LOCUS       NM_205768               3851 bp    mRNA    linear   PRI 27-MAY-2024
DEFINITION  Homo sapiens zinc finger and BTB domain containing 18 (ZBTB18),
            transcript variant 1, mRNA.
ACCESSION   NM_205768
VERSION     NM_205768.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3851)
  AUTHORS   Li,N., Kang,H., Zou,Y., Liu,Z., Deng,Y., Wang,M., Li,L., Qin,H.,
            Qiu,X., Wang,Y., Zhu,J., Agostino,M., Heng,J.I. and Yu,P.
  TITLE     A novel heterozygous ZBTB18 missense mutation in a family with
            non-syndromic intellectual disability
  JOURNAL   Neurogenetics 24 (4), 251-262 (2023)
   PUBMED   37525067
  REMARK    GeneRIF: A novel heterozygous ZBTB18 missense mutation in a family
            with non-syndromic intellectual disability.
REFERENCE   2  (bases 1 to 3851)
  AUTHORS   Brea-Fernandez,A.J., Souto-Trinei,F.A., Iglesias,E., Caamano,P.,
            Rodriguez Sanchez,B., Gomez Lado,C., Eiris,J., Fernandez-Prieto,M.,
            Barros,F., Brea,R.J. and Carracedo,A.
  TITLE     Expanding the Clinical and Molecular Spectrum of FOXG1- and
            ZBTB18-Associated Neurodevelopmental Disorders
  JOURNAL   Cytogenet Genome Res 163 (5-6), 301-306 (2023)
   PUBMED   38056433
  REMARK    GeneRIF: Expanding the Clinical and Molecular Spectrum of FOXG1-
            and ZBTB18-Associated Neurodevelopmental Disorders.
REFERENCE   3  (bases 1 to 3851)
  AUTHORS   Ferrarese,R., Izzo,A., Andrieux,G., Lagies,S., Bartmuss,J.P.,
            Masilamani,A.P., Wasilenko,A., Osti,D., Faletti,S., Schulzki,R.,
            Yuan,S., Kling,E., Ribecco,V., Heiland,D.H., Tholen,S., Prinz,M.,
            Pelicci,G., Kammerer,B., Boerries,M. and Carro,M.S.
  TITLE     ZBTB18 inhibits SREBP-dependent lipid synthesis by halting CTBPs
            and LSD1 activity in glioblastoma
  JOURNAL   Life Sci Alliance 6 (1), e202201400 (2022)
   PUBMED   36414381
  REMARK    GeneRIF: ZBTB18 inhibits SREBP-dependent lipid synthesis by halting
            CTBPs and LSD1 activity in glioblastoma.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3851)
  AUTHORS   Masilamani,A.P., Schulzki,R., Yuan,S., Haase,I.V., Kling,E.,
            Dewes,F., Andrieux,G., Borries,M., Schnell,O., Heiland,D.H.,
            Schilling,O., Ferrarese,R. and Carro,M.S.
  TITLE     Calpain-mediated cleavage generates a ZBTB18 N-terminal product
            that regulates HIF1A signaling and glioblastoma metabolism
  JOURNAL   iScience 25 (7), 104625 (2022)
   PUBMED   35800763
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3851)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   6  (bases 1 to 3851)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   7  (bases 1 to 3851)
  AUTHORS   Fuks,F., Burgers,W.A., Godin,N., Kasai,M. and Kouzarides,T.
  TITLE     Dnmt3a binds deacetylases and is recruited by a sequence-specific
            repressor to silence transcription
  JOURNAL   EMBO J 20 (10), 2536-2544 (2001)
   PUBMED   11350943
REFERENCE   8  (bases 1 to 3851)
  AUTHORS   Meng,G., Inazawa,J., Ishida,R., Tokura,K., Nakahara,K., Aoki,K. and
            Kasai,M.
  TITLE     Structural analysis of the gene encoding RP58, a sequence-specific
            transrepressor associated with heterochromatin
  JOURNAL   Gene 242 (1-2), 59-64 (2000)
   PUBMED   10721697
REFERENCE   9  (bases 1 to 3851)
  AUTHORS   Aoki,K., Meng,G., Suzuki,K., Takashi,T., Kameoka,Y., Nakahara,K.,
            Ishida,R. and Kasai,M.
