LOCUS       NM_001105539            9938 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens zinc finger and BTB domain containing 10 (ZBTB10),
            transcript variant 1, mRNA.
ACCESSION   NM_001105539
VERSION     NM_001105539.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9938)
  AUTHORS   Yang,M., Cai,W., Lin,Z., Tuohuti,A. and Chen,X.
  TITLE     Intermittent Hypoxia Promotes TAM-Induced Glycolysis in Laryngeal
            Cancer Cells via Regulation of HK1 Expression through Activation of
            ZBTB10
  JOURNAL   Int J Mol Sci 24 (19), 14808 (2023)
   PUBMED   37834257
  REMARK    GeneRIF: Intermittent Hypoxia Promotes TAM-Induced Glycolysis in
            Laryngeal Cancer Cells via Regulation of HK1 Expression through
            Activation of ZBTB10.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9938)
  AUTHORS   Wang,S., Xu,Z., Li,M., Lv,M., Shen,S., Shi,Y. and Li,F.
  TITLE     Structural insights into the recognition of telomeric variant
            repeat TTGGGG by broad-complex, tramtrack and bric-a-brac - zinc
            finger protein ZBTB10
  JOURNAL   J Biol Chem 299 (3), 102918 (2023)
   PUBMED   36657642
  REMARK    GeneRIF: Structural insights into the recognition of telomeric
            variant repeat TTGGGG by broad-complex, tramtrack and bric-a-brac -
            zinc finger protein ZBTB10.
REFERENCE   3  (bases 1 to 9938)
  AUTHORS   Zhang,A., Lu,R., Lang,H. and Wu,M.
  TITLE     MiR-361-5p promotes proliferation and inhibits apoptosis of
            fibroblast-like synoviocytes via targeting ZBTB10 in rheumatoid
            arthritis
  JOURNAL   Autoimmunity 55 (5), 310-317 (2022)
   PUBMED   35608340
  REMARK    GeneRIF: MiR-361-5p promotes proliferation and inhibits apoptosis
            of fibroblast-like synoviocytes via targeting ZBTB10 in rheumatoid
            arthritis.
REFERENCE   4  (bases 1 to 9938)
  AUTHORS   Wen,Y.C., Chen,W.Y., Tram,V.T.N., Yeh,H.L., Chen,W.H., Jiang,K.C.,
            Abou-Kheir,W., Huang,J., Hsiao,M. and Liu,Y.N.
  TITLE     Pyruvate kinase L/R links metabolism dysfunction to neuroendocrine
            differentiation of prostate cancer by ZBTB10 deficiency
  JOURNAL   Cell Death Dis 13 (3), 252 (2022)
   PUBMED   35306527
  REMARK    GeneRIF: Pyruvate kinase L/R links metabolism dysfunction to
            neuroendocrine differentiation of prostate cancer by ZBTB10
            deficiency.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 9938)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 9938)
  AUTHORS   Lai,Y., Zhang,X., Zhang,Z., Shu,Y., Luo,X., Yang,Y., Wang,X.,
            Yang,G., Li,L. and Feng,Y.
  TITLE     The microRNA-27a: ZBTB10-specificity protein pathway is involved in
            follicle stimulating hormone-induced VEGF, Cox2 and survivin
            expression in ovarian epithelial cancer cells
  JOURNAL   Int J Oncol 42 (2), 776-784 (2013)
   PUBMED   23254909
  REMARK    GeneRIF: Collectively, these results indicated that stimulation of
            ovarian cancer cell VEGF, Cox2 and survivin expression by FSH
            involves the microRNA27a: ZBTB10-specificity protein pathway.
REFERENCE   7  (bases 1 to 9938)
  AUTHORS   Eriksson,N., Tung,J.Y., Kiefer,A.K., Hinds,D.A., Francke,U.,
            Mountain,J.L. and Do,C.B.
