LOCUS       NM_020861               3103 bp    mRNA    linear   PRI 24-OCT-2024
DEFINITION  Homo sapiens zinc finger and BTB domain containing 2 (ZBTB2), mRNA.
ACCESSION   NM_020861
VERSION     NM_020861.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3103)
  AUTHORS   Kambe,G., Kobayashi,M., Ishikita,H., Koyasu,S., Hammond,E.M. and
            Harada,H.
  TITLE     ZBTB7A forms a heterodimer with ZBTB2 and inhibits ZBTB2
            homodimerization required for full activation of HIF-1
  JOURNAL   Biochem Biophys Res Commun 733, 150604 (2024)
   PUBMED   39197198
  REMARK    GeneRIF: ZBTB7A forms a heterodimer with ZBTB2 and inhibits ZBTB2
            homodimerization required for full activation of HIF-1.
REFERENCE   2  (bases 1 to 3103)
  AUTHORS   Song,J., Ke,B. and Fang,X.
  TITLE     APC and ZBTB2 May Mediate M2 Macrophage Infiltration to Promote the
            Development of Renal Fibrosis: A Bioinformatics Analysis
  JOURNAL   Biomed Res Int 2024, 5674711 (2024)
   PUBMED   39328595
  REMARK    GeneRIF: APC and ZBTB2 May Mediate M2 Macrophage Infiltration to
            Promote the Development of Renal Fibrosis: A Bioinformatics
            Analysis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3103)
  AUTHORS   Qi,C., Zhang,L. and Wang,W.
  TITLE     The novel circ_0004674/miR-139-5p/ZBTB2 regulatory cascade inhibits
            the development of oral squamous cell carcinoma
  JOURNAL   Head Neck 46 (7), 1671-1682 (2024)
   PUBMED   38665011
  REMARK    GeneRIF: The novel circ_0004674/miR-139-5p/ZBTB2 regulatory cascade
            inhibits the development of oral squamous cell carcinoma.
REFERENCE   4  (bases 1 to 3103)
  AUTHORS   Chow,C.C.T., Kobayashi,M., Kambe,G. and Harada,H.
  TITLE     ZBTB2 is Recruited to a Specific Subset of HIF-1 Target Loci to
            Facilitate Full Gene Expression Under Hypoxia
  JOURNAL   J Mol Biol 435 (15), 168162 (2023)
   PUBMED   37257772
  REMARK    GeneRIF: ZBTB2 is Recruited to a Specific Subset of HIF-1 Target
            Loci to Facilitate Full Gene Expression Under Hypoxia.
REFERENCE   5  (bases 1 to 3103)
  AUTHORS   Koyasu,S., Horita,S., Saito,K., Kobayashi,M., Ishikita,H.,
            Chow,C.C., Kambe,G., Nishikawa,S., Menju,T., Morinibu,A.,
            Okochi,Y., Tabuchi,Y., Onodera,Y., Takeda,N., Date,H.,
            Semenza,G.L., Hammond,E.M. and Harada,H.
  TITLE     ZBTB2 links p53 deficiency to HIF-1-mediated hypoxia signaling to
            promote cancer aggressiveness
  JOURNAL   EMBO Rep 24 (1), e54042 (2023)
   PUBMED   36341521
  REMARK    GeneRIF: ZBTB2 links p53 deficiency to HIF-1-mediated hypoxia
            signaling to promote cancer aggressiveness.
REFERENCE   6  (bases 1 to 3103)
  AUTHORS   Lafaye,C., Barbier,E., Miscioscia,A., Saint-Pierre,C., Kraut,A.,
            Coute,Y., Plo,I., Gasparutto,D., Ravanat,J.L. and Breton,J.
  TITLE     DNA binding of the p21 repressor ZBTB2 is inhibited by cytosine
            hydroxymethylation
  JOURNAL   Biochem Biophys Res Commun 446 (1), 341-346 (2014)
   PUBMED   24607898
  REMARK    GeneRIF: ZBTB2 being considered as a multifunctional cell
            proliferation activator, notably through p21 repression, this work
            points out new epigenetic processes potentially involved in
            carcinogenesis.
REFERENCE   7  (bases 1 to 3103)
  AUTHORS   Kim,D.H., Lee,S.T., Won,H.H., Kim,S., Kim,M.J., Kim,H.J., Kim,S.H.,
            Kim,J.W., Kim,H.J., Kim,Y.K., Sohn,S.K., Moon,J.H., Jung,C.W. and
            Lipton,J.H.
