LOCUS       NM_001243702            3372 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens zinc finger and BTB domain containing 14 (ZBTB14),
            transcript variant 3, mRNA.
ACCESSION   NM_001243702 NR_026569
VERSION     NM_001243702.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3372)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 3372)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 3372)
  AUTHORS   Kim,W., Zhao,F., Wu,R., Qin,S., Nowsheen,S., Huang,J., Zhou,Q.,
            Chen,Y., Deng,M., Guo,G., Luo,K., Lou,Z. and Yuan,J.
  TITLE     ZFP161 regulates replication fork stability and maintenance of
            genomic stability by recruiting the ATR/ATRIP complex
  JOURNAL   Nat Commun 10 (1), 5304 (2019)
   PUBMED   31757956
  REMARK    GeneRIF: ZFP161 acts as a scaffolding protein to facilitate the
            interaction between RPA and ATR/ATRIP. ZFP161 binds to RPA and
            ATR/ATRIP through distinct regions and stabilizes the RPA-ATR-ATRIP
            complex at stalled replication forks. This function of ZFP161 is
            important to the ATR signaling cascade and genome stability
            maintenance.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3372)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3372)
  AUTHORS   Chen,S., Fragoza,R., Klei,L., Liu,Y., Wang,J., Roeder,K., Devlin,B.
            and Yu,H.
  TITLE     An interactome perturbation framework prioritizes damaging missense
            mutations for developmental disorders
  JOURNAL   Nat Genet 50 (7), 1032-1040 (2018)
   PUBMED   29892012
REFERENCE   6  (bases 1 to 3372)
  AUTHORS   Numoto,M., Yokoro,K. and Koshi,J.
  TITLE     ZF5, which is a Kruppel-type transcriptional repressor, requires
            the zinc finger domain for self-association
  JOURNAL   Biochem Biophys Res Commun 256 (3), 573-578 (1999)
   PUBMED   10080939
REFERENCE   7  (bases 1 to 3372)
  AUTHORS   Obata,T., Yanagidani,A., Yokoro,K., Numoto,M. and Yamamoto,S.
  TITLE     Analysis of the consensus binding sequence and the DNA-binding
            domain of ZF5
  JOURNAL   Biochem Biophys Res Commun 255 (2), 528-534 (1999)
   PUBMED   10049742
REFERENCE   8  (bases 1 to 3372)
  AUTHORS   Sobek-Klocke,I., Disque-Kochem,C., Ronsiek,M., Klocke,R.,
            Jockusch,H., Breuning,A., Ponstingl,H., Rojas,K., Overhauser,J. and
            Eichenlaub-Ritter,U.
  TITLE     The human gene ZFP161 on 18p11.21-pter encodes a putative c-myc
            repressor and is homologous to murine Zfp161 (Chr 17) and
            Zfp161-rs1 (X Chr)
  JOURNAL   Genomics 43 (2), 156-164 (1997)
   PUBMED   9244432
  REMARK    Erratum:[Genomics 1997 Nov 1;45(3):633]
REFERENCE   9  (bases 1 to 3372)
  AUTHORS   Sugiura,K., Muro,Y., Nagai,Y., Kamimoto,T., Wakabayashi,T.,
            Ohashi,M. and Hagiwara,M.
  TITLE     Expression cloning and intracellular localization of a human ZF5
            homologue
  JOURNAL   Biochim Biophys Acta 1352 (1), 23-26 (1997)
   PUBMED   9177479
REFERENCE   10 (bases 1 to 3372)
  AUTHORS   Numoto,M., Niwa,O., Kaplan,J., Wong,K.K., Merrell,K., Kamiya,K.,
            Yanagihara,K. and Calame,K.
  TITLE     Transcriptional repressor ZF5 identifies a new conserved domain in
            zinc finger proteins
  JOURNAL   Nucleic Acids Res 21 (16), 3767-3775 (1993)
   PUBMED   8367294
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP001496.4, BI561601.1 and AW338628.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001243702.1.