  TITLE     Novel associations for hypothyroidism include known autoimmune risk
            loci
  JOURNAL   PLoS One 7 (4), e34442 (2012)
   PUBMED   22493691
REFERENCE   8  (bases 1 to 9938)
  AUTHORS   Paternoster,L., Standl,M., Chen,C.M., Ramasamy,A., Bonnelykke,K.,
            Duijts,L., Ferreira,M.A., Alves,A.C., Thyssen,J.P., Albrecht,E.,
            Baurecht,H., Feenstra,B., Sleiman,P.M., Hysi,P., Warrington,N.M.,
            Curjuric,I., Myhre,R., Curtin,J.A., Groen-Blokhuis,M.M.,
            Kerkhof,M., Saaf,A., Franke,A., Ellinghaus,D., Folster-Holst,R.,
            Dermitzakis,E., Montgomery,S.B., Prokisch,H., Heim,K.,
            Hartikainen,A.L., Pouta,A., Pekkanen,J., Blakemore,A.I.,
            Buxton,J.L., Kaakinen,M., Duffy,D.L., Madden,P.A., Heath,A.C.,
            Montgomery,G.W., Thompson,P.J., Matheson,M.C., Le Souef,P., St
            Pourcain,B., Smith,G.D., Henderson,J., Kemp,J.P., Timpson,N.J.,
            Deloukas,P., Ring,S.M., Wichmann,H.E., Muller-Nurasyid,M.,
            Novak,N., Klopp,N., Rodriguez,E., McArdle,W., Linneberg,A.,
            Menne,T., Nohr,E.A., Hofman,A., Uitterlinden,A.G., van Duijn,C.M.,
            Rivadeneira,F., de Jongste,J.C., van der Valk,R.J., Wjst,M.,
            Jogi,R., Geller,F., Boyd,H.A., Murray,J.C., Kim,C., Mentch,F.,
            March,M., Mangino,M., Spector,T.D., Bataille,V., Pennell,C.E.,
            Holt,P.G., Sly,P., Tiesler,C.M., Thiering,E., Illig,T., Imboden,M.,
            Nystad,W., Simpson,A., Hottenga,J.J., Postma,D., Koppelman,G.H.,
            Smit,H.A., Soderhall,C., Chawes,B., Kreiner-Moller,E., Bisgaard,H.,
            Melen,E., Boomsma,D.I., Custovic,A., Jacobsson,B.,
            Probst-Hensch,N.M., Palmer,L.J., Glass,D., Hakonarson,H.,
            Melbye,M., Jarvis,D.L., Jaddoe,V.W., Gieger,C., Strachan,D.P.,
            Martin,N.G., Jarvelin,M.R., Heinrich,J., Evans,D.M. and
            Weidinger,S.
  CONSRTM   Australian Asthma Genetics Consortium (AAGC); Genetics of
            Overweight Young Adults (GOYA) Consortium; EArly Genetics &
            Lifecourse Epidemiology (EAGLE) Consortium
  TITLE     Meta-analysis of genome-wide association studies identifies three
            new risk loci for atopic dermatitis
  JOURNAL   Nat Genet 44 (2), 187-192 (2011)
   PUBMED   22197932
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 9938)
  AUTHORS   Pathi,S.S., Jutooru,I., Chadalapaka,G., Sreevalsan,S., Anand,S.,
            Thatcher,G.R. and Safe,S.
  TITLE     GT-094, a NO-NSAID, inhibits colon cancer cell growth by activation
            of a reactive oxygen species-microRNA-27a: ZBTB10-specificity
            protein pathway
  JOURNAL   Mol Cancer Res 9 (2), 195-202 (2011)
   PUBMED   21156786
REFERENCE   10 (bases 1 to 9938)
  AUTHORS   Li,X., Mertens-Talcott,S.U., Zhang,S., Kim,K., Ball,J. and Safe,S.
