; ODA-8S; PRIMS; ZNF288"
                     /inference="alignment:Splign:2.1.0"
     exon            972..2576
                     /gene="ZBTB20"
                     /gene_synonym="DPZF; HOF; ODA-8S; PRIMS; ZNF288"
                     /inference="alignment:Splign:2.1.0"
     exon            2577..27503
                     /gene="ZBTB20"
                     /gene_synonym="DPZF; HOF; ODA-8S; PRIMS; ZNF288"
                     /inference="alignment:Splign:2.1.0"
     regulatory      25704..25709
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZBTB20"
                     /gene_synonym="DPZF; HOF; ODA-8S; PRIMS; ZNF288"
                     /note="hexamer: CATAAA"
     polyA_site      25734
                     /gene="ZBTB20"
                     /gene_synonym="DPZF; HOF; ODA-8S; PRIMS; ZNF288"
                     /note="major polyA site"
     regulatory      27298..27303
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZBTB20"
                     /gene_synonym="DPZF; HOF; ODA-8S; PRIMS; ZNF288"
                     /note="hexamer: AATAAA"
     polyA_site      27317
                     /gene="ZBTB20"
                     /gene_synonym="DPZF; HOF; ODA-8S; PRIMS; ZNF288"
ORIGIN      
        1 cttctgccga agaagtaggg gcggggggaa gtttaggagt tgaggaaaga agattaaaga
       61 gcgcgaggag gcactgccag gacttaccgt acaacactcc ttggcttctg gaattttatc
      121 tctgctcaca gtctacatta caacattagt tcattctggg cactttagct tccttgaatc
      181 tccagttgat ctcacaccca tgcctatgat attcttctcc tggttaatca agaattctct
      241 atttctgctc cgtcatccat gccactacaa ataaaaagaa gtgttaagaa ttgcctttgg
      301 gactctgaag gctgaagaat tgatgaattg caagtttgtg ccccatagct gcacagactg
      361 cctgaagtta catttagaga ctgaaatcac tgcaccttaa aaacaaaaga ttgagctgca
      421 ctgtattcct aatgtttcat cattactaac aggatattcc tcatgacatt gctgtctgat
      481 ctttgaccat cagtctgtga cctgcccctt ctctttacat gcagccgctc tctgctccct
      541 gccccaatga acatctgcac taggcccaag ccttggagta atttacctga agagtgacac
      601 cattgatttt gaaactacta tgaggaaact gaagcccaga gaggtgaagt gaggtgccca
      661 aggccacaca gcaagttaga ggcacagcta gtacggtagc tcaagtctcc tgactcccag
      721 tccagtgctc ctcccattac tccacgagtc ctgtctctaa gcttcctgac aaatgctaga
      781 acggaagaaa cccaagacag ctgaaaacca gaaggcatct gaggagaatg agattactca
      841 gccgggtgga tccagcgcca agccgggcct tccctgcctg aactttgaag ctgttttgtc
      901 tccagaccca gccctcatcc actcaacaca ttcactgaca aactctcacg ctcacaccgg
      961 gtcatctgat tgtgacatca gttgcaaggg gatgaccgag cgcattcaca gcatcaacct
     1021 tcacaacttc agcaattccg tgctcgagac cctcaacgag cagcgcaacc gtggccactt
     1081 ctgtgacgta acggtgcgca tccacgggag catgctgcgc gcacaccgct gcgtgctggc
     1141 agccggcagc cccttcttcc aggacaaact gctgcttggc tacagcgaca tcgagatccc
     1201 gtcggtggtg tcagtgcagt cagtgcaaaa gctcattgac ttcatgtaca gcggcgtgct
     1261 acgggtctcg cagtcggaag ctctgcagat cctcacggcc gccagcatcc tgcagatcaa
     1321 aacagtcatc gacgagtgca cgcgcatcgt gtcacagaac gtgggcgatg tgttcccggg
     1381 gatccaggac tcgggccagg acacgccgcg gggcactccc gagtcaggca cgtcaggcca
     1441 gagcagcgac acggagtcgg gctacctgca gagccaccca cagcacagcg tggacaggat
     1501 ctactcggca ctctacgcgt gctccatgca gaatggcagc ggcgagcgct ctttttacag
     1561 cggcgcagtg gtcagccacc acgagactgc gctcggcctg ccccgcgacc accacatgga
     1621 agaccccagc tggatcacac gcatccatga gcgctcgcag cagatggagc gctacctgtc
     1681 caccaccccc gagaccacgc actgccgcaa gcagccccgg cctgtgcgca tccagaccct
     1741 agtgggcaac atccacatca agcaggagat ggaggacgat tacgactact acgggcagca
     1801 aagggtgcag atcctggaac gcaacgaatc cgaggagtgc acggaagaca cagaccaggc
     1861 cgagggcacc gagagtgagc ccaaaggtga aagcttcgac tcgggcgtca gctcctccat
     1921 aggcaccgag cctgactcgg tggagcagca gtttgggcct ggggcggcgc gggacagcca
     1981 ggctgaaccc acccaacccg agcaggctgc agaagccccc gctgagggtg gtccgcagac
     2041 aaaccagcta gaaacaggtg cttcctctcc ggagagaagc aatgaagtgg agatggacag
     2101 cactgttatc actgtcagca acagctccga caagagcgtc ctacaacagc cttcggtcaa
     2161 cacgtccatc gggcagccat tgccaagtac ccagctctac ttacgccaga cagaaaccct
     2221 caccagcaac ctgaggatgc ctctgacctt gaccagcaac acgcaggtca ttggcacagc
     2281 tggcaacacc tacctgccag ccctcttcac tacccagccc gcgggcagtg gccccaagcc
     2341 tttcctcttc agcctgccac agcccctggc aggccagcag acccagtttg tgacagtgtc
     2401 ccagcccggt ctgtcgacct ttactgcaca gctgccagcg ccacagcccc tggcctcatc
     2461 cgcaggccac agcacagcca gtgggcaagg cgaaaaaaag ccttatgagt gcactctctg
     2521 caacaagact ttcaccgcca aacagaacta cgtcaagcac atgttcgtac acacaggtga
