LOCUS       NM_001199201            3807 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens zinc finger B-box domain containing (ZBBX), transcript
            variant 1, mRNA.
ACCESSION   NM_001199201
VERSION     NM_001199201.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3807)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
REFERENCE   2  (bases 1 to 3807)
  AUTHORS   Kimura,K., Wakamatsu,A., Suzuki,Y., Ota,T., Nishikawa,T.,
            Yamashita,R., Yamamoto,J., Sekine,M., Tsuritani,K., Wakaguri,H.,
            Ishii,S., Sugiyama,T., Saito,K., Isono,Y., Irie,R., Kushida,N.,
            Yoneyama,T., Otsuka,R., Kanda,K., Yokoi,T., Kondo,H., Wagatsuma,M.,
            Murakawa,K., Ishida,S., Ishibashi,T., Takahashi-Fujii,A.,
            Tanase,T., Nagai,K., Kikuchi,H., Nakai,K., Isogai,T. and Sugano,S.
  TITLE     Diversification of transcriptional modulation: large-scale
            identification and characterization of putative alternative
            promoters of human genes
  JOURNAL   Genome Res 16 (1), 55-65 (2006)
   PUBMED   16344560
REFERENCE   3  (bases 1 to 3807)
  AUTHORS   Ota,T., Suzuki,Y., Nishikawa,T., Otsuki,T., Sugiyama,T., Irie,R.,
            Wakamatsu,A., Hayashi,K., Sato,H., Nagai,K., Kimura,K., Makita,H.,
            Sekine,M., Obayashi,M., Nishi,T., Shibahara,T., Tanaka,T.,
            Ishii,S., Yamamoto,J., Saito,K., Kawai,Y., Isono,Y., Nakamura,Y.,
            Nagahari,K., Murakami,K., Yasuda,T., Iwayanagi,T., Wagatsuma,M.,
            Shiratori,A., Sudo,H., Hosoiri,T., Kaku,Y., Kodaira,H., Kondo,H.,
            Sugawara,M., Takahashi,M., Kanda,K., Yokoi,T., Furuya,T.,
            Kikkawa,E., Omura,Y., Abe,K., Kamihara,K., Katsuta,N., Sato,K.,
            Tanikawa,M., Yamazaki,M., Ninomiya,K., Ishibashi,T., Yamashita,H.,
            Murakawa,K., Fujimori,K., Tanai,H., Kimata,M., Watanabe,M.,
            Hiraoka,S., Chiba,Y., Ishida,S., Ono,Y., Takiguchi,S., Watanabe,S.,
            Yosida,M., Hotuta,T., Kusano,J., Kanehori,K., Takahashi-Fujii,A.,
            Hara,H., Tanase,T.O., Nomura,Y., Togiya,S., Komai,F., Hara,R.,
            Takeuchi,K., Arita,M., Imose,N., Musashino,K., Yuuki,H., Oshima,A.,
            Sasaki,N., Aotsuka,S., Yoshikawa,Y., Matsunawa,H., Ichihara,T.,
            Shiohata,N., Sano,S., Moriya,S., Momiyama,H., Satoh,N., Takami,S.,
            Terashima,Y., Suzuki,O., Nakagawa,S., Senoh,A., Mizoguchi,H.,
            Goto,Y., Shimizu,F., Wakebe,H., Hishigaki,H., Watanabe,T.,
            Sugiyama,A., Takemoto,M., Kawakami,B., Yamazaki,M., Watanabe,K.,
            Kumagai,A., Itakura,S., Fukuzumi,Y., Fujimori,Y., Komiyama,M.,
            Tashiro,H., Tanigami,A., Fujiwara,T., Ono,T., Yamada,K., Fujii,Y.,
            Ozaki,K., Hirao,M., Ohmori,Y., Kawabata,A., Hikiji,T., Kobatake,N.,
            Inagaki,H., Ikema,Y., Okamoto,S., Okitani,R., Kawakami,T.,
            Noguchi,S., Itoh,T., Shigeta,K., Senba,T., Matsumura,K.,
            Nakajima,Y., Mizuno,T., Morinaga,M., Sasaki,M., Togashi,T.,
            Oyama,M., Hata,H., Watanabe,M., Komatsu,T., Mizushima-Sugano,J.,
            Satoh,T., Shirai,Y., Takahashi,Y., Nakagawa,K., Okumura,K.,
            Nagase,T., Nomura,N., Kikuchi,H., Masuho,Y., Yamashita,R.,
            Nakai,K., Yada,T., Nakamura,Y., Ohara,O., Isogai,T. and Sugano,S.