            
            Transcript Variant: This variant (3) differs in the 5' UTR compared
            to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.249386.1,
                                           SRR1803611.246938.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000651870.1/ ENSP00000499212.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                AP001496.4         158473-158496       c
            25-290              BI561601.1         6-271
            291-2878            AP001496.4         152286-154873       c
            2879-3372           AW338628.1         16-509              c
FEATURES             Location/Qualifiers
     source          1..3372
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18p11.31"
     gene            1..3372
                     /gene="ZBTB14"
                     /gene_synonym="ZF5; ZFP-161; ZFP-5; ZFP161; ZNF478"
                     /note="zinc finger and BTB domain containing 14"
                     /db_xref="GeneID:7541"
                     /db_xref="HGNC:HGNC:12860"
                     /db_xref="MIM:602126"
     exon            1..75
                     /gene="ZBTB14"
                     /gene_synonym="ZF5; ZFP-161; ZFP-5; ZFP161; ZNF478"
                     /inference="alignment:Splign:2.1.0"
     exon            76..105
                     /gene="ZBTB14"
                     /gene_synonym="ZF5; ZFP-161; ZFP-5; ZFP161; ZNF478"
                     /inference="alignment:Splign:2.1.0"
     exon            106..189
                     /gene="ZBTB14"
                     /gene_synonym="ZF5; ZFP-161; ZFP-5; ZFP161; ZNF478"
                     /inference="alignment:Splign:2.1.0"
     CDS             187..1536
                     /gene="ZBTB14"
                     /gene_synonym="ZF5; ZFP-161; ZFP-5; ZFP161; ZNF478"
                     /note="zinc finger protein homologous to Zfp161 in mouse;
                     zinc finger protein 5 homolog; zinc finger protein 161
                     homolog; ZFP161 zinc finger protein; zinc finger protein
                     478"
                     /codon_start=1
                     /product="zinc finger and BTB domain-containing protein
                     14"
                     /protein_id="NP_001230631.1"
                     /db_xref="CCDS:CCDS11837.1"
                     /db_xref="GeneID:7541"
                     /db_xref="HGNC:HGNC:12860"
                     /db_xref="MIM:602126"
                     /translation="MEFFISMSETIKYNDDDHKTLFLKTLNEQRLEGEFCDIAIVVED
                     VKFRAHRCVLAACSTYFKKLFKKLEVDSSSVIEIDFLRSDIFEEVLNYMYTAKISVKK
                     EDVNLMMSSGQILGIRFLDKLCSQKRDVSSPDENNGQSKSKYCLKINRPIGDAADTQD
                     DDVEEIGDQDDSPSDDTVEGTPPSQEDGKSPTTTLRVQEAILKELGSEEVRKVNCYGQ
                     EVESMETPESKDLGSQTPQALTFNDGMSEVKDEQTPGWTTAASDMKFEYLLYGHHREQ
                     IACQACGKTFSDEGRLRKHEKLHTADRPFVCEMCTKGFTTQAHLKEHLKIHTGYKPYS
                     CEVCGKSFIRAPDLKKHERVHSNERPFACHMCDKAFKHKSHLKDHERRHRGEKPFVCG
                     SCTKAFAKASDLKRHENNMHSERKQVTPSAIQSETEQLQAAAMAAEAEQQLETIACS"
     exon            190..3372
                     /gene="ZBTB14"
                     /gene_synonym="ZF5; ZFP-161; ZFP-5; ZFP161; ZNF478"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2557..2562
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZBTB14"
                     /gene_synonym="ZF5; ZFP-161; ZFP-5; ZFP161; ZNF478"
                     /note="hexamer: AATAAA"
     polyA_site      2586
                     /gene="ZBTB14"
                     /gene_synonym="ZF5; ZFP-161; ZFP-5; ZFP161; ZNF478"
                     /note="major polyA site"
     regulatory      2700..2705
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZBTB14"
                     /gene_synonym="ZF5; ZFP-161; ZFP-5; ZFP161; ZNF478"
                     /note="hexamer: ATTAAA"
     polyA_site      2720
                     /gene="ZBTB14"
                     /gene_synonym="ZF5; ZFP-161; ZFP-5; ZFP161; ZNF478"
                     /note="major polyA site"
     regulatory      2996..3001
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZBTB14"
                     /gene_synonym="ZF5; ZFP-161; ZFP-5; ZFP161; ZNF478"
                     /note="hexamer: ATTAAA"
     polyA_site      3017
                     /gene="ZBTB14"
                     /gene_synonym="ZF5; ZFP-161; ZFP-5; ZFP161; ZNF478"
     regulatory      3361..3366
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZBTB14"
