LOCUS       NM_006006               8494 bp    mRNA    linear   PRI 01-JUL-2024
DEFINITION  Homo sapiens zinc finger and BTB domain containing 16 (ZBTB16),
            transcript variant 1, mRNA.
ACCESSION   NM_006006
VERSION     NM_006006.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8494)
  AUTHORS   Wang,K., Guo,D., Yan,T., Sun,S., Wang,Y., Zheng,H., Wang,G. and
            Du,J.
  TITLE     ZBTB16 inhibits DNA replication and induces cell cycle arrest by
            targeting WDHD1 transcription in lung adenocarcinoma
  JOURNAL   Oncogene 43 (23), 1796-1810 (2024)
   PUBMED   38654107
  REMARK    GeneRIF: ZBTB16 inhibits DNA replication and induces cell cycle
            arrest by targeting WDHD1 transcription in lung adenocarcinoma.
REFERENCE   2  (bases 1 to 8494)
  AUTHORS   Mao,Y., Su,X., Guo,Q., Yao,X., Zhao,Q., Guo,Y., Wang,Y., Li,X. and
            Lu,Y.
  TITLE     Long non-coding RNA LINC00930 targeting miR-6792-3p/ZBTB16
            regulates the proliferation and EMT of pancreatic cancer
  JOURNAL   BMC Cancer 24 (1), 638 (2024)
   PUBMED   38789960
  REMARK    GeneRIF: Long non-coding RNA LINC00930 targeting miR-6792-3p/ZBTB16
            regulates the proliferation and EMT of pancreatic cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8494)
  AUTHORS   Krontira,A.C., Cruceanu,C., Dony,L., Kyrousi,C., Link,M.H., Rek,N.,
            Pohlchen,D., Raimundo,C., Penner-Goeke,S., Schowe,A., Czamara,D.,
            Lahti-Pulkkinen,M., Sammallahti,S., Wolford,E., Heinonen,K.,
            Roeh,S., Sportelli,V., Wolfel,B., Kodel,M., Sauer,S.,
            Rex-Haffner,M., Raikkonen,K., Labeur,M., Cappello,S. and
            Binder,E.B.
  TITLE     Human cortical neurogenesis is altered via glucocorticoid-mediated
            regulation of ZBTB16 expression
  JOURNAL   Neuron 112 (9), 1426-1443 (2024)
   PUBMED   38442714
  REMARK    GeneRIF: Human cortical neurogenesis is altered via
            glucocorticoid-mediated regulation of ZBTB16 expression.
REFERENCE   4  (bases 1 to 8494)
  AUTHORS   Liu,T.M., Lee,E.H., Lim,B. and Shyh-Chang,N.
  TITLE     Concise Review: Balancing Stem Cell Self-Renewal and
            Differentiation with PLZF
  JOURNAL   Stem Cells 34 (2), 277-287 (2016)
   PUBMED   26676652
  REMARK    GeneRIF: Emerging evidence shows that PLZF regulates the balance of
            self-renewal and differentiation in stem cells.
            Review article
REFERENCE   5  (bases 1 to 8494)
  AUTHORS   Song,G., Wang,L., Bi,K. and Jiang,G.
  TITLE     Regulation of the C/EBPalpha signaling pathway in acute myeloid
            leukemia (Review)
  JOURNAL   Oncol Rep 33 (5), 2099-2106 (2015)
   PUBMED   25760953
  REMARK    Review article
REFERENCE   6  (bases 1 to 8494)
  AUTHORS   Zhang,T., Xiong,H., Kan,L.X., Zhang,C.K., Jiao,X.F., Fu,G.,
            Zhang,Q.H., Lu,L., Tong,J.H., Gu,B.W., Yu,M., Liu,J.X., Licht,J.,
            Waxman,S., Zelent,A., Chen,E. and Chen,S.J.
