LOCUS       NM_139119               2723 bp    mRNA    linear   PRI 03-OCT-2024
DEFINITION  Homo sapiens YY1 associated protein 1 (YY1AP1), transcript variant
            3, mRNA.
ACCESSION   NM_139119
VERSION     NM_139119.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2723)
  AUTHORS   Esposito,D., Pant,I., Shen,Y., Qiao,R.F., Yang,X., Bai,Y., Jin,J.,
            Poulikakos,P.I. and Aaronson,S.A.
  TITLE     ROCK1 mechano-signaling dependency of human malignancies driven by
            TEAD/YAP activation
  JOURNAL   Nat Commun 13 (1), 703 (2022)
   PUBMED   35121738
  REMARK    GeneRIF: ROCK1 mechano-signaling dependency of human malignancies
            driven by TEAD/YAP activation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2723)
  AUTHORS   Jin,Y., Yang,R., Ding,J., Zhu,F., Zhu,C., Xu,Q. and Cai,J.
  TITLE     KAT6A is associated with sorafenib resistance and contributes to
            progression of hepatocellular carcinoma by targeting YAP
  JOURNAL   Biochem Biophys Res Commun 585, 185-190 (2021)
   PUBMED   34808502
  REMARK    GeneRIF: KAT6A is associated with sorafenib resistance and
            contributes to progression of hepatocellular carcinoma by targeting
            YAP.
REFERENCE   3  (bases 1 to 2723)
  AUTHORS   Raggio,V., Dell'Oca,N., Simoes,C., Tapie,A., Medici,C., Costa,G.,
            Rodriguez,S., Greif,G., Garrone,E., Rovella,M.L., Gonzalez,V.,
            Halty,M., Gonzalez,G., Shin,J.Y., Shin,S.Y., Kim,C., Seo,J.S.,
            Grana,M., Naya,H. and Spangenberg,L.
  TITLE     Whole genome sequencing reveals a frameshift mutation and a large
            deletion in YY1AP1 in a girl with a panvascular artery disease
  JOURNAL   Hum Genomics 15 (1), 28 (2021)
   PUBMED   33971976
  REMARK    GeneRIF: Whole genome sequencing reveals a frameshift mutation and
            a large deletion in YY1AP1 in a girl with a panvascular artery
            disease.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2723)
  AUTHORS   Yi,L.J., Yi,L.J., Ding,N. and Ren,J.
  TITLE     CUL4A promotes proliferation and inhibits apoptosis of colon cancer
            cells via regulating Hippo pathway
  JOURNAL   Eur Rev Med Pharmacol Sci 24 (20), 10518-10525 (2020)
   PUBMED   33155207
  REMARK    GeneRIF: CUL4A promotes proliferation and inhibits apoptosis of
            colon cancer cells via regulating Hippo pathway.
REFERENCE   5  (bases 1 to 2723)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 2723)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
REFERENCE   7  (bases 1 to 2723)
  AUTHORS   Wang,C.Y., Liang,Y.J., Lin,Y.S., Shih,H.M., Jou,Y.S. and Yu,W.C.
  TITLE     YY1AP, a novel co-activator of YY1
  JOURNAL   J Biol Chem 279 (17), 17750-17755 (2004)
   PUBMED   14744866
  REMARK    GeneRIF: YY1AP is a novel co-activator of YY1
REFERENCE   8  (bases 1 to 2723)
  AUTHORS   Zeng,J.Z., Wang,H.Y., Chen,Z.J., Ullrich,A. and Wu,M.C.
  TITLE     Molecular cloning and characterization of a novel gene which is
            highly expressed in hepatocellular carcinoma
  JOURNAL   Oncogene 21 (32), 4932-4943 (2002)
   PUBMED   12118372
REFERENCE   9  (bases 1 to 2723)
  AUTHORS   Wang,Z., Hu,G., Wang,H. and Wu,M.
