LOCUS       NM_032367               6134 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens zinc finger BED-type containing 3 (ZBED3), transcript
            variant 1, mRNA.
ACCESSION   NM_032367
VERSION     NM_032367.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6134)
  AUTHORS   Gu,X., Li,P., Gao,X., Ru,Y., Xue,C., Zhang,S., Liu,Y. and Hu,X.
  TITLE     RNA 5-methylcytosine writer NSUN5 promotes hepatocellular carcinoma
            cell proliferation via a ZBED3-dependent mechanism
  JOURNAL   Oncogene 43 (9), 624-635 (2024)
   PUBMED   38182896
  REMARK    GeneRIF: RNA 5-methylcytosine writer NSUN5 promotes hepatocellular
            carcinoma cell proliferation via a ZBED3-dependent mechanism.
REFERENCE   2  (bases 1 to 6134)
  AUTHORS   Huang,T., Wang,Y., Li,M., Wang,W., Qi,Z. and Li,J.
  TITLE     Circular RNA hsa_circ_0119412 contributes to tumorigenesis of
            gastric cancer via the regulation of the miR-1298-5p/zinc finger
            BED-type containing 3 (ZBED3) axis
  JOURNAL   Bioengineered 13 (3), 5827-5842 (2022)
   PUBMED   35200111
  REMARK    GeneRIF: Circular RNA hsa_circ_0119412 contributes to tumorigenesis
            of gastric cancer via the regulation of the miR-1298-5p/zinc finger
            BED-type containing 3 (ZBED3) axis.
REFERENCE   3  (bases 1 to 6134)
  AUTHORS   Fu,A., Yu,Z., Zhang,E. and Song,J.
  TITLE     Long noncoding RNA ZBED3-AS1 restrains breast cancer progression by
            targeting the microRNA-513a-5p/KLF6 axis
  JOURNAL   Thorac Cancer 12 (20), 2719-2731 (2021)
   PUBMED   34427978
  REMARK    GeneRIF: Long noncoding RNA ZBED3-AS1 restrains breast cancer
            progression by targeting the microRNA-513a-5p/KLF6 axis.
REFERENCE   4  (bases 1 to 6134)
  AUTHORS   Liu,H., Shi,X., Fan,X., Zhang,D., Jiang,B., Zhao,Y. and Fan,C.
  TITLE     The function of BED finger domain of Zbed3 in regulating lung
            cancer cell proliferation
  JOURNAL   J Cell Biochem 120 (8), 12340-12347 (2019)
   PUBMED   30805970
  REMARK    GeneRIF: The function of BED finger domain of Zbed3 in regulating
            lung cancer cell proliferation.
REFERENCE   5  (bases 1 to 6134)
  AUTHORS   Shi,X., Zhao,Y. and Fan,C.
  TITLE     Zbed3 promotes proliferation and invasion of lung cancer partly
            through regulating the function of Axin-Gsk3beta complex
  JOURNAL   J Cell Mol Med 23 (2), 1014-1021 (2019)
   PUBMED   30417576
  REMARK    GeneRIF: Zbed3 enhances lung cancer cell proliferation.
REFERENCE   6  (bases 1 to 6134)
  AUTHORS   Jia,Y., Yuan,L., Hu,W., Luo,Y., Suo,L., Yang,M., Chen,S., Wang,Y.,
            Liu,H., Yang,G. and Li,L.
  TITLE     Zinc-finger BED domain-containing 3 (Zbed3) is a novel secreted
            protein associated with insulin resistance in humans
  JOURNAL   J Intern Med 275 (5), 522-533 (2014)
   PUBMED   24283382
  REMARK    GeneRIF: results suggest that the Zbed3 protein may be a cytokine
            associated with insulin resistance in humans that is influenced by
            glucose and insulin levels.
REFERENCE   7  (bases 1 to 6134)
  AUTHORS   Hayward,A., Ghazal,A., Andersson,G., Andersson,L. and Jern,P.
