LOCUS       NM_001395895           11697 bp    mRNA    linear   PRI 12-JUN-2024
DEFINITION  Homo sapiens zinc finger BED-type containing 6 (ZBED6), mRNA.
ACCESSION   NM_001395895
VERSION     NM_001395895.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 11697)
  AUTHORS   Liu,H., Pan,D., Li,P., Wang,D., Xia,B., Zhang,R., Lu,J., Xing,X.,
            Du,J., Zhang,X., Jin,L., Jiang,L., Yao,L., Li,M. and Wu,J.
  TITLE     Loss of ZBED6 Protects Against Sepsis-Induced Muscle Atrophy by
            Upregulating DOCK3-Mediated RAC1/PI3K/AKT Signaling Pathway in Pigs
  JOURNAL   Adv Sci (Weinh) 10 (29), e2302298 (2023)
   PUBMED   37551034
  REMARK    GeneRIF: Loss of ZBED6 Protects Against Sepsis-Induced Muscle
            Atrophy by Upregulating DOCK3-Mediated RAC1/PI3K/AKT Signaling
            Pathway in Pigs.
REFERENCE   2  (bases 1 to 11697)
  AUTHORS   Akhtar Ali,M., Younis,S., Wallerman,O., Gupta,R., Andersson,L. and
            Sjoblom,T.
  TITLE     Transcriptional modulator ZBED6 affects cell cycle and growth of
            human colorectal cancer cells
  JOURNAL   Proc Natl Acad Sci U S A 112 (25), 7743-7748 (2015)
   PUBMED   26056301
  REMARK    GeneRIF: results of this study show that the effect of ZBED6 on
            tumor development depends on the genetic background and the
            transcriptional state of its target genes
REFERENCE   3  (bases 1 to 11697)
  AUTHORS   Wang,X., Jiang,L., Wallerman,O., Engstrom,U., Ameur,A., Gupta,R.K.,
            Qi,Y., Andersson,L. and Welsh,N.
  TITLE     Transcription factor ZBED6 affects gene expression, proliferation,
            and cell death in pancreatic beta cells
  JOURNAL   Proc Natl Acad Sci U S A 110 (40), 15997-16002 (2013)
   PUBMED   24043816
REFERENCE   4  (bases 1 to 11697)
  AUTHORS   Hayward,A., Ghazal,A., Andersson,G., Andersson,L. and Jern,P.
  TITLE     ZBED evolution: repeated utilization of DNA transposons as
            regulators of diverse host functions
  JOURNAL   PLoS One 8 (3), e59940 (2013)
   PUBMED   23533661
REFERENCE   5  (bases 1 to 11697)
  AUTHORS   Butter,F., Kappei,D., Buchholz,F., Vermeulen,M. and Mann,M.
  TITLE     A domesticated transposon mediates the effects of a
            single-nucleotide polymorphism responsible for enhanced muscle
            growth
  JOURNAL   EMBO Rep 11 (4), 305-311 (2010)
   PUBMED   20134481
  REMARK    GeneRIF: Mouse MGR (Zbed6) is a repressor of Igf2.
REFERENCE   6  (bases 1 to 11697)
  AUTHORS   Markljung,E., Jiang,L., Jaffe,J.D., Mikkelsen,T.S., Wallerman,O.,
            Larhammar,M., Zhang,X., Wang,L., Saenz-Vash,V., Gnirke,A.,
            Lindroth,A.M., Barres,R., Yan,J., Stromberg,S., De,S., Ponten,F.,
            Lander,E.S., Carr,S.A., Zierath,J.R., Kullander,K., Wadelius,C.,
            Lindblad-Toh,K., Andersson,G., Hjalm,G. and Andersson,L.
  TITLE     ZBED6, a novel transcription factor derived from a domesticated DNA
            transposon regulates IGF2 expression and muscle growth
  JOURNAL   PLoS Biol 7 (12), e1000256 (2009)
   PUBMED   20016685
  REMARK    GeneRIF: Silencing of Zbed6 in mouse C2C12 myoblasts affected Igf2
            expression, cell proliferation, wound healing, and myotube
            formation.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC114402.2.