  TITLE     A genome-wide association study identifies novel loci associated
            with susceptibility to chronic myeloid leukemia
  JOURNAL   Blood 117 (25), 6906-6911 (2011)
   PUBMED   21540461
REFERENCE   8  (bases 1 to 3103)
  AUTHORS   Jeon,B.N., Choi,W.I., Yu,M.Y., Yoon,A.R., Kim,M.H., Yun,C.O. and
            Hur,M.W.
  TITLE     ZBTB2, a novel master regulator of the p53 pathway
  JOURNAL   J Biol Chem 284 (27), 17935-17946 (2009)
   PUBMED   19380588
  REMARK    GeneRIF: ZBTB2 is a potential proto-oncogenic master control gene
            of the p53 pathway and, in particular, is a potent transcription
            repressor of the cell cycle arrest gene p21 by inhibiting p53 and
            Sp1
REFERENCE   9  (bases 1 to 3103)
  AUTHORS   Jung,S.Y., Malovannaya,A., Wei,J., O'Malley,B.W. and Qin,J.
  TITLE     Proteomic analysis of steady-state nuclear hormone receptor
            coactivator complexes
  JOURNAL   Mol Endocrinol 19 (10), 2451-2465 (2005)
   PUBMED   16051665
REFERENCE   10 (bases 1 to 3103)
  AUTHORS   Mungall,A.J., Palmer,S.A., Sims,S.K., Edwards,C.A., Ashurst,J.L.,
            Wilming,L., Jones,M.C., Horton,R., Hunt,S.E., Scott,C.E.,
            Gilbert,J.G., Clamp,M.E., Bethel,G., Milne,S., Ainscough,R.,
            Almeida,J.P., Ambrose,K.D., Andrews,T.D., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Barker,D.J.,
            Barlow,K.F., Bates,K., Beare,D.M., Beasley,H., Beasley,O.,
            Bird,C.P., Blakey,S., Bray-Allen,S., Brook,J., Brown,A.J.,
            Brown,J.Y., Burford,D.C., Burrill,W., Burton,J., Carder,C.,
            Carter,N.P., Chapman,J.C., Clark,S.Y., Clark,G., Clee,C.M.,
            Clegg,S., Cobley,V., Collier,R.E., Collins,J.E., Colman,L.K.,
            Corby,N.R., Coville,G.J., Culley,K.M., Dhami,P., Davies,J.,
            Dunn,M., Earthrowl,M.E., Ellington,A.E., Evans,K.A., Faulkner,L.,
            Francis,M.D., Frankish,A., Frankland,J., French,L., Garner,P.,
            Garnett,J., Ghori,M.J., Gilby,L.M., Gillson,C.J., Glithero,R.J.,
            Grafham,D.V., Grant,M., Gribble,S., Griffiths,C., Griffiths,M.,
            Hall,R., Halls,K.S., Hammond,S., Harley,J.L., Hart,E.A.,
            Heath,P.D., Heathcott,R., Holmes,S.J., Howden,P.J., Howe,K.L.,
            Howell,G.R., Huckle,E., Humphray,S.J., Humphries,M.D., Hunt,A.R.,
            Johnson,C.M., Joy,A.A., Kay,M., Keenan,S.J., Kimberley,A.M.,
            King,A., Laird,G.K., Langford,C., Lawlor,S., Leongamornlert,D.A.,
            Leversha,M., Lloyd,C.R., Lloyd,D.M., Loveland,J.E., Lovell,J.,
            Martin,S., Mashreghi-Mohammadi,M., Maslen,G.L., Matthews,L.,
            McCann,O.T., McLaren,S.J., McLay,K., McMurray,A., Moore,M.J.,
            Mullikin,J.C., Niblett,D., Nickerson,T., Novik,K.L., Oliver,K.,
            Overton-Larty,E.K., Parker,A., Patel,R., Pearce,A.V., Peck,A.I.,
            Phillimore,B., Phillips,S., Plumb,R.W., Porter,K.M., Ramsey,Y.,
            Ranby,S.A., Rice,C.M., Ross,M.T., Searle,S.M., Sehra,H.K.,
            Sheridan,E., Skuce,C.D., Smith,S., Smith,M., Spraggon,L.,
            Squares,S.L., Steward,C.A., Sycamore,N., Tamlyn-Hall,G., Tester,J.,
            Theaker,A.J., Thomas,D.W., Thorpe,A., Tracey,A., Tromans,A.,
            Tubby,B., Wall,M., Wallis,J.M., West,A.P., White,S.S.,
            Whitehead,S.L., Whittaker,H., Wild,A., Willey,D.J., Wilmer,T.E.,
            Wood,J.M., Wray,P.W., Wyatt,J.C., Young,L., Younger,R.M.,
            Bentley,D.R., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E.,
            Dunham,I., Rogers,J. and Beck,S.