  TITLE     ZBED evolution: repeated utilization of DNA transposons as
            regulators of diverse host functions
  JOURNAL   PLoS One 8 (3), e59940 (2013)
   PUBMED   23533661
REFERENCE   8  (bases 1 to 6134)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   9  (bases 1 to 6134)
  AUTHORS   Chen,T., Li,M., Ding,Y., Zhang,L.S., Xi,Y., Pan,W.J., Tao,D.L.,
            Wang,J.Y. and Li,L.
  TITLE     Identification of zinc-finger BED domain-containing 3 (Zbed3) as a
            novel Axin-interacting protein that activates Wnt/beta-catenin
            signaling
  JOURNAL   J Biol Chem 284 (11), 6683-6689 (2009)
   PUBMED   19141611
  REMARK    GeneRIF: Zbed3 is a novel Axin-binding protein that is involved in
            Wnt/beta-catenin signaling modulation.
REFERENCE   10 (bases 1 to 6134)
  AUTHORS   Choy,K.W., Wang,C.C., Ogura,A., Lau,T.K., Rogers,M.S., Ikeo,K.,
            Gojobori,T., Lam,D.S. and Pang,C.P.
  TITLE     Genomic annotation of 15,809 ESTs identified from pooled early
            gestation human eyes
  JOURNAL   Physiol Genomics 25 (1), 9-15 (2006)
   PUBMED   16368877
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC008581.11, DN998543.1,
            BC007239.1 and BF508552.1.
            
            On Nov 22, 2018 this sequence version replaced NM_032367.3.
            
            Summary: This gene belongs to a class of genes that arose through
            hAT DNA transposition and that encode regulatory proteins. This
            gene is upregulated in lung cancer tissues, where the encoded
            protein causes an accumulation of beta-catenin and enhanced lung
            cancer cell invasion. In addition, the encoded protein can be
            secreted and be involved in resistance to insulin. [provided by
            RefSeq, Jul 2016].
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1 and 2 both encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163657.115576.1, BC007239.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMEA2148093, SAMN03267771
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000255198.3/ ENSP00000255198.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-39                AC008581.11        102069-102107       c
            40-80               DN998543.1         10-50
            81-1499             BC007239.1         1-1419
            1500-1515           AC008581.11        91513-91528         c
            1516-1529           BF508552.1         17-30               c
            1530-6134           AC008581.11        86894-91498         c
FEATURES             Location/Qualifiers
     source          1..6134
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q13.3"
     gene            1..6134
                     /gene="ZBED3"
                     /note="zinc finger BED-type containing 3"
                     /db_xref="GeneID:84327"
                     /db_xref="HGNC:HGNC:20711"
                     /db_xref="MIM:615250"
     exon            1..175
                     /gene="ZBED3"
                     /inference="alignment:Splign:2.1.0"
     exon            176..310
                     /gene="ZBED3"
                     /inference="alignment:Splign:2.1.0"
     exon            311..6134
                     /gene="ZBED3"