            
            Summary: The protein encoded by this transposon-derived intronless
            gene is a transcriptional repressor that binds to the consensus
            sequence 5'-GCTCGC-3'. The encoded protein has been shown to
            repress IGF2 transcription. This gene is located within the first
            intron of the ZC3H11A gene. [provided by RefSeq, Jul 2016].
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.258445.1,
                                           SRR1803613.186647.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000550078.3/ ENSP00000447879.1
            NMD candidate          :: translation inferred from conservation
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7394              AC114402.2         104694-112087
            7395-7593           AC114402.2         125997-126195
            7594-7713           AC114402.2         127641-127760
            7714-7837           AC114402.2         137370-137493
            7838-8041           AC114402.2         138522-138725
            8042-8158           AC114402.2         138851-138967
            8159-8239           AC114402.2         139194-139274
            8240-8350           AC114402.2         140732-140842
            8351-8413           AC114402.2         142862-142924
            8414-8512           AC114402.2         147037-147135
            8513-8581           AC114402.2         149377-149445
            8582-9085           AC114402.2         156255-156758
            9086-9162           AC114402.2         157402-157478
            9163-9478           AC114402.2         158782-159097
            9479-9645           AC114402.2         159586-159752
            9646-9713           AC114402.2         160128-160195
            9714-11697          AC114402.2         161212-163195
FEATURES             Location/Qualifiers
     source          1..11697
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q32.1"
     gene            1..11697
                     /gene="ZBED6"
                     /gene_synonym="MGR"
                     /note="zinc finger BED-type containing 6"
                     /db_xref="GeneID:100381270"
                     /db_xref="HGNC:HGNC:33273"
                     /db_xref="MIM:613512"
     exon            1..7394
                     /gene="ZBED6"
                     /gene_synonym="MGR"
                     /inference="alignment:Splign:2.1.0"
     CDS             1901..4840
                     /gene="ZBED6"
                     /gene_synonym="MGR"
                     /codon_start=1
                     /product="zinc finger BED domain-containing protein 6"
                     /protein_id="NP_001382824.1"
                     /db_xref="CCDS:CCDS55673.1"
                     /db_xref="GeneID:100381270"
                     /db_xref="HGNC:HGNC:33273"
                     /db_xref="MIM:613512"
                     /translation="MSVCTLSVPVSSLSPGRRCNTFSDSGILGCVPINSNTDEEDVVE
                     EKMVAEGVNKEAKQPAKKKRKKGLRIKGKRRRKKLILAKKFSKDLGSGRPVADAPALL
                     ASNDPEQDEESLFESNIEKQIYLPSTRAKTSIVWHFFHVDPQYTWRAICNLCEKSVSR
                     GKPGSHLGTSTLQRHLQARHSPHWTRANKFGVASGEEDFTLDVSLSPSSGSNGSFEYI