  TITLE     The DNA sequence and analysis of human chromosome 6
  JOURNAL   Nature 425 (6960), 805-811 (2003)
   PUBMED   14574404
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK291942.1 and BC020172.1.
            
            On Nov 23, 2018 this sequence version replaced NM_020861.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC020172.1, SRR3476690.882953.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142586 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000325144.5/ ENSP00000323183.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-865               AK291942.1         85-949
            866-1448            BC020172.1         849-1431
            1449-2065           AK291942.1         1533-2149
            2066-3103           BC020172.1         2049-3086
FEATURES             Location/Qualifiers
     source          1..3103
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q25.1"
     gene            1..3103
                     /gene="ZBTB2"
                     /gene_synonym="ZNF437"
                     /note="zinc finger and BTB domain containing 2"
                     /db_xref="GeneID:57621"
                     /db_xref="HGNC:HGNC:20868"
                     /db_xref="MIM:616595"
     exon            1..140
                     /gene="ZBTB2"
                     /gene_synonym="ZNF437"
                     /inference="alignment:Splign:2.1.0"
     exon            141..325
                     /gene="ZBTB2"
                     /gene_synonym="ZNF437"
                     /inference="alignment:Splign:2.1.0"
     CDS             153..1697
                     /gene="ZBTB2"
                     /gene_synonym="ZNF437"
                     /codon_start=1
                     /product="zinc finger and BTB domain-containing protein 2"
                     /protein_id="NP_065912.1"
                     /db_xref="CCDS:CCDS5231.1"
                     /db_xref="GeneID:57621"
                     /db_xref="HGNC:HGNC:20868"
                     /db_xref="MIM:616595"
                     /translation="MDLANHGLILLQQLNAQREFGFLCDCTVAIGDVYFKAHKSVLAS
                     FSNYFKMLFVHQTSECVRLKPTDIQPDIFSYLLHLMYTGKMAPQLIDPVRLEQGIKFL
                     HAYPLIQEASLASQGAFSHPDQVFPLASSLYGIQIADHQLRQATKIASAPEKLGRDPR
                     PQTSRISQEQVPEASQLSQLTSNLAQVNRTNMTPSDPLQTSLSPELVSTPVPPPPPGE
                     ETNLEASSSDEQPASLTIAHVKPSIMKRNGSFPKYYACHLCGRRFTLRSSLREHLQIH
                     TGVPFTSSQQGESRVPLTLCSNAADLGKDAMEVPEAGMISDSELQHISDSPIIDGQQQ
                     SETPPPSDIADIDNLEQADQEREVKRRKYECTICGRKFIQKSHWREHMYIHTGKPFKC
                     STCDKSFCRANQAARHVCLNQSIDTYTMVDKQTLELCTFEEGSQMDNMLVQTNKPYKC
                     NLCDKTFSTPNEVVKHSCQNQNSDVFALDEGRSILLGSGDSEVTEPDHPVLASIKKEQ
                     ETVLLD"
     exon            326..3103
                     /gene="ZBTB2"
                     /gene_synonym="ZNF437"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3080..3085
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZBTB2"
                     /gene_synonym="ZNF437"
                     /note="hexamer: AATAAA"
     polyA_site      3103
                     /gene="ZBTB2"
                     /gene_synonym="ZNF437"
                     /note="major polyA site"
ORIGIN      
        1 gcgccggaga caccgaccgc ggcggcagca gcagcagcag cagcgagagg cagaggcggc
       61 ggcggcgggg aggacagcac ggccgaggct gcccagaggc gcctcctcca caccccccgc
      121 cgcagcagca ccggcgacag attttttaaa aaatggattt ggccaaccat ggacttattc
      181 tactgcaaca gttaaacgct cagcgagagt ttggtttcct gtgtgactgc acggttgcaa
