LOCUS       NM_003443               2720 bp    mRNA    linear   PRI 03-SEP-2024
DEFINITION  Homo sapiens zinc finger and BTB domain containing 17 (ZBTB17),
            transcript variant 2, mRNA.
ACCESSION   NM_003443
VERSION     NM_003443.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2720)
  AUTHORS   Wu,S., Zhang,J., Chen,S., Zhou,X., Liu,Y., Hua,H., Qi,X., Mao,Y.,
            Young,K.H. and Lu,T.
  TITLE     Low NDRG2, regulated by the MYC/MIZ-1 complex and methylation,
            predicts poor outcomes in DLBCL patients
  JOURNAL   Ann Hematol 103 (8), 2877-2892 (2024)
   PUBMED   38842567
  REMARK    GeneRIF: Low NDRG2, regulated by the MYC/MIZ-1 complex and
            methylation, predicts poor outcomes in DLBCL patients.
REFERENCE   2  (bases 1 to 2720)
  AUTHORS   Jin,K., Shi,Y., Zhang,H., Zhangyuan,G., Wang,F., Li,S., Chen,C.,
            Zhang,J., Wang,H., Zhang,W. and Sun,B.
  TITLE     A TNFalpha/Miz1-positive feedback loop inhibits mitophagy in
            hepatocytes and propagates non-alcoholic steatohepatitis
  JOURNAL   J Hepatol 79 (2), 403-416 (2023)
   PUBMED   37040844
  REMARK    GeneRIF: A TNFalpha/Miz1-positive feedback loop inhibits mitophagy
            in hepatocytes and propagates non-alcoholic steatohepatitis.
REFERENCE   3  (bases 1 to 2720)
  AUTHORS   Yang,J., Hou,C., Wang,H., Perez,E.A., Do-Umehara,H.C., Dong,H.,
            Arunagiri,V., Tong,F., Van Scoyk,M., Cho,M., Liu,X., Ge,X.,
            Winn,R.A., Ridge,K.M., Wang,X., Chandel,N.S. and Liu,J.
  TITLE     Miz1 promotes KRAS-driven lung tumorigenesis by repressing the
            protocadherin Pcdh10
  JOURNAL   Cancer Lett 555, 216025 (2023)
   PUBMED   36538983
  REMARK    GeneRIF: Miz1 promotes KRAS-driven lung tumorigenesis by repressing
            the protocadherin Pcdh10.
REFERENCE   4  (bases 1 to 2720)
  AUTHORS   Krenz,B., Gebhardt-Wolf,A., Ade,C.P., Gaballa,A., Roehrig,F.,
            Vendelova,E., Baluapuri,A., Eilers,U., Gallant,P., D'Artista,L.,
            Wiegering,A., Gasteiger,G., Rosenfeldt,M.T., Bauer,S., Zender,L.,
            Wolf,E. and Eilers,M.
  TITLE     MYC- and MIZ1-Dependent Vesicular Transport of Double-Strand RNA
            Controls Immune Evasion in Pancreatic Ductal Adenocarcinoma
  JOURNAL   Cancer Res 81 (16), 4242-4256 (2021)
   PUBMED   34145038
  REMARK    GeneRIF: MYC- and MIZ1-Dependent Vesicular Transport of
            Double-Strand RNA Controls Immune Evasion in Pancreatic Ductal
            Adenocarcinoma.
REFERENCE   5  (bases 1 to 2720)
  AUTHORS   Yang,J., Perez,E.A., Hou,C., Zhang,P., Van Scoyk,M., Winn,R.A.,
            Rong,L. and Liu,J.
  TITLE     Identification of the SARS-CoV-2 Entry Receptor ACE2 as a Direct
            Target for Transcriptional Repression by Miz1
  JOURNAL   Front Immunol 12, 648815 (2021)
   PUBMED   34305888
  REMARK    GeneRIF: Identification of the SARS-CoV-2 Entry Receptor ACE2 as a
            Direct Target for Transcriptional Repression by Miz1.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2720)
  AUTHORS   Wu,L., Wu,H., Ma,L., Sangiorgi,F., Wu,N., Bell,J.R., Lyons,G.E. and
            Maxson,R.
  TITLE     Miz1, a novel zinc finger transcription factor that interacts with
            Msx2 and enhances its affinity for DNA
  JOURNAL   Mech Dev 65 (1-2), 3-17 (1997)
   PUBMED   9256341
  REMARK    Erratum:[Mech Dev 1997 Dec;69(1-2):219]
REFERENCE   7  (bases 1 to 2720)
  AUTHORS   Schneider,A., Peukert,K., Eilers,M. and Hanel,F.