     2581 gaagccccac caatgcagca tctgttggcg ctccttctcc ttaaaggatt accttatcaa
     2641 gcacatggtg acacacacag gagtgagggc ataccagtgt agtatctgca acaagcgctt
     2701 cacccagaag agctccctca acgtgcacat gcgcctccac cggggagaga agtcctacga
     2761 gtgctacatc tgcaaaaaga agttctctca caagaccctc ctggagcgac acgtggccct
     2821 gcacagtgcc agcaatggga ccccccctgc aggcacaccc ccaggtgccc gcgctggccc
     2881 cccaggcgtg gtggcctgca cggaggggac cacttacgtc tgctccgtct gcccagcaaa
     2941 gtttgaccaa atcgagcagt tcaacgacca catgaggatg catgtgtctg acggataagt
     3001 agtatctttc tctctttctt atgaacaaaa caaaacaaca acaaaaaaca aacaaacaaa
     3061 aaagctatgg cactagaatt taagaaatgt tttggtttca tttttacttt ctgtttttgt
     3121 ttttgtttcg tttcattttg tactacatga agaactgttt tttgcctgct ggtacattac
     3181 atttccggag gcttgggtga ataatagttt tcccagtctc cctcggatgg tggccttaag
     3241 gcctggtagt gcttcaagag gtccactggt tggatctcta gctactggcc tctaaataca
     3301 acccttcttt acaaaaaaat cttttaaaaa aaagtaaaaa aaaaaaaaaa atttccactt
     3361 gtgaagagca ctacaaaaaa tatataacaa aatctaaaag gcctactgtc tttaagtaca
     3421 ccgcttgcag tgtttcagtg gacattttca caattctggc cgcttggact tcacagtaac
     3481 cagttaaaac tgtggaatat cacttctggt tgaaaaccca gaggaaaggc cctgctgttt
     3541 tccacctacc acgttgtctg atttcataaa agggctgtgg gggtgggaag ggcagtgggt
     3601 tcggtggtgt gggaaagaaa gacgaatggc aggcttcttc cccagattct gcccgggtcc
     3661 acacaccctg gcccaccttc tccatatccc cctcttgcag cagaagccag gaagacttgg
     3721 acaagcaaca agcaacagtg gctatcgtat ttattcagtg tcttcgctga gccacagcct
     3781 cagcacaatc aagagggact ttcatgaaag gcaggaatgc agataaaaca aagatatcag
     3841 aaatttgcac ctatgtttct aggtacaaga gaaggattat ttccaacaat ctttgcaaaa
     3901 aaaaaaaaag tgtcaggata tattcttgtg gaagagaaaa agaaaaagaa atggagggtg
     3961 gggggaacaa taaaaagttc ttgaggcttt tttaattcaa aattttatag aggggcaaaa
     4021 gtgacgttta ccagatagaa tgctgatttt tttaatatat ttacaacagt atttgtgtaa
     4081 aaaaaaaaac aaaaaaagtg aaattgttaa aagtaatttt tttcattttg gttttgcata
     4141 cactgccacc aattccttct cttttatttt atttcacaca catatatata ttttttggta
     4201 agtcaagact gttaaggtta gcgatactgc ttccagatag aaagaataaa aggcaactaa
     4261 agttatattt gaaagagagg aaggatattt tcttcatatt ttttttaatt tttcttaatt
     4321 tttattattt taagtattgc ctgggttgat gagggcctct gtggccagcc catccctgct
     4381 gtaatttgaa ttgctgcttt gtattttgat atgtagttct ttgactttag caagcttaag
     4441 ttgccccact gaataatttt ttcaactgat tcatctagaa ttctgttctt tttcatggaa
     4501 gagactttat ctttcagaaa gagattgctt gcttctccaa aatttcattg agatcttaca
     4561 attctagaat ttctattgac tttacttttt ttcttagtga aacactaata gtctagaagt
     4621 cttgataaat ggggtctttt cttttgtgat cagccaggaa gaggagttca caaaactctg
     4681 ccatagctcc tcacccttcc caactacaaa gagcatcatt atgagaagcc tgttatagat
     4741 caagatgcat tgatgccaaa attacttttt tccttccaaa tatcaccttc tgactgtttc
     4801 caccatggtt aagagggctg aataagatga tcattcttta gatgacgaat taacccttgc
     4861 ttcttcgaaa ggttttaggg aaattaacaa aaaaattccc agatgccaac agccaccatt
     4921 caaaagacca ccaatctatt gcatcatacc agatgccact ctctcttcct agtagggatt
     4981 tctctcctcg gtcctgatca aggtgttata atagagacat tttcattata gacagtgtcc
     5041 tgaagggatt ccagctcaaa tataggaatt cttaaaccta gctgaaactc ccaaagtgat
     5101 ttcattgctg ggcatatttt aacatactta ggggaaagca aatctttaaa caaagcaaaa
     5161 caccaaacta cagttttaaa aagaagaaag gagagcgtat tttagtttca aaattacatt
     5221 acattttaat ttaattttcc ttctaatttt cctgtcagca ttttatttac aaaaactgtg
     5281 cagcaaacga gggaaaatct tccaacacaa acaactctgt aatgactaaa ttggttttat
     5341 tcatatattt tagacatttg gttaacttgg atctttttca taagttcttt gtgatgcttt
     5401 gtaaggttag tgtaactgaa gtgtttgtga gtttgatttg gtcccacagt gcttaattca
     5461 gtggatattt tgctagaagt tttaatgtaa acttgggtgg ttaactgact attaagtgta
     5521 acctattgtg atttctaaga ggagtcctgc caagaactgt atgtccaaaa ctgatctgtt
     5581 ttaacagtta gtgaggaaca gcttccgaga taaagtaagt tcatttttct attgctaatt
     5641 ttgcttttta aaatagcagt gttgtaagac taatatttcc acttaccacc aatagaggga
     5701 gcattaatta actatgtcat ggaattgttt tgatattttg gaaaacaagt gattccaccc
     5761 ataaaatgaa aagagaagat tgaccttaag aaaaaaactc ttaaagctag gagacaatga
     5821 catgaaatca ctcaatacat gttacaaatg aaagaaggcc aaaagccact ttaaaatatt
     5881 ttaaactgtt tcacagtaga tttgaaagtg tctttgttca aatttagcaa agtaggaaga
     5941 attttcacta ataccgcctg aaaagttgat cttaggtgcc attatgggcc acgtgtagct
     6001 ttctgtttct caaatctgag agagacccat ttgccttaat gctgatttgc catgtaaaat
     6061 gctaagcaat tgggttagaa tccacctttt cttttggtag aacatgtaga gaaaaagctg
     6121 caggtgactt gaaaccctga ggagtctatc atcctttccc tgtaaaggaa gtgtctctta