      241 tcggcgatgt atacttcaag gcacacaaat cagttcttgc ttcattctcc aattacttta
      301 agatgttgtt tgtccatcag accagtgagt gtgtccgctt gaaaccaact gacatacagc
      361 ccgacatctt cagctatctc ttacacttga tgtacactgg gaagatggcg cctcagctca
      421 tcgacccggt tcgattagaa cagggcatca agtttctgca cgcctacccg ctcattcagg
      481 aagccagcct cgccagccag ggagcctttt ctcaccctga ccaagttttc ccactggctt
      541 cttcattgta tggcattcag attgcagatc atcagttgag acaagccacc aagattgctt
      601 cagcacctga aaaactcggg cgagatccac ggccacagac ctccaggata agccaggagc
      661 aggtccctga ggcctcacag ctctcccagc tgacttcaaa tctggcccag gtgaatcgga
      721 caaatatgac tccctcagac cccctgcaga cctcgctgtc tccagaactt gtttccactc
      781 ctgttcctcc ccctcctccc ggggaggaga ccaatctgga agcatcttcc tccgatgagc
      841 agcctgcgtc cctcacaata gcccacgtca agccaagcat catgaagagg aatgggagct
      901 ttccaaagta ctatgcctgc cacctgtgtg gacggcgctt cactctccgg agcagcttac
      961 gtgaacacct ccagatccac acaggagtac ctttcacatc tagccaacag ggagaaagtc
     1021 gcgtccccct gactctctgt agcaatgcag ctgacctcgg gaaagatgcc atggaagtgc
     1081 ctgaagccgg gatgataagt gacagtgagc tgcagcacat ctctgattct cccatcatcg
     1141 atgggcagca gcagtcggaa accccacccc cctcagacat tgctgacatt gacaacctgg
     1201 agcaggccga ccaggagagg gaggtgaaga ggcggaagta cgagtgcaca atatgtggac
     1261 gcaaatttat ccagaaaagc cactggaggg aacacatgta catacacacc gggaagcctt
     1321 tcaagtgcag cacttgtgac aaaagctttt gcagggccaa ccaggctgcc cgccacgtgt
     1381 gcctcaacca gagcatcgac acttacacca tggtggacaa acagactctg gaactctgca
     1441 catttgagga agggagtcag atggacaaca tgctggtgca aacaaacaaa ccctacaaat
     1501 gcaacttgtg tgacaaaaca ttctccactc ccaatgaggt tgttaaacat tcatgccaaa
     1561 accagaactc ggatgttttt gccctagacg aagggcgatc cattctcctg ggcagtgggg
     1621 actcggaagt aacggagcct gaccacccag tgttagcttc catcaaaaag gaacaagaaa
     1681 ccgtcttact agactgaatg tcacttatct ttttaaaaaa ctctcatttt tacaaagact
     1741 atcttccctc ccttccctga attcagaact gtagttctcc atggcatgat acaaacaggt
     1801 ccttgttctc ttctcctctt ccccttttcc acatcccagc cccacctctg taaaggcttt
     1861 gtgcattata aacctggaat gtatcgactt tctttcaggg gatattggaa agataatggt
     1921 cattatactt ataaactcaa attttgagag gttttagatt attcagaagc atacttggaa
     1981 ctaatgaagg gtatataata aaacaactgg aatccaattt ggtaagctaa aattatgact
     2041 ttccctgggt aaaaagtctt ctcagaaaaa caatgtcaga aaataacagc gtgctgctta
     2101 gaaatacggc tgggctctgt actatgcaaa atctagaaag tgtggggaaa ctttaaaccc
     2161 aagaaaacgt tcttagtatt catcctccag gtgtcttact tcagaatgca tcctttgaga
     2221 ttatgtccac ttaagagaaa tcatcagtta agaaatctac tttaacaaaa caaaaaggag
     2281 aaaaagtaat aatgtgatgg caatcttaat ttttgggtac aacatgacaa gctgtgagtt
     2341 tgtgtgtttg taagagaaaa atgtgtgggt acttgctaat aaacaggtga attaatgcac
     2401 atccttatct cattgctggc ttctttccaa gttgagcaac aacaaaatgc tgtatttgag
     2461 tttctgacaa atttgtttta aaaatcaaat ttgaatgtac tattctataa attgcctttc
     2521 tgaatagaac atgacatgcc attttctagc agctgccagt gataatttgt tttacactaa
     2581 cttttaaatc agtgtgtgta ctgcagggaa aaggatatag gaatactcat cttacagggg
     2641 aatttgtgac cagaagatgt agtaacttca atgactgaaa gtcaatgctg atagtttact
     2701 ggcaacatta attgaagcat caaaaataaa tggcaaagag aaatcaggac aaaaaatcta
     2761 attgctgttt gggaaaaaac ttgattttga tgtttattct ccaggttttt ggttgttttt
     2821 ttttctttct tctttcttaa tgcctgaaat tttctccatt ggcccgaaag cagtaaaaat
     2881 tgttcattaa tcttccgtta ggccaataaa agaagggcct cacaagacaa aacaggagcc
     2941 agaagtaagg actgaaggag aaggggagaa tagctaatag ctatagtata tgtatatgtt
     3001 aaaaactgaa tatcccatca tcctatttca tgtatagttg agttctcaaa tttgtaagtt
     3061 tttatacatc ctttcattga ataaacgttt aattaaatga gta
//