                     PTDPLDDNRMGKKHDKSASDALRAERGRFLIKSNIVKHALIPGTRAKTSAVWNFFYTD
                     PQHISRAVCNICKRSVSRGRPGSHLGTSTLQRHLQATHPIHWAVANKDSGAVANGLDE
                     AETERSDLLSDTLHGEKSTGSQDLTAEDLSDSDSDEPMLEVENRSESPIPVAEQGTLM
                     RAQERETTCCGNPVSSHISQAIIQMIVEDMHPYNYFSTPAFQRFMQIVAPDYRLPSET
                     YFFTKAVPQLYDCVREKIFLTLENVQSQKIHLTVDIWTHDPSTDYFIVTVHWVSLETA
                     SFLNNGRIPDFRKWAVLCVTGLAKDCLITNILQELNDQIGLWLSPNFLIPSFIVSDNS
                     SNVVHAIKDGGFTHVPCFLHCLNMVIQDFFCEHKSIENMLVAARKTCHHFSHSVKARQ
                     ILQEFQNDHQLPWKNLKQDETGHWISTFYMLKWLLEHCYSVHHSLGRASGVVLTSLQW
                     TLMTYVCDILKPFEEATQKVSVKTAGLNQVLPLIHHLLLSLQKLREDFQVRGITQALN
                     LVDSLSLKLETDTLLSAMLKSKPCILATLLDPCFKNSLEDFFPQGADLETYKQFLAEE
                     VCNYMESSPEICQIPTSEASCPSVTVGADSFTSSLKEGTSSSGSVDSSAVDNVALGSK
                     SFMFPSAVAVVDEYFKEKYSEFSGGDDPLIYWQRKISIWPALTQVAIQYLSCPMCSWQ
                     SECIFTKNSHFHPKQIMSLDFDNIEQLMFLKMNLKNVNYDYSTLVLSWDPEQNEVVQS
                     SEKEILP"
     exon            7395..7593
                     /gene="ZBED6"
                     /gene_synonym="MGR"
                     /inference="alignment:Splign:2.1.0"
     exon            7594..7713
                     /gene="ZBED6"
                     /gene_synonym="MGR"
                     /inference="alignment:Splign:2.1.0"
     exon            7714..7837
                     /gene="ZBED6"
                     /gene_synonym="MGR"
                     /inference="alignment:Splign:2.1.0"
     exon            7838..8041
                     /gene="ZBED6"
                     /gene_synonym="MGR"
                     /inference="alignment:Splign:2.1.0"
     exon            8042..8158
                     /gene="ZBED6"
                     /gene_synonym="MGR"
                     /inference="alignment:Splign:2.1.0"
     exon            8159..8239
                     /gene="ZBED6"
                     /gene_synonym="MGR"
                     /inference="alignment:Splign:2.1.0"
     exon            8240..8350
                     /gene="ZBED6"
                     /gene_synonym="MGR"
                     /inference="alignment:Splign:2.1.0"
     exon            8351..8413
                     /gene="ZBED6"
                     /gene_synonym="MGR"
                     /inference="alignment:Splign:2.1.0"
     exon            8414..8512
                     /gene="ZBED6"
                     /gene_synonym="MGR"
                     /inference="alignment:Splign:2.1.0"
     exon            8513..8581
                     /gene="ZBED6"
                     /gene_synonym="MGR"
                     /inference="alignment:Splign:2.1.0"
     exon            8582..9085
                     /gene="ZBED6"
                     /gene_synonym="MGR"
                     /inference="alignment:Splign:2.1.0"
     exon            9086..9162
                     /gene="ZBED6"
                     /gene_synonym="MGR"
                     /inference="alignment:Splign:2.1.0"
     exon            9163..9478
                     /gene="ZBED6"
                     /gene_synonym="MGR"