     6181 aaaaaaaggg agtgggggag gaggtggagg atccctaaag aattcttaat gaggtgatat
     6241 aatcattgta gtccatgaca aaatggacca gccaggtttg catagcagta gacatattcc
     6301 tactgtacat ttatccttcc caaatatgtc acattctaaa atagttgaca aattattttg
     6361 tggaaagagg aagaagctgg attggagtgg gagatctaat ctggaggagc aaagaggtag
     6421 ttgtttattg ctatgttcct ggcccatcaa atggccactt tccaaactga cccacatttt
     6481 aggaaataaa ccaatctgga cctgtttcaa aaggatagag atgcttttag attgtcaatt
     6541 ctcactttta agttaaacaa tcacaaatat ctttagaaat agggaaagac atttgcttca
     6601 aaatcaaaga atgagtgtgg atctttttaa tttttttttg tttcaagtcc tacagtcatc
     6661 ttacatttag accttcatgg tagggtgata tgagtgctaa aaaaatttct ttctagtagc
     6721 caggaaacag atagataaga taaaagcaaa tgttccagat ttaagacttc ttaggatgag
     6781 tacaaggaag agagaaatag tatggaaagg acatttttta gcaatttata attttaaaat
     6841 ggaatttgcc aaacaaggga gaggaaaaaa agtcaaaggg gaatttttat ctcaagatat
     6901 ttagatatgg tttataaaaa aataatattt tctaccacta aaaacactgg tattatctca
     6961 gcatcatggg caatttttcc ttattacatg ccaatatttg tacaaaaaag gcccccaaat
     7021 gtgtgaaata taatcctaaa aaagaaaata attggaacac atggatctgt tacaattcta
     7081 cacaggggga aacaagctaa gcaaagaaaa aaaatctgaa atgaaaatct ctgtatcaaa
     7141 atggtttcct gtatctttta attgagaggt aaactttagc tcctaataac agttttatag
     7201 accgttctct tcccaaattc ctaatgcttt gaatctattt gtgccatgat taagtgtgct
     7261 ggataatttc ctgctcatat tctagcctca gttcattcct agtcatctta gagatcatag
     7321 tagctcttgg ccttagaaag acttgggttt gctgtgttta aaagtcataa gggttttatt
     7381 ttgtatcatc aaaatattct ataaggtccc aaatactctt tttcaaccca tgaacagtaa
     7441 gaatttgtga attctgataa tgaaaaaagt tttcctccag gtatgtttgt ttcacattca
     7501 gtcctaaagc cttgagctat gtgtacttcc ctcacacagg aacaccagct gtcctgtctg
     7561 tgctctgcct gcgcccaaaa ctcaatattt tctctcagca cagaagtcaa aaatgagata
     7621 tgccccttat aaaacccctt cgattcctga gaaaacataa taaagccata tgttgcttcc
     7681 ttgttggggc tcctccacaa tgctcccaac acctgtgacc cctaggaaga cagggagcaa
     7741 ggtggatctg gccaggagtc acaggatata cacccattct ggagctttcc tctgttgttc
     7801 tagaagatgt tatttgatta gttggggctg ggagcagggg atatatgatt ttgtggaaaa
     7861 ggtatcagat aatcaaatca ggtctgcctc tgctatagcc agtgtgctgc tgcattaaaa
     7921 gggaacaaaa ggaaggtgca acgtaagagc agacacaacc tgagatgccc ttgagattta
     7981 ggagaacagg agggcgccct ttctgttgtg acctgactct taaaagaaat cttctaaaag
     8041 aattctttaa tttggtaatg agttgaagtc cagggtaatg gaagctctag ggcagagaac
     8101 aaaagaattg caaaatgtat tcagcaccaa acaatgctaa accaagaaac atccaatcac
     8161 aaaactagga agtttggcaa gaagtggtta gagaaatctc tgggcttttc catgggcagg
     8221 gtcgacagac tctcttttca gtgatttctg gctctgagaa acctctttac tcactagaaa
     8281 agaactttat ttaaatggcc aattttgttc ctcagaaaaa gaaattaaaa aaaaagaaaa
     8341 ataggatact gaagacagaa ccatgtgact tggtgacaaa caaaaggagg ggtgcactag
     8401 aatttcaata ggctccctaa ttccatagaa aaagcaaagc aacccaatgc ctcctgagcc
     8461 tgcagtgcat gaagagagtg cttgagctga cccagccacc aggccttctg gggctagaca
     8521 taacttccca ctggaacagc agcagcctct ttcccctctt tgtgttttca tgaagaaaac
     8581 ggctgttctc ttaggtagcc aggaaataga ttacatgggg caaactttca aaagcaatct
     8641 ctaccctggt gctcaggcta catacagagg cagaaaaggg gcacggaaga gcccttgctc
     8701 ttgagagaga gtattttcat attcccaagg gctttccgtg tagagttgct atttctgata
     8761 tcacttaaac ctttacaaga aaaaaggctg tggtgactca gtgttcctat aaattcagaa
     8821 tgtggaaact actaatccaa agcatcattt ctagcactga gtatcaagac gatcagcctg
     8881 accaaaatat tgcaaagagt tttctaagtc tctgaagatt tttttctcct tgaacactga
     8941 gtctatagca gtcagcaatg taccttagcc gatccctggg aatggttatg gaacagtagg
     9001 gcttgtttcc atccttttta gagtgaagag atagaaaatt agggctacct agtgtgggtt
     9061 ctttttcaga actatgtatt ttctcctcac tgcatgatgg gtaaaaatgc cctgggttga
     9121 aacaagaaac attatctttc cacaccactg actaaaacac ctgccagtgg tttctttagg
     9181 ctccaccttt tgctccgtaa actgtagact ttcagactga aatctaatct taagtgacct
     9241 caattaaggt attttcacaa aaggctactt atagtgtagc attattgcct taaatcagaa
     9301 agccctggga agaggataaa agatatagaa atgagaaggc tctgaagtta taggcatttc
     9361 ttgctgttta atagttacat tatcacaaaa acaagcccta ttcatgattg aggactatgg
     9421 aaatagtgac ttcttgagga ggcaccaaac tttcctagaa ctgggtactc tcagatagtg
     9481 gctgctattt cctattctat ttcagtgacg taggttgggg ctgaatgtaa aatagacatc
     9541 atattactaa atagaatcct ataaaatgca atcacaggtg cccgggagta ctagttttaa
     9601 acatttcctt aacaaggaga acaatccagc aaaaagcttt ctttctctat acagtgtata
     9661 tctctaaact ttttttcctc agttttagag aacatctgtt ttatctggtg gttctttgtt
