LOCUS       NM_180990               1475 bp    mRNA    linear   PRI 11-OCT-2024
DEFINITION  Homo sapiens zinc activated ion channel (ZACN), mRNA.
ACCESSION   NM_180990
VERSION     NM_180990.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1475)
  AUTHORS   Madjroh,N., Mellou,E., AEbelo,L., Davies,P.A., Soderhielm,P.C. and
            Jensen,A.A.
  TITLE     Probing the molecular basis for signal transduction through the
            Zinc-Activated Channel (ZAC)
  JOURNAL   Biochem Pharmacol 193, 114781 (2021)
   PUBMED   34560053
  REMARK    GeneRIF: Probing the molecular basis for signal transduction
            through the Zinc-Activated Channel (ZAC).
REFERENCE   2  (bases 1 to 1475)
  AUTHORS   Trattnig,S.M., Gasiorek,A., Deeb,T.Z., Ortiz,E.J., Moss,S.J.,
            Jensen,A.A. and Davies,P.A.
  TITLE     Copper and protons directly activate the zinc-activated channel
  JOURNAL   Biochem Pharmacol 103, 109-117 (2016)
   PUBMED   26872532
REFERENCE   3  (bases 1 to 1475)
  AUTHORS   Houtani,T., Munemoto,Y., Kase,M., Sakuma,S., Tsutsumi,T. and
            Sugimoto,T.
  TITLE     Cloning and expression of ligand-gated ion-channel receptor L2 in
            central nervous system
  JOURNAL   Biochem Biophys Res Commun 335 (2), 277-285 (2005)
   PUBMED   16083862
  REMARK    GeneRIF: analysis of ligand-gated ion-channel receptor L2 in
            central nervous system
REFERENCE   4  (bases 1 to 1475)
  AUTHORS   Davies,P.A., Wang,W., Hales,T.G. and Kirkness,E.F.
  TITLE     A novel class of ligand-gated ion channel is activated by Zn2+
  JOURNAL   J Biol Chem 278 (2), 712-717 (2003)
   PUBMED   12381728
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB119720.1, AB223030.1 and AC018665.9.
            
            On May 17, 2019 this sequence version replaced NM_180990.3.
            
            Summary: LGICZ1 is a zinc-activated ligand-gated ion channel that
            defines a new subgroup of the cysteine-loop superfamily of
            ligand-gated ion channels (Davies et al., 2003 [PubMed
            12381728]).[supplied by OMIM, Mar 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB223030.1, BC110597.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000334586.10/ ENSP00000334854.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-86                DB119720.1         1-86
            87-1473             AB223030.1         1-1387
            1474-1475           AC018665.9         104267-104268       c
FEATURES             Location/Qualifiers
     source          1..1475
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.1"
     gene            1..1475
                     /gene="ZACN"
                     /gene_synonym="L2; LGICZ; LGICZ1; ZAC; ZAC1"
                     /note="zinc activated ion channel"
                     /db_xref="GeneID:353174"
                     /db_xref="HGNC:HGNC:29504"
                     /db_xref="MIM:610935"
     exon            1..180
                     /gene="ZACN"
                     /gene_synonym="L2; LGICZ; LGICZ1; ZAC; ZAC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             84..1322
                     /gene="ZACN"
                     /gene_synonym="L2; LGICZ; LGICZ1; ZAC; ZAC1"
                     /note="zinc activated ligand-gated ion channel 1;
                     zinc-activated ligand-gated ion channel; ligand-gated ion
                     channel subunit; ligand-gated ion-channel receptor L2;
                     ligand-gated ion channel zinc-activated 1; zinc-activated
                     channel; ligand-gated cation channel ZACN"
                     /codon_start=1
                     /product="ligand-gated cation channel ZACN precursor"
                     /protein_id="NP_851321.2"
                     /db_xref="CCDS:CCDS11740.2"
                     /db_xref="GeneID:353174"
                     /db_xref="HGNC:HGNC:29504"
                     /db_xref="MIM:610935"
                     /translation="MMALWSLLHLTFLGFSITLLLVHGQGFQGTAAIWPSLFNVNLSK
                     KVQESIQIPNNGSAPLLVDVRVFVSNVFNVDILRYTMSSMLLLRLSWLDTRLAWNTSA