  TITLE     [Clone of a novel liver cancer associated gene and analysis of the
            secondary structures of the predicted protein]
  JOURNAL   Zhonghua Gan Zang Bing Za Zhi 10 (1), 25-27 (2002)
   PUBMED   11856496
  REMARK    GeneRIF: human liver cancer associated gene
REFERENCE   10 (bases 1 to 2723)
  AUTHORS   Wang,Z.X., Wang,H.Y. and Wu,M.C.
  TITLE     Identification and characterization of a novel human hepatocellular
            carcinoma-associated gene
  JOURNAL   Br J Cancer 85 (8), 1162-1167 (2001)
   PUBMED   11710830
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC044887.1 and BC014906.2.
            
            On Aug 14, 2020 this sequence version replaced NM_139119.2.
            
            Transcript Variant: This variant (3) has an alternate 5' sequence,
            resulting in a downstream AUG start codon, as compared to variant
            10. The resulting isoform (3) has a shorter N-terminus, as compared
            to isoform 6. Variants 3, 8 and 9 encode the same isoform 3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC014906.2, SRR3476690.953399.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000355499.9/ ENSP00000347686.4
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-68                BC044887.1         1-68
            69-2723             BC014906.2         1-2655
FEATURES             Location/Qualifiers
     source          1..2723
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q22"
     gene            1..2723
                     /gene="YY1AP1"
                     /gene_synonym="GRNG; HCCA1; HCCA2; YY1AP"
                     /note="YY1 associated protein 1"
                     /db_xref="GeneID:55249"
                     /db_xref="HGNC:HGNC:30935"
                     /db_xref="MIM:607860"
     exon            1..116
                     /gene="YY1AP1"
                     /gene_synonym="GRNG; HCCA1; HCCA2; YY1AP"
                     /inference="alignment:Splign:2.1.0"
     exon            117..247
                     /gene="YY1AP1"
                     /gene_synonym="GRNG; HCCA1; HCCA2; YY1AP"
                     /inference="alignment:Splign:2.1.0"
     exon            248..288
                     /gene="YY1AP1"
                     /gene_synonym="GRNG; HCCA1; HCCA2; YY1AP"
                     /inference="alignment:Splign:2.1.0"
     CDS             268..2520
                     /gene="YY1AP1"
                     /gene_synonym="GRNG; HCCA1; HCCA2; YY1AP"
                     /note="isoform 3 is encoded by transcript variant 3;
                     hepatocellular carcinoma susceptibility protein;
                     hepatocellular carcinoma-associated protein 2"
                     /codon_start=1
                     /product="YY1-associated protein 1 isoform 3"
                     /protein_id="NP_620830.1"
                     /db_xref="CCDS:CCDS1116.1"
                     /db_xref="GeneID:55249"
                     /db_xref="HGNC:HGNC:30935"
                     /db_xref="MIM:607860"
                     /translation="MEDLFETFQDEMGFSNMEDDGPEEEERVAEPQANFNTPQALRFE
                     ELLANLLNEQHQIAKELFEQLKMKKPSAKQQKEVEKVKPQCKEVHQTLILDPAQRKRL
