LOCUS       NM_001136571            1584 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens zygote arrest 1 like (ZAR1L), mRNA.
ACCESSION   NM_001136571 XM_001717120 XM_929755 XM_941036
VERSION     NM_001136571.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1584)
  AUTHORS   Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
            Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   2  (bases 1 to 1584)
  AUTHORS   Misra,S., Sharma,S., Agarwal,A., Khedkar,S.V., Tripathi,M.K.,
            Mittal,M.K. and Chaudhuri,G.
  TITLE     Cell cycle-dependent regulation of the bi-directional overlapping
            promoter of human BRCA2/ZAR2 genes in breast cancer cells
  JOURNAL   Mol Cancer 9, 50 (2010)
   PUBMED   20202217
  REMARK    GeneRIF: BRCA2 gene promoter has bi-directional activity,
            expressing BRCA2 and a novel C4-type zinc finger containing
            transcription factor ZAR2.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1584)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   4  (bases 1 to 1584)
  AUTHORS   Sangiorgio,L., Strumbo,B., Brevini,T.A., Ronchi,S. and Simonic,T.
  TITLE     A putative protein structurally related to zygote arrest 1 (Zar1),
            Zar1-like, is encoded by a novel gene conserved in the vertebrate
            lineage
  JOURNAL   Comp Biochem Physiol B Biochem Mol Biol 150 (2), 233-239 (2008)
   PUBMED   18442940
REFERENCE   5  (bases 1 to 1584)
  AUTHORS   Dunham,A., Matthews,L.H., Burton,J., Ashurst,J.L., Howe,K.L.,
            Ashcroft,K.J., Beare,D.M., Burford,D.C., Hunt,S.E.,
            Griffiths-Jones,S., Jones,M.C., Keenan,S.J., Oliver,K., Scott,C.E.,
            Ainscough,R., Almeida,J.P., Ambrose,K.D., Andrews,D.T.,
            Ashwell,R.I., Babbage,A.K., Bagguley,C.L., Bailey,J., Bannerjee,R.,
            Barlow,K.F., Bates,K., Beasley,H., Bird,C.P., Bray-Allen,S.,
            Brown,A.J., Brown,J.Y., Burrill,W., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M.E., Clark,S.Y., Clarke,G., Clee,C.M.,
            Clegg,S.C., Cobley,V., Collins,J.E., Corby,N., Coville,G.J.,
            Deloukas,P., Dhami,P., Dunham,I., Dunn,M., Earthrowl,M.E.,
            Ellington,A.G., Faulkner,L., Frankish,A.G., Frankland,J.,
            French,L., Garner,P., Garnett,J., Gilbert,J.G., Gilson,C.J.,
            Ghori,J., Grafham,D.V., Gribble,S.M., Griffiths,C., Hall,R.E.,
            Hammond,S., Harley,J.L., Hart,E.A., Heath,P.D., Howden,P.J.,
            Huckle,E.J., Hunt,P.J., Hunt,A.R., Johnson,C., Johnson,D., Kay,M.,
            Kimberley,A.M., King,A., Laird,G.K., Langford,C.J., Lawlor,S.,
            Leongamornlert,D.A., Lloyd,D.M., Lloyd,C., Loveland,J.E.,
            Lovell,J., Martin,S., Mashreghi-Mohammadi,M., McLaren,S.J.,
            McMurray,A., Milne,S., Moore,M.J., Nickerson,T., Palmer,S.A.,
            Pearce,A.V., Peck,A.I., Pelan,S., Phillimore,B., Porter,K.M.,
            Rice,C.M., Searle,S., Sehra,H.K., Shownkeen,R., Skuce,C.D.,
            Smith,M., Steward,C.A., Sycamore,N., Tester,J., Thomas,D.W.,
            Tracey,A., Tromans,A., Tubby,B., Wall,M., Wallis,J.M., West,A.P.,
            Whitehead,S.L., Willey,D.L., Wilming,L., Wray,P.W., Wright,M.W.,
            Young,L., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E., Beck,S.,
            Bentley,D.R., Rogers,J. and Ross,M.T.
  TITLE     The DNA sequence and analysis of human chromosome 13
  JOURNAL   Nature 428 (6982), 522-528 (2004)
   PUBMED   15057823
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL445212.9, DB457084.1,
            BC146956.1 and DB522524.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jul 19, 2019 this sequence version replaced NM_001136571.1.
            
            Summary: This gene encodes a member of the ZAR1 family that is
            predominantly expressed in oocytes and early embryos. The protein
            may function as an RNA regulator in early embryos. [provided by
            RefSeq, Apr 2010].
