LOCUS       NM_030776               2142 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens Z-DNA binding protein 1 (ZBP1), transcript variant 1,
            mRNA.
ACCESSION   NM_030776
VERSION     NM_030776.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2142)
  AUTHORS   Beck,L.G., Krall,J.B., Nichols,P.J., Vicens,Q., Henen,M.A. and
            Vogeli,B.
  TITLE     Solution NMR backbone assignment of the N-terminal tandem
            Zalpha1-Zalpha2 domains of Z-DNA binding protein 1
  JOURNAL   Biomol NMR Assign 18 (2), 245-252 (2024)
   PUBMED   39215796
  REMARK    GeneRIF: Solution NMR backbone assignment of the N-terminal tandem
            Zalpha1-Zalpha2 domains of Z-DNA binding protein 1.
REFERENCE   2  (bases 1 to 2142)
  AUTHORS   Xie,F., Wu,D., Huang,J., Liu,X., Shen,Y., Huang,J., Su,Z. and Li,J.
  TITLE     ZBP1 condensate formation synergizes Z-NAs recognition and signal
            transduction
  JOURNAL   Cell Death Dis 15 (7), 487 (2024)
   PUBMED   38982083
  REMARK    GeneRIF: ZBP1 condensate formation synergizes Z-NAs recognition and
            signal transduction.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2142)
  AUTHORS   Cai,Z.Y., Wu,P., Liang,H., Xie,Y.Z., Zhang,B.X., He,C.L.,
            Yang,C.R., Li,H., Mo,W. and Yang,Z.H.
  TITLE     A ZBP1 isoform blocks ZBP1-mediated cell death
  JOURNAL   Cell Rep 43 (5), 114221 (2024)
   PUBMED   38748877
  REMARK    GeneRIF: A ZBP1 isoform blocks ZBP1-mediated cell death.
REFERENCE   4  (bases 1 to 2142)
  AUTHORS   Wusiman,S., Liu,Y., Li,H., Deng,Y., Qu,X., Tuerxun,H. and Liu,L.
  TITLE     Highly Expressed Z-DNA Binding Protein 1 in Esophageal Cancer
            Promotes Tumor Growth
  JOURNAL   Dig Dis Sci 69 (5), 1674-1690 (2024)
   PUBMED   38507125
  REMARK    GeneRIF: Highly Expressed Z-DNA Binding Protein 1 in Esophageal
            Cancer Promotes Tumor Growth.
REFERENCE   5  (bases 1 to 2142)
  AUTHORS   Ha,S.C., Kim,D., Hwang,H.Y., Rich,A., Kim,Y.G. and Kim,K.K.
  TITLE     The crystal structure of the second Z-DNA binding domain of human
            DAI (ZBP1) in complex with Z-DNA reveals an unusual binding mode to
            Z-DNA
  JOURNAL   Proc Natl Acad Sci U S A 105 (52), 20671-20676 (2008)
   PUBMED   19095800
  REMARK    GeneRIF: binding 2 DAIs to 1 dsDNA brings about dimerization of DAI
            that might facilitate DNA-mediated innate immune activation.
REFERENCE   6  (bases 1 to 2142)
  AUTHORS   Pham,H.T., Park,M.Y., Kim,K.K., Kim,Y.G. and Ahn,J.H.
  TITLE     Intracellular localization of human ZBP1: Differential regulation
            by the Z-DNA binding domain, Zalpha, in splice variants
  JOURNAL   Biochem Biophys Res Commun 348 (1), 145-152 (2006)
   PUBMED   16876127
REFERENCE   7  (bases 1 to 2142)
  AUTHORS   Ha,S.C., Van Quyen,D., Hwang,H.Y., Oh,D.B., Brown,B.A. 2nd,
            Lee,S.M., Park,H.J., Ahn,J.H., Kim,K.K. and Kim,Y.G.
  TITLE     Biochemical characterization and preliminary X-ray crystallographic
            study of the domains of human ZBP1 bound to left-handed Z-DNA
  JOURNAL   Biochim Biophys Acta 1764 (2), 320-323 (2006)
   PUBMED   16448869
  REMARK    GeneRIF: Z-DNA binding activities of two Zalpha domains in the
            human ZBP1, hZalpha(ZBP1) and hZbeta(ZBP1)were characterized.
REFERENCE   8  (bases 1 to 2142)
  AUTHORS   Rothenburg,S., Schwartz,T., Koch-Nolte,F. and Haag,F.