  TITLE     RP58 associates with condensed chromatin and mediates a
            sequence-specific transcriptional repression
  JOURNAL   J Biol Chem 273 (41), 26698-26704 (1998)
   PUBMED   9756912
REFERENCE   10 (bases 1 to 3851)
  AUTHORS   Becker,K.G., Lee,I.J., Nagle,J.W., Canning,R.D., Gado,A.M.,
            Torres,R., Polymeropoulos,M.H., Massa,P.T., Biddison,W.E. and
            Drew,P.D.
  TITLE     C2H2-171: a novel human cDNA representing a developmentally
            regulated POZ domain/zinc finger protein preferentially expressed
            in brain
  JOURNAL   Int J Dev Neurosci 15 (7), 891-899 (1997)
   PUBMED   9568537
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC036677.2, BC078175.1,
            AJ001388.1, AL050055.1 and AL590483.32.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Feb 27, 2020 this sequence version replaced NM_205768.2.
            
            Summary: This gene encodes a C2H2-type zinc finger protein which
            acts a transcriptional repressor of genes involved in neuronal
            development. The encoded protein recognizes a specific sequence
            motif and recruits components of chromatin to target genes.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, May 2013].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC036677.2, AK291408.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000358704.4/ ENSP00000351539.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-326               BC036677.2         1-326
            327-1474            BC078175.1         748-1895
            1475-2556           AJ001388.1         1822-2903
            2557-2635           AL050055.1         195-273
            2636-2636           AL590483.32        36738-36738
            2637-3669           AL050055.1         275-1307
            3670-3851           BC078175.1         4090-4271
FEATURES             Location/Qualifiers
     source          1..3851
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q44"
     gene            1..3851
                     /gene="ZBTB18"
                     /gene_synonym="C1DELq42q44; C1DELq43q44; C2H2-171;
                     DEL1Q42Q44; DEL1Q43Q44; MRD22; RP58; TAZ-1; ZNF238"
                     /note="zinc finger and BTB domain containing 18"
                     /db_xref="GeneID:10472"
                     /db_xref="HGNC:HGNC:13030"
                     /db_xref="MIM:608433"
     exon            1..162
                     /gene="ZBTB18"
                     /gene_synonym="C1DELq42q44; C1DELq43q44; C2H2-171;
                     DEL1Q42Q44; DEL1Q43Q44; MRD22; RP58; TAZ-1; ZNF238"
                     /inference="alignment:Splign:2.1.0"
     CDS             150..1745
                     /gene="ZBTB18"
                     /gene_synonym="C1DELq42q44; C1DELq43q44; C2H2-171;
                     DEL1Q42Q44; DEL1Q43Q44; MRD22; RP58; TAZ-1; ZNF238"
                     /note="isoform 1 is encoded by transcript variant 1; zinc
                     finger protein C2H2-171; 58 kDa repressor protein;
                     transcriptional repressor RP58; translin-associated zinc
                     finger protein 1; zinc finger and BTB domain-containing
                     protein 18; zinc finger protein 238"
                     /codon_start=1
                     /product="zinc finger and BTB domain-containing protein 18
