LOCUS       NM_206923               2754 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens YY2 transcription factor (YY2), mRNA.
ACCESSION   NM_206923
VERSION     NM_206923.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2754)
  AUTHORS   Chen,X.F., Duan,Y.Y., Jia,Y.Y., Dong,Q.H., Shi,W., Zhang,Y.,
            Dong,S.S., Li,M., Liu,Z., Chen,F., Huang,X.T., Hao,R.H., Zhu,D.L.,
            Jing,R.H., Guo,Y. and Yang,T.L.
  TITLE     Integrative high-throughput enhancer surveying and functional
            verification divulges a YY2-condensed regulatory axis conferring
            risk for osteoporosis
  JOURNAL   Cell Genom 4 (3), 100501 (2024)
   PUBMED   38335956
  REMARK    GeneRIF: Integrative high-throughput enhancer surveying and
            functional verification divulges a YY2-condensed regulatory axis
            conferring risk for osteoporosis.
REFERENCE   2  (bases 1 to 2754)
  AUTHORS   Wei,M., Nurjanah,U., Li,J., Luo,X., Hosea,R., Li,Y., Zeng,J.,
            Duan,W., Song,G., Miyagishi,M., Kasim,V. and Wu,S.
  TITLE     YY2-DRP1 Axis Regulates Mitochondrial Fission and Determines Cancer
            Stem Cell Asymmetric Division
  JOURNAL   Adv Sci (Weinh) 10 (23), e2207349 (2023)
   PUBMED   37300334
  REMARK    GeneRIF: YY2-DRP1 Axis Regulates Mitochondrial Fission and
            Determines Cancer Stem Cell Asymmetric Division.
REFERENCE   3  (bases 1 to 2754)
  AUTHORS   Li,Y., Li,J., Li,Z., Wei,M., Zhao,H., Miyagishi,M., Wu,S. and
            Kasim,V.
  TITLE     Homeostasis Imbalance of YY2 and YY1 Promotes Tumor Growth by
            Manipulating Ferroptosis
  JOURNAL   Adv Sci (Weinh) 9 (13), e2104836 (2022)
   PUBMED   35246964
  REMARK    GeneRIF: Homeostasis Imbalance of YY2 and YY1 Promotes Tumor Growth
            by Manipulating Ferroptosis.
REFERENCE   4  (bases 1 to 2754)
  AUTHORS   Li,L., Li,Y., Timothy Sembiring Meliala,I., Kasim,V. and Wu,S.
  TITLE     Biological roles of Yin Yang 2: Its implications in physiological
            and pathological events
  JOURNAL   J Cell Mol Med 24 (22), 12886-12899 (2020)
   PUBMED   32969187
  REMARK    GeneRIF: Biological roles of Yin Yang 2: Its implications in
            physiological and pathological events.
            Review article
REFERENCE   5  (bases 1 to 2754)
  AUTHORS   Figiel,M., Lakomska,J., Milek,P., Dziedzicka-Wasylewska,M. and
            Gorecki,A.
  TITLE     The transcription factor YY2 has less momentous properties of an
            intrinsically disordered protein than its paralog YY1
  JOURNAL   FEBS Lett 593 (14), 1787-1798 (2019)
   PUBMED   31131888
  REMARK    GeneRIF: different effects of YY1 and YY2 on gene expression
            patterns
            Erratum:[FEBS Lett. 2021 Apr;595(7):969. doi:
            10.1002/1873-3468.14069.. PMID: 33843055]
REFERENCE   6  (bases 1 to 2754)
  AUTHORS   Klar,M., Drews,D. and Dame,C.
  TITLE     Transcriptional activity of the novel identified human yy2 promoter
            is modified by DNA methylation
  JOURNAL   Gene 430 (1-2), 58-63 (2009)
   PUBMED   19026728
  REMARK    GeneRIF: yy2 expression is mediated by its own
            methylation-sensitive promoter.
REFERENCE   7  (bases 1 to 2754)
  AUTHORS   Kim,J.D., Faulk,C. and Kim,J.
  TITLE     Retroposition and evolution of the DNA-binding motifs of YY1, YY2
            and REX1
  JOURNAL   Nucleic Acids Res 35 (10), 3442-3452 (2007)
   PUBMED   17478514
REFERENCE   8  (bases 1 to 2754)
  AUTHORS   Luo,C., Lu,X., Stubbs,L. and Kim,J.
  TITLE     Rapid evolution of a recently retroposed transcription factor YY2
            in mammalian genomes
  JOURNAL   Genomics 87 (3), 348-355 (2006)
   PUBMED   16377127
REFERENCE   9  (bases 1 to 2754)
  AUTHORS   Klar,M. and Bode,J.
