LOCUS       NM_181842               1963 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens zinc finger and BTB domain containing 12 (ZBTB12),
            mRNA.
ACCESSION   NM_181842
VERSION     NM_181842.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1963)
  AUTHORS   Han,D., Liu,G., Oh,Y., Oh,S., Yang,S., Mandjikian,L., Rani,N.,
            Almeida,M.C., Kosik,K.S. and Jang,J.
  TITLE     ZBTB12 is a molecular barrier to dedifferentiation in human
            pluripotent stem cells
  JOURNAL   Nat Commun 14 (1), 632 (2023)
   PUBMED   36759523
  REMARK    GeneRIF: ZBTB12 is a molecular barrier to dedifferentiation in
            human pluripotent stem cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1963)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1963)
  AUTHORS   Noro,F., Gianfagna,F., Gialluisi,A., De Curtis,A., Di
            Castelnuovo,A., Napoleone,E., Cerletti,C., Donati,M.B., de
            Gaetano,G., Hoylaerts,M.F., Iacoviello,L. and Izzi,B.
  CONSRTM   Moli-family study Investigators
  TITLE     ZBTB12 DNA methylation is associated with coagulation- and
            inflammation-related blood cell parameters: findings from the
            Moli-family cohort
  JOURNAL   Clin Epigenetics 11 (1), 74 (2019)
   PUBMED   31077224
  REMARK    GeneRIF: Results find ZBTB12 hypomethylation to be linked to
            shorter TNF-a stimulated whole blood coagulation time and increased
            WBC and granulocyte counts, further elucidating the possible link
            between ZBTB12 methylation and cardiovascular disease risk.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1963)
  AUTHORS   Yin,Y., Morgunova,E., Jolma,A., Kaasinen,E., Sahu,B.,
            Khund-Sayeed,S., Das,P.K., Kivioja,T., Dave,K., Zhong,F.,
            Nitta,K.R., Taipale,M., Popov,A., Ginno,P.A., Domcke,S., Yan,J.,
            Schubeler,D., Vinson,C. and Taipale,J.
  TITLE     Impact of cytosine methylation on DNA binding specificities of
            human transcription factors
  JOURNAL   Science 356 (6337) (2017)
   PUBMED   28473536
REFERENCE   5  (bases 1 to 1963)
  AUTHORS   Armstrong,D.L., Zidovetzki,R., Alarcon-Riquelme,M.E., Tsao,B.P.,
            Criswell,L.A., Kimberly,R.P., Harley,J.B., Sivils,K.L., Vyse,T.J.,
            Gaffney,P.M., Langefeld,C.D. and Jacob,C.O.
  TITLE     GWAS identifies novel SLE susceptibility genes and explains the
            association of the HLA region
  JOURNAL   Genes Immun 15 (6), 347-354 (2014)
   PUBMED   24871463
REFERENCE   6  (bases 1 to 1963)
  AUTHORS   Png,E., Thalamuthu,A., Ong,R.T., Snippe,H., Boland,G.J. and
            Seielstad,M.
  TITLE     A genome-wide association study of hepatitis B vaccine response in
            an Indonesian population reveals multiple independent risk variants
            in the HLA region
  JOURNAL   Hum Mol Genet 20 (19), 3893-3898 (2011)
   PUBMED   21764829
REFERENCE   7  (bases 1 to 1963)
  AUTHORS   Xie,T., Rowen,L., Aguado,B., Ahearn,M.E., Madan,A., Qin,S.,
            Campbell,R.D. and Hood,L.
