LOCUS       NM_014415               5657 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens zinc finger and BTB domain containing 11 (ZBTB11),
            mRNA.
ACCESSION   NM_014415
VERSION     NM_014415.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5657)
  AUTHORS   Ortigoza-Escobar,J.D., Zamani,M., Dorison,N., Sadeghian,S.,
            Azizimalamiri,R., Alvi,J.R., Sultan,T., Galehdari,H., Shariati,G.,
            Saberi,A., Leeuwen,L., Zifarelli,G., Bauer,P., d'Hardemare,V.,
            Doummar,D., Roze,E., Travaglini,L., Nicita,F., Ojea Ponce,N.,
            Zahraei,S.M., Alabdi,L., Tamim,A., Hashem,M.O., Ababneh,F.,
            Morrow,M.M., Curry,C., Tam,A., Ruedy,J., Bhambhani,V., Veith,R.,
            Stromme,P., Efthymiou,S., Alkuraya,F.S., Moreno-De-Luca,A.,
            Burglen,L., Houlden,H. and Maroofian,R.
  TITLE     Biallelic ZBTB11 Variants: A Neurodevelopmental Condition with
            Progressive Complex Movement Disorders
  JOURNAL   Mov Disord 39 (9), 1624-1630 (2024)
   PUBMED   38899514
  REMARK    GeneRIF: Biallelic ZBTB11 Variants: A Neurodevelopmental Condition
            with Progressive Complex Movement Disorders.
REFERENCE   2  (bases 1 to 5657)
  AUTHORS   Xu,W., Yao,H., Wu,Z., Yan,X., Jiao,Z., Liu,Y., Zhang,M. and Wang,D.
  TITLE     Oncoprotein SET-associated transcription factor ZBTB11 triggers
            lung cancer metastasis
  JOURNAL   Nat Commun 15 (1), 1362 (2024)
   PUBMED   38355937
  REMARK    GeneRIF: Oncoprotein SET-associated transcription factor ZBTB11
            triggers lung cancer metastasis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5657)
  AUTHORS   Garipler,G., Lu,C., Morrissey,A., Lopez-Zepeda,L.S., Pei,Y.,
            Vidal,S.E., Zen Petisco Fiore,A.P., Aydin,B., Stadtfeld,M.,
            Ohler,U., Mahony,S., Sanjana,N.E. and Mazzoni,E.O.
  TITLE     The BTB transcription factors ZBTB11 and ZFP131 maintain
            pluripotency by repressing pro-differentiation genes
  JOURNAL   Cell Rep 38 (11), 110524 (2022)
   PUBMED   35294876
  REMARK    GeneRIF: The BTB transcription factors ZBTB11 and ZFP131 maintain
            pluripotency by repressing pro-differentiation genes.
REFERENCE   4  (bases 1 to 5657)
  AUTHORS   Wilson,B.C., Boehme,L., Annibali,A., Hodgkinson,A., Carroll,T.S.,
            Oakey,R.J. and Seitan,V.C.
  TITLE     Intellectual disability-associated factor Zbtb11 cooperates with
            NRF-2/GABP to control mitochondrial function
  JOURNAL   Nat Commun 11 (1), 5469 (2020)
   PUBMED   33122634
  REMARK    GeneRIF: Intellectual disability-associated factor Zbtb11
            cooperates with NRF-2/GABP to control mitochondrial function.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5657)
  AUTHORS   Fattahi,Z., Sheikh,T.I., Musante,L., Rasheed,M., Taskiran,I.I.,
            Harripaul,R., Hu,H., Kazeminasab,S., Alam,M.R., Hosseini,M.,
            Larti,F., Ghaderi,Z., Celik,A., Ayub,M., Ansar,M., Haddadi,M.,
            Wienker,T.F., Ropers,H.H., Kahrizi,K., Vincent,J.B. and
            Najmabadi,H.
  TITLE     Biallelic missense variants in ZBTB11 can cause intellectual
            disability in humans
  JOURNAL   Hum Mol Genet 27 (18), 3177-3188 (2018)
   PUBMED   29893856
  REMARK    GeneRIF: we report two ID families segregating ZBTB11 biallelic
            mutations disrupting Zn2+-binding motifs and provide functional
            evidence linking ZBTB11 dysfunction to this phenotype
REFERENCE   6  (bases 1 to 5657)
  AUTHORS   Colland,F., Jacq,X., Trouplin,V., Mougin,C., Groizeleau,C.,
            Hamburger,A., Meil,A., Wojcik,J., Legrain,P. and Gauthier,J.M.