                     isoform 1"
                     /protein_id="NP_991331.1"
                     /db_xref="CCDS:CCDS1622.1"
                     /db_xref="GeneID:10472"
                     /db_xref="HGNC:HGNC:13030"
                     /db_xref="MIM:608433"
                     /translation="MCPKGYEDSMEFPDHSRHLLQCLSEQRHQGFLCDCTVLVGDAQF
                     RAHRAVLASCSMYFHLFYKDQLDKRDIVHLNSDIVTAPAFALLLEFMYEGKLQFKDLP
                     IEDVLAAASYLHMYDIVKVCKKKLKEKATTEADSTKKEEDASSCSDKVESLSDGSSHI
                     AGDLPSDEDEGEDEKLNILPSKRDLAAEPGNMWMRLPSDSAGIPQAGGEAEPHATAAG
                     KTVASPCSSTESLSQRSVTSVRDSADVDCVLDLSVKSSLSGVENLNSSYFSSQDVLRS
                     NLVQVKVEKEASCDESDVGTNDYDMEHSTVKESVSTNNRVQYEPAHLAPLREDSVLRE
                     LDREDKASDDEMMTPESERVQVEGGMESSLLPYVSNILSPAGQIFMCPLCNKVFPSPH
                     ILQIHLSTHFREQDGIRSKPAADVNVPTCSLCGKTFSCMYTLKRHERTHSGEKPYTCT
                     QCGKSFQYSHNLSRHAVVHTREKPHACKWCERRFTQSGDLYRHIRKFHCELVNSLSVK
                     SEALSLPTVRDWTLEDSSQELWK"
     exon            163..3851
                     /gene="ZBTB18"
                     /gene_synonym="C1DELq42q44; C1DELq43q44; C2H2-171;
                     DEL1Q42Q44; DEL1Q43Q44; MRD22; RP58; TAZ-1; ZNF238"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3835..3840
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZBTB18"
                     /gene_synonym="C1DELq42q44; C1DELq43q44; C2H2-171;
                     DEL1Q42Q44; DEL1Q43Q44; MRD22; RP58; TAZ-1; ZNF238"
                     /note="hexamer: ATTATA"
     polyA_site      3851
                     /gene="ZBTB18"
                     /gene_synonym="C1DELq42q44; C1DELq43q44; C2H2-171;
                     DEL1Q42Q44; DEL1Q43Q44; MRD22; RP58; TAZ-1; ZNF238"
                     /note="major polyA site"
ORIGIN      
        1 agtgtgtgcg gatctgtggt ggagaaggta tctcattcct ctctaacatc atctccactt
       61 tgcatctgtc tctcttagtc tgcttttttt ccaccgatgt aacagacctg gagccagcag
      121 gactcagagg aaaggactta atcaggttta tgtgtcctaa aggttatgaa gacagtatgg
      181 agtttccaga ccatagtaga catttgctac agtgtctgag cgagcagaga caccagggtt
      241 ttctttgtga ctgcactgtt ctggtgggag atgcccagtt ccgagcgcac cgagctgtac
      301 tggcttcatg cagcatgtat ttccacctct tttacaagga ccagctggac aaaagagaca
      361 ttgttcatct gaacagcgac attgttacag cccccgcttt cgctctcctg cttgaattca
      421 tgtatgaagg gaaactccag ttcaaagact tgcccattga agacgtgcta gcagctgcca
      481 gttatctcca catgtatgac attgtcaaag tctgcaaaaa gaagctgaaa gagaaagcca
      541 ccacggaggc agacagcacc aaaaaggaag aagatgcttc aagttgttcg gacaaagtcg
      601 agagtctctc cgatggcagc agccacatag caggcgattt gcccagtgat gaagatgaag
      661 gagaagatga aaaattgaac atcctgccca gcaaaaggga cttggcggcc gagcctggga
      721 acatgtggat gcgattgccc tcagactcag caggcatccc ccaggctggc ggagaggcag
      781 agccacacgc cacagcagct ggaaaaacag tagccagccc ctgcagctca acagagtctt
      841 tgtcccagag gtctgtcacc tccgtgaggg attcggcaga tgttgactgt gtgctggacc
      901 tgtctgtcaa gtccagcctt tcaggagttg aaaatctgaa cagctcttat ttctcttcac
      961 aggacgtgct gagaagcaac ctggtgcagg tgaaggtgga gaaagaggct tcctgtgatg
     1021 agagtgatgt tggcactaat gactatgaca tggaacatag cactgtgaaa gaaagtgtga
     1081 gcactaataa cagggtacag tatgagccgg cccatctggc tcccctgagg gaggactcgg
     1141 tcttgaggga gctggaccgg gaggacaaag ccagtgatga tgagatgatg accccagaga