  TITLE     Genomic sequence, structural organization, molecular evolution, and
            aberrant rearrangement of promyelocytic leukemia zinc finger gene
  JOURNAL   Proc Natl Acad Sci U S A 96 (20), 11422-11427 (1999)
   PUBMED   10500192
REFERENCE   7  (bases 1 to 8494)
  AUTHORS   van Schothorst,E.M., Prins,D.E., Baysal,B.E., Beekman,M.,
            Licht,J.D., Waxman,S., Zelent,A., Cornelisse,C.J., van Ommen,G.J.,
            Richard,C.W. 3rd and Devilee,P.
  TITLE     Genomic structure of the human PLZF gene
  JOURNAL   Gene 236 (1), 21-24 (1999)
   PUBMED   10433962
REFERENCE   8  (bases 1 to 8494)
  AUTHORS   Reid,A., Gould,A., Brand,N., Cook,M., Strutt,P., Li,J., Licht,J.,
            Waxman,S., Krumlauf,R. and Zelent,A.
  TITLE     Leukemia translocation gene, PLZF, is expressed with a speckled
            nuclear pattern in early hematopoietic progenitors
  JOURNAL   Blood 86 (12), 4544-4552 (1995)
   PUBMED   8541544
REFERENCE   9  (bases 1 to 8494)
  AUTHORS   Chen,S.J., Zelent,A., Tong,J.H., Yu,H.Q., Wang,Z.Y., Derre,J.,
            Berger,R., Waxman,S. and Chen,Z.
  TITLE     Rearrangements of the retinoic acid receptor alpha and
            promyelocytic leukemia zinc finger genes resulting from
            t(11;17)(q23;q21) in a patient with acute promyelocytic leukemia
  JOURNAL   J Clin Invest 91 (5), 2260-2267 (1993)
   PUBMED   8387545
REFERENCE   10 (bases 1 to 8494)
  AUTHORS   Chen,Z., Brand,N.J., Chen,A., Chen,S.J., Tong,J.H., Wang,Z.Y.,
            Waxman,S. and Zelent,A.
  TITLE     Fusion between a novel Kruppel-like zinc finger gene and the
            retinoic acid receptor-alpha locus due to a variant t(11;17)
            translocation associated with acute promyelocytic leukaemia
  JOURNAL   EMBO J 12 (3), 1161-1167 (1993)
   PUBMED   8384553
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BX648973.1, BC029812.1,
            BM969145.1 and AP002518.3.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_006006.5.
            
            Summary: This gene is a member of the Krueppel C2H2-type
            zinc-finger protein family and encodes a zinc finger transcription
            factor that contains nine Kruppel-type zinc finger domains at the
            carboxyl terminus. This protein is located in the nucleus, is
            involved in cell cycle progression, and interacts with a histone
            deacetylase. Specific instances of aberrant gene rearrangement at
            this locus have been associated with acute promyelocytic leukemia
            (APL). Alternate transcriptional splice variants have been
            characterized. [provided by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.89400.1,
                                           DRR138518.289817.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000335953.9/ ENSP00000338157.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                BX648973.1         120-135
            17-2371             BC029812.1         1-2355