     9721 tgaatgcaaa ctcataactt tcaagtctcc ggtgcaagag cataatctac agatcatggg
     9781 caaaatctag ccacagtcct gagagtccag gcttctggga tgcccagctg ggtataaaag
     9841 tccctactaa ccctgtttca aattcagagg tttctttggt ttagaatgcc tcaatgagat
     9901 tttgatacat ccaagagaga aaaaaaaaaa aaaaaaaaaa aaaaccttgg gggcatctgt
     9961 ttctactagt gttgcaacag ttgtttttac ccagcaaact cattgcaatt tatatgtaga
    10021 ttctaataat gaaagagtct taacccatcc agtatgtcac cgctgctgtc caaaatgtct
    10081 ataaatgagt atacattatt tatacatgtg cacacacagt gtgagcttcc ctcagcacaa
    10141 aactgtttca cattcatatt gcccagtgac aacaagatac atttttgaac ttctggttag
    10201 aagtcgaagg tctgacatat ctcacgtatc tgcttatgct ttgttgcctt agttgggtgc
    10261 atcagtatct gtgatgagac tttagggcat tctgaaggag cccaaccatc agtaatttct
    10321 atgtatccgt ttcatgagaa acttgaatat gcttatgtgg agtagagtgc atttaacaaa
    10381 ctctacagtt ctattggatt tattgacatg tgtgcacatg tgtgtgtttg tgtatatact
    10441 tattgtcatc tggaagtgtg tgtgcccccc aaaggaagca cacacaggca gaggtcctcg
    10501 tgcatagata cagttgcctc ttcccaccat tgtgtttaag acttgtggct cccttcccag
    10561 gaagcagtca cctgcccact ctgttgcttt ttgtaatgtt tcagaattgg gagaaacaaa
    10621 tgcagcttgt tgaatccaca gcaaacccac agggacaggc tgttttcctc cataataagg
    10681 tataacagaa gtcttcaact ggtgagcaga caagagggag cagcagtcca gggcgtctcc
    10741 ccaggtctcc tggaggtggc aggggtgggg accaatgcca ggcaggcaaa gcccacacaa
    10801 actttggcct gagccatccc atagctcaaa ggtcttcatt cctttcctct atgcaatgca
    10861 gtgtgcacac acacacacac acacacacac acacacataa attttattct caaactaaag
    10921 cttcctaatt ctgcctgtac tcacaagata tcatcgtaat tcacaaactg tgtctcctga
    10981 aaccaatgtg gcctttgcca aagtctttcc aggagtgggt tgtttaccat gtctagcaaa
    11041 ccaatagact gttgggggga atgttttttg gtaatctgta ggaattgatt gctcttgccc
    11101 atctcaagca ttgaagtaga atgccactct agtataatat actgaatgaa tggactctga
    11161 gggtttggtg gcctggaatt caggattcag ttttctcact cccatgccct tcttttacta
    11221 gatggtttgt tattttttat gatttgtaca ttatttctgt tttacagaag tcagaggaca
    11281 ttttctttcc tcttctattc tggtgacttt tccccttccc ctgttaagta aggctactta
    11341 cagttgcaac ttttttgtcg ttattacttt ttaaaatgta tattgtcttt ctatatccaa
    11401 aagaagtctg taactgtaac cataggtatt tctttttact ggaaaaacaa ttagttgttt
    11461 cggttttatt ttttccttta attaacagta ctagtgactt tgtgaaagaa tatgagttac
    11521 tatttaggta tgcttactta actacaatac actacattgc agtatttctg aaacctagga
    11581 catacacatt atatataaca actctatatt gaaatatata ttacattata ttcattttaa
    11641 cttttgaatc tgcctatgat catgagttga ttgaaatatt atgtctttgc ttatatcacc
    11701 catcaccaac ctgctgcagt taatctggtg catctagtaa taatcattag tgctctaatt
    11761 tgctttttat attatcagct tcagtattgt ctttagagga ttttagaatt ttttaaagct
    11821 cagacttagc aaatgtagga aagtgaaaac tttttttgaa acttttttgt tggtgtgact
    11881 aatacaaaga ggttcatatt caaagtgatc ttgtttagct gacccactca atatctgaag
    11941 aacaaaagag gtgcatatga atgtatctgt gattttcccc tgtaggactg tcactgtcta
    12001 tatttgcttt taaaaatatg accaaggggc tacttaagtg ccacatgatc tgaccaacaa
    12061 taacaggctg cgtttcaaag ggccagtctt ctgaaaagcg taagacagtg aattacctag
    12121 ttgtccccac tgtattctca aacattcatt ttaatactgg atctttacac tttctttttt
    12181 caatacgctt agaattattt taactagtct tcaacctttc cctggaggca gcttggcaat
    12241 atagtgttca ttttcctggg agttgttttt tttttttttt tttttttttt tttccaaaaa
    12301 aagtaaaacc agagtttcag gaactcttta tccacagagg ctaatagaaa tagaatttgg
    12361 aaatatctat ctgagacatt tttaaatctg aggaatccgt aaaatggtgg ctcttgggta
    12421 tccagccctc aggatctcca tttacctgtt aaagtgagga tttggtgcct ttcttcttta
    12481 gttgggccat caagaaaact tcagaaatca ggcattctgt cttcctatac aataaatatt
    12541 ttcagatcat attttcagat aagagtcttc agcttccctc agctattcaa cccaatgcat
    12601 ggaaagcctc agttgaataa acttttccac catcccaggt gcctgaaact agtgtccttc
    12661 ttcacttcta cattcaggac aaaatgaagt caggttttta aaacctcagt ataaaagacc
    12721 ccctcacact ggtccaatat gaagacttct cagcgtgaac actggggaat tccttccttt
    12781 catctttcct aatagattgt tgttttctaa tcccatccca ttctgctgta cctctccagc
    12841 aagtcccttt tcaccttagc caagctccct gcaatgctct tcagttgtga agccttgtat
    12901 tcactaagga actacgtact cttagtctgc tttgaaaggg ctaatgtcta gtgtaatggc
    12961 aaaattacca atctgttctc caaagtgttc cagcagatat atttctacta gacaaacata
    13021 attgtgaatt gactgttagt gaggctgttt cttctctaat gatcacataa tatccaaatt
    13081 atatcaactt cattatttcc ctctttcctt ttcctaaccc tttcccttta tttcttgttt
    13141 ctcttgaaga ctacttcaaa ttacctattt gtcttcatta ctgcccccaa aactctaata
    13201 attgtgaccc ctaactgttc atttctcttc ctttctccac cccattctga acatccttct