                     /inference="alignment:Splign:2.1.0"
     exon            9479..9645
                     /gene="ZBED6"
                     /gene_synonym="MGR"
                     /inference="alignment:Splign:2.1.0"
     exon            9646..9713
                     /gene="ZBED6"
                     /gene_synonym="MGR"
                     /inference="alignment:Splign:2.1.0"
     exon            9714..11697
                     /gene="ZBED6"
                     /gene_synonym="MGR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      11568..11573
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZBED6"
                     /gene_synonym="MGR"
                     /note="hexamer: AATAAT"
     polyA_site      11607
                     /gene="ZBED6"
                     /gene_synonym="MGR"
     regulatory      11675..11680
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZBED6"
                     /gene_synonym="MGR"
                     /note="hexamer: AATAAA"
     polyA_site      11697
                     /gene="ZBED6"
                     /gene_synonym="MGR"
                     /note="major polyA site"
ORIGIN      
        1 agagcggagc ctgtagccag gcgccatctt tgacgctggc agtcttggtt ttctgctagt
       61 gctgctgctg ctgggaggac gacggacggc agcggccaag caagaagaaa gacgtggcag
      121 caagcgggag tcggggatag tgtcatcggt tcggtaaagt ttctgttctc tggtaactag
      181 acccgttttt ttgattcccg ggtggcttgg ggccggggag gtgggggaga gggcgagggg
      241 agtggcagcg gcctcccctc gcccctgggt cgcggcctat cccgggaagt cagagcggat
      301 ccttcagctt cgccgtaacg acccctcccc cccacctccc ggtcgcggcc ctcgccgggg
      361 ctggctggga gccccaggct cccgctcact tttcccatcc tccccacccc caccccgttc
      421 accccacccc cacggcgcct gctcctttcc cagccaacct tcctcccctc ccccacatcc
      481 ggtgttcgct aatctcgagg agcccggagc agccccgaaa accgactgtt cccccgaatc
      541 ccgaagagag aactgacact agattgcttt cttcggggca acagtttctc tagttgagcg
      601 gaccctcact gcctaaatca atcagactga gtgccgggcg ctgaatttac ctactctcat
      661 tcctctccag ggtcccggta ctttggagct tgtctcaaac tccacataca gaaagccacc
      721 gaccttattc cggtatccta cacccattcc ccactctcat tacactccca cccctggccc
      781 tcagcgtcgg agtcaagagc aacagggaca cttccgttct ccttgtagga ctggtgaaac
      841 cgtaatgaag aacaccccta aactcccata atcggtgcgg attcctatgg ggaaggccta
      901 tattgttgac atcttccagg ccttggttct ggaccttgag aaagaggctg tggaactaga
      961 gatagcgatg ctttttaggg taaatgtatg taggtattgg gggaagggga gggatcaatc
     1021 gaaaaatgga agtggtttaa agttcatatt tcactttttg ctatctctat agcgtacaac
     1081 ttgtgagtta cttacaggct gtaaaagctt ctcaagtcta aaaatatctg aaaactaaac
     1141 ttgaattaac tcttaataca aacagtactt tgaaaatgca gcatttaacc ttgttttaaa
     1201 atttttttct caaagcattt ttttccagcc actcacattt taaaaggttg tattactttt
     1261 agttagaact gaaagggctc aactagcatt tgctgtgacc agtatgcgga gtctgtgttg
     1321 gctttccaga attgactttt tgggttgtat tggcaaatca cagtcctaaa tgatgaatgt
     1381 tgaatgatgc actatgtttt tgtttaaatg agatttcctg aaaatagtta atttcagaat
     1441 taagggaaat tgatgtcgct atcatgaggc atcataaaaa tatgtatttt acaaggtgaa
     1501 ggcatttcaa gtagatatag ttcttgatga agcaggaaga acatggatct gggatttgga
     1561 agacctggct tctagctgct actaaccaac tctgtgactc tgggaaaggg ggactcagtt