            2372-2405           BM969145.1         16-49               c
            2406-8494           AP002518.3         44443-50531
FEATURES             Location/Qualifiers
     source          1..8494
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q23.2"
     gene            1..8494
                     /gene="ZBTB16"
                     /gene_synonym="PLZF; ZNF145"
                     /note="zinc finger and BTB domain containing 16"
                     /db_xref="GeneID:7704"
                     /db_xref="HGNC:HGNC:12930"
                     /db_xref="MIM:176797"
     exon            1..172
                     /gene="ZBTB16"
                     /gene_synonym="PLZF; ZNF145"
                     /inference="alignment:Splign:2.1.0"
     exon            173..1530
                     /gene="ZBTB16"
                     /gene_synonym="PLZF; ZNF145"
                     /inference="alignment:Splign:2.1.0"
     CDS             263..2284
                     /gene="ZBTB16"
                     /gene_synonym="PLZF; ZNF145"
                     /note="isoform 1 is encoded by transcript variant 1; zinc
                     finger protein 145 (Kruppel-like, expressed in
                     promyelocytic leukemia); promyelocytic leukaemia zinc
                     finger; zinc finger and BTB domain-containing protein 16;
                     zinc finger protein PLZF"
                     /codon_start=1
                     /product="zinc finger and BTB domain-containing protein 16
                     isoform 1"
                     /protein_id="NP_005997.2"
                     /db_xref="CCDS:CCDS8367.1"
                     /db_xref="GeneID:7704"
                     /db_xref="HGNC:HGNC:12930"
                     /db_xref="MIM:176797"
                     /translation="MDLTKMGMIQLQNPSHPTGLLCKANQMRLAGTLCDVVIMVDSQE
                     FHAHRTVLACTSKMFEILFHRNSQHYTLDFLSPKTFQQILEYAYTATLQAKAEDLDDL
                     LYAAEILEIEYLEEQCLKMLETIQASDDNDTEATMADGGAEEEEDRKARYLKNIFISK
                     HSSEESGYASVAGQSLPGPMVDQSPSVSTSFGLSAMSPTKAAVDSLMTIGQSLLQGTL
                     QPPAGPEEPTLAGGGRHPGVAEVKTEMMQVDEVPSQDSPGAAESSISGGMGDKVEERG
                     KEGPGTPTRSSVITSARELHYGREESAEQVPPPAEAGQAPTGRPEHPAPPPEKHLGIY
                     SVLPNHKADAVLSMPSSVTSGLHVQPALAVSMDFSTYGGLLPQGFIQRELFSKLGELA
                     VGMKSESRTIGEQCSVCGVELPDNEAVEQHRKLHSGMKTYGCELCGKRFLDSLRLRMH
                     LLAHSAGAKAFVCDQCGAQFSKEDALETHRQTHTGTDMAVFCLLCGKRFQAQSALQQH
                     MEVHAGVRSYICSECNRTFPSHTALKRHLRSHTGDHPYECEFCGSCFRDESTLKSHKR
                     IHTGEKPYECNGCGKKFSLKHQLETHYRVHTGEKPFECKLCHQRSRDYSAMIKHLRTH
                     NGASPYQCTICTEYCPSLSSMQKHMKGHKPEEIPPDWRIEKTYLYLCYV"
     exon            1531..1628
                     /gene="ZBTB16"
                     /gene_synonym="PLZF; ZNF145"
                     /inference="alignment:Splign:2.1.0"
     exon            1629..1715
                     /gene="ZBTB16"
                     /gene_synonym="PLZF; ZNF145"