  TITLE     MicroRNA-27a Indirectly Regulates Estrogen Receptor {alpha}
            Expression and Hormone Responsiveness in MCF-7 Breast Cancer Cells
  JOURNAL   Endocrinology 151 (6), 2462-2473 (2010)
   PUBMED   20382698
  REMARK    GeneRIF: Study show that miR-27a indirectly regulates
            E2-responsiveness in MCF-7 cells through suppression of ZBTB10,
            thereby enhancing expression of ERalpha.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC009812.17, BC127098.1, BC050061.1 and AI627858.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001105539.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.161878.1,
                                           SRR1660809.137198.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000455036.8/ ENSP00000412036.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1064              AC009812.17        86772-87835         c
            1065-1686           BC127098.1         90-711
            1687-4032           BC050061.1         1-2346
            4033-9458           AC009812.17        48276-53701         c
            9459-9938           AI627858.1         8-487               c
FEATURES             Location/Qualifiers
     source          1..9938
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q21.13"
     gene            1..9938
                     /gene="ZBTB10"
                     /gene_synonym="RINZF"
                     /note="zinc finger and BTB domain containing 10"
                     /db_xref="GeneID:65986"
                     /db_xref="HGNC:HGNC:30953"
                     /db_xref="MIM:618576"
     exon            1..1557
                     /gene="ZBTB10"
                     /gene_synonym="RINZF"
                     /inference="alignment:Splign:2.1.0"
     CDS             586..3201
                     /gene="ZBTB10"
                     /gene_synonym="RINZF"
                     /note="isoform a is encoded by transcript variant 1; zinc
                     finger protein RINZF; zinc finger and BTB
                     domain-containing protein 10; zinc finger protein RIN ZF"
                     /codon_start=1
                     /product="zinc finger and BTB domain-containing protein 10
                     isoform a"
                     /protein_id="NP_001099009.1"
                     /db_xref="CCDS:CCDS47880.1"
                     /db_xref="GeneID:65986"
                     /db_xref="HGNC:HGNC:30953"
                     /db_xref="MIM:618576"
                     /translation="MSFSEMNRRTLAFRGGGLVTASGGGSTNNNAGGEASAWPPQPQP
                     RQPPPPAPPALQPPNGRGADEEVELEGLEPQDLEASAGPAAGAAEEAKELLLPQDAGG
                     PTSLGGGAGGPLLAERNRRTLAFRGGGGGGLGNNGSSRGRPETSVWPLRHFNGRGPAT
                     VDLELDALEGKELMQDGASLSDSTEDEEEGASLGDGSGAEGGSCSSSRRSGGDGGDEV
                     EGSGVGAGEGETVQHFPLARPKSLMQKLQCSFQTSWLKDFPWLRYSKDTGLMSCGWCQ
                     KTPADGGSVDLPPVGHDELSRGTRNYKKTLLLRHHVSTEHKLHEANAQESEIPSEEGY