                     QQQMQQHVQLLTQIHLLATCNPNLNPEASSTRICLKELGTFAQSSIALHHQYNPKFQT
                     LFQPCNLMGAMQLIEDFSTHVSIDCSPHKTVKKTANEFPCLPKQVAWILATSKVFMYP
                     ELLPVCSLKAKNPQDKILFTKAEDNLLALGLKHFEGTEFLNPLISKYLLTCKTARQLT
                     VRIKNLNMNRAPDNIIKFYKKTKQLPVLGKCCEEIQPHQWKPPIEREEHRLPFWLKAS
                     LPSIQEELRHMADGAREVGNMTGTTEINSDQGLEKDNSELGSETRYPLLLPKGVVLKL
                     KPVADRFPKKAWRQKRSSVLKPLLIQPSPSLQPSFNPGKTPAQSTHSEAPPSKMVLRI
                     PHPIQPATVLQTVPGVPPLGVSGGESFESPAALPAMPPEARTSFPLSESQTLLSSAPV
                     PKVMMPSPASSMFRKPYVRRRPSKRRGARAFRCIKPAPVIHPASVIFTVPATTVKIVS
                     LGGGCNMIQPVNAAVAQSPQTIPIATLLVNPTSFPCPLNQPLVASSVSPLIVSGNSVN
                     LPIPSTPEDKAHMNVDIACAVADGENAFQGLEPKLEPQELSPLSATVFPKVEHSPGPP
                     PVDKQCQEGLSENSAYRWTVVKTEEGRQALEPLPQGIQESLNNSSPGDLEEVVKMEPE
                     DATEEISGFL"
     exon            289..392
                     /gene="YY1AP1"
                     /gene_synonym="GRNG; HCCA1; HCCA2; YY1AP"
                     /inference="alignment:Splign:2.1.0"
     exon            393..591
                     /gene="YY1AP1"
                     /gene_synonym="GRNG; HCCA1; HCCA2; YY1AP"
                     /inference="alignment:Splign:2.1.0"
     exon            592..678
                     /gene="YY1AP1"
                     /gene_synonym="GRNG; HCCA1; HCCA2; YY1AP"
                     /inference="alignment:Splign:2.1.0"
     exon            679..850
                     /gene="YY1AP1"
                     /gene_synonym="GRNG; HCCA1; HCCA2; YY1AP"
                     /inference="alignment:Splign:2.1.0"
     exon            851..995
                     /gene="YY1AP1"
                     /gene_synonym="GRNG; HCCA1; HCCA2; YY1AP"
                     /inference="alignment:Splign:2.1.0"
     exon            996..1146
                     /gene="YY1AP1"
                     /gene_synonym="GRNG; HCCA1; HCCA2; YY1AP"
                     /inference="alignment:Splign:2.1.0"
     exon            1147..1263
                     /gene="YY1AP1"
                     /gene_synonym="GRNG; HCCA1; HCCA2; YY1AP"
                     /inference="alignment:Splign:2.1.0"
     exon            1264..2723
                     /gene="YY1AP1"
                     /gene_synonym="GRNG; HCCA1; HCCA2; YY1AP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2698..2703
                     /regulatory_class="polyA_signal_sequence"
                     /gene="YY1AP1"
                     /gene_synonym="GRNG; HCCA1; HCCA2; YY1AP"
                     /note="hexamer: AATAAA"
     polyA_site      2723
                     /gene="YY1AP1"
                     /gene_synonym="GRNG; HCCA1; HCCA2; YY1AP"
                     /note="major polyA site"
ORIGIN      
        1 gtagggtggg ggtgctggcg gcggctgctt tggcggcggt tggtggccgt gcgggcgggg
       61 agggaggggg aggagagaag aggaggtgga gaaggcttgg gctcgcgccg ctgaagtcgg
      121 cttacccgct ggccgcctcc tgacaagcgg gagggatccg cggtggaccc agggaagcgg
      181 aggagcctgg cggccacccc ctcttcctca cttccctgta ctctcatcgc tctcggcctc