  TITLE     Enhanceosome formation over the beta interferon promoter underlies
            a remote-control mechanism mediated by YY1 and YY2
  JOURNAL   Mol Cell Biol 25 (22), 10159-10170 (2005)
   PUBMED   16260628
  REMARK    GeneRIF: the novel factor YY2 antagonizes the negative actions
            exerted by YY1
REFERENCE   10 (bases 1 to 2754)
  AUTHORS   Nguyen,N., Zhang,X., Olashaw,N. and Seto,E.
  TITLE     Molecular cloning and functional characterization of the
            transcription factor YY2
  JOURNAL   J Biol Chem 279 (24), 25927-25934 (2004)
   PUBMED   15087442
  REMARK    GeneRIF: YY2 can bind to and regulate some promoters known to be
            controlled by YY1. Similar to YY1, YY2 contains both
            transcriptional activation and repression functions.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK091850.1, DB029513.1,
            DB459498.2, BC137215.1 and U73479.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_206923.3.
            
            Summary: The protein encoded by this gene is a transcription factor
            that includes several Kruppel-like zinc fingers in its C-terminal
            region. It possesses both activation and repression domains, and it
            can therefore have both positive and negative effects on the
            transcription of target genes. This gene has an intronless coding
            region, and it appears to have arisen by retrotransposition of the
            related YY1 transcription factor gene, which is located on
            chromosome 14. [provided by RefSeq, May 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AK091850.1, SRR1803615.229321.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000429584.3/ ENSP00000389381.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-317               AK091850.1         1-317
            318-372             DB029513.1         70-124
            373-522             DB459498.2         55-204
            523-1671            BC137215.1         79-1227
            1672-2741           AK091850.1         1653-2722
            2742-2754           U73479.1           28048-28060
FEATURES             Location/Qualifiers
     source          1..2754
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp22.12"
     gene            1..2754
                     /gene="YY2"
                     /gene_synonym="ZNF631"
                     /note="YY2 transcription factor"
                     /db_xref="GeneID:404281"
                     /db_xref="HGNC:HGNC:31684"
                     /db_xref="MIM:300570"
     exon            1..2754
                     /gene="YY2"
                     /gene_synonym="ZNF631"
                     /inference="alignment:Splign:2.1.0"
     CDS             499..1617
                     /gene="YY2"
                     /gene_synonym="ZNF631"
                     /note="transcription factor yin yang 2; yin and yang 2;
                     zinc finger protein 631"
                     /codon_start=1
                     /product="transcription factor YY2"
                     /protein_id="NP_996806.2"
                     /db_xref="CCDS:CCDS14202.1"
                     /db_xref="GeneID:404281"
                     /db_xref="HGNC:HGNC:31684"
                     /db_xref="MIM:300570"
                     /translation="MASNEDFSITQDLEIPADIVELHDINVEPLPMEDIPTESVQYED
                     VDGNWIYGGHNHPPLMVLQPLFTNTGYGDHDQEMLMLQTQEEVVGYCDSDNQLGNDLE
                     DQLALPDSIEDEHFQMTLASLSASAASTSTSTQSRSKKPSKKPSGKSATSTEANPAGS
                     SSSLGTRKWEQKQMQVKTLEGEFSVTMWSPNDNNDQGAVGEGQAENPPDYSEYLKGKK
                     LPPGGLPGIDLSDPKQLAEFTKVKPKRSKGEPPKTVPCSYSGCEKMFRDYAAMRKHLH
                     IHGPRVHVCAECGKAFLESSKLRRHQLVHTGEKPFQCTFEGCGKRFSLDFNLRTHLRI
                     HTGDKPFVCPFDVCNRKFAQSTNLKTHILTHVKTKNNP"
     regulatory      2432..2437