                     CDFNSRPNENSYCYQLLRQLNEQRKKGILCDVSIVVSGKIFKAHKNILVAGSRFFKTL
                     YCFSNKESPNQNNTTHLDIAAVQGFSVILDFLYSGNLVLTSQNAIEVMTVASYLQMSE
                     VVQTCRNFIKDALNISIKSEAPESVVVDYNNRKPVNRDGLSSSRDQKIASFWATRNLT
                     NLASNVKIENDGCNVDEGQIENYQMNDSSWVQDGSPEMAENESEGQTKVFIWNNMGSQ
                     GIQETGKTRRKNQTTKRFIYNIPPNNETNLEDCSVMQPPVAYPEENTLLIKEEPDLDG
                     ALLSGPDGDRNVNANLLAEAGTSQDGGDAGTSHDFKYGLMPGPSNDFKYGLIPGTSND
                     FKYGLIPGASNDFKYGLLPESWPKQETWENGESSLIMNKLKCPHCSYVAKYRRTLKRH
                     LLIHTGVRSFSCDICGKLFTRREHVKRHSLVHKKDKKYKCMVCKKIFMLAASVGIRHG
                     SRRYGVCVDCADKSQPGGQEGVDQGQDTEFPRDEEYEENEVGEADEELVDDGEDQNDP
                     SRWDESGEVCMSLDD"
     exon            1558..2446
                     /gene="ZBTB10"
                     /gene_synonym="RINZF"
                     /inference="alignment:Splign:2.1.0"
     exon            2447..2545
                     /gene="ZBTB10"
                     /gene_synonym="RINZF"
                     /inference="alignment:Splign:2.1.0"
     exon            2546..2722
                     /gene="ZBTB10"
                     /gene_synonym="RINZF"
                     /inference="alignment:Splign:2.1.0"
     exon            2723..2895
                     /gene="ZBTB10"
                     /gene_synonym="RINZF"
                     /inference="alignment:Splign:2.1.0"
     exon            2896..9938
                     /gene="ZBTB10"
                     /gene_synonym="RINZF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7707..7712
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZBTB10"
                     /gene_synonym="RINZF"
                     /note="hexamer: TATAAA"
     polyA_site      7727
                     /gene="ZBTB10"
                     /gene_synonym="RINZF"
                     /note="major polyA site"
     regulatory      9918..9923
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZBTB10"
                     /gene_synonym="RINZF"
                     /note="hexamer: AATAAA"
     polyA_site      9938
                     /gene="ZBTB10"
                     /gene_synonym="RINZF"
ORIGIN      
        1 atttgccatt cgacctccgc cagggcctgg tcggacggaa acgctccgcc ggctttattg
       61 tcgcttcgtt atgtggcgga gccgagcagt ttagcgtgcc tctcaccctc agcgcctgcg
      121 aagccggcgg cggcgtcggg actcctcggc gcgcggagga aggatatctg tgtggaggat
      181 cggtgtgtgc gcgcgcggct ttaaagaggg ggcagcggag ggtctccccg cactccgctg
      241 ctcaacttcg aaggcctcgc tcgctgcagg ctcgctcctc acctctccgc cgcccgcccc
      301 cttctccgcg cgggacgctg cccggagcgc ggcggggcgg gggtggagga cgagagagcg
      361 gtcggaggcg tcggcccggc agcggcagcg gcagcggacg cgtgcagcag acccgggagc
      421 gagcgcgagc cgggctgccg ggcgagaggg cgaggccgag ccccgcgaga ccggaacgcc
      481 gggggcgggg gcgagacaga gggggagccg cggggagcgc gcgggacgcg gcccgaggcc
      541 gtgcgcgagc cggggcaccg ggcggcggcg gcggcggcgc gcgccatgtc gttcagtgaa