                     /inference="alignment:Splign:2.1.0"
     exon            1716..1886
                     /gene="ZBTB16"
                     /gene_synonym="PLZF; ZNF145"
                     /inference="alignment:Splign:2.1.0"
     exon            1887..2054
                     /gene="ZBTB16"
                     /gene_synonym="PLZF; ZNF145"
                     /inference="alignment:Splign:2.1.0"
     exon            2055..8494
                     /gene="ZBTB16"
                     /gene_synonym="PLZF; ZNF145"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7681..7686
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZBTB16"
                     /gene_synonym="PLZF; ZNF145"
                     /note="hexamer: AATAAA"
     polyA_site      7706
                     /gene="ZBTB16"
                     /gene_synonym="PLZF; ZNF145"
                     /note="major polyA site"
     regulatory      8475..8480
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZBTB16"
                     /gene_synonym="PLZF; ZNF145"
                     /note="hexamer: AATAAA"
     polyA_site      8494
                     /gene="ZBTB16"
                     /gene_synonym="PLZF; ZNF145"
ORIGIN      
        1 agcagagagg agttgagggc gatgagagcg ggtactgcga actgccgggc gatgctgtcg
       61 ctgccgccgt gatacggaga gcaacagttc cccagcaaca cccctccccg acacaggcac
      121 acaccccccg acaggcacgc acacccaccc cacagtgccc ggctcggctg cgcctcctct
      181 attggcccag gaagcccacc cagccccgcc acgcagagcc cagaaggaaa gaaagcctca
      241 tgcctgagcc gaggggagca ccatggatct gacaaaaatg ggcatgatcc agctgcagaa
      301 ccctagccac cccacggggc tactgtgcaa ggccaaccag atgcggctgg ccgggacttt
      361 gtgcgatgtg gtcatcatgg tggacagcca ggagttccac gcccaccgga cggtgctggc
      421 ctgcaccagc aagatgtttg agatcctctt ccaccgcaat agtcaacact atactttgga
      481 cttcctctcg ccaaagacct tccagcagat tctggagtat gcatatacag ccacgctgca
      541 agccaaggcg gaggacctgg atgacctgct gtatgcggcc gagatcctgg agatcgagta
      601 cctggaggaa cagtgcctga agatgctgga gaccatccag gcctcagacg acaatgacac
      661 ggaggccacc atggccgatg gcggggccga ggaagaagag gaccgcaagg ctcggtacct
      721 caagaacatc ttcatctcga agcattccag cgaggagagt gggtatgcca gtgtggctgg
      781 acagagcctc cctgggccca tggtggacca gagcccttca gtctccactt catttggtct
      841 ttcagccatg agtcccacca aggctgcagt ggacagtttg atgaccatag gacagtctct
      901 cctgcaggga actcttcagc cacctgcagg gcccgaggag ccaactctgg ctgggggtgg
      961 gcggcaccct ggggtggctg aggtgaagac ggagatgatg caggtggatg aggtgcccag
     1021 ccaggacagc cctggggcag ccgagtccag catctcagga gggatggggg acaaggttga
     1081 ggaaagaggc aaagaggggc ctgggacccc gactcgaagc agcgtcatca ccagtgctag
     1141 ggagctacac tatgggcgag aggagagtgc cgagcaggtg ccacccccag ctgaggctgg
     1201 ccaggccccc actggccgac ctgagcaccc agcacccccg cctgagaagc atctgggcat
     1261 ctactccgtg ttgcccaacc acaaggctga cgctgtattg agcatgccgt cttccgtgac
     1321 ctctggcctc cacgtgcagc ctgccctggc tgtctccatg gacttcagca cctatggggg