  TITLE     Functional proteomics mapping of a human signaling pathway
  JOURNAL   Genome Res 14 (7), 1324-1332 (2004)
   PUBMED   15231748
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA907277.1, BC028062.1, AK312859.1, AB208862.1, AI636025.1 and
            AC084198.31.
            
            On May 17, 2019 this sequence version replaced NM_014415.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.135535.1,
                                           SRR1660805.41393.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2149398 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000312938.5/ ENSP00000326200.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                DA907277.1         13-26
            15-764              BC028062.1         1-750
            765-3380            AK312859.1         769-3384
            3381-4761           AB208862.1         2106-3486
            4762-5107           AI636025.1         14-359              c
            5108-5657           AC084198.31        51736-52285         c
FEATURES             Location/Qualifiers
     source          1..5657
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q12.3"
     gene            1..5657
                     /gene="ZBTB11"
                     /gene_synonym="MRT69; ZNF-U69274; ZNF913"
                     /note="zinc finger and BTB domain containing 11"
                     /db_xref="GeneID:27107"
                     /db_xref="HGNC:HGNC:16740"
                     /db_xref="MIM:618181"
     exon            1..528
                     /gene="ZBTB11"
                     /gene_synonym="MRT69; ZNF-U69274; ZNF913"
                     /inference="alignment:Splign:2.1.0"
     CDS             219..3380
                     /gene="ZBTB11"
                     /gene_synonym="MRT69; ZNF-U69274; ZNF913"
                     /codon_start=1
                     /product="zinc finger and BTB domain-containing protein
                     11"
                     /protein_id="NP_055230.2"
                     /db_xref="CCDS:CCDS2943.1"
                     /db_xref="GeneID:27107"
                     /db_xref="HGNC:HGNC:16740"
                     /db_xref="MIM:618181"
                     /translation="MSSEESYRAILRYLTNEREPYAPGTEGNVKRKIRKAAACYVVRG
                     GTLYYQRRQRHRKTFAELEVVLQPERRRDLIEAAHLGPGGTHHTRHQTWHYLSKTYWW
                     RGILKQVKDYIKQCSKCQEKLDRSRPISDVSEMLEELGLDLESGEESNESEDDLSNFT
                     SSPTTASKPAKKKPVSKHELVFVDTKGVVKRSSPKHCQAVLKQLNEQRLSNQFCDVTL
                     LIEGEEYKAHKSVLSANSEYFRDLFIEKGAVSSHEAVVDLSGFCKASFLPLLEFAYTS
                     VLSFDFCSMADVAILARHLFMSEVLEICESVHKLMEEKQLTVYKKGEVQTVASTQDLR
                     VQNGGTAPPVASSEGTTTSLPTELGDCEIVLLVNGELPEAEQNGEVGRQPEPQVSSEA
                     ESALSSVGCIADSHPEMESVDLITKNNQTELETSNNRENNTVSNIHPKLSKENVISSS
                     PEDSGMGNDISAEDICAEDIPKHRQKVDQPLKDQENLVASTAKTDFGPDDDTYRSRLR
                     QRSVNEGAYIRLHKGMEKKLQKRKAVPKSAVQQVAQKLVQRGKKMKQPKRDAKENTEE
                     ASHKCGECGMVFQRRYALIMHKLKHERARDYKCPLCKKQFQYSASLRAHLIRHTRKDA
                     PSSSSSNSTSNEASGTSSEKGRTKREFICSICGRTLPKLYSLRIHMLKHTGVKPHACQ
                     VCGKTFIYKHGLKLHQSLHQSQKQFQCELCVKSFVTKRSLQEHMSIHTGESKYLCSVC
                     GKSFHRGSGLSKHFKKHQPKPEVRGYHCTQCEKSFFEARDLRQHMNKHLGVKPFQCQF
                     CDKCYSWKKDWYSHVKSHSVTEPYRCNICGKEFYEKALFRRHVKKATHGKKGRAKQNL
                     ERVCEKCGRKFTQLREYRRHMNNHEGVKPFECLTCGVAWADARSLKRHVRTHTGERPY
                     VCPVCSEAYIDARTLRKHMTKFHRDYVPCKIMLEKDTLQFHNQGTQVAHAVSILTAGM