      241 cgacacgaaa aggaagcaaa tgagctgatg gaagatctgt ttgaaacttt ccaagatgag
      301 atgggattct ccaacatgga agatgatggc ccagaagagg aggagcgtgt ggctgagcct
      361 caagctaact ttaacacccc tcaagctcta cggtttgagg aactactggc caacctacta
      421 aatgaacaac atcagatagc gaaggaacta tttgaacagc tgaagatgaa gaaaccttca
      481 gccaaacagc agaaggaggt agagaaggtt aaaccccagt gtaaggaagt tcatcagacc
      541 ctgattctgg acccagcaca aaggaagaga ctccagcagc agatgcagca gcatgttcag
      601 ctcttgacac aaatccacct tcttgccacc tgcaacccca atctcaatcc ggaggccagt
      661 agcaccagga tatgtcttaa agagctggga acctttgctc aaagctccat cgcccttcac
      721 catcagtaca accccaagtt tcagaccctg ttccaaccct gtaacttgat gggagctatg
      781 cagctgattg aagacttcag cacacatgtc agcattgact gcagccctca taaaactgtc
      841 aagaagactg ccaatgaatt tccctgtttg ccaaagcaag tggcttggat cctggccaca
      901 agcaaggttt tcatgtatcc agagttactt ccagtgtgtt ccctgaaggc aaagaatccc
      961 caggataaga tcctcttcac caaggctgag gacaatttgt tagctttagg actgaagcat
     1021 tttgaaggga ctgagtttct taaccctcta atcagcaagt accttctaac ctgcaagact
     1081 gcccgccaac tgacagtgag aatcaagaac ctcaacatga acagagctcc tgacaacatc
     1141 attaaatttt ataagaagac caaacagctg ccagtcctag gaaaatgctg tgaagagatc
     1201 cagccacatc agtggaagcc acctatagag agagaagaac accggctccc attctggtta
     1261 aaggccagtc tgccatccat ccaggaagaa ctgcggcaca tggctgatgg tgctagagag
     1321 gtaggaaata tgactggaac cactgagatc aactcagatc aaggcctaga aaaagacaac
     1381 tcagagttgg ggagtgaaac tcggtaccca ctgctattgc ctaagggtgt agtcctgaaa
     1441 ctgaagccag ttgccgaccg tttccccaag aaggcttgga gacagaagcg ttcatcagtc
     1501 ctgaaacccc tccttatcca acccagcccc tctctccagc ccagcttcaa ccctgggaaa
     1561 acaccagccc aatcaactca ttcagaagcc cctccgagca aaatggtgct ccggattcct
     1621 cacccaatac agccagccac tgttttacag acagttccag gtgtccctcc actgggggtc
     1681 agtggaggtg agagttttga gtctcctgca gcactgcctg ctatgccccc tgaggccagg
     1741 acaagcttcc ctctgtctga gtcccagact ttgctctctt ctgcccctgt gcccaaggta
     1801 atgatgccct cccctgcctc ttccatgttt cgaaagccat atgtgagacg gagaccctca
     1861 aaaagaaggg gagccagggc ctttcgctgt atcaaacctg cccctgttat ccaccctgca
     1921 tctgttatct tcactgttcc tgctaccact gtgaagattg tgagccttgg cggtggctgt
     1981 aacatgatcc agcctgtcaa tgcggctgtg gcccagagtc cccagactat tcccatcgcc
     2041 accctcttgg ttaaccctac ttccttcccc tgtccattga accagcccct tgtggcctcc
     2101 tctgtctcac ccttaattgt ttctggcaat tctgtgaatc ttcctatacc atccacccct
     2161 gaagataagg cccacatgaa tgtggacatt gcttgtgctg tggctgatgg ggaaaatgcc
     2221 tttcagggcc tagaacccaa attagagccc caggaactat ctcctctctc tgctactgtt
     2281 ttccccaaag tggaacatag cccagggcct ccaccagtcg ataaacagtg ccaagaagga
     2341 ttgtcagaga acagtgccta tcgctggacc gttgtgaaaa cagaggaggg aaggcaagct
     2401 ctggagccgc tccctcaggg catccaggag tctctaaaca actcttcccc tggggattta
     2461 gaggaagttg tcaagatgga acctgaagat gctacagagg aaatcagtgg atttctttga
     2521 gctaggagaa taagagtctg gagactggga gccttcactt cggcctccga ttggtggcgc
     2581 atagggtgta accaatagga aacccctaaa gggtacttaa accccagatt ttgcaactgg
     2641 ggctcttgag cagcttgctt tagcctgctc ccactctgtg gaatatactt ttgcttcaat
     2701 aaatctgtgc ttttattgct tca
//
