LOCUS       NM_001123329            3642 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens zinc finger and BTB domain containing 1 (ZBTB1),
            transcript variant 1, mRNA.
ACCESSION   NM_001123329
VERSION     NM_001123329.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3642)
  AUTHORS   Liu,J. and Liu,J.
  TITLE     Circ_0000442 functions as a tumor repressor in breast cancer by
            impacting miR-1229-3p and upregulating ZBTB1
  JOURNAL   Mamm Genome 33 (3), 543-554 (2022)
   PUBMED   35394175
  REMARK    GeneRIF: Circ_0000442 functions as a tumor repressor in breast
            cancer by impacting miR-1229-3p and upregulating ZBTB1.
REFERENCE   2  (bases 1 to 3642)
  AUTHORS   Cheng,M.Y., Zeng,Y., Sun,Y., Shi,C.W., Wang,J.H., Li,F.D., Lu,Y.Y.,
            Wang,J.Y., Wang,R.Y., Li,X.Y., Li,X.X., Fan,S.H., Yang,G.L.,
            Cao,X., Xu,B. and Wang,C.F.
  TITLE     Preliminary analysis of the expression of ZBTB1 in human pancreatic
            carcinoma
  JOURNAL   J Cell Mol Med 25 (17), 8573-8576 (2021)
   PUBMED   34312970
  REMARK    GeneRIF: Preliminary analysis of the expression of ZBTB1 in human
            pancreatic carcinoma.
REFERENCE   3  (bases 1 to 3642)
  AUTHORS   Zhang,P., Yang,Y., Qian,K., Li,L., Zhang,C., Fu,X., Zhang,X.,
            Chen,H., Liu,Q., Cao,S. and Cui,J.
  TITLE     A novel tumor suppressor ZBTB1 regulates tamoxifen resistance and
            aerobic glycolysis through suppressing HER2 expression in breast
            cancer
  JOURNAL   J Biol Chem 295 (41), 14140-14152 (2020)
   PUBMED   32690611
  REMARK    GeneRIF: A novel tumor suppressor ZBTB1 regulates tamoxifen
            resistance and aerobic glycolysis through suppressing HER2
            expression in breast cancer.
REFERENCE   4  (bases 1 to 3642)
  AUTHORS   Williams,R.T., Guarecuco,R., Gates,L.A., Barrows,D.,
            Passarelli,M.C., Carey,B., Baudrier,L., Jeewajee,S., La,K.,
            Prizer,B., Malik,S., Garcia-Bermudez,J., Zhu,X.G., Cantor,J.,
            Molina,H., Carroll,T., Roeder,R.G., Abdel-Wahab,O., Allis,C.D. and
            Birsoy,K.
  TITLE     ZBTB1 Regulates Asparagine Synthesis and Leukemia Cell Response to
            L-Asparaginase
  JOURNAL   Cell Metab 31 (4), 852-861 (2020)
   PUBMED   32268116
  REMARK    GeneRIF: ZBTB1 Regulates Asparagine Synthesis and Leukemia Cell
            Response to L-Asparaginase.
REFERENCE   5  (bases 1 to 3642)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 3642)
  AUTHORS   Punwani,D., Simon,K., Choi,Y., Dutra,A., Gonzalez-Espinosa,D.,
            Pak,E., Naradikian,M., Song,C.H., Zhang,J., Bodine,D.M. and
            Puck,J.M.
  TITLE     Transcription factor zinc finger and BTB domain 1 is essential for
            lymphocyte development
  JOURNAL   J Immunol 189 (3), 1253-1264 (2012)
   PUBMED   22753936
REFERENCE   7  (bases 1 to 3642)
  AUTHORS   Liu,Q., Yao,F., Wang,M., Zhou,B., Cheng,H., Wang,W., Jin,L., Lin,Q.
            and Wang,J.C.
  TITLE     Novel human BTB/POZ domain-containing zinc finger protein ZBTB1
            inhibits transcriptional activities of CRE
  JOURNAL   Mol Cell Biochem 357 (1-2), 405-414 (2011)
   PUBMED   21706167
  REMARK    GeneRIF: ZBTB1 protein may act as a transcription repressor in the
            activation of CREB and cAMP-mediated signal transduction pathways
            to mediate cellular functions.
REFERENCE   8  (bases 1 to 3642)
  AUTHORS   Matic,I., Schimmel,J., Hendriks,I.A., van Santen,M.A., van de
            Rijke,F., van Dam,H., Gnad,F., Mann,M. and Vertegaal,A.C.