      601 atgaaccgca ggacgctggc gttccgagga ggcgggttgg tcaccgctag cggcggcggc
      661 tccacgaaca ataacgctgg cggggaggcc tcagcttggc ctccgcagcc ccagccgaga
      721 cagcccccgc cgccagcgcc gcccgcgctt cagccgccta atgggcgggg ggccgacgag
      781 gaagtggaat tggagggcct ggagccccaa gacctggagg cctccgccgg gccggccgcc
      841 ggcgccgccg aggaagccaa ggagttgctg ctcccccaag acgcgggcgg ccccacctcg
      901 cttggcggtg gcgcgggggg ccccctgcta gcggaaagga accgtcggac tctggccttc
      961 cgaggcggcg gcggcggggg tctcggcaac aatggcagta gccgcggccg ccccgagacc
     1021 tcggtgtggc ccttgaggca tttcaatggg cgagggccgg cgactgtgga tctggagctg
     1081 gacgcgctgg aggggaagga gttgatgcag gacggcgcgt ccctgagcga cagcaccgag
     1141 gacgaggagg agggggcgag cctgggcgac ggcagcgggg cggaaggcgg cagctgcagc
     1201 agcagcaggc ggtcgggcgg cgatggcggg gacgaagtgg agggcagcgg tgtgggagct
     1261 ggcgaaggag agactgtcca gcacttcccg ctcgcgcggc ccaagtctct aatgcagaag
     1321 ctccaatgct ccttccagac ctcctggctc aaggactttc cctggctgcg ctattccaag
     1381 gatactggtc ttatgtcttg cggctggtgc caaaagaccc ctgcagatgg gggaagcgtg
     1441 gaccttcccc cagtggggca tgatgagctt tcgcgaggga cccgcaacta caagaaaacc
     1501 ctcctcctga ggcaccacgt ctctaccgag cacaaactcc acgaagccaa cgcccaggag
     1561 tcagaaatac catcagagga ggggtactgt gactttaata gtaggccaaa tgagaactct
     1621 tattgctatc aacttctgcg acaactaaat gaacagagaa agaaaggtat tctttgtgat
     1681 gtcagcattg tggtaagcgg aaaaatcttc aaagctcata agaacatcct ggttgcaggc
     1741 agccgtttct ttaagacttt atattgcttt tcaaacaaag aaagccctaa ccaaaacaat
     1801 actacccact tagatattgc tgcagttcaa ggtttttcag tcatcttgga cttcttgtat
     1861 tctggtaacc tggtgctcac aagccaaaat gccattgaag ttatgaccgt ggccagctat
     1921 cttcaaatga gtgaagttgt tcaaacttgc cgaaatttca ttaaagatgc cttaaatata
     1981 agcattaaat cagaagctcc agagtctgta gttgtggact ataataatag aaaaccagtt
     2041 aatagagatg gtctgtcttc atcacgggat caaaaaattg ccagtttttg ggcaacacgg
     2101 aatcttacca atttggcaag taatgtaaag attgaaaatg atggttgtaa tgtcgacgag
     2161 ggccaaatag aaaactacca aatgaatgac agtagttggg tccaggatgg atctcctgaa
     2221 atggctgaaa atgaatctga aggtcaaaca aaagtgttta tttggaataa tatgggctcc
     2281 cagggaattc aagagactgg caaaacaagg aggaaaaacc aaactacaaa aagatttatt
     2341 tataatattc cacctaataa tgaaacgaat ttagaagatt gctcagtaat gcagccacct
     2401 gttgcctatc cagaagaaaa tacactactc atcaaggaag aaccagattt agatggtgct
     2461 ctactctcgg ggccagatgg tgataggaat gtgaatgcaa atttattggc tgaagctggc
     2521 actagtcaag atggaggtga tgctggtact tcacatgatt tcaagtatgg tttgatgcct
     2581 ggtccttcaa atgatttcaa gtatggattg ataccaggta cttcaaatga tttcaagtat
     2641 ggattgatac caggtgcttc aaatgatttc aagtatggat tattgccaga atcttggcca
     2701 aaacaagaaa cctgggaaaa tggtgaatca tctctaatca tgaacaagtt aaaatgccct
     2761 cattgtagct atgtagccaa atacagacga acactaaaaa ggcacttgct cattcacaca
     2821 ggagtgagat catttagctg tgatatttgt ggaaaactgt ttactcgaag agaacatgta
     2881 aaaagacatt ccctggtgca taaaaaggat aaaaaataca aatgtatggt gtgtaagaag