                     /regulatory_class="polyA_signal_sequence"
                     /gene="YY2"
                     /gene_synonym="ZNF631"
                     /note="hexamer: AATAAA"
     polyA_site      2462
                     /gene="YY2"
                     /gene_synonym="ZNF631"
                     /note="major polyA site"
ORIGIN      
        1 attaaataag agaaaaaagc ataaaaggag taggcttttt tggcagatac tgttatatgg
       61 gatggacagg aggggaagac atgaaaatca actaaaatga aatacataaa aaatcagtaa
      121 agagcctgct tacgaaagtg gaaaaacaac agctgggcgg ggtcgcaggg tggcaaacgt
      181 acgcgggcac gtgcacgtgc ttttggggcc gacagacgcg ccagttgcct aggcgcatgc
      241 gtctggctat cccagaagca cctgcgcctt ccggctcgtg ctttcctcag tctcgcgcct
      301 ttctctgcag ctcgcgcctt tctctgcagc tcgcgccttt ctctgcagct cgcgcctttc
      361 tctgcagctc gcgcctttct ctgcagctcg ccccttcctc tgcagctcgc cccttcctct
      421 gcagctccca cctcactccc ctcagcgttc tttttcccac ggtcttcccg ttgccgctaa
      481 cctaactaac tctcagccat ggcctccaac gaagatttct ccatcacaca agacctggag
      541 atcccggcag atattgtgga gctccacgac atcaatgtgg agccccttcc tatggaggac
      601 attccgacgg aaagcgtcca gtacgaggat gtggatggca attggatcta cggtggccac
      661 aaccatccgc cattgatggt gttgcagccg ctcttcacga acacgggcta tggcgaccac
      721 gaccaggaaa tgcttatgtt gcagacacaa gaggaagtgg tgggctattg cgactcagac
      781 aaccagctag gcaacgactt ggaggaccag ttggccctcc cggatagcat tgaagacgag
      841 cacttccaga tgaccctggc ctctctgtcg gcctcggcgg catcaacatc aacatcaacc
      901 cagagccgca gcaaaaagcc cagcaaaaag cccagcggca agagtgccac cagcactgag
      961 gccaacccgg caggcagcag ctccagcctg ggcacgagga agtgggagca gaagcaaatg
     1021 caggtcaaaa cgctggaggg tgagttttcc gtgactatgt ggtcccctaa cgataacaat
     1081 gaccaagggg cagtgggtga aggccaggct gaaaacccac ctgattattc cgagtacttg
     1141 aaagggaaga aacttcctcc tggggggtta ccaggcattg atctctcaga tcctaaacag
     1201 ctggcagaat ttactaaagt gaagcccaaa aggtccaaag gagaacctcc caaaacagtc
     1261 ccttgctctt atagcggctg cgaaaagatg ttccgggatt acgccgccat gagaaaacat
     1321 ctccacatcc acgggcccag agtccacgta tgtgcagaat gtggcaaagc ttttcttgag
     1381 agctcaaagc tgagacgaca ccagctggtc cacaccggcg agaagccctt tcagtgcaca
     1441 ttcgaaggct gcgggaaacg cttttccctt gatttcaatt tgcgcacaca cttgcgcatc
     1501 cacaccggcg ataagccctt cgtgtgcccc ttcgatgttt gcaacaggaa gttcgctcag
     1561 tcaaccaacc tgaaaaccca catattaacg catgtgaaga ccaaaaacaa cccgtgaaaa
     1621 ggagaagacc cctctcagac ttgggaatta tcttccagga ctgcggtagg gaataaatat
     1681 gcctctcaaa gctttgtatg ttgtttctaa gagttttaaa aaaaaatgaa tcctgcacat
     1741 ttaaggttcg tgttttgtta gagtagtaaa aatagaattt aaacgttttt aaaaaggtaa
     1801 accttgacat aagataatag tgctaagatg ccatagcttg ttctgtaact atttttgtaa
     1861 agtttggtcc caacaggaga aaaattcgta gacttcacat caagagacgg ttcttacaaa
     1921 ctgtttaaaa tgggactttt cacattctta gaaataggaa gttcatttat tgtttacaat
     1981 gtttttaaaa aacttgttaa aaaattcaaa gtgttcatgt ttatactttt aggaatatgc
     2041 ttaataagtc tatgtatggt ttttctggag gttgataact ttgggaaaga tttactttaa
     2101 aagagtgaac aattatatgc atacgtgaag tattttcctg cttaaaaaag ttatataggt
     2161 gttatttgtt ttaatcttgg ttgtagtctt ggatgttaac acatcttgca ttttagctgt
     2221 attaggtcat gtagtattga tattaggtga tttaatagta ctagtttaaa cctattttag
     2281 tcattttatt ttccccaaaa tactaccaga tgctgttgtt tagtgtaatt tctttgcctg
     2341 ttcagttaaa gtagtgcttg cttgtagaat atattgtgta tatgttgact ttaacactta
     2401 agaagtacat cctgtgtaat agaaaaagca aaataaaaca cctcttctaa agaaggaaaa
     2461 aagtagtttg cctatatcag tacagaagtt agaactaaag aaaaggggga gggtgctact
     2521 ggcatctggt gagtggaggg agatcaggaa tgccactaaa catcctacaa tgcacagaca
     2581 gccccacgaa acacataatt atttggctaa aatgccaata gtgtcaggtg caggggctca
     2641 ggcctgtaat gtcaacactt tgggaggccg aggtgggtgg atcgtttgag ctcaggaatt
     2701 gaacatcagc ctgggcaaca tggcataact cggtctctac caaaaataaa aaaa
//