  TITLE     Complete sequencing and characterization of 21,243 full-length
            human cDNAs
  JOURNAL   Nat Genet 36 (1), 40-45 (2004)
   PUBMED   14702039
REFERENCE   4  (bases 1 to 3807)
  AUTHORS   Bonaldo,M.F., Lennon,G. and Soares,M.B.
  TITLE     Normalization and subtraction: two approaches to facilitate gene
            discovery
  JOURNAL   Genome Res 6 (9), 791-806 (1996)
   PUBMED   8889548
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB078376.1, BC144444.1, AC107311.8, DA590037.1, BC034229.1,
            CB321707.1 and AC117463.5.
            
            On Jan 17, 2020 this sequence version replaced NM_001199201.1.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038192.329624.1,
                                           SRR14038194.936515.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968189,
                                           SAMEA1968540 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000675490.1/ ENSP00000502603.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-53                DB078376.1         1-53
            54-735              BC144444.1         1-682
            736-769             AC107311.8         117821-117854
            770-1228            DA590037.1         117-575
            1229-1868           BC144444.1         1176-1815
            1869-2216           BC034229.1         1816-2163
            2217-2360           BC144444.1         2164-2307
            2361-3018           BC034229.1         2191-2848
            3019-3363           CB321707.1         9-353               c
            3364-3807           AC117463.5         30614-31057         c
FEATURES             Location/Qualifiers
     source          1..3807
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q26.1"
     gene            1..3807
                     /gene="ZBBX"
                     /note="zinc finger B-box domain containing"
                     /db_xref="GeneID:79740"
                     /db_xref="HGNC:HGNC:26245"
     exon            1..51
                     /gene="ZBBX"
                     /inference="alignment:Splign:2.1.0"
     exon            52..206
                     /gene="ZBBX"
                     /inference="alignment:Splign:2.1.0"
     exon            207..288
                     /gene="ZBBX"
                     /inference="alignment:Splign:2.1.0"
     exon            289..405
                     /gene="ZBBX"
                     /inference="alignment:Splign:2.1.0"
     CDS             338..2857
                     /gene="ZBBX"
                     /note="isoform 1 is encoded by transcript variant 1; zinc
                     finger B-box domain-containing protein 1"
                     /codon_start=1
                     /product="zinc finger B-box domain-containing protein 1
                     isoform 1"
                     /protein_id="NP_001186130.1"
                     /db_xref="CCDS:CCDS56296.1"
                     /db_xref="GeneID:79740"
                     /db_xref="HGNC:HGNC:26245"
                     /translation="MNRKDFVVLPWGKPGNSVKLKYRNAQELRMEKVQLEFENQEMEK
                     KLQEFRSTRNKEKEDRESSEYYWKSGKVGKLVNQSYMMSQNKGNVVKFSAGKVKLKLL
                     KEQIQEPVKPTVNYKMANSSECEKPKINGKVCGQCENKAALLVCLECGEDYCSGCFAK
                     VHQKGALKLHRTTLLQAKSQILFNVLDVAHQFIKDVNPDEPKEENNSTKETSKIQHKP
                     KSVLLQRSSSEVEITTMKRAQRTKPRKSLLCEGSFDEEASAQSFQEVLSQWRTGNHDD
                     NKKQNLHAAVKDSLEECEVQTNLKIWREPLNIELKEDILSYMEKLWLKKHRRTPQEQL
                     FKMLPDTFPHPHETTGDAQCSQNENDEDSDGEETKVQHTALLLPVETLNIERPEPSLK
                     IVELDDTYEEEFEEAENIVPYKVKLADADSQRSCAFHDCQKNSFPYENGIHQHHVFDK
                     GKRDFLNLCLRNSSTYYKDNSKAETSNTDFDNIVDPDVYSSDIEKIEESTSFERNLKE
                     KNIGLESNQKSDDSCVSLESKDTLLGRDLEKAPIEEKLSQDIKESLELSNLYKRPSFE
                     ESKTTKSSLLLQEIACRSKPITKQYQGLERFFIFDTNERLNLLPSHRLECNNSSTRIT
                     LAEDREWIPDHSLSEYADNAIVLGVLQGAQSPSSSRKQQKMGQKSQRPSTANFPLSNS