  TITLE     Analysis of the gene-dense major histocompatibility complex class
            III region and its comparison to mouse
  JOURNAL   Genome Res 13 (12), 2621-2636 (2003)
   PUBMED   14656967
REFERENCE   8  (bases 1 to 1963)
  AUTHORS   Mungall,A.J., Palmer,S.A., Sims,S.K., Edwards,C.A., Ashurst,J.L.,
            Wilming,L., Jones,M.C., Horton,R., Hunt,S.E., Scott,C.E.,
            Gilbert,J.G., Clamp,M.E., Bethel,G., Milne,S., Ainscough,R.,
            Almeida,J.P., Ambrose,K.D., Andrews,T.D., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Barker,D.J.,
            Barlow,K.F., Bates,K., Beare,D.M., Beasley,H., Beasley,O.,
            Bird,C.P., Blakey,S., Bray-Allen,S., Brook,J., Brown,A.J.,
            Brown,J.Y., Burford,D.C., Burrill,W., Burton,J., Carder,C.,
            Carter,N.P., Chapman,J.C., Clark,S.Y., Clark,G., Clee,C.M.,
            Clegg,S., Cobley,V., Collier,R.E., Collins,J.E., Colman,L.K.,
            Corby,N.R., Coville,G.J., Culley,K.M., Dhami,P., Davies,J.,
            Dunn,M., Earthrowl,M.E., Ellington,A.E., Evans,K.A., Faulkner,L.,
            Francis,M.D., Frankish,A., Frankland,J., French,L., Garner,P.,
            Garnett,J., Ghori,M.J., Gilby,L.M., Gillson,C.J., Glithero,R.J.,
            Grafham,D.V., Grant,M., Gribble,S., Griffiths,C., Griffiths,M.,
            Hall,R., Halls,K.S., Hammond,S., Harley,J.L., Hart,E.A.,
            Heath,P.D., Heathcott,R., Holmes,S.J., Howden,P.J., Howe,K.L.,
            Howell,G.R., Huckle,E., Humphray,S.J., Humphries,M.D., Hunt,A.R.,
            Johnson,C.M., Joy,A.A., Kay,M., Keenan,S.J., Kimberley,A.M.,
            King,A., Laird,G.K., Langford,C., Lawlor,S., Leongamornlert,D.A.,
            Leversha,M., Lloyd,C.R., Lloyd,D.M., Loveland,J.E., Lovell,J.,
            Martin,S., Mashreghi-Mohammadi,M., Maslen,G.L., Matthews,L.,
            McCann,O.T., McLaren,S.J., McLay,K., McMurray,A., Moore,M.J.,
            Mullikin,J.C., Niblett,D., Nickerson,T., Novik,K.L., Oliver,K.,
            Overton-Larty,E.K., Parker,A., Patel,R., Pearce,A.V., Peck,A.I.,
            Phillimore,B., Phillips,S., Plumb,R.W., Porter,K.M., Ramsey,Y.,
            Ranby,S.A., Rice,C.M., Ross,M.T., Searle,S.M., Sehra,H.K.,
            Sheridan,E., Skuce,C.D., Smith,S., Smith,M., Spraggon,L.,
            Squares,S.L., Steward,C.A., Sycamore,N., Tamlyn-Hall,G., Tester,J.,
            Theaker,A.J., Thomas,D.W., Thorpe,A., Tracey,A., Tromans,A.,
            Tubby,B., Wall,M., Wallis,J.M., West,A.P., White,S.S.,
            Whitehead,S.L., Whittaker,H., Wild,A., Willey,D.J., Wilmer,T.E.,
            Wood,J.M., Wray,P.W., Wyatt,J.C., Young,L., Younger,R.M.,
            Bentley,D.R., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E.,
            Dunham,I., Rogers,J. and Beck,S.
  TITLE     The DNA sequence and analysis of human chromosome 6
  JOURNAL   Nature 425 (6960), 805-811 (2003)
   PUBMED   14574404
REFERENCE   9  (bases 1 to 1963)
  AUTHORS   Herberg,J.A., Beck,S. and Trowsdale,J.
  TITLE     TAPASIN, DAXX, RGL2, HKE2 and four new genes (BING 1, 3 to 5) form
            a dense cluster at the centromeric end of the MHC
  JOURNAL   J Mol Biol 277 (4), 839-857 (1998)
   PUBMED   9545376
REFERENCE   10 (bases 1 to 1963)
  AUTHORS   Peterson,S.N., Trabalzini,L., Brtva,T.R., Fischer,T.,
            Altschuler,D.L., Martelli,P., Lapetina,E.G., Der,C.J. and
            White,G.C. 2nd.
  TITLE     Identification of a novel RalGDS-related protein as a candidate
            effector for Ras and Rap1
  JOURNAL   J Biol Chem 271 (47), 29903-29908 (1996)
   PUBMED   8939933
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL671762.10.
            
            On May 17, 2019 this sequence version replaced NM_181842.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC043609.1, SRR7346977.1142761.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000375527.3/ ENSP00000364677.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-94                AL671762.10        109841-109934       c
            95-250              AL671762.10        109685-109840       c
            251-1959            AL671762.10        107465-109173       c
            1960-1963           AL671762.10        107461-107464       c
FEATURES             Location/Qualifiers
     source          1..1963
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.33"
     gene            1..1963