  TITLE     Site-specific identification of SUMO-2 targets in cells reveals an
            inverted SUMOylation motif and a hydrophobic cluster SUMOylation
            motif
  JOURNAL   Mol Cell 39 (4), 641-652 (2010)
   PUBMED   20797634
REFERENCE   9  (bases 1 to 3642)
  AUTHORS   Ravasi,T., Suzuki,H., Cannistraci,C.V., Katayama,S., Bajic,V.B.,
            Tan,K., Akalin,A., Schmeier,S., Kanamori-Katayama,M., Bertin,N.,
            Carninci,P., Daub,C.O., Forrest,A.R., Gough,J., Grimmond,S.,
            Han,J.H., Hashimoto,T., Hide,W., Hofmann,O., Kamburov,A., Kaur,M.,
            Kawaji,H., Kubosaki,A., Lassmann,T., van Nimwegen,E.,
            MacPherson,C.R., Ogawa,C., Radovanovic,A., Schwartz,A.,
            Teasdale,R.D., Tegner,J., Lenhard,B., Teichmann,S.A., Arakawa,T.,
            Ninomiya,N., Murakami,K., Tagami,M., Fukuda,S., Imamura,K., Kai,C.,
            Ishihara,R., Kitazume,Y., Kawai,J., Hume,D.A., Ideker,T. and
            Hayashizaki,Y.
  TITLE     An atlas of combinatorial transcriptional regulation in mouse and
            man
  JOURNAL   Cell 140 (5), 744-752 (2010)
   PUBMED   20211142
  REMARK    Erratum:[Cell. 2010 Apr 16;141(2):369. Kamburov, Atanas [added];
            Kaur, Mandeep [added]; MacPherson, Cameron Ross [added];
            Radovanovic, Aleksandar [added]; Schwartz, Ariel [added]]
REFERENCE   10 (bases 1 to 3642)
  AUTHORS   Petroziello,J., Yamane,A., Westendorf,L., Thompson,M., McDonagh,C.,
            Cerveny,C., Law,C.L., Wahl,A. and Carter,P.
  TITLE     Suppression subtractive hybridization and expression profiling
            identifies a unique set of genes overexpressed in non-small-cell
            lung cancer
  JOURNAL   Oncogene 23 (46), 7734-7745 (2004)
   PUBMED   15334068
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX248777.1, BC050719.1, AW965994.1 and BM975910.1.
            
            On Aug 14, 2020 this sequence version replaced NM_001123329.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853566.8402.1,
                                           SRR11853564.8749.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000683701.1/ ENSP00000506911.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1447              BX248777.1         197-1643
            1448-2589           BC050719.1         1684-2825
            2590-2993           AW965994.1         112-515
            2994-3642           BM975910.1         15-663              c
FEATURES             Location/Qualifiers
     source          1..3642
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q23.3"
     gene            1..3642
                     /gene="ZBTB1"
                     /gene_synonym="ZNF909"
                     /note="zinc finger and BTB domain containing 1"
                     /db_xref="GeneID:22890"
                     /db_xref="HGNC:HGNC:20259"
                     /db_xref="MIM:616578"
     exon            1..177
                     /gene="ZBTB1"
                     /gene_synonym="ZNF909"
                     /inference="alignment:Splign:2.1.0"
     exon            178..3642
                     /gene="ZBTB1"
                     /gene_synonym="ZNF909"
                     /inference="alignment:Splign:2.1.0"
     CDS             196..2337
                     /gene="ZBTB1"
                     /gene_synonym="ZNF909"
                     /note="isoform 1 is encoded by transcript variant 1; zinc
                     finger and BTB domain-containing protein 1"
                     /codon_start=1
                     /product="zinc finger and BTB domain-containing protein 1