    13261 ttaagtttta tttaatgaaa gaacactaaa gtgagtgagt tcataaactt gagactcgta
    13321 ggcagagtga agcatgtctt cattttagct tcagagttta aaagttatca atattctttt
    13381 gagagtggga ggacctgagt cacagtttta aatgtcaact gtactagctg aggtcattaa
    13441 ttccccttac cttcacgttt ggccaaaaat gaagagaaaa atattttctg tttttttttt
    13501 aaataccaca gtgttcaggt tcttcatatg agtaaatcac ttttgacgga gaaaaaaaga
    13561 atcattaatg ttgactgttt ccactagtca aattacttgt ttatcagact ttagattata
    13621 ggaatctaaa gaaaagagta acatttcaaa ataattttga taactgttca agccttagtg
    13681 agctcttctc aaacaagaaa agccacatcc acttgaacac attgtaggaa aaattaggaa
    13741 gagttttttt atttattgcc tttttgaaaa aaaaatcatt gatttgttta gaactttgag
    13801 cagtaactta ctaatggatg aaaagatcca taaagttttg aaagtgtctg tttttgcaac
    13861 cagagattgc ctaaacataa acttaatata tacttaaata aaataataac agagctaaat
    13921 ggatacctaa agagccatgc agtgcactcc ccagcaccta aatacgcccc atataatttg
    13981 gttgtcatgc tagatctccc tgcagtggat tacaactgtc tggtcaccag agcattgccc
    14041 aaaagactga ctgataccat tctgggtgta tccttttcag gatgcttata atatcacatt
    14101 cacaacaact tcgtaacaca gtctttcctg acttctggtc caatattctt gccatgatac
    14161 cacatcgcct ctcagcttta atgaagacaa gtcctgtgac atttagagta ctatgtggtt
    14221 ttgagtgcat aggcggtatg ctttcagttc ttgctttacc ctttgacaaa aagaatcaac
    14281 atttaatatc agaaatgtat ttttatttga cttgagattt gacccagctt ttatcttaat
    14341 caaaccagtt tataacatca actcacacca tagagaacaa tgaaataaat agcagttttg
    14401 aaagccttta tgaggcatgc atctagtagg aaaacaacat ctcttaaagg caatatttac
    14461 attgcttagg actatgatct tcacttggaa tgttctccca atcaatccta tatccttctt
    14521 tttctttgtc cattctaact cctggtattt tttttttctt aaagtactct ttatctaaag
    14581 taatcctctc cttaggcact ggcttccaaa ggaagaaaga ctcttttaaa tcctaaaatg
    14641 ctgtcattta aagtataata tggaggagga gaggctctgg ttctgataga tcttacttgg
    14701 tcctcaatct gggatgcctt cttgatgctg ttctttctag ttccccaaga agtattccaa
    14761 ccccaagacc cagaatttct caccacaacc tctgtgttag tctcagatta atgtctaaat
    14821 cctgtttgat attctagaga ctccagggtg tgaatttatt attgcttatg agcctcctgt
    14881 ctttccaagc tgacacctgt caggagcatc aatagcccta acagtaacta atgcatcaaa
    14941 ataatagaca gaaacactat agtatatatt cgtgaggata ggaagatttt tttttcttct
    15001 tttctccagg aaaagcttgc tttgctcccc tctccctctg caacacacac acatacaatg
    15061 catttcagaa agtctgcatc ttattttaca gatatgtagc tctagaattt acaaatatag
    15121 cttaggaaat gttctgagat tgaggctggt agcaaacaag tttattttct gcactggact
    15181 tcaggataag tgtgcataga tgcaattcct tcaaagaaag tgaaacatgg tagagcaaag
    15241 ggataatact ttcacacatt caaacagttg tttgctatct ataaaccttg atttaagcat
    15301 aattattact ttttagaaat ctgaaactgg aggaatgtgt attttagtaa ggtttttttg
    15361 ttgatttatt tgtttccctt tctttcttct caagatagta aaggattttt atttcttaat
    15421 ttgttactgt ccatggacag tcaaataact gctcaccctt actgtattat tttcccctta
    15481 gaaagaaaag ccttccatcc taccatgaag gaatttttcc tccaaaaaat cttatcttcc
    15541 atttcaaata gcactcatga gcttttaaga gagaaattct ctctttactt tgaggataga
    15601 acagttaaaa caaaaacctg ttccttgaga aagaaaccgt atttacctaa actaacaggt
    15661 ctggggccaa agaatagatt tttttattga ttgcagatga agaccatgca ttttgtacta
    15721 caaatcctta ttgcctcctc aaatcctttt tggaataagg ctgggaataa attagtttaa
    15781 ttaaattctt tgggtatttc taattaatat ctactgcaag atacccagga aagaaaagga
    15841 aggggtgctg ccgaaatgcc aaaatcaatt gatctgttga tttttatcat tgtagttgtt
    15901 gcttttctag ccatttcaag actgtatgtg ttcatgaagt cttaagtaga gaaacacctg
    15961 tttccccatt gcttctctct ccttccccac acccctgcac ctgccccaac cccaggcact
    16021 agagggaaca gtaacagagg gagattggca ctgcattgcc agtacttcac ccatctatac
    16081 ccctccacca caaaagaagg aaaaaacaaa ttagaaacta tttttttaaa aaaggaaatt
    16141 gtagtacttc atttgaaagc atactgtttt caactcaact cgattaacag atagcctgac
    16201 aacgtttttg taacctttct tttgtgctat aattgacatt cttggctcaa tctttaaaat
    16261 aattgcaatt tcaattaagt gaacagagaa aaacaaagag agggaacagg acaatgtgat
    16321 gggaccaaat ttgatacagg tctggattcc taaagccagt tgtcaaggtt accggagaaa
    16381 gttagcacta ctcacccctt gttgttcttg cctatctctc attattacaa ttcaaagaat
    16441 tagtaagtta actatacttc tttgtgatta aagatttctc ttcatgctgc caaacacttc
    16501 tagagaaatt gtagaaactc ctgacttcta tacctaatgt gctatccggg cccgagagga
    16561 gtgtacagag agatcactga aaataaaata atagttcaaa tttgagataa gattttcctg
    16621 tagttcaaag tgctttatgc atgttcacaa ctaggggaat ctttgaaaac aaaggctagt
    16681 tactctgctc ttgctctcct tgggacaaac tttaatttgg aaccagctgt agatttacag
    16741 gagaaaattc tcaaaggtat tttcagctgc taaacttctt ctttaggccc gttgatttga
    16801 acctcagttt tcctgaggag cctattgaga tataaattaa gggtaatttg catatatcta