                     /gene_synonym="ZF5; ZFP-161; ZFP-5; ZFP161; ZNF478"
                     /note="hexamer: AATATA"
     polyA_site      3372
                     /gene="ZBTB14"
                     /gene_synonym="ZF5; ZFP-161; ZFP-5; ZFP161; ZNF478"
ORIGIN      
        1 agacgcgcgt tctcgccgag ctctggggca ccagccagct ccaggatgtg cggcggccgc
       61 cagcggcgcg gcgcggatat gggtctgcag gatggagttc ttccggtctg gcgtgctcct
      121 gatcagagtt actctgatct gaagattttg gcgttcaagg cattaagata atagcctgag
      181 ttgttcatgg agtttttcat cagtatgtct gaaaccatta aatataatga cgatgatcat
      241 aaaactctgt ttctgaaaac actaaatgaa caacgcctgg aaggagaatt ttgtgatatt
      301 gctattgtgg ttgaggatgt gaaattcaga gcacacagat gtgttcttgc tgcctgcagc
      361 acttacttta aaaagctttt caagaagctt gaggttgata gttcttcggt catagaaata
      421 gattttcttc gttctgatat atttgaagag gtcctgaact acatgtacac agcaaagatt
      481 tccgtgaaaa aagaagatgt taacttaatg atgtcatcgg gtcagattct tggtatccga
      541 tttttggata aactgtgttc tcagaagcgt gatgtgtcca gtcccgatga aaacaatggt
      601 cagtccaaaa gtaagtattg ccttaaaata aatcgcccca ttggagatgc tgctgacacc
      661 caggatgatg atgtagagga aatcggggat caggatgaca gtccttctga tgacacagta
      721 gaaggcacac ccccgagtca ggaggacggc aagtcgccca ccacaacgct cagggttcag
      781 gaagcgatcc tgaaagagct ggggagtgag gaagttcgga aggtcaattg ctacggccag
      841 gaagtagaat ccatggagac cccagaatca aaagacttgg ggtcccagac ccctcaagcc
      901 ttaacattta atgatgggat gagtgaagtg aaagatgaac agacaccagg ctggacaaca
      961 gccgccagtg acatgaagtt tgagtatttg ctttatggtc accatcggga gcagattgcc
     1021 tgccaggcgt gtgggaagac gttttctgat gaaggcagat tgaggaagca tgagaaactc
     1081 cacacggcgg acaggccatt tgtttgtgaa atgtgcacaa aaggtttcac cacacaggcc
     1141 cacctgaaag aacacctaaa aatccacaca ggatataagc cctatagctg tgaggtgtgt
     1201 ggaaaatcat ttatccgtgc cccagactta aagaagcatg agagagttca cagtaatgaa
     1261 agaccgtttg cgtgccacat gtgtgacaaa gccttcaaac acaagtctca cctcaaggat
     1321 catgaaagaa gacacagagg ggaaaagcct tttgtgtgtg gctcctgcac caaggcattt
     1381 gccaaggcat ctgatctgaa aaggcacgag aacaatatgc acagtgaaag gaagcaggtt
     1441 acccccagtg ccatccagag cgagacagaa cagttgcagg cggcagcgat ggctgcggaa
     1501 gcagaacagc agctggagac gatagcctgt agctagaggc ggtgggacag ggacactttg
     1561 cctggaaagt ggagactgag atgacgtgga tcataatgag tgaatgccag ttacaatatt
     1621 tttgtggaaa cgtatggaac attgtactca ctggacttaa ggcagtgctt ggttagctat
     1681 ttttaagact tttcaaggaa atggtgttcc tcagttctga ccaaaccgtt tcactgtctt
     1741 gtctggtgtc tagtattaat gttgcccagt aagcacctct ctcccttttt tttttttatt
     1801 attttaattt gagaactcct gtgtccagtt tagaagtgag agacttccat ttttagttcc
     1861 tttacactca ccaccctagc aagtgccctg cacagagtaa taagtaaatt gatttcctaa
     1921 tcacaattct atgtgactta tggtcaaaag agcagtttta ataactttaa aagtacttca
     1981 gatagacgca gaaaattggt gagtggttga ccaagaacac tgcacaaata taaaaaaagt
     2041 tctggaaatg cagaatggcg ttagatttat atttggtttg ttaattttat atcactgttt
     2101 ttcactgttt ttgtggacaa ataatggttg ctttgctgaa gtgttcttcc tcaatcttga
     2161 ttgccctgta cctacccaaa agctgtagtc acacatccta aaggccaagc aaacccaccg
     2221 ggatggtggg gggtcttgga gccaagctct taggttcctc ttatttgggg cagtaccagt
     2281 ccataccagc tgcgatttgt gagtggacct gtggtaagaa gaatagaaaa ggctctcaga
     2341 gataaggttt tttacatgtg taacaatccc aagatttcct agattaaaat cttaattgat
     2401 tttgaaattg gatttttatt tagaatcaaa attaggacaa gaacagataa cttcttcaga
     2461 tacatttgtg taactttaca gaatgtcatc aagctttggg gctctgtggg gcacatgatt
     2521 tatccataaa ggagatgcag tatgcttact taaattaata aatttaaaat cttttaagtg
     2581 tgtaaatagt agtgttggtc ttacgtattt caagtaaaaa gtagacagct gcactttttt
     2641 tgcacattgg attaaaataa cttccatcag caacaaacat cagactgttt ttaacaaata
     2701 ttaaagattg tcagaccaaa tgtttatgtt ttcgaaatat atttcatcac tggttacagt
     2761 tttaaataga agttgattgc cttttcatag ccgtaaatga gaattataaa ctctattcca
     2821 gttttggtat actaaatgtt cttttaacca tctttaggaa tatattgaaa tgccaacaat
     2881 agtttgaatt gtgttctgta aaaaagtatt agtcaattat ttttcaaaat gtagaattgt
     2941 agaaaatgtc aatttttcaa actcattttt cattgctagg atttctttta aaaaaattaa
     3001 agtaatttca cttcatagct tgttgcatta acacctgtaa ttctattgtg aaagaaattt
     3061 gattttttaa ttggtgtgtg ttatgcccaa gatgttagga tgaagatgct acctttttaa
     3121 aaattttagt tattggtaaa atgtttaatt ttacttaaaa ttaatttctt ttcttgaaag
     3181 ttgtttattc tgttctaaaa gtagtcctgt cactgtgttt ttatgctact tatagaaggg
     3241 gaactgattg ccgttcctag gctgttttaa ccaaagcaaa ggaaaaataa ttttaacatc
     3301 ttgtcaatag ctacttcaac aaaccatatt ttgggacttc attttttgta tataaaagaa
     3361 aatatacttc ta
//