                     isoform 1"
                     /protein_id="NP_001116801.1"
                     /db_xref="CCDS:CCDS45126.1"
                     /db_xref="GeneID:22890"
                     /db_xref="HGNC:HGNC:20259"
                     /db_xref="MIM:616578"
                     /translation="MAKPSHSSYVLQQLNNQREWGFLCDCCIAIDDIYFQAHKAVLAA
                     CSSYFRMFFMNHQHSTAQLNLSNMKISAECFDLILQFMYLGKIMTAPSSFEQFKVAMN
                     YLQLYNVPDCLEDIQDADCSSSKCSSSASSKQNSKMIFGVRMYEDTVARNGNEANRWC
                     AEPSSTVNTPHNREADEESLQLGNFPEPLFDVCKKSSVSKLSTPKERVSRRFGRSFTC
                     DSCGFGFSCEKLLDEHVLTCTNRHLYQNTRSYHRIVDIRDGKDSNIKAEFGEKDSSKT
                     FSAQTDKYRGDTSQAADDSASTTGSRKSSTVESEIASEEKSRAAERKRIIIKMEPEDI
                     PTDELKDFNIIKVTDKDCNESTDNDELEDEPEEPFYRYYVEEDVSIKKSGRKTLKPRM
                     SVSADERGGLENMRPPNNSSPVQEDAENASCELCGLTITEEDLSSHYLAKHIENICAC
                     GKCGQILVKGRQLQEHAQRCGEPQDLTMNGLGNTEEKMDLEENPDEQSEIRDMFVEML
                     DDFRDNHYQINSIQKKQLFKHSACPFRCPNCGQRFETENLVVEHMSSCLDQDMFKSAI
                     MEENERDHRRKHFCNLCGKGFYQRCHLREHYTVHTKEKQFVCQTCGKQFLRERQLRLH
                     NDMHKGMARYVCSICDQGNFRKHDHVRHMISHLSAGETICQVCFQIFPNNEQLEQHMD
                     VHLYTCGICGAKFNLRKDMRSHYNAKHLKRT"
     regulatory      2622..2627
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZBTB1"
                     /gene_synonym="ZNF909"
                     /note="hexamer: ATTAAA"
     polyA_site      2647
                     /gene="ZBTB1"
                     /gene_synonym="ZNF909"
                     /note="major polyA site"
     regulatory      3317..3322
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZBTB1"
                     /gene_synonym="ZNF909"
                     /note="hexamer: AATAAA"
     polyA_site      3337
                     /gene="ZBTB1"
                     /gene_synonym="ZNF909"
     regulatory      3349..3354
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZBTB1"
                     /gene_synonym="ZNF909"
                     /note="hexamer: TATAAA"
     polyA_site      3373
                     /gene="ZBTB1"
                     /gene_synonym="ZNF909"
     regulatory      3619..3624
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZBTB1"
                     /gene_synonym="ZNF909"
                     /note="hexamer: AATAAA"
     polyA_site      3642
                     /gene="ZBTB1"
                     /gene_synonym="ZNF909"
                     /note="major polyA site"
ORIGIN      
        1 gttgcagcac agtccctggc agagccagag cctctccgcg cagcccagcc cgagcgccga
       61 gcgccgcgcg ccgccgccac tgcagctcgc ggccccttcg ccttcgcccg cctttcccgc
      121 ggctgatttg ccttaaactc cctaaaatct ccgcagctct ggttcctgtt gcggccggtc
      181 tctaattaac agaagatggc aaagcccagc cacagcagct atgtccttca gcagctaaac
      241 aaccaaagag aatggggttt tctctgtgac tgctgtattg caattgatga catttacttt
      301 caagcacaca aggcagttct agctgcctgt agctcctatt ttagaatgtt tttcatgaac
      361 catcagcata gtactgcaca actgaatctc agcaacatga aaattagtgc agaatgtttt
      421 gatctcattt tgcagtttat gtatttagga aaaattatga cagctccctc cagttttgag
      481 cagtttaaag tggcaatgaa ctacctacag ctatacaatg ttcctgactg tttagaagac
      541 atccaggatg cagattgttc tagttcaaaa tgttcctctt ctgcttccag caaacagaac
      601 agcaaaatga tatttggggt aagaatgtat gaagatactg tggctcgaaa tggcaatgaa
      661 gccaacaggt ggtgtgcaga gccaagttca acggtaaata caccacataa tagagaggct
      721 gatgaagagt ctttacaatt aggtaatttt cctgagccac tatttgatgt atgtaaaaaa
      781 agttccgtgt ccaaattatc tactccaaaa gaacgtgtgt caagacgctt tgggcggagt