     1621 cttacttctg taacatgagg acactggact atttgaattc agaacttaga aaattggaag
     1681 ggaccttaaa gccctctaag aaagagttcg ggaatgttct ccattgctgt cagttttcct
     1741 ccaaaaataa cctggcttgg aagttattgg tccagtggga atttgattcc ccatagaaac
     1801 tggagaaaag gtaatgcaag tagagaggaa cagctgtatt tctgcttgag taataaaccc
     1861 actaacagat tctggtacga attgtggaga cataaagaga atgagtgtat gtactctaag
     1921 tgtaccagtt tcttcactct ctcctggcag aagatgcaac acttttagtg attctgggat
     1981 tctgggatgt gttcctatta attctaatac agatgaagaa gatgtggtag aggaaaagat
     2041 ggtagcagaa ggagtgaata aagaggcaaa acagcctgct aaaaagaaaa gaaagaaggg
     2101 tttgcgaatt aaggggaaaa ggcgtcgaaa aaaattgatt cttgccaaaa agtttagtaa
     2161 ggatttggga tctgggaggc ctgttgcaga tgcccctgct ttgttagctt ccaatgaccc
     2221 tgagcaggat gaagaaagtc tttttgagag caatatagaa aaacagatct atctacctag
     2281 tactagagcc aagacctcca ttgtgtggca cttctttcat gttgaccccc agtacacctg
     2341 gcgggccatt tgtaacctct gtgagaaaag cgtcagcagg ggtaaaccag gtagccatct
     2401 tggtacatct actcttcaac gacatctgca agcaaggcat tcacctcatt ggaccagggc
     2461 caacaagttt ggagttgcta gtggagagga ggactttacc ttggatgtgt ctttatctcc
     2521 ctcttctgga agcaatggaa gctttgaata tattcctact gatccattag atgataatag
     2581 aatgggcaag aagcatgata aatcagcatc tgatgcccta agggcagaaa gagggagatt
     2641 tctcatcaaa agtaacattg tcaagcatgc tttaattcct ggaactagag ccaagacatc
     2701 tgccgtttgg aatttttttt acactgatcc tcagcacatc tcaagagctg tgtgtaatat
     2761 atgtaaaaga agtgtgagcc ggggtaggcc agggtcccac ttagggactt caacacttca
     2821 acgacacctg caagccacac atcctatcca ttgggctgtt gccaacaaag acagtggtgc
     2881 tgttgcaaat ggattagatg aagctgagac tgagagaagt gatctcttga gtgatacctt
     2941 gcatggagaa aagtctacag gcagccaaga tttaacagct gaggacctta gtgactctga
     3001 ttcagatgaa cctatgttag aggttgaaaa cagatctgaa agtcctattc ccgttgcaga
     3061 gcaaggcact ctgatgcgtg cgcaggagag agaaacaaca tgttgtggaa atccagtctc
     3121 aagtcacata agtcaggcaa ttatccaaat gattgtggag gatatgcatc cttacaacta
     3181 tttctcaacc ccagcctttc agaggttcat gcagattgtg gcccctgatt ataggttgcc
     3241 atcagagact tactttttca ctaaggctgt acctcagtta tatgattgtg tcagagaaaa
     3301 aattttctta actttagaga atgttcaaag ccaaaagata cacctgactg ttgacatatg
     3361 gacccatgac ccatccactg actattttat tgtgactgta cactgggttt ctttggaaac
     3421 tgcgtctttt ctcaataatg gcaggatccc cgattttaga aagtgggcag tgctttgtgt
     3481 tacaggtttg gctaaagact gtttgataac caatatttta caagaattaa atgaccagat
     3541 tggtctgtgg ctttctccaa atttccttat ccctagcttc attgtttctg acaattcctc
     3601 taatgtggta catgcaatca aagatggtgg ttttacccat gtgccatgct tcctgcattg
     3661 tttaaatatg gtcattcagg actttttctg cgagcacaaa agcattgaga atatgttagt
     3721 ggctgccagg aaaacttgtc atcattttag tcattcggtc aaggcccgtc agatactgca
     3781 agagttccaa aatgatcacc aacttccatg gaagaatttg aagcaggacg aaactggcca
     3841 ttggatttct actttttata tgttaaaatg gctcttggag cattgctact cagttcacca
     3901 tagtcttggt agagccagtg gagttgtgct cacctccctt cagtggactc taatgactta
     3961 tgtttgtgat attcttaagc catttgagga ggctacccag aaagtgagcg tgaagaccgc
     4021 aggattgaat caggtgctac ccctaatcca tcatctactc ctttccctgc agaaactcag
     4081 agaagatttt caagtcagag gtattactca ggccctcaat ctggtggata gtttatctct
