LOCUS       NM_001143667            2687 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens zinc finger BED-type containing 5 (ZBED5), transcript
            variant 2, mRNA.
ACCESSION   NM_001143667
VERSION     NM_001143667.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2687)
  AUTHORS   Hayward,A., Ghazal,A., Andersson,G., Andersson,L. and Jern,P.
  TITLE     ZBED evolution: repeated utilization of DNA transposons as
            regulators of diverse host functions
  JOURNAL   PLoS One 8 (3), e59940 (2013)
   PUBMED   23533661
REFERENCE   2  (bases 1 to 2687)
  AUTHORS   Woodard,L.E., Li,X., Malani,N., Kaja,A., Hice,R.H., Atkinson,P.W.,
            Bushman,F.D., Craig,N.L. and Wilson,M.H.
  TITLE     Comparative analysis of the recently discovered hAT transposon
            TcBuster in human cells
  JOURNAL   PLoS One 7 (11), e42666 (2012)
   PUBMED   23166581
REFERENCE   3  (bases 1 to 2687)
  AUTHORS   Smit,A.F.
  TITLE     Interspersed repeats and other mementos of transposable elements in
            mammalian genomes
  JOURNAL   Curr Opin Genet Dev 9 (6), 657-663 (1999)
   PUBMED   10607616
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA785416.1, AK315033.1 and
            BQ028130.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001143667.1.
            
            Summary: This gene is unusual in that its coding sequence is mostly
            derived from Charlie-like DNA transposon; however, it does not
            appear to be an active DNA transposon as it is not flanked by
            terminal inverted repeats. The encoded protein is conserved among
            the mammalian Laurasiatheria branch. Multiple alternatively spliced
            variants, encoding the same protein, have been identified.
            [provided by RefSeq, Jan 2009].
            
            Transcript Variant: This variant (2) uses an alternate splice site
            in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode
            the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.163994.1,
                                           SRR1803616.242737.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467146, SAMEA2467150
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000413761.7/ ENSP00000415939.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-161               DA785416.1         21-181
            162-2529            AK315033.1         146-2513
            2530-2687           BQ028130.1         18-175              c
FEATURES             Location/Qualifiers
     source          1..2687
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.4"
     gene            1..2687
                     /gene="ZBED5"
                     /gene_synonym="Buster1"
                     /note="zinc finger BED-type containing 5"
                     /db_xref="GeneID:58486"
                     /db_xref="HGNC:HGNC:30803"
                     /db_xref="MIM:615251"
     exon            1..192
                     /gene="ZBED5"
                     /gene_synonym="Buster1"
                     /inference="alignment:Splign:2.1.0"
     exon            193..306
                     /gene="ZBED5"
                     /gene_synonym="Buster1"
                     /inference="alignment:Splign:2.1.0"
     exon            307..2687
                     /gene="ZBED5"
                     /gene_synonym="Buster1"
                     /inference="alignment:Splign:2.1.0"
     CDS             448..2529
                     /gene="ZBED5"
                     /gene_synonym="Buster1"
                     /note="transposon-derived Buster1 transposase-like
                     protein"
                     /codon_start=1
                     /product="zinc finger BED domain-containing protein 5"
                     /protein_id="NP_001137139.1"
                     /db_xref="GeneID:58486"
                     /db_xref="HGNC:HGNC:30803"
                     /db_xref="MIM:615251"
                     /translation="MIAPLLCILSYNFNTFAILNVYSKLTMFCTTNSLPMDLLLKQGS
                     LKQEVESFCYQIVSESNDQKVGILQSEDKQLQPSVSKKSEGELSRVKFISNSNKITFS
                     KKPKRRKYDESYLSFGFTYFGNRDAPHAQCVLCKKILSNSSLAPSKLRRHLETKHAAY
                     KDKDISFFKQHLDSPENNKPPTPKIVNTDNESATEASYNVSYHIALSGEAHTIGELLI
                     KPCAKDVVMRMFDEQYSKKIDAVQLSNSTVARRIKDLAADIEEELVCRLKICDGFSLQ
                     LDESADVSGLAVLLVFVRYRFNKSIEEDLLLCESLQSNATGEEIFNCINSFMQKHEIE
                     WEKCVDVCSDASRAVDGKIAEAVTLIKYVAPESTSSHCLLYRHALAVKIMPTSLKNVL
                     DQAVQIINYIKARPHQSRLLKILCEEMGAQHTALLLNTEVRWLSRGKVLVRLFELRRE