                     QEQESSGPQELETVVVTGETMEALEAVAATEEYPSVSTLSDQSIMQVVNYVLAQQQGQ
                     KLSEVAEAIQTVKVEVAHISGGE"
     exon            529..764
                     /gene="ZBTB11"
                     /gene_synonym="MRT69; ZNF-U69274; ZNF913"
                     /inference="alignment:Splign:2.1.0"
     exon            765..996
                     /gene="ZBTB11"
                     /gene_synonym="MRT69; ZNF-U69274; ZNF913"
                     /inference="alignment:Splign:2.1.0"
     exon            997..1841
                     /gene="ZBTB11"
                     /gene_synonym="MRT69; ZNF-U69274; ZNF913"
                     /inference="alignment:Splign:2.1.0"
     exon            1842..2018
                     /gene="ZBTB11"
                     /gene_synonym="MRT69; ZNF-U69274; ZNF913"
                     /inference="alignment:Splign:2.1.0"
     exon            2019..2264
                     /gene="ZBTB11"
                     /gene_synonym="MRT69; ZNF-U69274; ZNF913"
                     /inference="alignment:Splign:2.1.0"
     exon            2265..2409
                     /gene="ZBTB11"
                     /gene_synonym="MRT69; ZNF-U69274; ZNF913"
                     /inference="alignment:Splign:2.1.0"
     exon            2410..2527
                     /gene="ZBTB11"
                     /gene_synonym="MRT69; ZNF-U69274; ZNF913"
                     /inference="alignment:Splign:2.1.0"
     exon            2528..2686
                     /gene="ZBTB11"
                     /gene_synonym="MRT69; ZNF-U69274; ZNF913"
                     /inference="alignment:Splign:2.1.0"
     exon            2687..2862
                     /gene="ZBTB11"
                     /gene_synonym="MRT69; ZNF-U69274; ZNF913"
                     /inference="alignment:Splign:2.1.0"
     exon            2863..5657
                     /gene="ZBTB11"
                     /gene_synonym="MRT69; ZNF-U69274; ZNF913"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5073..5078
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZBTB11"
                     /gene_synonym="MRT69; ZNF-U69274; ZNF913"
                     /note="hexamer: AATAAA"
     polyA_site      5103
                     /gene="ZBTB11"
                     /gene_synonym="MRT69; ZNF-U69274; ZNF913"
                     /note="major polyA site"
     regulatory      5140..5145
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZBTB11"
                     /gene_synonym="MRT69; ZNF-U69274; ZNF913"
                     /note="hexamer: CATAAA"
     polyA_site      5160
                     /gene="ZBTB11"
                     /gene_synonym="MRT69; ZNF-U69274; ZNF913"
     regulatory      5198..5203
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZBTB11"
                     /gene_synonym="MRT69; ZNF-U69274; ZNF913"
                     /note="hexamer: AATAAA"
     polyA_site      5217
                     /gene="ZBTB11"
                     /gene_synonym="MRT69; ZNF-U69274; ZNF913"
     regulatory      5236..5241
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZBTB11"
                     /gene_synonym="MRT69; ZNF-U69274; ZNF913"
                     /note="hexamer: ATTAAA"
     polyA_site      5255
                     /gene="ZBTB11"
                     /gene_synonym="MRT69; ZNF-U69274; ZNF913"
ORIGIN      
        1 agtcgccagc ggatcccgcg cgctggagaa gtgcagttcc ccctggttac caactcgccc
       61 gcttttcctt cggactaagg gagccgtcga agagcgctcg ccaaaggcgc agccgtttct