  TITLE     Association of Myc with the zinc-finger protein Miz-1 defines a
            novel pathway for gene regulation by Myc
  JOURNAL   Curr Top Microbiol Immunol 224, 137-146 (1997)
   PUBMED   9308237
REFERENCE   8  (bases 1 to 2720)
  AUTHORS   Tommerup,N. and Vissing,H.
  TITLE     Isolation and fine mapping of 16 novel human zinc finger-encoding
            cDNAs identify putative candidate genes for developmental and
            malignant disorders
  JOURNAL   Genomics 27 (2), 259-264 (1995)
   PUBMED   7557990
REFERENCE   9  (bases 1 to 2720)
  AUTHORS   Lichter,P., Bray,P., Ried,T., Dawid,I.B. and Ward,D.C.
  TITLE     Clustering of C2-H2 zinc finger motif sequences within telomeric
            and fragile site regions of human chromosomes
  JOURNAL   Genomics 13 (4), 999-1007 (1992)
   PUBMED   1505991
REFERENCE   10 (bases 1 to 2720)
  AUTHORS   Bray,P., Lichter,P., Thiesen,H.J., Ward,D.C. and Dawid,I.B.
  TITLE     Characterization and mapping of human genes encoding zinc finger
            proteins
  JOURNAL   Proc Natl Acad Sci U S A 88 (21), 9563-9567 (1991)
   PUBMED   1946370
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB064089.1, BC126163.1 and BQ575263.1.
            
            On Feb 27, 2020 this sequence version replaced NM_003443.2.
            
            Summary: This gene encodes a zinc finger protein involved in the
            regulation of c-myc. The symbol MIZ1 has also been associated with
            PIAS2 which is a different gene located on chromosome 18. [provided
            by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK223618.1, Y09723.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000375743.9/ ENSP00000364895.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-106               DB064089.1         32-137
            107-2693            BC126163.1         1-2587
            2694-2720           BQ575263.1         17-43               c
FEATURES             Location/Qualifiers
     source          1..2720
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.13"
     gene            1..2720
                     /gene="ZBTB17"
                     /gene_synonym="MIZ-1; pHZ-67; ZNF151; ZNF60"
                     /note="zinc finger and BTB domain containing 17"
                     /db_xref="GeneID:7709"
                     /db_xref="HGNC:HGNC:12936"
                     /db_xref="MIM:604084"
     exon            1..119
                     /gene="ZBTB17"
                     /gene_synonym="MIZ-1; pHZ-67; ZNF151; ZNF60"
                     /inference="alignment:Splign:2.1.0"
     exon            120..206
                     /gene="ZBTB17"
                     /gene_synonym="MIZ-1; pHZ-67; ZNF151; ZNF60"
                     /inference="alignment:Splign:2.1.0"
     exon            207..413
                     /gene="ZBTB17"
                     /gene_synonym="MIZ-1; pHZ-67; ZNF151; ZNF60"
                     /inference="alignment:Splign:2.1.0"
     CDS             209..2620
                     /gene="ZBTB17"
                     /gene_synonym="MIZ-1; pHZ-67; ZNF151; ZNF60"
                     /note="isoform 2 is encoded by transcript variant 2; zinc
                     finger protein 60; zinc finger protein 151 (pHZ-67); zinc
                     finger and BTB domain-containing protein 17;
                     Myc-interacting Zn finger protein-1"
                     /codon_start=1
                     /product="zinc finger and BTB domain-containing protein 17
                     isoform 2"
                     /protein_id="NP_003434.2"
                     /db_xref="CCDS:CCDS165.1"
                     /db_xref="GeneID:7709"
                     /db_xref="HGNC:HGNC:12936"