     4141 gaaacttgaa acagataccc tactaagtgc catgcttaaa tccaagccct gtatcttggc
     4201 tactttgtta gatccttgct ttaaaaacag tttggaagac ttttttcctc aaggtgctga
     4261 tttagaaact tataagcagt tccttgcaga agaggtctgt aattatatgg aatcttcacc
     4321 agagatctgc caaattccaa cttcagaagc ttcttgtccc tcagttacag tgggagctga
     4381 ttcatttacc tcatctctaa aagaaggcac ctccagttca ggttctgttg atagctcagc
     4441 tgtagacaat gttgcccttg gaagcaaaag cttcatgttc ccttctgctg tagcagttgt
     4501 ggatgagtac ttcaaagaga agtattcaga gttctcagga ggtgatgacc ctttaattta
     4561 ctggcagagg aagataagca tatggccggc tttgacccag gttgccatcc agtatctaag
     4621 ttgccccatg tgtagttggc aatctgaatg tatctttact aaaaatagcc actttcatcc
     4681 aaaacagatc atgagcctgg actttgacaa tatagaacaa ctgatgtttc tgaaaatgaa
     4741 cttgaaaaat gttaactacg attattctac gttggttctg agctgggatc ctgagcagaa
     4801 tgaagttgtt caaagcagtg aaaaagaaat actgccttaa tttctttttc tccatttaaa
     4861 atgggcaact ttttgctgtg ttactgtatc ttaatagctg tagttgttaa atataatcat
     4921 tatctttata aacacatctg gggaaacctg aaatcacaca agggctgaaa attcctcaga
     4981 ggcaatataa ttttgataaa atgaagatta aagatttcat agctataact gtggcgctag
     5041 cacttgaaaa ttttgcttat accaatgaga gagaagatat ttttaattaa aaaaaatata
     5101 gtgcagcatt gaaaggcctt aggctttctt cctggtagat tgaactagta attggtttta
     5161 agtaaaactt cccccaccat gggaaatttt attgctctga aatcaacgaa atgagaaaaa
     5221 agtacactgg ctggcattcc tcctgcccct gtttttctgt ttccttaaaa accctgatgc
     5281 ttaattacaa cttggcaaaa agaaaacccg tgaaattgtt ttatatttgg aaatttctaa
     5341 ttgcctcctc atactggtca gctttataat ttcaaattgt tgagtgtgat agtgttaccc
     5401 tttagaattg gatcttatat aaaagggaaa tattagaaaa caattaggaa aatatacttt
     5461 tagtctttga aatgcctgtt ttaaccttta taaaatatta taaaaataga ttgtgtaggt
     5521 actttcaaat aatttatggg taaaaacaga ctaaaatgtt tgcaagaatt ggaaaaggtt
     5581 gaatgggaat tgtaatgaga gccctttgaa catgcttgga aaaacccagt agacatttcc
     5641 caaagattgt ttctgtaatt ttaggtaatc tttttaaaaa catacttaat gacccattat
     5701 actgtattaa ctgtgcggtt gttttggcca ctgaattctt aatgaaaact aagcagtcgg
     5761 tatttttatg tgttaggaat cattggtgaa atgagtgaat tgatctcatt ttaagatccc
     5821 tttctactct gaaagtatgt ttctgagatt gagtaggagg ccagaaaatg atgactttta
     5881 gtaaaagtct attaaaagtt tcagactgaa taactaatgt gagatcccaa tttttccttt
     5941 ttttcatttt agatttgggg atattccctg cccaaaaaat tcctggaaaa ttgactagta
     6001 ttaagtgtga gtaaaaggtg tccacttttt tttaagtttt gattttagtt ttgtcttgga
     6061 tagtatttgg caagatttag cctagaaatt atgtagtatt tattacataa gaatcaaaat
     6121 tgctttgtta ctgggctggt ttcaaagttt agaactcatt tctatgtatc aaaatcgggt
     6181 tttttttggt tttgattttt ttttttttta aattcttaaa tggtaaatat gccattgtga
     6241 aatgaaatct caactccaaa agtttaccct tttactaact ggagtaaatg tatacttaca
     6301 aagtctttag ctgtagccat tagtagtaaa gaatttggac ctaggctgcg taagcaagcc
     6361 tttccagggc cactatttaa tggcaaacca gtgatactgg tgttgataca aaataagaaa
     6421 taaattttcc cttagataaa gctttctgtg ttttgacagt gccagtttag aatggctata
     6481 atgctgctct gccttctaca gcttgctgca ccactctgta gttactctat taccatacgt
     6541 ttctatcttt tttggttaaa cactccctga tgacgatgat ggatatatat acatacatcc
     6601 atattataca taatgatata tgtgtaagga tttaccttcg tctttatttt gtgggctggg