     1381 gctgctgccc cagggcttca tccagaggga gctgttcagc aagctggggg agctggctgt
     1441 gggcatgaag tcagagagcc ggaccatcgg agagcagtgc agcgtgtgtg gggtcgagct
     1501 tcctgataac gaggctgtgg agcagcacag gaagctgcac agtgggatga agacgtacgg
     1561 gtgcgagctc tgcgggaagc ggttcctgga tagtttgcgg ctgagaatgc acttactggc
     1621 tcattcagcg ggtgccaaag cctttgtctg tgatcagtgc ggtgcacagt tttcgaagga
     1681 ggatgccctg gagacacaca ggcagaccca tactggcact gacatggccg tcttctgtct
     1741 gctgtgtggg aagcgcttcc aggcgcagag cgcactgcag cagcacatgg aggtccacgc
     1801 gggcgtgcgc agctacatct gcagtgagtg caaccgcacc ttccccagcc acacggctct
     1861 caaacgccac ctgcgctcac atacaggcga ccacccctac gagtgtgagt tctgtggcag
     1921 ctgcttccgg gatgagagca cactcaagag ccacaaacgc atccacacgg gtgagaaacc
     1981 ctacgagtgc aatggctgtg gcaagaagtt cagcctcaag catcagctgg agacgcacta
     2041 tagggtgcac acaggtgaga agccctttga gtgtaagctc tgccaccagc gctcccggga
     2101 ctactcggcc atgatcaagc acctgagaac gcacaacggc gcctcgccct accagtgcac
     2161 catctgcaca gagtactgcc ccagcctctc ctccatgcag aagcacatga agggccacaa
     2221 gcccgaggag atcccgcccg actggaggat agagaagacg tacctctacc tgtgctatgt
     2281 gtgaagggag gcccgcggcg gtggagccga gcggggagcc aggaaagaag agttggagtg
     2341 agatgaagga aggactatga caaataaaaa aggaaaagaa aaaaaaaaac agaaggaaaa
     2401 ggaaacctgg tagctttttg gccttggatt ctctctgggc tccagatgac ctggatgcca
     2461 agccactgcc cctcctctgg gggcctccac cctcctctcc cggctggagg tttgcctgat
     2521 tttctgggat ggggttgggt attttgttca ctcaaatggt ggcacatttt tctccttcct
     2581 tcacccagac cttcttttat gtgtccagaa atggaggcta gaaagcaggt gagaggtcct
     2641 ctggtcagag ccacacggtc tgtgccggcc ttcctccacc aagaccccca ggagatgaag
     2701 ggagggagga ggtgagccag aagggcgctc ccctgctgat gggtctgggc tgggtcacta
     2761 gctgctcaaa atggcagctc tagtttgctg gcggctgact ggggaggaga agggctctgt
     2821 ttctcttccc accactcagc ccacctgctg ctttcctctg ctttgccaca tctgggtgtc
     2881 ccccggtggt ctctgagagc ctcaggaccc ctgcccctcc tccagctctt tgttcccagc
     2941 ctccccttga ctcctgtcct ccaagtccca ggggagtccc agcccctcag ggacctggcg
     3001 gtgtctccat ccttctccgg ttccctagtg ggatagctgc ctctgacttc agggtccctc
     3061 ctaccctcag ccttctgaga acacaaaaca aatccaatac cccaccctag tccagcacca
     3121 tcgtgagcaa gattcctgct gcgctgcttc caaaatggaa aagcatcaca actaaatacc
     3181 taatatccta ccaaacaaac cacagtccct acgtagccct acttcagtcc caggagaagg
     3241 aatccatgaa tgggctgagg ttccgagggt aggttgtgga tgtctttctc tagaggggtc
     3301 ccacacctgg aaaagaggac acccagcccg tgggatgagg gaagctgggc aagggagaaa
     3361 gttgttgagt cacactgggg accccagatg tagtgagctc agcaagaaaa gccaggtcca
     3421 gagagagtcg cacagaattc ctgactcaca gcgcccctcg gtccacagtg gagaggagga
     3481 ggaggaggag cagaaggagg gggaggagct gcaggaggag gaggatttga aagcgctttg
     3541 gccttgtgtt atgttttgct tcttttctgt gtcccctgtt agcacattgt acttgaatta
     3601 cctcagtttt ttgtgacctc atgagctttc ttaacctctg tatctctttt tcggttgggg
     3661 cttggaggaa tggggagggt gttcttttct gtttcttgtg taaattaata gttgttttta
     3721 tagacttcag ctggtcaaga ccctccccgt gcccctggag accagcctcc cagctggcag