                     /inference="alignment:Splign:2.1.0"
     CDS             328..1032
                     /gene="ZBED3"
                     /note="2610005H11Rik; zinc finger, BED domain containing
                     3; axin-interacting protein"
                     /codon_start=1
                     /product="zinc finger BED domain-containing protein 3"
                     /protein_id="NP_115743.1"
                     /db_xref="CCDS:CCDS4036.1"
                     /db_xref="GeneID:84327"
                     /db_xref="HGNC:HGNC:20711"
                     /db_xref="MIM:615250"
                     /translation="MRSGEPACTMDQARGLDDAAARGGQCPGLGPAPTPTPPGRLGAP
                     YSEAWGYFHLAPGRPGHPSGHWATCRLCGEQVGRGPGFHAGTSALWRHLRSAHRRELE
                     SSGAGSSPPAAPCPPPPGPAAAPEGDWARLLEQMGALAVRGSRRERELERRELAVEQG
                     ERALERRRRALQEEERAAAQARRELQAEREALQARLRDVSRREGALGWAPAAPPPLKD
                     DPEGDRDGCVITKVLL"
     regulatory      4508..4513
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZBED3"
                     /note="hexamer: AATAAA"
     polyA_site      4528
                     /gene="ZBED3"
                     /note="major polyA site"
     regulatory      4548..4553
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZBED3"
                     /note="hexamer: AATAAA"
     polyA_site      4567
                     /gene="ZBED3"
                     /note="major polyA site"
     regulatory      4737..4742
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZBED3"
                     /note="hexamer: AATATA"
     polyA_site      4742
                     /gene="ZBED3"
     polyA_site      4762
                     /gene="ZBED3"
     regulatory      5876..5881
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZBED3"
                     /note="hexamer: AATAAA"
     polyA_site      5894
                     /gene="ZBED3"
     regulatory      6108..6113
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZBED3"
                     /note="hexamer: ATTAAA"
     polyA_site      6134
                     /gene="ZBED3"
ORIGIN      
        1 acacgtgacg gccccccttt ccccgcagac gtgtgaatgc agcgctgtgt ctttaagggg
       61 cacgcgcgga ggttttccgt ccgggacaaa atgtcagcga ggcgcctgga gggggatcta
      121 ccatctcgga ctcccgaccc gccgccggct ccggccgcgt ttcccgggta aagggcactg
      181 ctgatggttc ttcagaactc aggaatcgtg ttgcatgcat tgtttctacc cacctgagat
      241 ggttggaaac cctgaggcaa tgacagggac cccagaatcc ttgggaaatt acccactgtc
      301 taatttaaag cgtgcgggcg ccgcagaatg aggagtggcg agccggcctg caccatggac
      361 caggcccgcg ggctggacga cgcggcggcg cggggcggtc agtgtccggg actggggccg
      421 gcgccgacgc cgacgcctcc cggccgcctg ggggcgccat actccgaggc ctggggctac
      481 ttccacctgg cgccggggcg ccccgggcat ccgtcgggcc actgggccac ctgccgtctg
      541 tgcggggagc aggtgggccg cggcccgggc ttccacgcgg ggacctcggc gttgtggagg
      601 cacctgagga gcgcgcaccg gcgggagctg gagagcagcg gcgccgggag ctccccacct
      661 gccgcgccct gcccgccgcc gcccggcccc gctgcggccc ccgagggcga ctgggcgcgc
      721 ctgctggaac agatgggcgc gctggccgtg cgcggcagcc ggcgggagcg ggagctggag
      781 cggcgcgagc tggccgtgga gcagggcgag cgcgccctgg agcggaggcg gagggcgctg
      841 caggaggaag agcgcgccgc ggcccaggcg cgccgggaac tgcaggccga gcgggaggcg
      901 ctgcaggcgc ggctgcggga tgtgagccgc cgtgagggcg ccctgggctg ggcccccgct