      121 ccctacggtg ccgccgctcc tcctgcagcc gcccgtaggt agcgggccgt tttcctcacc
      181 tgtccctgac aggcgccctc agggagccgc ggtccgcgat gtcaagcgag gaaagctacc
      241 gggccatcct gcgttacctg acgaacgagc gcgagccgta tgcgccgggc accgagggca
      301 atgtcaagcg taaaatccga aaagctgccg cctgctacgt ggtgcgcggc gggactctgt
      361 attaccagcg gcggcagcgg caccgcaaga ccttcgcgga gctggaggtg gtgctgcagc
      421 cggagcgacg ccgggacctc atcgaggcgg cgcacctggg tcccggcggc actcaccaca
      481 cccggcatca gacctggcac tacttgtcca agacgtactg gtggcgaggt atattgaagc
      541 aagtcaaaga ttacattaaa cagtgtagca aatgccagga gaaactagat cgatcccgtc
      601 caatatcaga tgtttcagaa atgttggaag aattgggact agaccttgaa tctggagaag
      661 aaagtaatga atcggaagat gacctgagca actttacttc atctccaact acagcatcca
      721 agcctgcaaa aaagaagcca gtatccaaac atgaacttgt gtttgttgac accaaaggag
      781 tggtaaaacg ttcttctcca aaacattgtc aggctgtctt aaaacagctg aacgaacaga
      841 gactttccaa ccagttctgt gatgttactt tgttaattga aggagaagag tacaaagctc
      901 ataaatctgt tttgtcagca aatagcgagt attttcgaga tctttttatt gagaaaggag
      961 ctgtttccag tcatgaggct gtggtggatc tttctggttt ttgtaaggcc agcttccttc
     1021 ctttactgga atttgcctat acttctgtac taagttttga tttctgtagc atggctgatg
     1081 tagccatctt agctcgtcat cttttcatgt cagaagtctt agagatttgt gaaagtgtac
     1141 ataagctaat ggaagagaag cagctaacag tatataagaa gggcgaagta caaacagttg
     1201 catccaccca ggacttacga gtacagaatg gaggtacagc acctcctgtt gctagcagtg
     1261 agggaaccac aacaagttta cctactgaac ttggggattg tgaaattgta ctactggtaa
     1321 atggagaatt gccagaagct gagcagaatg gagaggtagg acgacagcct gagccccagg
     1381 tttcttcaga ggctgaatct gccctgtcat cagtaggatg tatagctgat tcccatcctg
     1441 aaatggagtc tgttgattta ataacaaaaa acaaccagac agaactagaa acttcaaaca
     1501 acagagaaaa taacacagtt tctaatatac accctaaact ttcaaaagag aatgtaatta
     1561 gtagctcgcc agaggatagt ggtatgggaa atgatatatc agctgaggat atttgtgccg
     1621 aagacattcc aaaacatagg cagaaagttg accaaccttt aaaagatcag gaaaatctag
     1681 ttgcatcaac agcaaagaca gactttggcc ctgatgatga tacttataga agcaggcttc
     1741 gacaacgttc tgttaatgaa ggggcatata ttcgactaca caagggaatg gagaaaaagc
     1801 tgcagaaacg gaaagccgtt cccaagtcag cagttcaaca ggtggctcag aagttagttc
     1861 aaagaggaaa aaagatgaaa cagccaaaaa gagatgctaa agagaacaca gaagaagcat
     1921 ctcataaatg tggggaatgt ggaatggttt ttcagagacg atacgccctt ataatgcaca
     1981 aactgaaaca tgaaagagct agagattaca aatgtccatt gtgtaaaaaa cagtttcagt
     2041 acagtgcctc tttgcgagca catcttattc gtcataccag aaaagatgca ccctcttcat
     2101 cctcgtccaa ttccacgtct aatgaagcat cgggaacatc atctgagaag ggcagaacca
     2161 agcgggaatt tatatgttcc atatgtggaa gaacattacc taaattatat tctctccgaa
     2221 tacatatgtt aaagcacaca ggtgtaaagc cacatgcatg ccaggtctgt ggaaagactt
     2281 ttatctataa gcatggtcta aaattacatc agagtcttca tcaatcacag aagcagttcc
     2341 agtgtgaact gtgtgttaag tcatttgtta ccaaacggag tcttcaagaa catatgagta
     2401 ttcacacagg agagtccaag tacctttgct cagtttgtgg aaagtctttt cataggggct
     2461 ctggactcag caagcacttc aagaaacacc aaccaaagcc tgaggttcga ggctatcatt
     2521 gtactcaatg tgaaaaaagt ttctttgaag ctagagatct tcgccagcac atgaacaaac
     2581 atcttggtgt gaagccattc cagtgccaat tttgtgataa gtgctatagt tggaagaaag
     2641 attggtattc ccatgtgaag tctcattctg tcactgagcc ttataggtgt aatatatgtg
     2701 gcaaagaatt ttatgaaaaa gctttgttca gaaggcatgt aaagaaagct acccatggga
     2761 agaaaggaag agcaaagcaa aacctggaac gggtgtgtga aaaatgtgga agaaaattca
     2821 ctcagctaag agagtatagg agacacatga acaaccatga aggagttaag ccatttgagt
