LOCUS       NM_024508               2214 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens zinc finger BED-type containing 2 (ZBED2), mRNA.
ACCESSION   NM_024508
VERSION     NM_024508.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2214)
  AUTHORS   Somerville,T.D.D., Xu,Y., Wu,X.S., Maia-Silva,D., Hur,S.K., de
            Almeida,L.M.N., Preall,J.B., Koo,P.K. and Vakoc,C.R.
  TITLE     ZBED2 is an antagonist of interferon regulatory factor 1 and
            modifies cell identity in pancreatic cancer
  JOURNAL   Proc Natl Acad Sci U S A 117 (21), 11471-11482 (2020)
   PUBMED   32385160
  REMARK    GeneRIF: ZBED2 is an antagonist of interferon regulatory factor 1
            and modifies cell identity in pancreatic cancer.
REFERENCE   2  (bases 1 to 2214)
  AUTHORS   Finnegan,A., Cho,R.J., Luu,A., Harirchian,P., Lee,J., Cheng,J.B.
            and Song,J.S.
  TITLE     Single-Cell Transcriptomics Reveals Spatial and Temporal Turnover
            of Keratinocyte Differentiation Regulators
  JOURNAL   Front Genet 10, 775 (2019)
   PUBMED   31552090
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2214)
  AUTHORS   Hayward,A., Ghazal,A., Andersson,G., Andersson,L. and Jern,P.
  TITLE     ZBED evolution: repeated utilization of DNA transposons as
            regulators of diverse host functions
  JOURNAL   PLoS One 8 (3), e59940 (2013)
   PUBMED   23533661
REFERENCE   4  (bases 1 to 2214)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   5  (bases 1 to 2214)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC055748.21, CV575511.1 and BC071956.1.
            
            On Nov 23, 2018 this sequence version replaced NM_024508.4.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DRR138511.44208.1,
                                           SRR1163658.175946.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000317012.5/ ENSP00000321370.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                AC055748.21        142713-142723
            12-106              CV575511.1         1-95
            107-546             AC055748.21        143052-143491
            547-2214            BC071956.1         1-1668
FEATURES             Location/Qualifiers
     source          1..2214
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q13.13"
     gene            1..2214
                     /gene="ZBED2"
                     /note="zinc finger BED-type containing 2"
                     /db_xref="GeneID:79413"
                     /db_xref="HGNC:HGNC:20710"
                     /db_xref="MIM:615246"
     exon            1..47
                     /gene="ZBED2"
                     /inference="alignment:Splign:2.1.0"
     exon            48..2214
                     /gene="ZBED2"
                     /inference="alignment:Splign:2.1.0"
     CDS             913..1569
                     /gene="ZBED2"
                     /note="zinc finger, BED domain containing 2"
                     /codon_start=1
                     /product="zinc finger BED domain-containing protein 2"
                     /protein_id="NP_078784.2"
                     /db_xref="CCDS:CCDS2960.2"
                     /db_xref="GeneID:79413"
                     /db_xref="HGNC:HGNC:20710"
                     /db_xref="MIM:615246"
                     /translation="MMRREDEEEEGTMMKAKGDLEMKEEEEISETGELVGPFVSAMPT