                     VKESSSCLSSSHPRSRSAAAQSSSRAASEISEIEYIDITDQNELSLDDTTDQHTLDNL
                     EKELQVLRSLADTSEKLYSLTSEEFPDFSSQSLNISQISTDFLKTSHVRGPCGVEELS
                     CSGRDTKIQSLLSLSESSTDEEEEDFLNKQHVITLPWSKST"
     exon            406..519
                     /gene="ZBBX"
                     /inference="alignment:Splign:2.1.0"
     exon            520..610
                     /gene="ZBBX"
                     /inference="alignment:Splign:2.1.0"
     exon            611..659
                     /gene="ZBBX"
                     /inference="alignment:Splign:2.1.0"
     exon            660..769
                     /gene="ZBBX"
                     /inference="alignment:Splign:2.1.0"
     exon            770..865
                     /gene="ZBBX"
                     /inference="alignment:Splign:2.1.0"
     exon            866..1024
                     /gene="ZBBX"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1199
                     /gene="ZBBX"
                     /inference="alignment:Splign:2.1.0"
     exon            1200..1320
                     /gene="ZBBX"
                     /inference="alignment:Splign:2.1.0"
     exon            1321..1430
                     /gene="ZBBX"
                     /inference="alignment:Splign:2.1.0"
     exon            1431..1531
                     /gene="ZBBX"
                     /inference="alignment:Splign:2.1.0"
     exon            1532..1611
                     /gene="ZBBX"
                     /inference="alignment:Splign:2.1.0"
     exon            1612..1754
                     /gene="ZBBX"
                     /inference="alignment:Splign:2.1.0"
     exon            1755..2062
                     /gene="ZBBX"
                     /inference="alignment:Splign:2.1.0"
     exon            2063..2216
                     /gene="ZBBX"
                     /inference="alignment:Splign:2.1.0"
     exon            2217..2333
                     /gene="ZBBX"
                     /inference="alignment:Splign:2.1.0"
     exon            2334..2591
                     /gene="ZBBX"
                     /inference="alignment:Splign:2.1.0"
     exon            2592..2730
                     /gene="ZBBX"
                     /inference="alignment:Splign:2.1.0"
     exon            2731..3807
                     /gene="ZBBX"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2994..2999
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZBBX"
                     /note="hexamer: AATAAA"
     regulatory      3000..3005
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZBBX"
                     /note="hexamer: AGTAAA"
     polyA_site      3015
                     /gene="ZBBX"
                     /note="major polyA site"
     polyA_site      3018
                     /gene="ZBBX"
                     /note="major polyA site"
     regulatory      3782..3787
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZBBX"
                     /note="hexamer: ATTAAA"
     polyA_site      3807
                     /gene="ZBBX"
                     /note="major polyA site"
ORIGIN      
        1 agctatccgc ggccatccgg cggtggtgac gcgagaggct ggggtctcca gcctttagtc
       61 tgcctgcgcg ttcacatgca cccacttact tcttgaagtc tactcctcac aagtaagggc
      121 tatggtgcgg ggtgcccgat tcctgagaaa tctgaagatg tggaagttta ttttttcttc
      181 ccaaaatcag cagtagaggg actcaggacc aactcctctt catcttcgtc ttcctcagcc
      241 tgctcaatgt gaagcccctg atcatgattc acttccactt aataaataaa gtgtttacaa
      301 atcagaataa cttttagaca atattaaggt ggtaatcatg aacagaaaag attttgtagt
      361 tcttccatgg ggaaaacctg gaaattctgt aaagctaaaa tatagaaatg ctcaagaact
      421 gcgaatggag aaagtacagt tagagtttga gaaccaagag atggagaaga aactgcaaga
      481 attccgatcc acaagaaaca aagaaaagga agatagagag tcaagcgagt attactggaa
      541 atctggaaaa gtgggcaaat tggtcaatca atcatatatg atgtcacaaa ataaaggaaa
      601 tgttgttaag ttttctgctg gaaaagtgaa attaaaattg ctgaaggaac agattcaaga
