LOCUS       NM_003403               6534 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens YY1 transcription factor (YY1), mRNA.
ACCESSION   NM_003403
VERSION     NM_003403.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6534)
  AUTHORS   Yin,X., Wang,J., Shen,Z., Jia,Q., Bian,Y., Yang,Z., Liu,Y., Li,Y.
            and Zhang,H.
  TITLE     ENAH transcriptionally activated by YY1 promotes growth and
            invasion of laryngocarcinoma cells through PI3K/AKT signaling
  JOURNAL   Eur J Pharmacol 983, 176991 (2024)
   PUBMED   39265883
  REMARK    GeneRIF: ENAH transcriptionally activated by YY1 promotes growth
            and invasion of laryngocarcinoma cells through PI3K/AKT signaling.
REFERENCE   2  (bases 1 to 6534)
  AUTHORS   Yang,G., Shi,X., Zhang,M., Wang,K., Tian,X. and Wang,X.
  TITLE     DEAD/H-box helicase 11 is transcriptionally activated by Yin Yang-1
            and accelerates oral squamous cell carcinoma progression
  JOURNAL   Cell Biol Int 48 (11), 1731-1742 (2024)
   PUBMED   39090819
  REMARK    GeneRIF: DEAD/H-box helicase 11 is transcriptionally activated by
            Yin Yang-1 and accelerates oral squamous cell carcinoma
            progression.
REFERENCE   3  (bases 1 to 6534)
  AUTHORS   Liang,S., Zhu,L., Yang,F. and Dong,H.
  TITLE     Transcription factor YY1-activated GNG5 facilitates glioblastoma
            cell growth, invasion, stemness and glycolysis through
            Wnt/beta-catenin pathway
  JOURNAL   Sci Rep 14 (1), 25234 (2024)
   PUBMED   39448763
  REMARK    GeneRIF: Transcription factor YY1-activated GNG5 facilitates
            glioblastoma cell growth, invasion, stemness and glycolysis through
            Wnt/beta-catenin pathway.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6534)
  AUTHORS   Zhou,Y., Chen,Y., Zhao,P., Xian,T., Gao,Y., Fan,S., Fang,J.H.,
            Huang,M. and Bi,H.
  TITLE     The YY1-CPT1C signaling axis modulates the proliferation and
            metabolism of pancreatic tumor cells under hypoxia
  JOURNAL   Biochem Pharmacol 227, 116422 (2024)
   PUBMED   38996932
  REMARK    GeneRIF: The YY1-CPT1C signaling axis modulates the proliferation
            and metabolism of pancreatic tumor cells under hypoxia.
REFERENCE   5  (bases 1 to 6534)
  AUTHORS   Antonio-Andres,G., Morales-Martinez,M., Jimenez-Hernandez,E. and
            Huerta-Yepez,S.
  TITLE     The Role of PTEN in Chemoresistance Mediated by the HIF-1alpha/YY1
            Axis in Pediatric Acute Lymphoblastic Leukemia
  JOURNAL   Int J Mol Sci 25 (14), 7767 (2024)
   PUBMED   39063014
  REMARK    GeneRIF: The Role of PTEN in Chemoresistance Mediated by the
            HIF-1alpha/YY1 Axis in Pediatric Acute Lymphoblastic Leukemia.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6534)
  AUTHORS   Yang,W.M., Inouye,C.J. and Seto,E.
  TITLE     Cyclophilin A and FKBP12 interact with YY1 and alter its
            transcriptional activity
  JOURNAL   J Biol Chem 270 (25), 15187-15193 (1995)
   PUBMED   7541038
REFERENCE   7  (bases 1 to 6534)
  AUTHORS   Lee,J.S., Galvin,K.M., See,R.H., Eckner,R., Livingston,D., Moran,E.
            and Shi,Y.