     3781 gaactgtgca ggaggagttg atactcagga tctgaatgtg agggccgagg agggcgaaga
     3841 gcgtgggtgg ggaggggatg ttgctttggg gtctcatggt ccccagaggg cactagggag
     3901 tcacttttgg ctccgctggt gcatgaagtc acctgtggcc accatccgtt ccgcctaaaa
     3961 cactctggag agaatcccac ctttcttaca atttgctggg ccattgaggt ttgagggcct
     4021 gtgtttggat ccttgcaact gtgtggtctc acctctgtgc gtgcattctc attgccagaa
     4081 ttggtctatt ttcacggctg gtctttgggg aggggggcgg gatccagcct ttgttttgtt
     4141 gtgttggggt gggggtgttg tttttctaaa agctacctct tatgtttgtc cagttgttct
     4201 tttgttcctt tcccgcctcc cattctgctg ctcttcctcc ctcttttccc caacctcccc
     4261 cgaccctcct gaattttgga aagcacattt gcaatattcg tgtttgcttt gggacggacc
     4321 ctccgtttca tctcatgctt tatgtgtaag agttttttat tattattttt tctttccttt
     4381 ctctctctga gaaagttgtg gctgcgtttt gatcttaggt tttacaaagt ggtttaggga
     4441 agcggttttg gggagaagga tcacgaggaa tgtagggaag ccggagggat gggtgctgct
     4501 gcgacgaccc ccccgtccct cggccccagc cctcctgccc tccccttcaa tctcatccac
     4561 caaatctgaa ggccttaaaa ttgtgtgttg ggaggatgtg aattgggagg acggtgtcac
     4621 tagactgtgg attagggatg gtaaagtagg gaggatgcta ttttgcaact atagtaacga
     4681 cttagtgttt tggaaaggaa aagaagttaa acttgaaata cgtgactaga acagttgtca
     4741 tgtttataat gtgaaaaggg tgaaatcatt tgggggaggg gccgtctgta agaaatcatt
     4801 atgcactatg gcttcctcct ctggtctggg aagaagcggg gactggctgg ccctcagggg
     4861 atctgtaaat cccagaaaac agtattttta acagcaagat gtcattcaac attggtgggg
     4921 aaggaagaga aaaaaatcaa actattccat agaactagct ggccccctca ctcccatgcc
     4981 cttcccactc agcctgggcc cctccccgct ccattcataa aagctgagag ggttgagcta
     5041 atcttcacaa attgtaatat ttttgtagta tctgttagtt ccttcgtcag ttctgcagaa
     5101 ccttgccctt tccttttgta atgtgaatag gaagacaaaa gacaaaaaaa aatccaccac
     5161 caccaaaata tccctttgta catgtatgtg cgtgtgcgcg tgtgctttgt gtgtgtggtt
     5221 gtgtgttaaa tcatgcagta ttgtcgtaat ctggtgttgc agcaatggat ggtactaaat
     5281 cagcacctgg atgccccacc caaccccgtg ggccctgcag accccagtag ggaggtatgg
     5341 ggagagctca ggggagtgtg gtttctgagg gctactgtct ggggacacct ctgaacttac
     5401 tgtaccttcc tctccccatg aagacacctg aatagagtct aacatgcctc ttctccaact
     5461 tcctacctac aacaacagaa cagttctaat gttgcacggc ctagtggcca gggggcaagc
     5521 taagaggctg tctggaggct ttatatgtgt ctggagttaa ggggagagga ggagggtaga
     5581 caggggtctc tccccaggtg ggatctgaat atctgtcctc ccctcttctt catgccacct
     5641 gactccttcg gccccctggc tgcctttagc tgtggtactg ctgacaaccc tgcttgctac
     5701 tgccttatcc agcacagtga aaaacttctc cagcctggca aggccacgtt ggttaatagt
     5761 ccctttccca tgtccagctc ctacaaatat gtcccttaat gcatttggtg acatttacac
     5821 ctcatgtgct ctttccctat tcactccttc actcattcaa agcattaaaa tcctatgtat
     5881 atataggata gacaaatata tagatatata gatatatata tatatagcaa gagattgata
     5941 taaaatagta aatatcattg ctgctttggg ctgctttgga ggaggaggcc atgaatatgg
     6001 ggaaggcaga tctggggtgc aggggtaggt agggaggctg ggggacccag tgattcagta
     6061 caatccaagg gatgcaacgc gggcttgttt aatctttgtg cctgaacagt ttttccatgt