  TITLE     Complex regulation of the human gene for the Z-DNA binding protein
            DLM-1
  JOURNAL   Nucleic Acids Res 30 (4), 993-1000 (2002)
   PUBMED   11842111
  REMARK    GeneRIF: molecular cloning and structure analysis
REFERENCE   9  (bases 1 to 2142)
  AUTHORS   Schwartz,T., Behlke,J., Lowenhaupt,K., Heinemann,U. and Rich,A.
  TITLE     Structure of the DLM-1-Z-DNA complex reveals a conserved family of
            Z-DNA-binding proteins
  JOURNAL   Nat Struct Biol 8 (9), 761-765 (2001)
   PUBMED   11524677
REFERENCE   10 (bases 1 to 2142)
  AUTHORS   Schwartz,T., Rould,M.A., Lowenhaupt,K., Herbert,A. and Rich,A.
  TITLE     Crystal structure of the Zalpha domain of the human editing enzyme
            ADAR1 bound to left-handed Z-DNA
  JOURNAL   Science 284 (5421), 1841-1845 (1999)
   PUBMED   10364558
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AJ300575.1, AL035541.15 and
            DB331848.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_030776.2.
            
            Summary: This gene encodes a Z-DNA binding protein. The encoded
            protein plays a role in the innate immune response by binding to
            foreign DNA and inducing type-I interferon production.
            Alternatively spliced transcript variants encoding multiple
            isoforms have been observed for this gene. [provided by RefSeq, Dec
            2011].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK290918.1, AJ300575.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000371173.8/ ENSP00000360215.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-903               AJ300575.1         48-950
            904-904             AL035541.15        87671-87671         c
            905-2141            AJ300575.1         952-2188
            2142-2142           DB331848.1         5-5                 c
FEATURES             Location/Qualifiers
     source          1..2142
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.31"
     gene            1..2142
                     /gene="ZBP1"
                     /gene_synonym="C20orf183; DAI; DLM-1; DLM1"
                     /note="Z-DNA binding protein 1"
                     /db_xref="GeneID:81030"
                     /db_xref="HGNC:HGNC:16176"
                     /db_xref="MIM:606750"
     exon            1..165
                     /gene="ZBP1"
                     /gene_synonym="C20orf183; DAI; DLM-1; DLM1"
                     /inference="alignment:Splign:2.1.0"
     CDS             132..1421
                     /gene="ZBP1"
                     /gene_synonym="C20orf183; DAI; DLM-1; DLM1"
                     /note="isoform a is encoded by transcript variant 1; tumor
                     stroma and activated macrophage protein DLM-1;
                     DNA-dependent activator of IRFs"
                     /codon_start=1
                     /product="Z-DNA-binding protein 1 isoform a"
                     /protein_id="NP_110403.2"
                     /db_xref="CCDS:CCDS13461.1"
                     /db_xref="GeneID:81030"
                     /db_xref="HGNC:HGNC:16176"
                     /db_xref="MIM:606750"
                     /translation="MAQAPADPGREGHLEQRILQVLTEAGSPVKLAQLVKECQAPKRE
                     LNQVLYRMKKELKVSLTSPATWCLGGTDPEGEGPAELALSSPAERPQQHAATIPETPG
                     PQFSQQREEDIYRFLKDNGPQRALVIAQALGMRTAKDVNRDLYRMKSRHLLDMDEQSK
                     AWTIYRPEDSGRRAKSASIIYQHNPINMICQNGPNSWISIANSEAIQIGHGNIITRQT
                     VSREDGSAGPRHLPSMAPGDSSTWGTLVDPWGPQDIHMEQSILRRVQLGHSNEMRLHG
                     VPSEGPAHIPPGSPPVSATAAGPEASFEARIPSPGTHPEGEAAQRIHMKSCFLEDATI
                     GNSNKMSISPGVAGPGGVAGSGEGEPGEDAGRRPADTQSRSHFPRDIGQPITPSHSKL
                     TPKLETMTLGNRSHKAAEGSHYVDEASHEGSWWGGGI"
     exon            166..390
                     /gene="ZBP1"
                     /gene_synonym="C20orf183; DAI; DLM-1; DLM1"
                     /inference="alignment:Splign:2.1.0"
     exon            391..459
                     /gene="ZBP1"