  TITLE     Relief of YY1 transcriptional repression by adenovirus E1A is
            mediated by E1A-associated protein p300
  JOURNAL   Genes Dev 9 (10), 1188-1198 (1995)
   PUBMED   7758944
  REMARK    Erratum:[Genes Dev 1995 Aug 1;9(15):1948-9]
REFERENCE   8  (bases 1 to 6534)
  AUTHORS   Nabais Sa,M.J., Gabriele,M., Testa,G. and de Vries,B.B.A.
  TITLE     Gabriele-de Vries Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   31145572
REFERENCE   9  (bases 1 to 6534)
  AUTHORS   Park,K. and Atchison,M.L.
  TITLE     Isolation of a candidate repressor/activator, NF-E1 (YY-1, delta),
            that binds to the immunoglobulin kappa 3' enhancer and the
            immunoglobulin heavy-chain mu E1 site
  JOURNAL   Proc Natl Acad Sci U S A 88 (21), 9804-9808 (1991)
   PUBMED   1946405
REFERENCE   10 (bases 1 to 6534)
  AUTHORS   Shi,Y., Seto,E., Chang,L.S. and Shenk,T.
  TITLE     Transcriptional repression by YY1, a human GLI-Kruppel-related
            protein, and relief of repression by adenovirus E1A protein
  JOURNAL   Cell 67 (2), 377-388 (1991)
   PUBMED   1655281
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC037308.1, DA234524.1 and
            AL157871.5.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_003403.4.
            
            Summary: YY1 is a ubiquitously distributed transcription factor
            belonging to the GLI-Kruppel class of zinc finger proteins. The
            protein is involved in repressing and activating a diverse number
            of promoters.  YY1 may direct histone deacetylases and histone
            acetyltransferases to a promoter in order to activate or repress
            the promoter, thus implicating histone modification in the function
            of YY1. [provided by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.180557.1,
                                           SRR1803617.36481.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000262238.10/ ENSP00000262238.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1891              BC037308.1         12-1902
            1892-2216           BC037308.1         1904-2228
            2217-2780           DA234524.1         25-588
            2781-6534           AL157871.5         87007-90760
FEATURES             Location/Qualifiers
     source          1..6534
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q32.2"
     gene            1..6534
                     /gene="YY1"
                     /gene_synonym="DELTA; GADEVS; INO80S; NF-E1; UCRBP;
                     YIN-YANG-1"
                     /note="YY1 transcription factor"
                     /db_xref="GeneID:7528"
                     /db_xref="HGNC:HGNC:12856"
                     /db_xref="MIM:600013"
     exon            1..780
                     /gene="YY1"
                     /gene_synonym="DELTA; GADEVS; INO80S; NF-E1; UCRBP;
                     YIN-YANG-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             102..1346
                     /gene="YY1"
                     /gene_synonym="DELTA; GADEVS; INO80S; NF-E1; UCRBP;
                     YIN-YANG-1"
                     /note="Yin and Yang 1 protein; INO80 complex subunit S;
                     YY-1; delta transcription factor"