      961 gcgccgccgc cgctcaagga cgaccccgag ggtgacaggg acggctgcgt catcacaaag
     1021 gtcctcctgt aggggtgtgg ccacttcccc accccaggac agcgcttctc cgtccaatgc
     1081 caatgccttc agaccccgct gggaccgaag ccgtaaccga agccaggccc gcagccgcta
     1141 ctcactcgga agctccagct aactgtagga tcttccacac cctaaggctt cagcttgaga
     1201 agcacttcga agccagagca gaaccaaaac tcacttccat ggggtcaccg ggggtgcctg
     1261 ggcggccttt cgtgggcatg cacgcaagga attggggtgg cacacgggac acccgagagc
     1321 tccaggagcc ccgtgaaccc agaccaccca gtgccatggc cacttagggc tgggaacccg
     1381 aacctggtga ctttgaaagg atagagcttc attccatacc aaagacttat cacaccatgt
     1441 gcctatacac ccagcagccc aaggtggagg gtgcgtggaa atgagaaagc tttttaccca
     1501 aaaaaaaaaa aaaaagagtt cctaatgcat aatctgccca acaccaagtt ctgaagggtg
     1561 ggtgagggac gtcccctcta gtttccatga ctgctgtaga cccgcatcat ctctagccct
     1621 catcggggca gtcccagagc ccgctttttt actgcccata ttattcaacc aataccaggt
     1681 gcactctgtc tcccctcggc catccttccc ttgcttcaga cctaatgaca agtgtggcac
     1741 atatgtccac tttcaggcct cacatctgcc accttagcaa gacatcacct catccccttg
     1801 tcactaggaa gagggcttct tccccacatg tcgtcatagt gctcacctct gggctgaagg
     1861 ggaaagcatc cctccgctta aggccacatc tacctgtcat tttccatccc attcctctcc
     1921 cacgtttact gggtctttcc tcctgtagta ttcccccttt cgctgtctca gtccctccct
     1981 ttcccccagg ctcttcttcc tcagcaatgt gcagtctccc tttcttactg aaaagaaaga
     2041 cttaacccag aagggccaac aagtcctggc tgcctatcct tcctccccag tttttactcc
     2101 ctcactctgg gtcagttttc ttttcttttt ttctttatgt gtgtatatat tatatatata
     2161 tatacatata tacatatata tatacatata tacatatata tatacatata tacatatata
     2221 tatacatata tacatataca tatatatata tatatatata tgtatatata atactttaag
     2281 ttctagggtg catgtcagtt ttctatgctt caccagacta tttccaagct gccacaatct
     2341 cccagtgacc aaatatgatg atctatttgc agccttcatt ttgcttaatc tctcccttga
     2401 aattgctctc ttggtaggtg gatcctgttt ttccttcaaa gaattccttt tcctgttgca
     2461 tactggttcc cagtttttcc ataggcctct tttttttctt atttttttat attgaaaaat
     2521 tccacacatc cagaaaaagt tgaaaggcta gcacaatgaa tactcagata catactctcc
     2581 acttggattg aatagttgtt aacattttgc cagatttact attctctcca ccccatgcat
     2641 gtgtacatag aatgacattt cgacccctga gtattaccac atagatttcc tgagcacaaa
     2701 gacaccgttc tacatgatta cattaagatg atcatgccta aaaatataaa cagtaacttc
     2761 tttatagcct ctaatacaga gcccttaatc agtattcaac aattgtctcc agaatgtttg
     2821 tctttaaaaa caacgacaac aaccaggtcc catcaaggtt catacattct tttggtttca
     2881 actctagtca ctttcagtct acaacaaccc caacatattt tcccatgata ctttttgaag
     2941 catccaggcc agctgtctta gcaaatgtcc tctattctgg aagtgtctga ttgcttcctt
     3001 aggcctatgt ctacactcca ctcgtggctc atatccctgc agagttgtaa tctcctctgg
     3061 gccagggact cctgaatatc tccaggccga gtgttctccc cgggcctgga gaaaaccttc
     3121 atgcccaatc ccttgctgca tgtctccacc cctccttgca catcctgcct ctatgagtgg
     3181 acgaggcaaa tctactcaac cccacatccc acccctcacc tgataactaa catttactgg
     3241 gcactaacaa tgtatcaggc acatactaca cacttaacat gcattgcttt cacataccag
     3301 ctccatggta acattgcgct ggctttacag ctaaagaaac tgagctagaa aggggttaag
     3361 tatcctgtac aagatcacag ctggccagca atagaggtgg gatcccactg cagacagtct
     3421 cccccacaga tgccatgctc ccactgtacc accatgtact gcttcctgag atctctgctt
     3481 ccttcagtcg acccagctga cacctgtttc cttcctaact ccaactaatt aattccagtt