                     /db_xref="MIM:604084"
                     /translation="MDFPQHSQHVLEQLNQQRQLGLLCDCTFVVDGVHFKAHKAVLAA
                     CSEYFKMLFVDQKDVVHLDISNAAGLGQVLEFMYTAKLSLSPENVDDVLAVATFLQMQ
                     DIITACHALKSLAEPATSPGGNAEALATEGGDKRAKEEKVATSTLSRLEQAGRSTPIG
                     PSRDLKEERGGQAQSAASGAEQTEKADAPREPPPVELKPDPTSGMAAAEAEAALSESS
                     EQEMEVEPARKGEEEQKEQEEQEEEGAGPAEVKEEGSQLENGEAPEENENEESAGTDS
                     GQELGSEARGLRSGTYGDRTESKAYGSVIHKCEDCGKEFTHTGNFKRHIRIHTGEKPF
                     SCRECSKAFSDPAACKAHEKTHSPLKPYGCEECGKSYRLISLLNLHKKRHSGEARYRC
                     EDCGKLFTTSGNLKRHQLVHSGEKPYQCDYCGRSFSDPTSKMRHLETHDTDKEHKCPH
                     CDKKFNQVGNLKAHLKIHIADGPLKCRECGKQFTTSGNLKRHLRIHSGEKPYVCIHCQ
                     RQFADPGALQRHVRIHTGEKPCQCVMCGKAFTQASSLIAHVRQHTGEKPYVCERCGKR
                     FVQSSQLANHIRHHDNIRPHKCSVCSKAFVNVGDLSKHIIIHTGEKPYLCDKCGRGFN
                     RVDNLRSHVKTVHQGKAGIKILEPEEGSEVSVVTVDDMVTLATEALAATAVTQLTVVP
                     VGAAVTADETEVLKAEISKAVKQVQEEDPNTHILYACDSCGDKFLDANSLAQHVRIHT
                     AQALVMFQTDADFYQQYGPGGTWPAGQVLQAGELVFRPRDGAEGQPALAETSPTAPEC
                     PPPAE"
     exon            414..602
                     /gene="ZBTB17"
                     /gene_synonym="MIZ-1; pHZ-67; ZNF151; ZNF60"
                     /inference="alignment:Splign:2.1.0"
     exon            603..743
                     /gene="ZBTB17"
                     /gene_synonym="MIZ-1; pHZ-67; ZNF151; ZNF60"
                     /inference="alignment:Splign:2.1.0"
     exon            744..869
                     /gene="ZBTB17"
                     /gene_synonym="MIZ-1; pHZ-67; ZNF151; ZNF60"
                     /inference="alignment:Splign:2.1.0"
     exon            870..1135
                     /gene="ZBTB17"
                     /gene_synonym="MIZ-1; pHZ-67; ZNF151; ZNF60"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..1278
                     /gene="ZBTB17"
                     /gene_synonym="MIZ-1; pHZ-67; ZNF151; ZNF60"
                     /inference="alignment:Splign:2.1.0"
     exon            1279..1579
                     /gene="ZBTB17"
                     /gene_synonym="MIZ-1; pHZ-67; ZNF151; ZNF60"
                     /inference="alignment:Splign:2.1.0"
     exon            1580..1667
                     /gene="ZBTB17"
                     /gene_synonym="MIZ-1; pHZ-67; ZNF151; ZNF60"
                     /inference="alignment:Splign:2.1.0"
     exon            1668..1784
                     /gene="ZBTB17"
                     /gene_synonym="MIZ-1; pHZ-67; ZNF151; ZNF60"
                     /inference="alignment:Splign:2.1.0"
     exon            1785..1905
                     /gene="ZBTB17"
                     /gene_synonym="MIZ-1; pHZ-67; ZNF151; ZNF60"
                     /inference="alignment:Splign:2.1.0"
     exon            1906..2036
                     /gene="ZBTB17"
                     /gene_synonym="MIZ-1; pHZ-67; ZNF151; ZNF60"
                     /inference="alignment:Splign:2.1.0"
     exon            2037..2246
                     /gene="ZBTB17"
                     /gene_synonym="MIZ-1; pHZ-67; ZNF151; ZNF60"
                     /inference="alignment:Splign:2.1.0"
     exon            2247..2336
                     /gene="ZBTB17"
                     /gene_synonym="MIZ-1; pHZ-67; ZNF151; ZNF60"
                     /inference="alignment:Splign:2.1.0"
     exon            2337..2720
                     /gene="ZBTB17"
                     /gene_synonym="MIZ-1; pHZ-67; ZNF151; ZNF60"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2699..2704
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZBTB17"