                     /codon_start=1
                     /product="transcriptional repressor protein YY1"
                     /protein_id="NP_003394.1"
                     /db_xref="CCDS:CCDS9957.1"
                     /db_xref="GeneID:7528"
                     /db_xref="HGNC:HGNC:12856"
                     /db_xref="MIM:600013"
                     /translation="MASGDTLYIATDGSEMPAEIVELHEIEVETIPVETIETTVVGEE
                     EEEDDDDEDGGGGDHGGGGGHGHAGHHHHHHHHHHHPPMIALQPLVTDDPTQVHHHQE
                     VILVQTREEVVGGDDSDGLRAEDGFEDQILIPVPAPAGGDDDYIEQTLVTVAAAGKSG
                     GGGSSSSGGGRVKKGGGKKSGKKSYLSGGAGAAGGGGADPGNKKWEQKQVQIKTLEGE
                     FSVTMWSSDEKKDIDHETVVEEQIIGENSPPDYSEYMTGKKLPPGGIPGIDLSDPKQL
                     AEFARMKPRKIKEDDAPRTIACPHKGCTKMFRDNSAMRKHLHTHGPRVHVCAECGKAF
                     VESSKLKRHQLVHTGEKPFQCTFEGCGKRFSLDFNLRTHVRIHTGDRPYVCPFDGCNK
                     KFAQSTNLKSHILTHAKAKNNQ"
     exon            781..943
                     /gene="YY1"
                     /gene_synonym="DELTA; GADEVS; INO80S; NF-E1; UCRBP;
                     YIN-YANG-1"
                     /inference="alignment:Splign:2.1.0"
     exon            944..1004
                     /gene="YY1"
                     /gene_synonym="DELTA; GADEVS; INO80S; NF-E1; UCRBP;
                     YIN-YANG-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..1163
                     /gene="YY1"
                     /gene_synonym="DELTA; GADEVS; INO80S; NF-E1; UCRBP;
                     YIN-YANG-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1164..6534
                     /gene="YY1"
                     /gene_synonym="DELTA; GADEVS; INO80S; NF-E1; UCRBP;
                     YIN-YANG-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2311..2316
                     /regulatory_class="polyA_signal_sequence"
                     /gene="YY1"
                     /gene_synonym="DELTA; GADEVS; INO80S; NF-E1; UCRBP;
                     YIN-YANG-1"
                     /note="hexamer: AATAAA"
     polyA_site      2335
                     /gene="YY1"
                     /gene_synonym="DELTA; GADEVS; INO80S; NF-E1; UCRBP;
                     YIN-YANG-1"
                     /note="major polyA site"
     regulatory      6511..6516
                     /regulatory_class="polyA_signal_sequence"
                     /gene="YY1"
                     /gene_synonym="DELTA; GADEVS; INO80S; NF-E1; UCRBP;
                     YIN-YANG-1"
                     /note="hexamer: AATAAA"
     polyA_site      6534
                     /gene="YY1"
                     /gene_synonym="DELTA; GADEVS; INO80S; NF-E1; UCRBP;
                     YIN-YANG-1"
                     /note="major polyA site"
ORIGIN      
        1 ctccctctgc cttccttccc cacggccggc cgcctcctcg cccgcccgcc cgcagccgag
       61 gagccgaggc cgccgcggcc gtggcggcgg agccctcagc catggcctcg ggcgacaccc
      121 tctacatcgc cacggacggc tcggagatgc cggccgagat cgtggagctg cacgagatcg
      181 aggtggagac catcccggtg gagaccatcg agaccacagt ggtgggcgag gaggaggagg
      241 aggacgacga cgacgaggac ggcggcggtg gcgaccacgg cggcgggggc ggccacgggc
      301 acgccggcca ccaccaccac caccatcacc accaccacca cccgcccatg atcgctctgc