            
            ##Evidence-Data-START##
            CDS exon combination :: BC146965.1, DR731263.1 [ECO:0000331]
            RNAseq introns       :: partial sample support SAMEA1968968,
                                    SAMEA2148093 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000533490.7/ ENSP00000437289.2
            RefSeq Select criteria    :: based on single protein-coding
                                         transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                AL445212.9         83533-83551         c
            20-512              DB457084.1         2-494
            513-1512            BC146956.1         102-1101
            1513-1583           DB522524.1         392-462
            1584-1584           AL445212.9         71887-71887         c
FEATURES             Location/Qualifiers
     source          1..1584
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q13.1"
     gene            1..1584
                     /gene="ZAR1L"
                     /gene_synonym="Z3CXXC7; ZAR2"
                     /note="zygote arrest 1 like"
                     /db_xref="GeneID:646799"
                     /db_xref="HGNC:HGNC:37116"
                     /db_xref="MIM:620424"
     exon            1..49
                     /gene="ZAR1L"
                     /gene_synonym="Z3CXXC7; ZAR2"
                     /inference="alignment:Splign:2.1.0"
     exon            50..270
                     /gene="ZAR1L"
                     /gene_synonym="Z3CXXC7; ZAR2"
                     /inference="alignment:Splign:2.1.0"
     exon            271..1092
                     /gene="ZAR1L"
                     /gene_synonym="Z3CXXC7; ZAR2"
                     /inference="alignment:Splign:2.1.0"
     CDS             439..1404
                     /gene="ZAR1L"
                     /gene_synonym="Z3CXXC7; ZAR2"
                     /note="ZAR1-like protein; zinc finger, 3CxxC-type 7;
                     zygote arrest protein 1-like"
                     /codon_start=1
                     /product="protein ZAR1-like"
                     /protein_id="NP_001130043.1"
                     /db_xref="CCDS:CCDS45023.1"
                     /db_xref="GeneID:646799"
                     /db_xref="HGNC:HGNC:37116"
                     /db_xref="MIM:620424"
                     /translation="MERFVRVPYGLYQGYGSTVPLGQPGLSGHKQPDWRQNMGPPTFL
                     ARPGLLVPANAPDYCIDPYKRAQLKAILSQMNPSLSPRLCKPNTKEVGVQVSPRVDKA
                     VQCSLGPRTLSSCSPWDGRDPQEPLPACGVTSPATGRRGLIRLRRDGDEAESKALPGP
                     AEASQPQPPSRRSGADRQEEPGQLEESGEKDAPCPQETKSKQVPGDAASEPLRRPNFQ
                     FLEPKYGYFHCKDCKTRWESAYVWCISGTNKVYFKQLCCKCQKSFNPYRVEAIQCQTC
                     SKSHCSCPQKKRHIDLRRPHRQELCGRCKDKRFSCGNIYSFKYVM"
     exon            1093..1185
                     /gene="ZAR1L"
                     /gene_synonym="Z3CXXC7; ZAR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1186..1260
                     /gene="ZAR1L"
                     /gene_synonym="Z3CXXC7; ZAR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1261..1584
                     /gene="ZAR1L"
                     /gene_synonym="Z3CXXC7; ZAR2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1564..1569
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZAR1L"
                     /gene_synonym="Z3CXXC7; ZAR2"
                     /note="hexamer: AATAAA"
     polyA_site      1584
                     /gene="ZAR1L"
                     /gene_synonym="Z3CXXC7; ZAR2"
                     /note="major polyA site"
ORIGIN      
        1 gtcaggcatc ccaaccgtca gtatctgacc gaataaagcg ggagctggag attcggatca
       61 cctgtcttcc tcgcaggctg aactggaaga cctgacttca tctccgaatt cgttggttct
      121 gtaacatgcc taatacaagg ctgaataggg tttgttgtaa gacctacaaa accttcaaat
      181 ggattcagtg agagttgctc ccatgggggc cttgctgctt ccagaaggtg cttgagcagt
      241 aaacagaagc aaccttggat taggaaaagg ggtaataagc agcagctccc attagaatct
      301 gaaataaatg gagaagccag gaatgaatct gaaccaacct gatgaagaga aagaaggggc
      361 ggatgaagga ggaaggcaaa ataaggaccc aaacaaactg gctaggatat tagactgcgc
      421 ctgagcacct gagagcggat ggagcgcttt gtccgtgttc cctatggctt gtaccagggt
      481 tatgggagca cagtgccttt gggccagcct ggactctcag ggcacaaaca gcccgactgg
      541 aggcaaaata tgggtcctcc cacttttctg gccaggccag ggctgctggt gcccgcgaac
      601 gcccctgact actgcattga cccttacaag agggcgcagc ttaaggccat tctctcccag
      661 atgaacccca gcctgagccc gcggctgtgc aagcccaaca ccaaggaggt gggcgtgcag
      721 gtgagcccgc gggtggacaa ggctgtgcag tgctctctgg ggcctcgcac cctcagcagc
      781 tgctccccct gggacggcag agacccccag gagcccctgc cagcctgtgg ggtcacttcg
      841 cccgccaccg gccgcagggg cttgatccgc ctgcggagag atggggacga agcggagagc
      901 aaggcgctcc cgggccctgc ggaggccagc cagccgcagc caccatcacg gaggtcagga
      961 gctgacaggc aggaggagcc cgggcagctg gaggaatcgg gggagaaaga cgccccgtgc
     1021 cctcaggaga cgaagagcaa gcaggtgcct ggagacgccg cctccgagcc gctccggagg
     1081 cccaacttcc agtttttgga accaaaatat ggctatttcc actgtaaaga ttgtaagacc
     1141 aggtgggaga gtgcttacgt gtggtgcatt tctggaacga acaaggttta tttcaaacaa
     1201 ctctgttgta aatgccaaaa gagttttaac ccttatcgag tagaagcaat ccaatgtcag
     1261 acctgctcaa agtctcattg ttcctgtcct caaaagaaga gacacattga tctaaggagg
     1321 cctcatcgac aggaactgtg tggtcgctgc aaagacaaga gattctcctg tggcaatatt
     1381 tacagcttta aatatgtgat gtgacttgta cagtgtgact tgtaatggac ccctgagctc
     1441 ttcttgtaac ttactgtgct gtcttccttt tttgcaactt ggctctgacc tggcatcgga
     1501 aaatggctag gcttttgtac tttttgtaga ttgtgtaaca attgtacaat gtgaatagaa
     1561 taaaataaat gcatgtgaac taga
//