     2941 atcttcatgt tagcagccag tgttggaata agacatggat ctcgacgtta tggtgtttgt
     3001 gtagactgtg cagataaatc acagccagga gggcaagaag gtgtagatca gggacaggat
     3061 acagaattcc ctcgggatga agaatacgag gagaatgaag taggagaagc tgatgaagag
     3121 ctagttgatg atggagaaga tcagaatgat ccctctcgat gggatgaatc aggagaagtt
     3181 tgtatgtctc tagatgatta actgacctac tatactcctc aaggatgctg catttggacc
     3241 taatatgaat cgacaatttg gattgttgaa cttgaaggct tgcaaaatat ggtacatgct
     3301 ggatagtagt tatgttgctg tgaaaactgt agggtcaaag ccttatagca aaaaaaattt
     3361 ttttttatat ttgcacagga ctatacagca aacaaccatg tggttggatt acatggagtc
     3421 cccacatact cagtcagtta tcaaagtaaa atatttttta tttataggat atacagtaac
     3481 tatttgggtc ctatgaaaat agtccttaaa gagcttacat tcatgtgcta ctttaacatg
     3541 aatggagaaa atccgtttat ggaagtacag tgacaattga cccaatcact ctgtccatca
     3601 aaccactcag gctagtttgt actagtagag ttttgtttct atttttattt ttattaattt
     3661 tatttttttt aatacagatt ttcagtgagg ggctttttca accccattgg ttctattttc
     3721 ttgtattttt ccatttaatt tgcttcataa cttaaaccaa gtctcttcta gtcttaggta
     3781 ttatttctcg attttgtgct gatgggcatg tttataagaa ctggagaggt aatttattgg
     3841 aatgaactaa ctgacttcct ccattcccct cttccttttt gacatgaatt ttactacttc
     3901 acaaatgaag aatgatgtta tgaagttacc gtggcgaagt tgacaaatac cactaaaatg
     3961 attatgattt agaagtaact ttcttctgct gctctaatct gataaatggt tactatatga
     4021 tattttctga catggtattt ggttttgggt atctgttact ttggcactat tcttgtttgc
     4081 ctctttattt ttgccagtgt actatacctc agtcctattt gaaagaccta attgaaagaa
     4141 aaatcataga aataagtaaa atgatttgtt ttataattta tccaccatgt ccagtttggt
     4201 tagcttgtta tgcaatataa gtgaaatatc aggtttttac ccgtgtccct tttatcatga
     4261 aaattaacac aaaatgtgca ttctcttttg tttcatactt agcgggatat tgattgtttt
     4321 gaaattatga tcaatactta atttattttt ttctgtcctt gaagtcacta caccttgata
     4381 cagtctttct agtagtcacc atgattcaac agtctcaaaa atcttacaaa taaaattctg
     4441 agaagcttta ttattctata aattcttcag ggtacaaagg gtgacatatt gaggtgaaat
     4501 tgtcagattt acttagcctg gtgacatgaa ttagctgatt gtggaactct cagcagcatt
     4561 tcacgtattg ttaacatgta tggcatttat tagcatattg tatattatat aagattgagg
     4621 gatgtcatat tttcagcttt cttttaaata aaaattgagt atattttcct attttatatc
     4681 aggtaactaa attatgctag ttatgtggaa aaaattgcaa agatgctttg acagatataa
     4741 tccctttggt gctccatctg atcaaagttg aaaagttgat gttttttaag agacaagctt
     4801 tatcattgtc tctgatttca gtagaataat ggtttattgt tagacaatga tgtttctgct
     4861 tggataaatc aaagataaat tacagttaca tggttagatg catcttttgt catctatatt
     4921 gtagtttcta cataactgta aacctgacag ataagaatag tttcggtttg atttttgttt
     4981 aaaacagatg agtacttctt aatgttctag acaaatgagt aaaatgtatt tctggtagaa
     5041 attagttggg caaagatact atgaatgaaa aagtatttta aacgtaaaat gttctttgtg
     5101 aatatgtaag tatagtataa agatttcttt catcccattt atccccttcc tttaaataaa
     5161 ctagtttaca attggtagat ctgtctatat ataaatatat attaaagaac aaagatatat
     5221 atctaaaaat cacctaaatc tgctttatta gactacagtt cacttattgc atagaaactg