                     PMPHNKGTRFSEAWEYFHLAPARAGHHPNQYATCRLCGRQVSRGPGVNVGTTALWKHL
                     KSMHREELEKSGHGQAGQRQDPRPHGPQLPTGIEGNWGRLLEQVGTMALWASQREKEV
                     LRRERAVEWRERAVEKRERALEEVERAILEMKWKVRAEKEACQREKELPAAVHPFHFV
                     "
     regulatory      2194..2199
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZBED2"
                     /note="hexamer: ATTAAA"
     polyA_site      2214
                     /gene="ZBED2"
                     /note="major polyA site"
ORIGIN      
        1 actctgcgca ggaaagatca gagagaagtc cagagccttg cctgcttgtg atcctggtgg
       61 agaaggtgga gtatggtgag ctgcttgcta aggacagcca ggcaacgctg tgtttgtgaa
      121 gatgtgctcc accttctcct ctgtgcatcc cagctcctcc tgctgaaaca gctgagcttg
      181 ctttttggat ttcttagact cctggcctct gagagacacc tctaaggaca aactgacctt
      241 gcattgggaa ctttattatc cagatcctca taggctttgt ctactctgga ttgcttgttg
      301 caacagttct taggaagcaa gattgtctcc tgcaccagca tctgcctgtg tttgctttta
      361 cctactttga gcaagaccca gtgaggccct agctctgttg gtcctgaaaa gcctgaaccc
      421 tgaggctgtt tctcctgcct ccaaaatgca attataggaa ataagaagca cagaaacagt
      481 ggaaacaacc aggaggagaa acaagaaaac ctaaaatttt caatattcaa aaatacctgt
      541 cgtggtggtt gatgcagaaa acactgagtt catcaaagag ctttgtaatt gttggaccag
      601 agaacccctt tgctacagga actgatatgt tttgtctttc tggcctagtc aagggaggat
      661 aagtaagtat ctggggcatg gaaggaatgc actcttgggc tgttttgctt gtatctgact
      721 cacccctgac tctccagtga agcagaaagg aagaaacctc acaccaccca ggtgtggcca
      781 gactttggcc attattgtga atccccaaga gttaccacag gcccttccca aatatatatt
      841 taatcttgtg gttcaaataa gcttttggct cacatctaag cacatcataa agaacgctgt
      901 agaagaggtg acatgatgag gcgggaagac gaggaagagg agggaacaat gatgaaggca
      961 aaaggggact tagagatgaa ggaggaggaa gagattagtg agacaggaga actggttggc
     1021 ccttttgtga gtgctatgcc cactccaatg ccccacaaca agggcacccg gttctctgag
     1081 gcatgggaat atttccacct agctcctgct cgtgctgggc accatcccaa ccagtatgcc
     1141 acctgccgcc tgtgtggcag gcaggtgagc cgtggccctg gggtcaacgt gggcaccact
     1201 gcactgtgga agcatctgaa aagcatgcac agagaggagc tggagaagag tggccatggt
     1261 caggctgggc agcgccagga tccaaggccc cacgggcccc agctccccac aggcattgag
     1321 ggtaactggg gtaggctcct ggagcaggtg ggcaccatgg ctttgtgggc cagccaaagg
     1381 gaaaaggagg tgcttaggag ggaaagggca gtggaatggc gggagagggc tgtggaaaaa
     1441 agggagcgag ccctggagga ggtggaaagg gccatcctgg agatgaagtg gaaggtgagg
     1501 gctgagaagg aggcatgcca gcgggagaaa gagctgcctg cagcagtaca tcccttccat
     1561 tttgtttaaa ttgggcttgg agaatctatt ctgaaaacat tgactctaga cttgtagaaa
     1621 agagccattt tagtttcaac tcaaatgtaa agcaaagtag tttggtgaca ttttgctttt
     1681 atgtgaaata gtgcacagta tgagttaatc tgagcaggtc tgaattgacc aaatgcttat
     1741 ctacgaggtt cctagagctc tgctgaccct tggccgaaac tctaaaatgt acctattaaa
     1801 gataaatgct tctaccaaag taaaactctg tgagttgttt cagggcagaa tgtaccagcc
     1861 agtcagcgtt gtttaacaaa ataatcagat ttttgcctag cactcggttt tggtggagct
     1921 gacgattttg agggctgagg ctggttaggt agctggaatg tgcctatgtg accagctcac
     1981 ttgcagacac cctgccggaa gcagagctta atcttcctag gactgaggtc ttagcacatg
     2041 tactggtgga gtttccagac caccagtatg aataaaagct tgttctgtgt gacccagcaa
     2101 gtggaaggac aaagaactgt gagcctcaga tctttggacc tttccaatgc gtctctttct
     2161 cctgttattg ctgcaatgta ttttcttgct tatattaaag ttgtttcatc agta
//