                     LLVFMDSAFRLSDCLTNSSWLLRLAYLADIFTKLNEVNLSMQGKNVTVFTVFDKMSSL
                     LRKLEFWASSVEEENFDCFPTLSDFLTEINSTVDKDICSAIVQHLRGLRATLLKYFPV
                     TNDNNAWVRNPFTVTVKPASLVARDYESLIDLTSDSQVKQNFSELSLNDFWSSLIQEY
                     PSIARRAVRVLLPFATMHLCETGFSYYAATKTKYRKRLDAAPHMRIRLSNITPNIKRI
                     CDKKTQKHCSH"
     regulatory      2576..2581
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZBED5"
                     /gene_synonym="Buster1"
                     /note="hexamer: AATAAA"
     polyA_site      2596
                     /gene="ZBED5"
                     /gene_synonym="Buster1"
                     /note="major polyA site"
     regulatory      2619..2624
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZBED5"
                     /gene_synonym="Buster1"
                     /note="hexamer: AATAAA"
     polyA_site      2625
                     /gene="ZBED5"
                     /gene_synonym="Buster1"
     polyA_site      2646
                     /gene="ZBED5"
                     /gene_synonym="Buster1"
     polyA_site      2687
                     /gene="ZBED5"
                     /gene_synonym="Buster1"
ORIGIN      
        1 agaccggcga ccgcgccagc cgcgaatcgg atctctatgg agatggccta ggcgatatcc
       61 ctgagctgag agcatcaccc tgtccccgaa tccttctttc ctctctgttt tgtttttcat
      121 tcccctccct ctctcccctc cccctccagt ccacgacgac tggctgttga ccctgttcag
      181 gcctcggtga aggcttttgg ttactcccct tcccacccca tcccttaatt ttattctttt
      241 gaagagtgca tttcaagctg ccaaggtgga gagagggatt acagaaagga gaacacctta
      301 tttcagaaaa ggtgtaccat acctgagagc accaggaagt cgcatgagag atcacctgat
      361 acatgaacgt atgatgttcc atctgcgcat tgatgaatag gcagcattta caaattaact
      421 gatgtgttgc tgtatatcat ctctttgatg attgctcctc ttctttgtat cctgtcttat
      481 aatttcaaca catttgcgat actcaatgtc tattctaaat taaccatgtt ttgtaccaca
      541 aactcattgc ccatggatct gttgctgaaa caaggaagtc ttaaacaaga agtggaatct
      601 ttctgttatc agattgtgtc tgaatcaaat gatcagaagg ttggaatatt acaaagtgaa
      661 gataagcagt tgcaaccttc agtttctaaa aaatcagaag gtgagctttc cagggtcaaa
      721 tttatatcca attccaacaa aataacattt agtaaaaaac caaaaagaag aaaatatgat
      781 gaaagttatt tgtcttttgg atttacttac ttcggaaata gagatgcacc tcatgctcag
      841 tgtgtattat gtaagaaaat tttatcaaat agctctttag cccctagtaa gcttcgaaga
      901 catttggaaa ctaaacatgc tgcatataaa gacaaagaca taagcttttt caagcaacat
      961 ctcgattcac ctgaaaataa taaaccccca acacctaaaa ttgtgaatac agataatgaa
     1021 agtgctacag aagcatcata caatgtaagt taccatatag cgctgagtgg agaggctcat
     1081 actattggag aattgcttat caaaccttgt gcaaaagatg tagtgatgcg gatgtttgat
     1141 gaacaatata gtaaaaaaat agatgcagta cagctatcaa acagtactgt tgcacgtcga
     1201 attaaggatc tagctgctga cattgaagaa gagcttgttt gtagactgaa aatttgcgat
     1261 gggttttcac tgcaactaga tgaatcagct gatgtttcag gacttgctgt gctgcttgtg
     1321 tttgttcgtt ataggtttaa taagtctatt gaggaagacc tactcctgtg tgaatctttg
     1381 caaagtaatg ctaccggtga agaaatattc aactgtatca acagttttat gcagaaacat
     1441 gaaattgaat gggaaaaatg tgttgatgtt tgtagtgatg cttctagggc agtggatggg
     1501 aaaattgccg aagctgtcac cttaataaaa tatgtggctc ccgaaagcac cagtagtcac
     1561 tgcctattat acagacatgc actggcagtt aaaataatgc ctacatctct aaaaaatgtg
     1621 ctagaccagg cagtacaaat catcaattat attaaagctc gaccacatca atccagacta
     1681 ttaaaaattt tatgtgagga aatgggtgct cagcacacag cacttcttct aaatacagag
     1741 gtgaggtggc tttctcgagg taaagttctt gtaagacttt ttgaacttcg tcgtgaactt
     1801 ttggttttca tggattctgc ttttcgacta tctgattgtt taacaaattc atcttggctg
     1861 ctaagacttg catatcttgc agatattttt actaaattaa atgaagttaa tttgtcaatg
     1921 caaggaaaaa atgtgaccgt ttttacagta tttgataaaa tgtcgtcatt gttaagaaaa
     1981 ttggaatttt gggcctcatc tgtagaagaa gaaaactttg attgttttcc tacactcagt
     2041 gattttttga ctgaaattaa ttctacagtt gataaagata tttgcagtgc cattgtgcag
     2101 cacctaaggg gtttgcgcgc tactctgtta aaatactttc ctgtaacaaa tgacaataat
     2161 gcttgggtta gaaatccatt tacagttact gttaaaccag cttcattagt agcacgggac
     2221 tatgagagcc tgattgattt aacatctgat tctcaagtga agcaaaattt tagtgaactt
     2281 tcactaaatg atttttggag tagcctaatt caggaatacc caagcattgc aaggcgtgca
     2341 gtgcgtgtac ttcttccttt tgctacaatg cacctgtgtg aaacggggtt ttcatattac
     2401 gctgcaacaa aaacaaaata taggaaaaga cttgatgctg cacctcatat gcgaatccga
     2461 cttagcaata ttacacctaa tattaagcgg atatgtgata aaaagacaca aaaacactgt
     2521 tctcattaaa attggaggag tttgcatgtc tcatgataac caaatgtaag atgaaaataa
     2581 aagatgattt acttcatctc tggtatttgg gggatttaaa taaaatgatt ccattttttt
     2641 atactattta gattttaaga aggctaaaga atcaaacgtt ttaaaca
//