                     HPRHAITLPWESLWTPRLTILEALWVDWRDQSPQARVDQDGHVKLNLALATETNCNFE
                     LLHFPRDHSNCSLSFYALSNTAMELEFQAHVVNEIVSVKREYVVYDLKTQVPPQQLVP
                     CFQVTLRLKNTALKSIIALLVPAEALLLADVCGGLLPLRAIERIGYKVTLLLSYLVLH
                     SSLVQALPSSSSCNPLLIYYFTILLLLLFLSTIETVLLAGLLARGNLGAKSGPSPAPR
                     GEQREHGNPGPHPAEEPSRGVKGSQRSWPETADRIFFLVYVVGVLCTQFVFAGIWMWA
                     ACKSDAAPGEAAPHGRRPRL"
     exon            181..305
                     /gene="ZACN"
                     /gene_synonym="L2; LGICZ; LGICZ1; ZAC; ZAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            306..350
                     /gene="ZACN"
                     /gene_synonym="L2; LGICZ; LGICZ1; ZAC; ZAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            351..457
                     /gene="ZACN"
                     /gene_synonym="L2; LGICZ; LGICZ1; ZAC; ZAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            458..627
                     /gene="ZACN"
                     /gene_synonym="L2; LGICZ; LGICZ1; ZAC; ZAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            628..752
                     /gene="ZACN"
                     /gene_synonym="L2; LGICZ; LGICZ1; ZAC; ZAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            753..963
                     /gene="ZACN"
                     /gene_synonym="L2; LGICZ; LGICZ1; ZAC; ZAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            964..1131
                     /gene="ZACN"
                     /gene_synonym="L2; LGICZ; LGICZ1; ZAC; ZAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1132..1475
                     /gene="ZACN"
                     /gene_synonym="L2; LGICZ; LGICZ1; ZAC; ZAC1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1454..1459
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZACN"
                     /gene_synonym="L2; LGICZ; LGICZ1; ZAC; ZAC1"
                     /note="hexamer: AATAAA"
     polyA_site      1475
                     /gene="ZACN"
                     /gene_synonym="L2; LGICZ; LGICZ1; ZAC; ZAC1"
                     /note="major polyA site"
ORIGIN      
        1 aattgctcag ctgccagaga agtgactgga atagaggttg tagcttaggc accgctgctc
       61 cctccagtcc ctccgtgcag ccgatgatgg ccctatggtc cctgctccat ctcaccttcc
      121 tggggttcag cattaccttg ctgttggtcc acgggcaggg cttccaaggg acagcagcca
      181 tctggccatc cctcttcaac gtcaacttgt ccaagaaggt tcaggaaagc atccagatcc
      241 cgaacaatgg gagtgcgccc ctgctcgtgg atgtgcgggt gtttgtctcc aacgtgttta
      301 atgtggacat cctgcgatac acaatgtcct ccatgctgct gcttaggctg tcctggctgg
      361 acactcgcct ggcctggaac actagtgcac acccgcggca cgccatcacg ctgccctggg
      421 agtctctctg gacaccaagg ctcaccatcc tggaggcgct ctgggtggac tggagggacc
      481 agagccccca ggctcgagta gaccaggacg gccacgtgaa gctcaacctg gccctcgcca
      541 cggagaccaa ctgcaacttt gagctcctcc acttcccccg ggaccacagc aactgcagcc
      601 tcagcttcta cgctctcagc aacacggcga tggagttaga gttccaggcc cacgtggtga
      661 acgagattgt gagtgtcaag agggaatacg tagtttatga tctgaagacc caagtcccac
      721 cccagcagct ggtgccctgc ttccaggtga cgctgaggct gaagaacacg gcgctcaagt
      781 ccatcatcgc tctcttggtg cctgcagagg cactgctgtt ggctgacgtg tgcggggggt
      841 tgctgcccct ccgggccatt gagcgcatag gctacaaggt gacattgctg ctgagttacc
      901 tcgtcctcca ctcctccctg gtgcaggccc tgcccagctc ctcctcctgc aacccactgc
      961 tcatttacta cttcaccatc ctgctgctgc tgctcttcct cagcaccata gagactgtgc
     1021 tgctggctgg gctgctggcc cggggcaacc ttggggccaa gagcggcccc agcccagccc
     1081 cgagagggga acagcgagag cacggcaacc cagggcctca tcctgctgaa gagccctcca
     1141 gaggagtaaa ggggtcacag agaagctggc ctgagactgc tgaccgcatc ttcttcctcg
     1201 tgtatgtggt tggggtgctg tgcacccaat tcgtctttgc aggaatctgg atgtgggcag
     1261 cgtgcaagtc tgacgcagcc cctggagagg ctgcacccca tggcaggcgg cctagactgt
     1321 aaaggggcag ggcctgggct gcacacctta ggatgaagtt tgctttccca tggctggggg
     1381 cgggccatga cagggcctct ggattaagcc accctgagct ctccctccgc tagcacacaa
     1441 gcacagagcg tgaaataaac ccatctccag tgcaa
//