                     /gene_synonym="C20orf183; DAI; DLM-1; DLM1"
                     /inference="alignment:Splign:2.1.0"
     exon            460..633
                     /gene="ZBP1"
                     /gene_synonym="C20orf183; DAI; DLM-1; DLM1"
                     /inference="alignment:Splign:2.1.0"
     exon            634..801
                     /gene="ZBP1"
                     /gene_synonym="C20orf183; DAI; DLM-1; DLM1"
                     /inference="alignment:Splign:2.1.0"
     exon            802..1005
                     /gene="ZBP1"
                     /gene_synonym="C20orf183; DAI; DLM-1; DLM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1224
                     /gene="ZBP1"
                     /gene_synonym="C20orf183; DAI; DLM-1; DLM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1225..2142
                     /gene="ZBP1"
                     /gene_synonym="C20orf183; DAI; DLM-1; DLM1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2126..2131
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZBP1"
                     /gene_synonym="C20orf183; DAI; DLM-1; DLM1"
                     /note="hexamer: AATAAA"
     polyA_site      2142
                     /gene="ZBP1"
                     /gene_synonym="C20orf183; DAI; DLM-1; DLM1"
                     /note="major polyA site"
ORIGIN      
        1 agagctgcaa gaagcaccag gctcggccac ttcagaagcc ccagcctcga cctagcccac
       61 cctctcaggg ccacagtgca gaagcctgca cacctgccaa gtctctccga ctccttgcag
      121 ctgctgtcag catggcccag gctcctgctg acccgggcag agaaggccac cttgaacaaa
      181 gaatcctgca ggtgctgaca gaggctggct ccccggtgaa acttgcccag ctggtgaagg
      241 aatgccaagc acccaagagg gagctcaacc aagtcctcta ccgaatgaaa aaggagttga
      301 aagtctccct cacatcccct gccacctggt gcttgggcgg gactgatcct gaaggcgagg
      361 gtcctgcaga gctggccttg tccagccctg ccgagaggcc ccagcaacat gcagctacaa
      421 ttccagagac ccctggccct cagttcagcc aacaacggga ggaagacatc tacaggtttc
      481 tcaaagacaa tggtccccag agggccctgg tcatcgccca agcactggga atgaggacag
      541 caaaagatgt gaaccgagac ttgtacagga tgaagagcag gcaccttctg gacatggatg
      601 agcagtccaa agcatggacg atttaccgcc cagaagattc tggaagaaga gcaaagtcag
      661 cctcaattat ttaccagcac aatccaatca acatgatctg ccagaatgga cccaacagct
      721 ggatttccat tgcaaactcc gaagccatcc agattggaca cgggaacatc attacaagac
      781 agacagtctc cagggaggac ggttccgccg gtccacgcca cctcccttca atggcaccag
      841 gtgattcctc aacttggggg accctagttg atccctgggg gccccaggac atccacatgg
      901 agcagtccat actgagacgg gtgcagctgg gacacagcaa tgagatgagg ctccacggcg
      961 tcccgtccga gggccctgcc cacatccccc ctggcagccc cccagtctct gccactgctg
     1021 ccggcccaga agcttcgttt gaagcaagaa ttcccagtcc aggaactcac cctgaggggg
     1081 aagccgccca gagaatccac atgaaatcgt gctttctcga ggacgccacc atcggcaaca
     1141 gcaacaaaat gtctatcagc ccaggggtgg ctggcccagg aggagtcgca gggtctggag
     1201 agggggagcc aggggaggac gcaggtcgtc gtcccgcaga cacacaatcc agaagtcact
     1261 ttcctcgaga cattggtcag cccatcactc ccagccactc gaagctcacc cccaagctgg
     1321 aaactatgac tcttggaaac aggagtcaca aagctgcaga aggcagccac tatgtggatg
     1381 aagcctcaca cgaggggagc tggtggggag gtgggattta gtgcacagcc tcacgtgggg
     1441 cttggacaca ggctgggggt gggcgcatgc tagggagact agcctgctgc tctctgcatt
     1501 ccttagcgtc ttgtttgacc tgcttgcttc cagacataac ctgcatgaat cagttttggg
     1561 ggaatggacc tggcatgggg atgggttcag gccaggtctt ttgatggcca ggagtagatg
     1621 acagggagtt gccttgggga acctttggtg tgccaagagg aggtgggtag atgggagtgg
     1681 ggctcggtcc cccaggccca ggggactctc tccactcttt cctgggctcg gggcatctgc
     1741 ctggagttac cttccatcat ggctacctgc tgtggtttga atgtttgagt cccaacaaaa
     1801 ttcatatcaa aacataatcc caactgggtg cagtggctca cgcctgtaat cccagcactt
     1861 tgggaggccg aggcgggcgg atcaataggt caggaaatcc agaccgtcct ggctaacatg
     1921 gtgaaacccc gtctctacta aaaaaaaaaa tacaaaaaat tagccgggcg ttgtggcggg
     1981 cacctggagt cccagctact ccggaggctg agggaggaga atggtgtgaa cccgggaggt
     2041 ggagcttcca gtgagccgag atcgcgccac tgcactccag gctgggcgac agagcgagac
     2101 tccgtctcaa aaaaataaat acataaataa aaaataaacc aa
//