     2881 gcttaacatg tggagtagct tgggctgatg cccgatctct aaaacgccat gtcagaacac
     2941 atactggtga acggccctat gtctgtcctg tatgtagcga agcctacata gatgctcgaa
     3001 cactccgtaa acatatgact aaattccaca gagactatgt gccttgcaaa attatgctgg
     3061 aaaaagacac ccttcagttt cataaccaag gaactcaagt ggcacatgct gttagcatct
     3121 taacagcagg catgcaggaa caagaaagca gtggtcctca agaacttgag actgtggtag
     3181 tgacaggaga aactatggaa gctctggaag ctgttgcagc tactgaagag tatccatcgg
     3241 tatctacact ttctgaccaa agtattatgc aagtggttaa ttatgtatta gcacaacagc
     3301 aaggacagaa gctatctgaa gttgcagaag ctattcaaac tgttaaagta gaggtagcac
     3361 atatttcagg aggagaatga gtatgttaat gaagataaaa agaagtgaca tctcttgtac
     3421 actgaactca cagaacattt gtttacaatt ctgtgtgact gtctgcttgg agtttacata
     3481 tcaaagttct gggctgtttg gtaacgtaac gtttccaaac attttgtctg gccaatgggt
     3541 tctatagaaa agtccgttta gtgtagagaa attgaaaaca gatctattag gttggtgcaa
     3601 ttgcttttgc accaacctaa tatttgatgg cagtggttta tcatgatata ccttttatga
     3661 attaatgttt ataaatgact gtactgaatt taaaaccgta cagtttcatt tgcattttga
     3721 cattacttta ttatacattt tgcatttaaa aggctgcacc agttggcttt tcttctgttt
     3781 tattctcaaa atatagagat tctgtgattt atttgccctg tttatggatt aaaaagaaaa
     3841 ttctaatata aagcatttca ataggatgca taggtatatt acgtttttta aatgctttag
     3901 atctgtgatt cttgacttac tatttatttt atcccctttt aagtcaggga tgctttattc
     3961 tattttaaag cacttatgag ttacatgttg taatcaagtt tgcacaatat atttatctat
     4021 atgaggaacc cataaatgaa tagctaattt ttaaaatgcc attaaaatgc atgaaatgct
     4081 tattaaaacc ttactatact atttcttcaa ggcaagtaaa ttgaccatga gaaaagaaca
     4141 cagttattaa acactgttga caggaaaatt ctccttgata acataggaca attaatggaa
     4201 aaaaaaattc tcattatttg caaagaatga acaagttaat gaacaaacaa actagatttg
     4261 gtatgttttc agcttttgta tcatgtttaa ttgtttaatt tggttgaaaa actgcagttg
     4321 agaaatcaga tagcaatata gacattcaca gcagctctgt ggataccatg taattgtcag
     4381 gtaatttcag aatgttgaaa attattcagt gcagccctca tagtatcata cttgaagaaa
     4441 ttgattacag ttccactaaa ttgttgaaga taaattattt ttaaaggtta tgaaaactaa
     4501 gttatattaa ttcatatgtt tgatttttaa atcccacctc ctcaagctat ccaattttct
     4561 gactttgaaa ataaccatga gagatgccac atttctctct gggaaactac cactcaaaga
     4621 ataattgtta aaaattaagc ttttaggtat tagaagctgt tataaagtat aaaattaaga
     4681 tataagcaga tcacatgtaa atcattccta aagcacaaga aaagaatgtg ccttgatgta
     4741 catatattac taagttgcct ctcccagttt actttaaaaa tggctttaag gataaagaat
     4801 aaatgtgata gctgtgcatg cattatatat ttgcatttgc aaatttccca ttgttttaac
     4861 agctgtgtgg ctgactttca attttaagac gtgaattgac atacagccca taactttata
     4921 atggctgctc atttatctta tctttcagtt agtggaaaaa catttcaacc tgactaaaat
     4981 ttggaattgt gtcttttatg ttccatcctc tgttgttact agatttagtt taaaaattgt
     5041 gtatgaccat taatgtatgt cataaacatg taaataaaag atgttgaatc ttgttgaaaa
     5101 gcatgaactt tggagttgag cttgttacta ttttcagttc ataaatcagt tgttacttga
     5161 tgtgttatta agttaattta tttttaaagg gaaaggaaat aaaacactaa aaaataacga
     5221 ttggaggaac acaatattaa aacttcttac tcttacatat aattgatatg gacaagaggc
     5281 aaggaaataa tgggtagaag agggcagttc cccagcaaaa gcctggaaac ccatggccct
     5341 aaatgggaac aggcattcct gttttcatgc ccaaatgttg ccttttggcc caccacgccc
     5401 tcctatcctg tatccatata aaccctaaac cccaggctcc atgagcagaa gagtgttgcg
     5461 gcagaggaga gaagagagga gcatctaaac gtccagagga gttcagctgg ggacggttgg
     5521 agaggagatc atcttcccac tccatcccct ttccagctcc ccatccatcc tgctgagagc
     5581 cacctttatc cagcaataaa atcccctgca tttaccatcc ttcaatttgt ccatgtgacc
     5641 tgattcttcc tggacgc
//