    16861 attaaaattg ttcctacact attgttgaaa gaattatggt tttcagagta gatgaaagca
    16921 gggtgtctta gtaatcttca tcatggcaaa caaaggtgag aagctgatat gatagagaaa
    16981 atctatggta acttgatatt ttaaggtaat ttgagtgtgc tgaccccact atgcttaatt
    17041 cctttcccac aatctatttt aaactacact ttgattctct tgagacttac agcatgcatg
    17101 tgtgggtatg agcagacaag cagacttacc tttggagggt gaagacccag acaaactgaa
    17161 gaaacggatt cctgaggatg atcaaataca aatcattttt ccagaatcac tcaatattgc
    17221 cacatcccaa actaattcta gactaatctt tagaaagaag taagctcctt aagaaatcct
    17281 actatgaatg ttttttcttc ttatggaata acacaagaag aggtacaatg cagactctta
    17341 attttgctgt aataattcac ttttgtattt aataattgta cttctgtgtg agtgtgtcac
    17401 tgagctattt gtaccaattt tcaattgatc attctgagag gggccttgag aatttctgtg
    17461 tatgtgtatg tatatctgta tttatgtgta gtcagaaaaa aaaaagaata ggagactaat
    17521 gaggtgaggg aaaaagtgat caatgtagaa aagtgagtgc tcctagtgta cctatttatg
    17581 ttatgttagg tggctgctgc ctgtagccct tgaggaatag ctgattgcac tattcaaaaa
    17641 taaaagccca gcactgttaa atttaggacc gtgtttcaag aaacaggaaa gctttatctt
    17701 tttctgaacc cattcccctt agcattagag ccatctgaca tgatgaaaac tattaagtaa
    17761 aaaccactac tgacctttac attaaatagc tgttttcctc ttctaaataa tacccttgat
    17821 tttaactaga ctacttcctt ttattttctg cctattggct taatgtttta cagaaaatac
    17881 ataggtgcat gctagtttct ctactttgag ctgaaacaaa caggagcaac aaaagagatg
    17941 actcacataa gtgtgagata gactgaattt cccaccttcg tagcactggt aacctttgta
    18001 agagctgttt agagttgagc tttgggttat aatagggctt ttttttgcac taaatatgac
    18061 tgcactgcat tgcactactg aaatgtactt acttgtgctg ggagagagtg tgttacgtat
    18121 gggaaagaaa aaggcaaatt atggaagtag gagcatcact aaaatgcaga gttattttca
    18181 tcatgcttga tcttagcagg gttggcgaga atctgtggaa tctctgtcaa ctcttgatca
    18241 ggcctaggaa ccaccatgct gataggatct gttttcttac tgtaaagaag ctgagttagt
    18301 acagcaatta agaacattta agaaaaagtt tacccaatct tgtttctgac tgagctctca
    18361 gtaagagttt taacagtgaa gaagccaatt gatatgatgt agaagtcttt gccttggcct
    18421 cctccacaaa gccccttgct tgtgcacatt ttagtgtggc agagggcagt aggatgtgct
    18481 cctttcaaaa acacatagcc ttgtccatat tggaattact tttcagcctg attatgcttc
    18541 tccatccctg ggtgaaacct agatcaggct aaccaaagag gaaggctatg catgtggtaa
    18601 agtcctttaa gatgacagat agggaacagt gcaataaaca ctgaaaacca gtgaagtgaa
    18661 aggtttattt tgaaacaagc taggccaact tggacattgg aggatggatt agaacatact
    18721 agctgctcca tcatagacta tccttactaa gcagaagacc ttaatagtgc ctaaaagttt
    18781 agttttgaaa ttggtttttt cctaactttt ctttgttaaa tttattttta ttatcttttt
    18841 taatcttaga agtaatcaga gtttgacagc tctttagtaa ctgttaataa aagaatcttt
    18901 catcacagga taagcaatag attgtgtggg aaataataac acaagagtaa agatgctgaa
    18961 ggactcttct ggaactcaaa gtgacagttt tgaaggttct ggcacagtag gaaaggatca
    19021 caacccatat aaatggctaa tgttgaattt ctctgaacac tgtcacatat ggggcatcaa
    19081 tttggaaaat tctcaattga ggccccttcc ctaagattac aacattgata acctgtcttt
    19141 ttctctctct tctttactat ccgtccaagt ctactattcc aagtttaaat attgttcaga
    19201 aagttgtcag ccttgttagt cagaaaaact ccatttagag ccatccaaac tagcataaga
    19261 aattccttaa gcactcaaag cattatctct gttttaagta agaaactaaa tccagagctt
    19321 ttaacaggta cttagaaata agtattgggt aatcactaag aggacattga ctgcaccaaa
    19381 ccaaagctat agaaagaaat gattgacttt ttaaaatata ttcacattaa ctgtcctagg
    19441 atacttctct tgaggctttg gaaaacttct tccttgaaat ttgcatatcc actccagttc
    19501 tgtcaccaaa gattttaatc ttcagatcgc aatttcctct ctcccagaaa aaagtactac
    19561 aacaggctca agggatatgc tttggtggtc aagggattac actatggttt tccttctgtt
    19621 cacaatggta tttacaggag accttgtcat cagaggacgt actgaactat ctttatgact
    19681 ttggatttga tcagaggttt aaaaaataga aaaaaataaa caacactact tgacactgta
    19741 aatgatcttt aatagagtca tgacctggag actgatggag agaaagaaac ttccatggaa
    19801 gagagtgagc taaatcattt agaaccaaac aaaggtcact ggtgaaacat agggcagcat
    19861 gtacacagtg cagatcaggg ttctgtatgg ccagagccaa cagcagtgac cggtgggaga
    19921 gtcagacaac tggccaatga attcaagtgt tgaaaaagcc acagtctgga ttttgttgtg
    19981 atttctggag tggttgaaac gcccatgccc atggcaagga aaatgcttgg aggctgatct
    20041 gttgtgatag tgcctttctt gtcgtagtga gtactagatt aataatttat tcagttacgc
    20101 ttttctgtac cattgcctcc agtcttctga ggaggtttga agggacagta tccacttagg
    20161 atgaagggac aggatattgc tctggaatgc tgtgatttga tgatatttgc actagattct
    20221 aaactctcct ttaaactgga gcaactgact gagagaaaaa ccaaggacag ctcaaagtta
    20281 aaagaaacca aaagcagtat tttctgacag ataccatttc tttttctcct tctttttttc
    20341 ctggaagaaa acttcacact agttggctac cgagctcaac tcttaccagt tctttctctt