     1201 gcgagcgtgt ccaggtggag ggaggcatgg agagcagtct gctcccctac gtctccaaca
     1261 tcctgagccc cgcgggccag atcttcatgt gccccctgtg caacaaggtc ttccccagcc
     1321 cccacatcct gcagatccac ctgagcacgc acttccgcga gcaggacggc atccgcagca
     1381 agcccgccgc cgatgtcaac gtgcccacgt gctcgctgtg tgggaagact ttctcttgca
     1441 tgtacaccct caagcgccac gagaggactc actcggggga gaagccctac acatgcaccc
     1501 agtgcggcaa gagcttccag tactcgcaca acctgagccg ccatgccgtg gtgcacaccc
     1561 gcgagaagcc gcacgcctgc aagtggtgcg agcgcaggtt cacgcagtcc ggggacctgt
     1621 acagacacat tcgcaagttc cactgtgagt tggtgaactc cttgtcggtc aaaagcgaag
     1681 cactgagctt gcctactgtc agagactgga ccttagaaga tagctctcaa gaactttgga
     1741 aataatttta tatatatata aataatatat atatatatac atatatataa atagatctct
     1801 atatagttgt ggtacggtct aaaagcagtc ttgtttcctg gaaataaaaa gttgggatat
     1861 taacttgttt ttgcacttta gaatagcatg agaatctcac taatttagca ttctgataaa
     1921 agaaacttta gagcaagtca gaatagagag gtgtttttcc tttgagggga taggggaagt
     1981 aagccaataa gaacctttta aacaaatcgt cctgtcacaa aatgctttca tatggcttaa
     2041 ttttgtcaac actgcattgt cttttgagct cttttttccc ccccaacaaa gtttttttgt
     2101 tttttgtttt tttttttaag tagaaattcc ctccagtttt attagcctct ttatatgtct
     2161 caaattgcat gaattttttc tggctgttgg aaacctgaat gcttttagac ccaaatggaa
     2221 aatttctgaa atgctggatt atctattttt aaacaagcag ttgacttaaa actttctgtg
     2281 gcaacttctg gttttctgac agttcccagt gagagaaatg ctgaaagtac actgggatca
     2341 ctgggacact gtcttatgaa ggtttgcttg ggatgaaaaa ggatattgca gcttcagcag
     2401 tgttgaactg tgtgtttaaa aatgtgaatt actgttattg tatactgtaa ttgattacat
     2461 gggctggggg ggtgtcaaag aacttgacag gttgtgttga tgctcttagt tgagtcttga
     2521 aaagtaaata ttaacgctac agaaatgcat gagtttcaat atattttttg tctttgtttg
     2581 cattgtataa ctttaacgag tgagtttaaa attatttaat ttccttagaa aaataacacc
     2641 atttggaaaa aaaaactggt gttatgaaga acgtaaatgc actgttttta tttttatttt
     2701 atataattta aattgacttt cccactgtct ttaagttgaa actgttaagc tgaataaaaa
     2761 cttaagctgc aaattgataa cttcgctaca taacaaggaa aatataaatg tttacaaaca
     2821 gcttaaagat ttgcatgtgc agtgtgcatt tataacaaac ttctaattgc acaaaaccca
     2881 tgccagctca gagtttaggt gtacacattt acccagttga gcgttcttag aataactact
     2941 gcacaagttg acaataggtc gttctctctt tttttttgtt tgctcccttt ttctttttct
     3001 ccccttcctc cttaccctcc ctcccttact ctcccccccc accaccaccc tccaccccca
     3061 actcatgaaa agattctatg gactgaaaaa gccccaggct gaaaggactg gactgccttg
     3121 attgacatgg ggaagggggt tagtagacta tgtggattgc ggcagcagag gctgcagcct
     3181 aacgtgtggt tttaatgacc agcacgcaag gcaaaagcat tttgcacagt gtttgttttc
     3241 ctgtcttgca cttacaaata aggtctatgg gagtagcatg gaaaacgttt gctgtttttc
     3301 cctttttttt ttaattgctt ttgtttaaaa tttgatcgcc ttaactactg taaacatagc
     3361 ctatttttgt gcttaagata ctgaatggaa aactccattg tgtgttgctg gactgttttg
     3421 gaaatatttg gttaaatgtg tgttaatttg gctgtaatgg catttaaagc aaacaaacaa
     3481 acaaaaaaag ctgtgaaaat ggccttggag cattatcttt agttacttga agagtttcta
     3541 gtttttttaa aatacagttt atgttaaaat aatttttatt aatttagaga agacaatcaa
     3601 tgtctgtgag aaaacggact ttcttttgga ttttcttttt gtggtcattg tgagtgattg
     3661 ctttttcctt ttcttagttt cacattcttc ctttgttcta aaacttagac tgacatctag
     3721 ctttgacaat catagtatgt tttattttcc tgagggggaa taacttataa tgctgtttag
     3781 ttttgtacta ttggtgtgtt ggtgaatttt taaactgtgt gctaactgca ataaattata
     3841 tgaactgaga a
//