     6121 tgagaaaaaa aagaaaaaaa aactgctgca atttttcaca agtgtatggt acctttctgg
     6181 atgctattgg tacaattgct gtggatggaa gagggccatt gagcttacct ccctataggg
     6241 gagagagcag aggtggggca gcctttcgac tctgtccatg acggctggca gggtcagggt
     6301 agtttctggg cctgcttccc ggcaagccga gctagggtga aaactggggg cgcaccagga
     6361 tgtgagacag aaaagcagaa gatgagactc tgttcattca cttttcctag gcccatcctg
     6421 tggtcatctt tccccctccc atcatacctc ctccttcctg gagcctctgc cggcttggct
     6481 gtaatggtgg cacttacctg gatatttcag tgggaggatg aaaggcgaga ctcaccctac
     6541 gcggtgggac agatggggag aggaaaaagg cagagatggc caggagaggg gtgcaggaca
     6601 aaccagagag gttgggtcag gggaaaaggg tggggagaaa gaggggtgca ggccctgcag
     6661 gccggttagc cagcagctgc ggcctccccg ggcccttggc atccaacttc gcagacaggg
     6721 taccagcctc ctggtgtgta tcataggatt tgttcacata gtgttatgca tgatcttcgt
     6781 aaggttaaga agccgtggtg gtgcaccatg acatccaacc cgtatatata aagataaata
     6841 tatatatata tgtatgtaaa ttatagcact gagggccctg ctgccctgct ggaccaagca
     6901 aaactaagcc ttttggtttg ggtattatgt ttcgttttgt tatttgtttg tttttgtggc
     6961 ttgtcttatg tcgtgatagc acaagtgcca gtcggattgc tctgtattac agaatagtgt
     7021 ttttaattca tcaatgttct agttaatgtc tacctcagca cctcctctta gcctaatttt
     7081 aggaggttgc ccaattttgt ttcttcaatt ttactggtta cttttttgta caaatcaatc
     7141 tctttctctc tttctctcct ccccacctct cacccttgcc ctctccatct ccctctcccg
     7201 ccctcccctc ctccctctgg ctccccgtct catttctgtc cactccattc tctctccctc
     7261 tctcctgcct cctgctgccc cctccccagc ccacttcccc gagttgtgct tgccgctcct
     7321 tatctgttct agttccgaag cagtttcact cgaagttgtg cagtcctggt tgcagctttc
     7381 cgcatctgcc ttcgtttcgt gtagattgac gcgtttcttt gtaatttcag tgtttctgac
     7441 aagatttaaa aaaaaaaaaa aaggaaaaaa aaagaaaaaa tgaatttact gctgcaggtt
     7501 tttttctctc tccatgtgtc actaagtgaa gtttgtgcct tctatagcaa agagaatatt
     7561 ttttacatcc tactaacagt agattttttt gtagtgaaca ttttttgtat ttttatttat
     7621 aagtctcata agaaaaatag caatgttcag ttgtatacct tgaatctgca gttagaagag
     7681 aataaagtta attcagttgt ctctcgcttg aagcgtccca cctttttatt gaagtacttg
     7741 gttttgtttt gttttttttt tttgtttttt ttgccttttc ttgtgtgggg aacatggtag
     7801 aggaattaag atttttgtgt ggggactggg aaaaagaaag ctctgtatta cacatattta
     7861 gacttatcta tgtgtcactt ttatgccaca tttacaaggc acagatgcac tgaataacat
     7921 ttttctaata ctttttagtt aaaaaatgtt aaatacgtta atatcgtatg atccttggta
     7981 caatgtgcta ggtaggcact tgttcactta ttcagcaaga ccaccatgta ccagttactg
     8041 ttgtcggcgc tgggaattac agcaaaggac aaacagacaa accctggccg ccctggggct
     8101 accatgctag cgggccgctg agtcggaatc cgtggctgtg ttaggataac ttgctcagga
     8161 ttgcacggct ggtgagcagc agtcagaact ccatccacct ctcctgatac caggccaggt
     8221 tcctttactc cagagttctc aaagcagggg tctcacgtct tctttagtct ttagagagac
     8281 attttcaact gactccttag tggctaagca agcttcagaa atttctcaac aagaagcttc
     8341 cacacaatca aaggtccctg cctgcgtctg tagcagccaa gagctgttaa gaaaggagat
     8401 tggagcaggt ggccttgtgc aggggagggg atgggtggga ggtggccgtg caagctctgc
     8461 attgtcatgg acggaataaa ggatttccac aaca
//