    20401 tattttttgt ttccatatgg aaccatctgt gtgaattagt catcagttag gtatagttaa
    20461 cgtaaagagc ccctgccatt gaaactttgc acaccttctc tgctttattg aaggcaaggg
    20521 ccagtgggca gtgatagcag gggagggacc ctccagaacc acccagccct ccaggaggcc
    20581 aataagcatg gatatcatgt caggagctga gctgacatat atttactcag aggacattgg
    20641 ggtctgtagc taatcctaaa gaatgctccg caacagaagg aaaccaatgc attgtagaaa
    20701 acaaagggag atggtgcccg aagtctgcct gtttctcttc tcttttcttt cccatctcac
    20761 caccatgtcc tctctaacag aattatattt catctcatat attatatgtt actagaaaag
    20821 tcatttggtt ccttggtttc tctctttatc agtgggctgg aaattcctcc aaattaaata
    20881 taaataccag tagcagctcc cctgtgtcca gccagtttct caaatgctgt ccacctggtc
    20941 ttactgtcca cctaacataa cttggaggct ttggctggct caaccacctg ttcactttat
    21001 tttgttttca tttccatttg aacttgaagt gaggctatgg aaaggtggaa atcatgggca
    21061 aggtttggag gctgcaattc tagggcatag cttgtcagga gtttatatta tctaaaatat
    21121 atctttctat accccttttc attttaatct gttgccctga ttataatttc tttatatttg
    21181 tggttatttt tataagaata gagtccattt gctatgtcta tttgagtact ttttttctat
    21241 tgtccccaca tggatgcagt accaacctgt taatgaaata tctttttatt atattattaa
    21301 tatgtaattc tactgtagac caaaaatata aaaacaaatt tgttcatttt aaagatataa
    21361 agaactaggg agtaaaagat taaaagttga aggaaaagac agaagagcag tggttaacta
    21421 tgttgagtta gaaatctaag agtagcctta cctgtttttt aaccagtgct tgccaatcat
    21481 accatagttg gaattatgta atcttggctc cttcatactt atgttctata attcttgttt
    21541 gtctatttgt tttctttgat ataattgagg ttgcacatca tgctattctt ggcaatgcct
    21601 gattctattg tattgtactt ttgttagtca tttcctttag aaagatgggg ggaaacgttt
    21661 atttcttctt ttaatttaaa atttgtttaa tgcactggaa ataaaattgg acatatttca
    21721 ctgtttaaaa aatcagaaac aaaacaaagc aaaaccatga gggaaaaaaa cagcaaataa
    21781 gcaacagggg aaaacagcta tgaaaaaaat atatttgtac tgaatacaca tacaaactac
    21841 atcccacatg aaagattaat atcatcaagt aagaaaaata catagtttaa actacaatgc
    21901 tgaaaatata aaaggaacct ggtagttcaa tggggatgga gaaaacagag cattcctctg
    21961 agagcagaga tcttgtcatt attgcaatta atgcccaaac aggttaaatg tggaagaaag
    22021 tatggaggaa ataaccccag ccttcctcat accactggat ttccacatca ccttttaact
    22081 tatgcttgag ctcccttttg agaaaaaata tttaaaaaca aattggctat gtaacaaatt
    22141 tgtgtgtgtg tgtgtatata tatatgtata tgcttatata tatatatata tgtatatgct
    22201 tgagaaagtg gtttttcaag atgtatgtgt acagtacaca catggacacg cttcagtcct
    22261 ctgacttccc atgtgctacc tcatgtgttt ctcttctcat gaggatttgc aatggatagt
    22321 tgtacaacct ggggactgtc agtgactcat tggtatcagc atatgctaaa gaagctcttg
    22381 aatccaatct tgaaacctga tctcccttcg tcaacattcc ccaataccaa actggcccgt
    22441 ttacccatac aaatgcacag taaagggaag aacagcggta tttttcctag ccaactgact
    22501 ctatcatttg tttaatgttt gctggttttt ttctggtttt gttttgtttt agagcagggg
    22561 tgggagtggc tgtaacttca caatcctaat acagtaaatg ttttgcatct tccatgtttt
    22621 atgcaaaaac agacatttaa atcaataaat aattgtgccc tagactgaag gttaatgttt
    22681 aggagaggaa aaaaattgtt ggaatttttt ctacattttt ttgtgaagaa tcttttttgg
    22741 aaaggaagga tacatatttt tgttgtgtaa tattttctat ttttgaatgc attttattgg
    22801 tacaagactg tttttttggt gaagacatta tttaaaaaaa aaaaaagaaa aaaactaatc
    22861 gaaaagtttg cccttaagga tatgctgcag ttttgaggtt aaaaaaaaat tactgattca
    22921 agatgcgtgt taaaagttgg gattatattg ttgttttttg taattgttac aagaagaagt
    22981 ttgtacccac tgctgtttat tttgtttcag atgagtaagt aaagggattg ttcttgtttt
    23041 attctttttt tagagaaaaa aagctattta tgaaatgtca aaaacactgg actgtgagtt
    23101 taagtgtgga agcattttac caccctgtgt cttcaaccaa ttatgggaaa ccccttttct
    23161 cttcccccta ccccctgcct tagccttgcc aaatgagaaa aatataacag ctgtcagatt
    23221 atcaaagcca ccgaagccct gctttaattt ttatggtttg aaaaagttgg aaaaccaaag
    23281 ttaaatttgt ttctgaaatc ctgctgtgcg ttgccctttt ttgtatgaca cagccgggct
    23341 ctgcctctct atctcaaatc attgccttct tagggactgg gggccaacct gatgcaaaga
    23401 gaggcataaa ggtggtgagc ctgagagttg aggtctcacg aagtaaaatg tgagtgggac
    23461 ttcaccctct cagtgggcaa ccacactttc ccatcctgag atgaggctgc caagagagca
    23521 cactgctaac actgcctgag gagagcacgc ctcctgtctc cttcaccctc tgcttctgag
    23581 accctcctgt tactgttatc atcgttccct agcctggctc tgcctttctc agcagcccac
    23641 attccatgga tgggagcagg ggggcaggga cccaaaggag ggaaatggct gtgggtggtg
    23701 tgaaggcccc ccagccctca ggaaggtggg gcaagagacc actgagcaca agggatcttg
    23761 cccacctcct ctttgactct gtggattatc catccatctg ctcactgtga agatggagag
    23821 gcagtgccct aaggctgttc aatagctttt ccatattttt tcaacattga aaaaataatt
    23881 tttaaaaact gtgatttttt taaaaaatca tttggctgga gggaagggaa aagggaaaca