     5281 gacttggctt tacattctta atgtactttt acttttcctc aagatatgaa cttactctct
     5341 tgaagctgaa ttttctttta ctacttaaat catttatgta tatctggtaa attatgacca
     5401 aatttttgtt agattgcata cagtaaattg aaatacacac ttggtacact acgggattgt
     5461 tgtgcttttg tttggtttta gttggaaata aggtttgatg tagatggctt gttactgtta
     5521 atttaaaata ttctataatt gtccattact ttatgttgtg ttgtgacaga tttggctata
     5581 tttttagtca attgaaatat gatactttaa aagtttgttt ttaggtaatc caaaggaaaa
     5641 gtgtttatac tcttgaatat attagcctca gcctatataa aaatttcttt gaagtaaaca
     5701 ttttaccgga aacagaattg acagattttt ctacttgctg actgcctaac ttattttgtt
     5761 tcatgatctc gagggactgc cttttcccat ctagatcttt taaaaaaata gttttagtac
     5821 taaggtatac tactggacat ttctattttt ttaagtgtat tctttttctg acttacagta
     5881 aaatttcagg aagttgatag atactaagaa cttatgattg gtctcagagg taacaatgaa
     5941 atactcataa ttttgtctgt ggaactctgg cagaattatg ttacacattt ggcgaagttg
     6001 tctcttgtaa tttatatttt aaatgaaaaa gtattttaga gcttttaatg aaggggaaga
     6061 gtataaactt tctttcatat tcactctgta gttacagacc gtctcataaa tcaagattgt
     6121 gcattattag agttctcaga gacagatact tccatatgga cccctgttca tttttcttat
     6181 ttactagata ttttgctaaa tttagcacac tagcaattaa gagtttaaaa aagaagaaac
     6241 gttataggaa agggaaactg aacagtaatg agtagctttg aaattgggga aaacacacta
     6301 gctgggttag gtacagctat cctaatggag aagagtgagc taaatgcgtt aattcatgta
     6361 aagtgcttag aacactggta cataataggt gcataacaca tcttaaagtt gtttaataat
     6421 agataagaac caagaggaaa aagaaataag aaaagatggg ggaaaggaag gagaaaatag
     6481 gaaatgaaag gattaggact tgggcattta tattaataca aaatggtgta aacggcctga
     6541 atatcactgt agtagtatca tacgggggaa agtgtgatgg aaaataggtt taaaaatctt
     6601 aatttttaaa actttagtaa gctttattta tattttttag gattttctga acatagcatg
     6661 aagggtttag attcattttt ctgaaaaacg attaaaaaaa ctaccaattt tttttttgag
     6721 tgcccacact tgccgttgtg ctgtatacat gattttacct taatcctcta taaggtaggt
     6781 gctaattgtc tccattttat agatgaggaa aggctcagag aaattcagaa acttggctaa
     6841 tttaacacag ctgtgacaga gctcgaattt gaccacgtct gattctgaag cccatactct
     6901 ttcagggagg ctctattgct gcctcattaa acaactcttg tagaatttca gctcttaatg
     6961 gagtctatgg attatatttt tcctataaga cagctgtgtt tagaattttg agtgtctttc
     7021 ctccccccaa taaatttcct tactactctt tcttcataaa gcagttgttt tgtcactttg
     7081 actatattaa gacacatcag tgtagcacat gctcttaact ggctgtggca ttttaatttt
     7141 ataaaagaat ggtttttatc tgaagaacta gatagaaacc ccagtttttg tgccgttcag
     7201 tcacccagat ccttaaactt aactatggta cataatatcc acacttagaa ctaacaggtg
     7261 tttagtcact ttaggactta aaatggaaag tttttttttt tttcctgctg tatctctgct
     7321 ttcaactgaa gttaaagaat tctagatagt ttaaaatgtg ttagggataa gcacacttca
     7381 aaagatgttt tctagcccta aattttatga cattgggtac ttaaatttgg agtacactag
     7441 ctattgagaa caatattttg ggttgaggag agatggttga ggccattatt tagtgggagc
     7501 attggcattt tgaacactgt aaacaaaaga acacttccgc ctgctgtttg taaaagctct
     7561 ttgggaagat cttttacgaa gaccaacttt ttaaaatgta aattacctac ctaatataag