     6661 caaaatttag tgtaacaata acttcatgat actttggtat aagagtaagt tctttatttt
     6721 tataatgaac ccaaatctaa agtcttttat agtgcatttt aaaaggggaa acttatccaa
     6781 atgttatatt tctatacatt tttgtgtata tgtgtgtgtg tataagccag ttagtatata
     6841 tctgtatgta tattatatac ataaaacact atatttttac atacaagtat gcttttatta
     6901 tacagataat aaagatgggg gaaggtttct gtttttttct taataggtga agaaatcttg
     6961 aagaccagaa attggatctt actgaaaaac tgatgttttt ttgttttttt tttaaattat
     7021 attgttcagc tatggaagat ggagtttttt ttcatgatcc tttaactctc aagttcatct
     7081 ttaaatgaac tctttttttt tgtttttttt ttgttttgtt ttgttttgtt tttgaggaga
     7141 taactaaccc tagctgtctc cagtctgaca aaggttattt gaatggactt aatctcccag
     7201 tagttgggag atgttttaaa aacacatgct gtgtttgaat tgtggctgag aggttttctt
     7261 ggcaatgtga ggaggaaatt tttttctgcc tcattattat taattcatgg attgagtgtt
     7321 ggttcgacct acaggcgtaa tagattggaa ctcagtgaag acacagatgt tcctgttcag
     7381 agcaaccagc taatgattac agtttaaaga caatttctgt gatcaagttg tcatttggaa
     7441 gattaaaccc atttcacgag gacttggagc ctggtccttg ctttgaggaa gcagtggctt
     7501 gtttcaagaa gccacttctg atctaagaat ctacccagca tgcctaatca aggagaagac
     7561 tgctattttt ttttctattc cacatgtacc aaaggtgaca gctgcccatt ccgtcactgt
     7621 gaagctgcaa taggaaatga aactgtttgc acattatggc aagaagggcg ctgttttcga
     7681 caggtgtgca ggtttcggca catggagatt gataaaaaac gcagtgaaat tccttgttat
     7741 tgggaaaatc agccaacagg atgtcaaaaa ttaaactgcg ctttccatca caatagagga
     7801 cgatatgttg atggcctttt cctacctccg agcaaaactg tgttgcccac tgtgcctgag
     7861 tcaccagaag aggaagtgaa ggctagccaa ctttcagttc agcagaacaa attgtctgtc
     7921 cagtccaatc cttcccctca gctgcggagc gttatgaaag tagaaagttc cgaaaatgtt
     7981 cctagcccca cgcatccacc agttgtaatt aatgctgcag atgatgatga agatgatgat
     8041 gatcagtttt ctgaggaagg tgatgaaacc aaaacaccta ccctgcaacc aactcctgaa
     8101 gttcacaatg gattacgagt gacttctgtc cggaaacctg cagtcaatat aaagcaaggt
     8161 gaatgtttga attttggaat aaaaactctt gaggaaatta agtcaaagaa aatgaaggaa
     8221 aaatctaaga agcaaggtga gggttcttca ggagtttcca gtcttttact ccaccctgag
     8281 cccgttccag gtcctgaaaa agaaaatgtc aggactgtgg tgaggacagt aactctctcc
     8341 accaaacaag gagaagaacc cttggttaga ttgagtctta ctgagagact ggggaaacga
     8401 aaattttcag caggcggtga cagtgatcct ccattaaagc gtagcctggc acagaggcta
     8461 gggaagaaag ttgaagctcc agaaactaac attgacaaaa caccaaagaa agctcaagtt
     8521 tccaagtctc ttaaggagcg attaggcatg tcagctgatc cagataatga ggatgcaaca
     8581 gataaagtta ataaagttgg tgagatccat gtgaagacat tagaagaaat tcttcttgaa
     8641 agagccagtc agaaacgtgg agaattgcaa actaaactca agacagaagg accttcaaaa
     8701 actgatgatt ctacttcagg agcaagaagc tcctccacta tccgtatcaa aaccttctct
     8761 gaggtcctgg ctgaaaaaaa acatcggcag caggaagcag agagacaaaa aagcaaaaag
     8821 gatacaactt gcatcaagct aaagattgat agtgaaatta aaaaaacagt agttttgcca
     8881 cccattgttg ccagcagagg acaatcagag gagcctgcag gtaaaacaaa gtctatgcag
     8941 gaggtgcaca tcaagacgct ggaagaaatt aaactggaga aggcactgag ggtgcagcag
     9001 agctctgaga gcagcaccag ctccccgtct caacacgagg ccactccagg ggcaaggcgg
     9061 ctgctgcgaa tcaccaaaag aacagggatg aaagaagaga agaaccttca ggaaggaaat
     9121 gaagttgatt ctcagagcag tattagaaca gaagctaaag aggcttcagg tgagaccaca