      661 gccagtgaaa ccaacagtta attataaaat ggcaaattct tcagaatgtg aaaaacccaa
      721 gataaatggg aaagtatgtg gacagtgtga gaacaaagct gctctactgg tatgccttga
      781 atgtggagaa gattattgtt caggatgctt tgctaaagtt caccagaaag gggcactaaa
      841 gctccacaga acaactcttt tgcaggcaaa atctcaaata ttattcaatg tattggatgt
      901 tgcccatcag tttataaagg atgttaatcc agatgaaccc aaagaggaga ataattctac
      961 aaaggaaacc agtaaaattc aacataaacc caaatctgta cttctccaga ggagcagctc
     1021 tgaggtagaa attacaacga tgaaaagagc acaacgtaca aaaccaagaa agagtctgtt
     1081 gtgtgaaggg tcattcgatg aagaagcttc tgcacagtcc tttcaggaag tgttaagtca
     1141 atggagaacc ggaaatcatg atgacaacaa gaaacagaat ttacatgcag cagtaaaaga
     1201 ctcattggaa gaatgcgaag tacagactaa tctgaaaatt tggagagaac cacttaatat
     1261 tgaacttaaa gaagacattc tatcctatat ggaaaaatta tggcttaaaa aacacaggag
     1321 aactccacaa gagcaacttt ttaaaatgct accagatacg ttcccacatc cacatgaaac
     1381 cactggtgat gcacagtgtt ctcaaaatga aaacgatgaa gatagtgatg gtgaggagac
     1441 caaagtacaa cacacagctc ttttattgcc agtagaaaca ttaaacatag agagacctga
     1501 accatctcta aagatagtcg aactggatga tacttatgaa gaggaatttg aagaagcaga
     1561 aaatattgtg ccttacaaag ttaaattagc tgatgcagac agtcaacgaa gttgtgcttt
     1621 tcatgattgt cagaagaata gctttccata tgaaaatggc atccatcaac atcatgtttt
     1681 cgataaggga aagagagact tcttaaatct ttgtctgaga aacagctcta cttattataa
     1741 agataattca aaagcagaaa cttcaaacac agattttgac aacatcgtgg atcctgatgt
     1801 gtattcttct gacattgaaa aaattgagga aagcacctcc tttgaaagaa atttaaagga
     1861 gaaaaatata ggtttagaaa gtaatcaaaa gtctgatgat tcctgtgtat cacttgaaag
     1921 caaggacact ttgctaggta gagatttaga aaaagctccc attgaggaga aattatctca
     1981 agacatcaaa gaatccttgg aattgagcaa tctgtataag aggccaagct ttgaagaatc
     2041 aaaaactaca aagtcatcac tgttgttaca agaaatagcc tgcagaagta agcctataac
     2101 aaaacaatat caaggacttg agagattctt tatttttgat acaaatgaaa gactcaactt
     2161 acttccttct catcgtttag aatgcaacaa ttccagtact aggattacac ttgcagaaga
     2221 cagagaatgg attccagacc atagcttaag tgaatatgct gataatgcaa ttgtcttggg
     2281 tgttctgcag ggtgctcaga gtccatcatc aagtagaaaa cagcaaaaga tgggtcagaa
     2341 atcacagaga ccttcaacag caaattttcc actttccaac tctgttaaag aaagctccag
     2401 ttgcctttca tcctctcatc ctcgatcaag aagtgcagct gctcaatcat catctagagc
     2461 tgcttctgaa atttcagaaa ttgaatatat tgatattact gaccagaatg agctttcctt
     2521 agatgacact actgatcaac atactttaga caatttggaa aaagaattac aagtgctgag
     2581 atctcttgca gatacttcag aaaagcttta cagcttaacc tcagaagagt tcccagattt
     2641 cagcagccaa tcactgaata taagtcagat ttccacagat ttccttaaga cctcacatgt
     2701 gaggggtccc tgtggagttg aggaattgag ctgttctgga agagatacca aaattcagtc
     2761 tttgctgtca ctttctgaga gcagtacaga tgaggaggag gaagattttc tcaacaagca
     2821 acatgtcatc acactaccgt ggtcaaagag tacttaaaga ttatttgttc attactgttt
     2881 ccattttgta cccagagtaa agcaaacaac tgagaaaagt aaccaagtga ttacctatcc
     2941 aagtgctgga gattttgatt actaatgtct ttgatgtttc aaggctacaa actaataaaa
     3001 gtaaaattat aagttcaagg gcttattctt ccaatgatat attatatgtc aaccactaat
     3061 ctatattgca gattatgtta gtaaaatatg gtgaatttga agaaataact gttacaactg
     3121 tgtctataaa acctactata gggcagaaca tgattatact taaagaaata tttcatcgtc
     3181 caattatatt ttaaataatt atgtcatcaa caagagtgtg catttgacag ccaagtcaca
     3241 ctagttagta tcatcaattg aacctataat tacactgttt attttctggt ttttaacatt
     3301 tatagaagtt ctggtatctt caaaaatttg caataaaaga aaaaaagagg accaaaaata
     3361 aaatgggtgt gaaacttttc atactctgct ctagcaaaac acagtaaaga cctctaagca
     3421 tcttttttta agaaggtcaa tgtagtgatt agctttatgt gaaaatgtga ctggtctaca
     3481 atacccaaat gatatgggtt ggctctgtcc ccacccagat ctcatcttga attgtagttt
     3541 ctataatctc caggtgtcct gggagggacc tggtgggaag taattgaatc atgggggcag
     3601 ttacccctat gctgctgttc tcgtgataat gagttctcat gtgatctgat ggttttataa
     3661 ggggctgtcc ccccttttgc tcaggacttc tctttgctgc tccacttgaa gaagaatgtg
     3721 tttgcttccc ctttcaccat gatttcctga ggcctccccc accatgctga actgtgagtc
     3781 aattaaacct ctgtccttta taaatta
//