    23941 ccaaaagctg taccatgatg aactggagat atttaactgg ggcactttcc agaccaagac
    24001 aaacaaattc ctttctggac tctaaagcag ccgaatcttg agactgtcaa tgacagaaag
    24061 ctgaagagag gcctctattt cttccttttt cctttcttct gtctaaaaac tctctcttgt
    24121 tccccttttc cagcttccct tggactactg ccccaatggc cccttggact cgcgtttcat
    24181 gtatgcgagc acacacacac acaaacttgc aaaataccgt ttttcttaag gattgtggga
    24241 ccgaataata tcacgtgcct tcatcttttc cttttatagt tagatgaacc tcttcctctt
    24301 tacaattttt ttaaaaagtg ataggggagg ttgatgtgtt agtggaagat ttgggcatcg
    24361 tttgagaagt aacttttgtt taacacattc cccctaaaca ttgaacacaa acatttcaac
    24421 cccttcatga cactctttgg acatttaaag cattgagtaa ccatgtacat gacagcctaa
    24481 atccgtttga tttcagagca tttcctgaac attgtatttc atagacttct ctgatttttt
    24541 caaaaatgag gtgagcaatg gcaagcagcc ttgttctccc aatttggtgc ttttgctttt
    24601 ggtgtggggt gggcatgggg ggttgggggt ggtgtgggtg tgtttagaaa aaagatgcat
    24661 tcctgaagat ctctggtgct gaagggcctc gagttccttt cagagactgt atttgacaca
    24721 ctttaggtac acacaaacga atggtatcac atgcaatatt ttaatggagc aatgggagag
    24781 gctctttgaa atggggtttg catctttttg taacattttg atttctctgg tgccttattc
    24841 ctacttgatg ctggcactca catacccaca agaagctgac acagaagtca gccttaggcg
    24901 tggggacata tgggtgatgt ttgagcatgc aggggccatg gggagtttgg tgtcagttgg
    24961 tggagaaggg actagatggc atctcttagc cgaggccaac aggaactgca caagtccatt
    25021 atagtcaaag ttagcaattt tgatacgtaa acacaatact tcattcttcc tcatctgagc
    25081 tttccttcct tcttcctttt ctatctctac cttctcataa aggtgctgct gctgctgcta
    25141 aggtgcccgg agtccagaat gtccattaat cactcaggca cgagcctggc actgccacgt
    25201 cagcccccag catgaccaaa cccaggtttc tcttgcttgg ggctgagaac tgtcagattt
    25261 ttctcatcaa aaatgttttc caaggaatca gtggattaca gtttttctgc attgaaaatg
    25321 cactttaaaa aataaattaa agctccagac tgtttaaaat atacagaggg agcaggggaa
    25381 agttaagcat gtgctagtgt ctgaacccag ttcagtttat ctccagttga aacgatatac
    25441 actatattat gtataaatgt atacacactt cctatatgta tccacatata tatagtgtat
    25501 atattataca tgtataggtg tgtatatgtg catatataca cacatgcaca taacaaaatc
    25561 agatgctcat tacaaatcca gatgctcatt acaaaaccag atgctacaca aacagcagca
    25621 gaggaaacaa ggttggactc ttgcaacaga tcacaaaaaa taaaaacagc tacttgcagt
    25681 gactttggtc atttctgtat gttcataaag aatggattgt aacaaggaaa aaaaggaaca
    25741 gtgttagtga aaaaggaaaa atgggcgaaa ccatcttgat ccgatgcgaa tgcagtaatg
    25801 ttctatatac catttcatca gttatttctt ttagtcatgt tgatttgatt tcagtttctg
    25861 gctatgaaaa acatttttaa actcgtcacc cacaacaaac tgaacaaaac tactacagtg
    25921 aaagcccttt tcagtgaaag atgtcagaaa cctcaaaacc tttggcctga ctcagaacta
    25981 ccatgtgaaa atcagtactc tcttaatgtt tgaaataaaa actgaaaaaa aaaacaaaaa
    26041 aacaaaaaac cttttttgaa gcaccttaac gtggccatcc atttgagaag tgggtgccac
    26101 ttttttcttt gagcacctta ttgatgtgtt tgctatctgc tgtctttctg ttacctgttg
    26161 gctgaatggc tagctgttaa catatacatg tgcacagaag agatatctgg gcatgtatgt
    26221 tctcaatgaa gtttactgtg gtgactgctg aaaggtgaac ccatttcctg attttcccgc
    26281 cgcagtgttg tgataagatt cgaagaaacc tttttccctg cacagaaatg tttcttatca
    26341 cattgtatct tagtatggaa aggaatatgg tccctttttt gcaattgcta ctgtgtacac
    26401 acacacacac acacacacac acacacacac acactgtatg tttagaccta aaatacacac
    26461 acccacgcac acactgtatg tttatgtgac ctaaaacata cacacatgca cacacacata
    26521 catatccatt cattcattca ttcaagtggt gtttccagtg tctgtgtgtc actgtttatg
    26581 cagtttccat ttcccagtga attatgagtg gagggcaact tttctaacca gattgtcttt
    26641 tcagaacaaa gacctgggaa ttgaggaaga gtttggaaag agggagaggc aaggaaagag
    26701 agctttaaat tgaaaggtta atttcctaag aggaacctgg gctgaatgac tgcagtgtta
    26761 taccctccaa tctttgcagg tgggcatgga acactgcttg tatcactctg tgcacggtat
    26821 aaatccatat atccacaaaa acacacatcc atccatcaac atatacatgg tttgggatga
    26881 gcaggtcaat agttttgaga gggagtttgt tccttttttt ttctcattat actcttaaat
    26941 tgttgtcagt tatcaaacaa acaaacagaa aaattgtttg gaaaaacctt gcatacgcct
    27001 tttctatcaa gtgctttaaa atatagacta aatacacaca tcctgccagt tttttcttac
    27061 agtgacagta tccttacctg ccatttaata ttagcctcgt atttttctca cgtatattta
    27121 cctgtgactt gtatttgtta tttaaacagg aaaaaaaaca ttcaaaaaaa gaaaaattaa
    27181 ctgtagcgct tcattatact attatattat tattattatt gtgacatttt ggaatactgt
    27241 gaagttttat ctcttgcata tactttatac ggaagtatta cgccttaaaa atacgaaaat
    27301 aaattttaca aggtttctgt tttgtgtgga agagtaattg atgttgctaa gaatgatgtt
    27361 tgtttttttg gggtttttgt tgtttttttt ttaaatgtta ccagcacttt ttttgtaagt
    27421 ttcactttcc gaggtattgt acaagttcac actgtttgtg aagtttgaat atgaaggaat
    27481 aattaaaaaa aaaaaaactc ttc
//