     9181 ggagttgaca tcactaaaat tcaagtcaag agatgtgaga ccatgagaga gaagcacatg
     9241 cagaaacagc aggagaggga aaaatcagtc ttgacacctc ttcggggaga tgtagcctct
     9301 tgcaataccc aagtggcaga gaaaccagtg ctcactgctg tgccaggaat cacacggcac
     9361 ctgaccaagc ggcttcccac aaagtcatcc cagaaggtgg aggtagaaac ctcagggatt
     9421 ggagactcat tattgaatgt gaaatgtgca gcacagacct tggaaaaaag gggtaaagct
     9481 aaacccaaag tgaacgtgaa gccatctgtg gttaaagttg tgtcatcccc caaattggcc
     9541 ccaaaacgta aggcagtgga gatgcacgct gctgtcattg ccgctgtgaa gccactcagc
     9601 tccagcagtg tcctacagga acccccagcc aaaaaggcag ctgtggctgt tgtcccgctt
     9661 gtctctgagg acaaatcagt cactgtgcct gaagcagaaa atcctagaga cagtcttgtg
     9721 ctgcctccaa cccagtcctc ttcagattcc tcacccccgg aggtgtctgg cccttcctca
     9781 tcccaaatga gcatgaaaac tcgccgactc agctctgcct caacaggaaa gcccccactc
     9841 tctgtggagg atgattttga gaaactaata tgggagattt caggaggcaa attggaagct
     9901 gagattgacc tggatcctgg gaaagatgaa gatgaccttc tgcttgagct atcagaaatg
     9961 attgatagct gaaggtggta gtgaggacac tttaaaaaaa aaatcgccaa aaaactggac
    10021 ttagtttcat ctattgtaac atttacctga gatgatcatt tctttagtct agaatttgcc
    10081 ccaaatcaga agtatacctc tgaattatct gtatgtgtcc tggattcctt ggggtcagat
    10141 ttttaaagtt actttataac cattttgtcc atttgatgcc attgtttatc atcttttgag
    10201 aaaaaagttc tgtcataccc ttctctccac aaaaaagaga ctgagaggga gatcaagtga
    10261 aagggtgcaa gcgaacttag tgactccttg aggtgtttgt cagttttggc ttttttcttc
    10321 tttgttgtat tctttatgta ttgtcttgat gtacttaata ttacctgagt ttgaaatgga
    10381 tgaagacagc tgctaccatt aaggaccaaa ttttatgcta ccactaaaca aaaataccca
    10441 ctcagtctgt gttaaattgt atgtcttttt aaaggtattt aaagattcaa ctaagcttta
    10501 aagagggctg agcagctcag gaagcctgta atgtgggcat aactctttgg acctgatctt
    10561 gatgcttctg ctgctctgtt agcctctgaa gagcaatatc taatttatta ttactgtaat
    10621 tttttaaaag gctttaaagt gcctcagggg tcccctgaaa ctaattttct atttctggga
    10681 ttccctggat tcattatatg agatggtgac atgattagag gaattctttt ttagtatgaa
    10741 aattgtcctt tttcttcttc agtacttgcc tccttgctgg cattgaatta acacagggac
    10801 aaaatttggt taatttttta tttctaactc tcccaacaaa cccctgttgc ccagtatttg
    10861 tttggtggcc tttaaccacc tgagggaaaa aatgagctta ttcaagctgc caatatttat
    10921 ctatgggctg tagcagtaca ctgaattgta ctgtgccagg gatattgaga tgctctgggg
    10981 gtgtattgta tacctgccag ttttcttcat ttctgaattg agttttcttt tcttgatgtt
    11041 ggtttccttc atatcacctc aaggtttaga tttgtgaagg aataagcatg atggaaataa
    11101 tagtcttgaa aggagatatg ttgtatataa tcaggaggaa gaggaaggaa ggacttaccc
    11161 attttgatat tttgctgtag gtggccagtt ttgtttctca tagggaaatc tgacccacct
    11221 gtcatgttgg ctcctaagga actgctgttg taagcggctc atcaagagtt gaacttcacg
    11281 tagccttgtt gggaatatgg aaaaggaaga aagccacagg actgcccatt cagtcttggg
    11341 aagattggga tgattctgca caagcaaaaa tgactgaagt ttatgtatag acacacctct
    11401 accaatccat cttcagctga ctgaatgttg tatgatagcc cttctccaaa gcagaggtag
    11461 aatgttcagg tttcaccatg gattttctac ttatttcgtt tttggaatca gcttacagat
    11521 tccaggtccc ttttgtatat attctttatt cttttgcttt tttaaaaaat aattttgttt
    11581 catatttaaa gcacttgtat tagtcaatgt ttcgtgttcc gcattatttg aaccatttgc
    11641 ccttacagaa agagaaatac ttgtttgtgt tttaaataaa actgatgtag gaaagtc
//