                     /gene="ZBTB12"
                     /gene_synonym="Bat9; C6orf46; D6S59E; G10; NG35"
                     /note="zinc finger and BTB domain containing 12"
                     /db_xref="GeneID:221527"
                     /db_xref="HGNC:HGNC:19066"
     exon            1..250
                     /gene="ZBTB12"
                     /gene_synonym="Bat9; C6orf46; D6S59E; G10; NG35"
                     /inference="alignment:Splign:2.1.0"
     exon            251..1963
                     /gene="ZBTB12"
                     /gene_synonym="Bat9; C6orf46; D6S59E; G10; NG35"
                     /inference="alignment:Splign:2.1.0"
     CDS             271..1650
                     /gene="ZBTB12"
                     /gene_synonym="Bat9; C6orf46; D6S59E; G10; NG35"
                     /note="HLA-B-associated transcript 9"
                     /codon_start=1
                     /product="zinc finger and BTB domain-containing protein
                     12"
                     /protein_id="NP_862825.1"
                     /db_xref="CCDS:CCDS4727.1"
                     /db_xref="GeneID:221527"
                     /db_xref="HGNC:HGNC:19066"
                     /translation="MASGVEVLRFQLPGHEAATLRNMNQLRAEERFCDVTIVADSLKF
                     RGHKVILAACSPFLRDQFLLNPSSELQVSLMHSARIVADLLLSCYTGALEFAVRDIVN
                     YLTAASYLQMEHVVEKCRNALSQFIEPKIGLKEDGVSEASLVSSISATKSLLPPARTP
                     KPAPKPPPPPPLPPPLLRPVKLEFPLDEDLELKAEEEDEDEDEDVSDICIVKVESALE
                     VAHRLKPPGGLGGGLGIGGSVGGHLGELAQSSVPPSTVAPPQGVVKACYSLSEDAEGE
                     GLLLIPGGRASVGATSGLVEAAAVAMAARGAGGSLGAGGSRGPLPGGFSGGNPLKNIK
                     CTKCPEVFQGVEKLVFHMRAQHFIFMCPRCGKQFNHSSNLNRHMNVHRGVKSHSCGIC
                     GKCFTQKSTLHDHLNLHSGARPYRCSYCDVRFAHKPAIRRHLKEQHGKTTAENVLEAS
                     VAEINVLIR"
ORIGIN      
        1 cttcctcctc cccgagtcct agccgacgcc gccgccgccg cgcgcgcggg gcctggaaca
       61 cacggcacga gccgcccccg cccctccccc cttacgccca cgcggagccg gccccgcgcg
      121 cgcgcgcgtc ccgtgcatcc ccgcgcctgc gcgctgccca ggccctgccc gtgtgtgggg
      181 gtcgctgccg gccccggggg ggggtgggga aaataaggga ttaaaaaaac agcgcgcgga
      241 accgggccag ggttgcccac ccccgccaca atggcctctg gggtggaagt cctgcgcttc
      301 cagctgcccg gccacgaggc cgcaacgcta cggaacatga accagctccg ggcagaggag
      361 cggttctgcg acgtgaccat tgtggccgac agcctcaagt ttcgaggcca caaggtcatc
      421 ttggccgcct gctcaccctt cctgcgggac cagttcctgc tgaaccccag ctcggagctg
      481 caggtctccc tgatgcacag tgcacgcatc gtggccgact tgctcctctc ctgctacacg
      541 ggcgccttgg aattcgctgt tagggacatc gtcaactacc ttacagccgc ctcctacctg
      601 cagatggagc acgtggtgga gaaatgccgg aatgccctca gccagttcat tgagcccaaa
      661 ataggcctca aagaggatgg ggtcagtgag gctagccttg tgagcagcat cagcgccacc
      721 aagtccctcc tccctccagc caggacccca aagccagccc cgaagccccc acccccacct
      781 cctctacccc ctccactcct gcggccagtg aagctggagt tcccactgga tgaagacttg
      841 gagctgaaag ccgaggaaga ggatgaggat gaggatgagg acgtgtctga catctgcatc
      901 gtcaaggtgg agtcggccct ggaggtggca caccggctca aaccccctgg aggcctggga
      961 gggggtctgg gcattggagg ctccgtgggt ggccaccttg gggagctggc ccagagcagc
     1021 gttcccccca gcactgtagc cccaccgcag ggtgtggtga aggcctgcta tagcctgtcg
     1081 gaagatgcag aaggggaggg cctgctgttg attcccggag gccgggccag cgtgggggcc
     1141 acctcgggcc tggtggaagc agcagcggtg gccatggctg cccggggggc ggggggcagc
     1201 ctgggggcgg ggggcagccg gggacccctg cctgggggct tctcaggtgg aaacccctta
     1261 aagaacatca agtgcaccaa gtgcccggaa gtgttccagg gcgtggagaa gctggtcttc
     1321 cacatgcggg cgcagcactt catcttcatg tgccctcgct gtggcaagca gttcaaccac
     1381 agcagcaacc tcaaccgcca catgaacgtg catcgtggtg tcaagtcaca ctcgtgcggc
     1441 atctgcggca agtgcttcac acagaagtcc acccttcacg accacctcaa cctgcactcg
     1501 ggagcgcggc cctaccgctg ctcctactgc gacgtgcgct tcgcccacaa gcctgccatt
     1561 aggcggcacc tcaaggagca acacggcaag accacggccg agaacgtgct ggaggccagt
     1621 gtggccgaga ttaacgtcct catccgctag ccgcgcaggc gtggaggcca ggaggctggg
     1681 gcccctgggc tgcgtggaaa aagggctctt tggcccagga gaattggggg gtggggggtc
     1741 tggggcagaa aggtaagagt gggaggctga gcagatgcac acatcctgag agagggaaga
     1801 tgattccttg gagagacttg ctcttgagag tgcaagaatc tggagctggg aaaagggttc
     1861 ttggaggcca ggggaatacg gggtcccaga gaaagatttc cttctcttag aagtgcatgt
     1921 atatgtggag ggagggaaaa gggtcctata gaatgaggga aga
//