                     /gene_synonym="MIZ-1; pHZ-67; ZNF151; ZNF60"
                     /note="hexamer: AATAAA"
     polyA_site      2720
                     /gene="ZBTB17"
                     /gene_synonym="MIZ-1; pHZ-67; ZNF151; ZNF60"
                     /note="major polyA site"
ORIGIN      
        1 gaggtcggtt ccgcccgact ctaacatggc ggcgcccttt gtctgctctg gagtgccgtc
       61 cccggccttc tcgcggccgt gatgcacctc cctctgcggt ggggtccggg acatggcagg
      121 taatgagccg gacgagggga gccaagctgg agtttacaca ggcaaactgt cagaaaagag
      181 tagcctgggc tgtctggaaa tctgagccat ggactttccc cagcacagcc agcatgtctt
      241 ggaacagctg aaccagcagc ggcagctggg gcttctctgt gactgcacct ttgtggtgga
      301 cggtgttcac tttaaggctc ataaagcagt gctggcggcc tgcagcgagt acttcaagat
      361 gctcttcgtg gaccagaagg acgtggtgca cctggacatc agtaacgcgg caggcctggg
      421 gcaggtgctg gagtttatgt acacggccaa gctgagcctg agccctgaga acgtggatga
      481 tgtgctggcc gtggccactt tcctccaaat gcaggacatc atcacggcct gccatgccct
      541 caagtcactt gctgagccgg ctaccagccc tgggggaaat gcggaggcct tggccacaga
      601 aggaggggac aagagagcca aagaggagaa ggtggccacc agcacgctga gcaggctgga
      661 gcaggcagga cgcagcacac ccataggccc cagcagggac ctcaaggagg agcgcggcgg
      721 tcaggcccag agtgcggcca gcggtgcaga gcagacagag aaagccgatg cgccccggga
      781 gccgccgcct gtggagctca agccagaccc cacgagtggc atggctgctg cagaagctga
      841 ggccgctttg tccgagagct cggagcaaga aatggaggtg gagcccgccc ggaaagggga
      901 agaggagcaa aaggagcaag aggagcaaga ggaggagggc gcagggccag ctgaggtcaa
      961 ggaggagggt tcccagctgg agaacggaga ggcccccgag gagaacgaga atgaggagtc
     1021 agcgggcaca gactcggggc aggagctcgg ctccgaggcc cggggcctgc gctcaggcac
     1081 ctacggcgac cgcacggagt ccaaggccta cggctccgtc atccacaagt gcgaggactg
     1141 tgggaaggag ttcacgcaca cggggaactt caagcggcac atccgcatcc acacggggga
     1201 gaagcccttc tcgtgccggg agtgcagcaa ggccttttcc gacccggccg cgtgcaaggc
     1261 ccatgagaag acgcacagcc ctctgaagcc ctacggctgc gaggagtgcg ggaagagcta
     1321 ccgcctcatc agcctgctga acctgcacaa gaagcggcac tcgggcgagg cgcgctaccg
     1381 ctgcgaggac tgcggcaagc tcttcaccac ctcgggcaac ctcaagcgcc accagctggt
     1441 gcacagcggc gagaagccct accagtgcga ctactgcggc cgctccttct ccgaccccac
     1501 ttccaagatg cgccacctgg agacccacga cacggacaag gagcacaagt gcccacactg
     1561 cgacaagaag ttcaaccagg tagggaacct gaaggcccac ctgaagatcc acatcgctga
     1621 cgggcccctc aagtgccgag agtgtgggaa gcagttcacc acctcaggga acctgaagcg
     1681 gcaccttcgg atccacagcg gggagaagcc ctacgtgtgc atccactgcc agcgacagtt
     1741 tgcagacccc ggcgctctgc agcggcacgt ccgcattcac acaggtgaga agccatgcca
     1801 gtgtgtgatg tgcggtaagg ccttcaccca ggccagctcc ctcatcgccc acgtgcgcca
     1861 gcacaccggg gagaagccct acgtctgcga gcgctgcggc aagagattcg tccagtccag
     1921 ccagttggcc aatcatattc gccaccacga caacatccgc ccacacaagt gcagcgtgtg
     1981 cagcaaggcc ttcgtgaacg tgggggacct gtccaagcac atcatcattc acactggaga
     2041 gaagccttac ctgtgtgata agtgtgggcg tggcttcaac cgggtagaca acctgcgctc
     2101 ccacgtgaag accgtgcacc agggcaaggc aggcatcaag atcctggagc ccgaggaggg
     2161 cagtgaggtc agcgtggtca ctgtggatga catggtcacg ctggctaccg aggcactggc
     2221 agcgacagcc gtcactcagc tcacagtggt gccggtggga gctgcagtga cagccgatga
     2281 gacggaagtc ctgaaggccg agatcagcaa agctgtgaag caagtgcagg aagaagaccc
     2341 caacactcac atcctctacg cctgtgactc ctgtggggac aagtttctgg atgccaacag
     2401 cctggctcag catgtgcgaa tccacacagc ccaggcactg gtcatgttcc agacagacgc
     2461 ggacttctat cagcagtatg ggccaggtgg cacgtggcct gccgggcagg tgctgcaggc
     2521 tggggagctg gtcttccgcc ctcgcgacgg ggctgagggc cagcccgcac tggcagagac
     2581 ctcccctaca gctcctgaat gtcccccgcc tgccgagtga gctggcggcc cttctgactg
     2641 tttatttaag gatggatggc accctggaac cgggaagggt ggcctgttcc ctagagagaa
     2701 taaattggat tattttctaa
//