     7621 tgtcctaaga catgtatgta aacttccgga actgttttgt ctgtgtattt agaaaataca
     7681 caagaatctt tattcaaacc taaaaatata aacttgtgag cactaaactg cttctggctt
     7741 tgtgaatttt attgactgac atttaattca gatttctttg caagtgtact aatttagact
     7801 aattggggta aggggaacac cttaatgaac tttgacttat gtataattca gatatctttg
     7861 tacttaaggc ttacaagttt gaattatgga atactataag ggttttttgt ttatttgtat
     7921 gtttttatat gaaagtacat aaatgacaga ctacctccaa gtaatcctgc tttaattaat
     7981 agcagtgatt tgtaatcagt gtatctttta agattctcta caggttttag aaaatattaa
     8041 aaattccctg taatttacat ttgtgcataa tcttggaaat gggttgaaaa gcaaaggtaa
     8101 actgcttcat cccatgttgt atatttgtgg actgattgac tacaagtgat gtgatgttat
     8161 aaatttgaag tctttgaaac tttattaatg tagagaaaac ataactagct ttttaggtta
     8221 tttcaaagtt agtaatagag caaaggaaat cagaactggc cagatattca gacttgactt
     8281 agaaaaacag gagtttgttg attttgtttg gagaagggca caataaaggg gagcccacat
     8341 agcattataa tgcctagtat ctttaaacat gtaaagagct atcatgaggc agaagaatta
     8401 agaaacttta tatgtttcta aggggtcatg attgggacca ttggctcaag attgaaaatc
     8461 ggtttttaat tatccaaaga tgaaatgggg ctgcttcaga aaaaggtcta ccactggaga
     8521 taacgctatg aaaagtgaaa gagattactt aatcattttg acaaaggcag tattgaccag
     8581 acatttctat ttcagagttg gatttgtgct tagttttttt taggtgttgg gacccttgta
     8641 gttgcttttt attttgctta gtcaacaaac actaaaatga taaaatttgg tatgtataag
     8701 tactggacga aggatgtttt gacactaaaa aggacataat ttaggaaatt aagaatttag
     8761 acaccaagtt tggcttaata gaaaaagtca ctatctgaac ttctttcttt ttcaccacaa
     8821 atcaccgcag accagtgttt gggagcaggt gtaggaaatt gaattattgg atctatgttt
     8881 aggtaagaaa actaaaggta cttcagaatt taggctatga cataactgtc tttctgaagt
     8941 ttaaagaaag aaagtgaact atagaaatct attcagctaa ttaaagtgaa tgaaaaatat
     9001 tacagattcc ataactgcat ggcgccttac ctgctattaa tactgccgcc ttactgtcag
     9061 ccagatgatt ttttcccacc acggccagtc ttaaatttgg caataagaaa aagctaatct
     9121 tccaagtgta agtaggtatg tgttagaatc ttggtgaaag ataaacacaa gacagtcttc
     9181 ttggcgcagg tcctaacagt tggtgagata atacataaga tggtttcagg attattgtag
     9241 aattatttag gttgaaagag actgtaagag actaatgaag catacccaga gaggttgcta
     9301 cagtgactcc agtcagtttt aggacccagg actcctgaac ttcaatttca gtattatttt
     9361 tctgtaccaa actcattcaa taaatacttg agattaggga taagtttgaa gttagaagat
     9421 tccagagtac actcaaatag tatttggcac atagcttgtt gatcaaaagt atttactaag
     9481 tgagtgacaa aaggcactag caactttaag gattttgcct attagtatca tatggcatgt
     9541 agctatcaag ccagtttcgt ttagttattt tgtgttgcca agcatatgat acgtggtgtc
     9601 acactgagcc tttgggatcc tttccctgga tacataaccc tagtagataa tgttactgca
     9661 agatgtaatg accaaatcca acctactgca aatgttacta tggaaatctc aatgcaaaag
     9721 tagcctttgt gatttttttt ttaaaccgtc tccataacag aacacttaga attattagcc
     9781 atttgctgca aagtatttgt tttaaaatgt ctggcatata caccactaac atttaaatgc
     9841 ccaacattcg gtctatacgt gaaaaaacta gaagaaaagc cctgttggag ttttgatgta
     9901 gagtgcaata atacatcaat aaaggtattt taaaatga
//