     3541 aatggaattg actggaatta gtgacattaa tatttactga gcattcccca tgtgtcatca
     3601 gagctgtgct aaatgcttta caagaataat tacctgccat aaagcaaccc tatgacatag
     3661 gtgctactat gcccattttg tagatgagac aggttcaggg gagttagtat caccttcaag
     3721 tcatacagtg gctaagaatc tgtggtctcg ctgaatgctg ggcgcctgct ctgctaagtc
     3781 tatttctaca aaacattgca ctgccttcct gttgcctgcc aagctcaggg cccatttatc
     3841 atgcatcttc ccatccttgt ctcccccaac tgtcccttac ctgagtcaca atttcgccaa
     3901 agccaaaggg attgtcctaa gccaatgttg atttatcact cttcctgctc aaaagccccc
     3961 aagatcacct atcaatcacc tacttgagtg caagctttga ctctgtcacc tgacattcaa
     4021 gtccccctct gcccccatgc cagtcttatc ccctccccta catatgccct atcctgcagc
     4081 caaattggac tctgttcttc ctgacaagac ctggtattgg catctctatg cctcagtttg
     4141 ccttccctcc actttaaaaa gcctcttcag tctcgataca aaaaacatcc cacacatgtt
     4201 ctaaaaccat gctttccttg atttctcctc atgtcaagac atttcttact tctctagtct
     4261 cctagcattt tgtgcctcac aaccctcagg acaggccagc tagtgtatgg ctgtgggttt
     4321 ttatctcacc tcccctgcct gaccctgagc ccttgtgggg agtatactca ccctactcct
     4381 acagtgcctt gcattccgta gctgctcagt acattaaccc attcaatgtc tttaagattt
     4441 ttacaagtta gttttcctgt aattactaat catttatctt taattctgag taaaattcac
     4501 aacaacaaat aaaaggaaat agtagtaatt ttttaagctg tttagtcaat aaagatttaa
     4561 tgcgtcagtt attggactgt ttggtttgaa gccaatcaac cattctggta tgtaaatcta
     4621 cttttttatt atacaagtaa cacaaaatgt attgcctcag tcaaggaaga agaacagaaa
     4681 aaaacaacac cccaaaatcc tgtcacctct gtaaaactgc tattaattaa cattttaata
     4741 tattttcttt tgtcttttgc aatttttata ttactctaag ttattttcaa gtattggaac
     4801 ttaacttctt catatggatt tataaattgg gctagatgat ctgaatttcc tttttagaag
     4861 gaaaaaaaaa gacttccaca aatgttactc ttctatctca ccaattgtaa gaaccattaa
     4921 aacataggaa aggatttaga atcttaacta ctccctcaaa gatggctagt gcgagcctga
     4981 atgtcctgtt caggagacag agaacaatta acctgagtgc tgagttaagg gaagaggttt
     5041 ttactttctg ctttatacac ttctgcattg ttgtaatttt ttacacaaag tatgaattac
     5101 ttttatgata aaaaaatttt gtttgtagac aacattcctc tccttcagca ttcagcatcc
     5161 ttagttaaaa taaaatctcc aacgaaagca tggatataat ccccatttcc agaaaatccc
     5221 agaaagaaat gcagcccttg ttcagtccaa ctccatcatt tgatagatta ggaaaatagg
     5281 ttctagagag tgacttgtcc actgtcagga gatggtgact gtggcgcgtc atctgactcc
     5341 agcctactta atgcatttca gtctctttgg ccttaagggc tcctgctgct cacctgaaat
     5401 cattcccaag gaacccacaa gagcaggttc cctgggagga ttcctgagaa cacctacaca
     5461 caagcctcag agatctgcca agacattctc tttctgataa atactattaa atatttttct
     5521 atcaaatagt tgccaaatga cctgctccag tcaaaactca atctgacttg tgactacaaa
     5581 gtaatctgag gaatcccaaa ggtatataaa aatctatcca tctaagtcat ctctcttcaa
     5641 agtagaagac ctggaagact atacagttat tcccaaaatg cttcaacatt tctggaactc
     5701 ctcttttaga gtggccatga gtccctagca cattctttaa aacatccttg agttggcaaa
     5761 tactcctctt tccaggataa atttgatttt ttaaaagaac tgccaattat tcagtctggt
     5821 gaatatggta gatgattaac cagattaaca tttctggtta ataaggtgag attataataa
     5881 aacaatgata attattttag tgtggctcat aaattggtct tgatagtggt atattaaggt
     5941 taagtaaagg cagcatggtc accatacaga ttaaagccca ttttagttgg tttatgatgt
     6001 gaatgaattc aggtagcact gggagtcatt atatgtttaa atagtattaa aggtttcttt
     6061 ttataaaaat cttaattatg acattctctg aaatctggtt tcacagtatt aaaatgaggc
     6121 tttaaggaaa aaca
//