      841 tttacctgtg atagctgtgg atttggcttt agctgtgaaa aattattaga tgagcatgtg
      901 ctaacctgta ctaacagaca tttataccaa aacacaagat cttaccatag aatagtagat
      961 attagagatg gaaaagacag taacatcaaa gctgaatttg gtgaaaaaga ttcttccaaa
     1021 acattttctg cacagacgga caaatacaga ggagacacaa gccaggctgc tgatgattca
     1081 gcttcaacca ctggaagcag aaaaagtagc acagtggagt ctgaaatagc aagcgaagag
     1141 aaaagcagag ctgctgagag gaaaaggatt attattaaga tggagccaga agatattcct
     1201 acagatgaac tgaaagactt taacattatt aaagttactg ataaagactg taatgaatcc
     1261 actgacaatg atgaattaga agatgaacct gaagagccat tttatagata ctatgttgaa
     1321 gaagatgtca gcataaaaaa aagtggtagg aaaactctaa aacctcgaat gtcagtaagt
     1381 gctgatgaaa gaggtggttt agagaatatg aggcccccta acaacagcag tccagtacaa
     1441 gaggatgctg aaaatgcatc ttgtgagctg tgtggactta caataaccga ggaggacctg
     1501 tcatctcatt acttagccaa acacattgaa aatatctgtg catgtggtaa atgtggacaa
     1561 atacttgtaa agggtaggca gcttcaggaa catgctcaac gatgtggcga gccccaagat
     1621 ctgaccatga atgggttagg aaatactgag gagaaaatgg acttggaaga gaatcctgat
     1681 gagcagtccg aaataagaga tatgtttgtt gaaatgctgg atgattttag ggacaatcat
     1741 taccagataa acagtatcca aaaaaagcag ttatttaaac attctgcctg cccttttcga
     1801 tgtcctaatt gtggccagcg ttttgaaact gaaaatctag tggttgaaca tatgtctagc
     1861 tgcttagatc aagatatgtt taagagtgcc atcatggaag aaaatgaaag agatcacaga
     1921 cgaaagcatt tttgtaatct gtgtggaaaa ggattttatc agcggtgtca cttaagagaa
     1981 cactatactg ttcatactaa ggaaaaacag tttgtttgtc aaacatgtgg aaagcagttt
     2041 ttaagagagc gtcagttgcg actgcacaat gatatgcaca aaggcatggc caggtatgtc
     2101 tgttccattt gtgatcaagg aaacttcaga aaacatgacc atgtacggca tatgatttct
     2161 catttatctg ctggtgagac tatatgccag gtctgctttc agatattccc aaataatgaa
     2221 cagttggagc agcacatgga tgttcatctg tatacatgtg gaatatgtgg agcaaaattt
     2281 aatttgagga aagatatgag atcacattat aatgccaagc atttgaaaag aacctgagtg
     2341 attttctact gtactaatgt ttagatgata gcagataaaa caccaaagca aaggatatga
     2401 gctatttagg aattgattat ataagatgat ttgttagaaa caaatttcaa ggccctttta
     2461 actttaatat ttttgtttag gattttaagt atctacattt aggtattaaa tgtttatcat
     2521 ttttgttgtt tcttaataga attatttgtt tttagttttt cttagctatg attaaaattt
     2581 ttaaatgtag actacaagtg gttgttaccc attcaatgac tattaaactt tagtttttca
     2641 tcaataaggt gatgacttca ctatttctat gtgttttttt ttttttaagg ttatcctgtg
     2701 aaattttaaa cccagaatca ttggccattt ctgtttaaat tttaaaaatt ccttaagtaa
     2761 ttatttgaaa ctatcccgtt tgcttttagt gagttaacta ctctttattc ccccttatta
     2821 atgaaattca tattcttaaa ttgacaagct tattaggcaa gttaggtgca ctgaatctaa
     2881 cctttaaggt tgacatgggc tcaaacttgg cctaaaaaga ttgatgaacc tgaggaaatt
     2941 tttataaatg aatatttcct ataattgata aaatattatc atttaattat cacatttaaa
     3001 acttatatta agtgtaaatt ccagtggctt tacctcactt gaaaaattag tggggataag
     3061 ccattttgtt ttgtgatatt aaatttaact atgatagtta attaaaaaga catatcttgt
     3121 attcattaaa aatattttaa tttaaaatat tctgatttct aaagtgtgtt agcttatcaa
     3181 ttatttttgt ttataaatag actttaatag ctctctaaga atatgacctc taaaggaaaa
     3241 gatgattttt tacaatacat acttctggaa ctttgagatt tgagaaagct tccatgtata
     3301 ttgataaatc taataaaata aagagatcaa ttataaacct ggttgttcta taaaagtaga
     3361 gtgcacaaaa aaatgtcttg tgttttatac tgtctaagat ttggaggaaa tgtggcaaat
     3421 tgcagtttat cgccatattt tattatcatt tttttctgta aaagactata aaacttgagg
     3481 attataaaat aatcacagag tatatcaatg gaaacagttt atcatttttt cagttaaagt
     3541 agtagtattg ttagttgttg ctgacacagg gtctacataa ttacatgtga attaaaacat
     3601 tggcaaaact gacccaccaa taaacacatc tattgaatag aa
//