      361 agccgctggt caccgacgac ccgacccagg tgcaccacca ccaggaggtg atcctggtgc
      421 agacgcgcga ggaggtggtg ggcggcgacg actcggacgg gctgcgcgcc gaggacggct
      481 tcgaggatca gattctcatc ccggtgcccg cgccggccgg cggcgacgac gactacattg
      541 aacaaacgct ggtcaccgtg gcggcggccg gcaagagcgg cggcggcggc tcgtcgtcgt
      601 cgggaggcgg ccgcgtcaag aagggcggcg gcaagaagag cggcaagaag agttacctca
      661 gcggcggggc cggcgcggcg ggcggcggcg gcgccgaccc gggcaacaag aagtgggagc
      721 agaagcaggt gcagatcaag accctggagg gcgagttctc ggtcaccatg tggtcctcag
      781 atgaaaaaaa agatattgac catgagacag tggttgaaga acagatcatt ggagagaact
      841 cacctcctga ttattcagaa tatatgacag gaaagaaact tcctcctgga ggaatacctg
      901 gcattgacct ctcagatccc aaacaactgg cagaatttgc tagaatgaag ccaagaaaaa
      961 ttaaagaaga tgatgctcca agaacaatag cttgccctca taaaggctgc acaaagatgt
     1021 tcagggataa ctcggccatg agaaaacatc tgcacaccca cggtcccaga gtccacgtct
     1081 gtgcagaatg tggcaaagct tttgttgaga gttcaaaact aaaacgacac caactggttc
     1141 atactggaga gaagcccttt cagtgcacgt tcgaaggctg tgggaaacgc ttttcactgg
     1201 acttcaattt gcgcacacat gtgcgaatcc ataccggaga caggccctat gtgtgcccct
     1261 tcgatggttg taataagaag tttgctcagt caactaacct gaaatctcac atcttaacac
     1321 atgctaaggc caaaaacaac cagtgaaaag aagagagaag acccttctcg accacgggaa
     1381 gcatcttcca gaagtgtgat tgggaataaa tatgcctctc ctttgtatat tatttctagg
     1441 aagaatttta aaaatgaatc ctacacacct aagggacatg ttttgataaa gtagtaaaaa
     1501 ttaaaaaaaa aaaactttac taagatgaca ttgctaagat gctctatctt gctctgtaat
     1561 ctcgtttcaa aaacacagtg tttttgtaaa gtgtggtccc aacaggagga caattcatga
     1621 acttcgcatc aaaagacaat tctttataca acagtgctaa aaatgggact tcttttcaca
     1681 ttcttataaa tatgaagctc acctgttgct tacaattttt ttaattttgt attttccaag
     1741 tgtgcatatt gtacactttt ttggggatat gcttagtaat gctacgtgtg atttttctgg
     1801 aggttgataa ctttgcttgc agtagatttt ctttaaaaga atgggcagtt acatgcatac
     1861 ttcaaaagta ttttcctgta aaaaaaaaaa agttatatag gttttgtttg ctatcttaat
     1921 tttggttgta ttctttgatg ttaacacatt ttgtataatt gtatcgtata gctgtattga
     1981 atcatgtagt atcaaatatt agatgtgatt taatagtgtt aatcaattta aacccatttt
     2041 agtcactttt tttttccaaa aaaatactgc cagatgctga tgttcagtgt aatttctttg
     2101 cctgttcagt tacagaaagt ggtgctcagt tgtagaatgt attgtacctt ttaacacctg
     2161 atgtgtacat cccatgtaac agaaagggca acaataaaat agcaatccta aagcaagaat
     2221 atggcagaac aagatctgta agcacagtct tattttcttt tgttgtccag aatacttata
     2281 attcttgagc ctcccagaaa ttggaagcta aataaagcaa ctcaagtttc ctttattttg
     2341 cactcaatta cagtgattat tgatgaaagc gatgcatgga tattttaata cttcctacat
     2401 gtcctgactt ctgaaagaga gtaggtaaca ggcatcccga gttcaggaac tacctcagaa
     2461 caccccaggc caggttggtc ataggctgtg attttagccc ccggcaagtg tgagtgaagc
     2521 atctgtacca ccgcgcaggc tgagcgcctg cgcagggtaa ggtgccacct ggcagtgggg
     2581 cacacagagg gaagaccagg cctgtccatc agccggctgc cttcagaggc agctccagca
     2641 ggaccttggc ttgtctgaca ggaaatgctt gtggtcgttg gttatttggt ttgagagccc
     2701 ttgttcctcc atctagtgga gtccttatta aatgctagca atgtggcaat tgagtgccag
     2761 tagcttaatt tcatgtttct aaatggacac tgggtgcaaa tcggcaaggt gattagatta
     2821 ttagaaaatt ctgctcaatg agtacctctc acattgtaac ctcttaaatg tacgattata
     2881 atgttggatc ttaggtcaaa taacagactt gagaatactt tataaactgc catgatacag
     2941 caaaatctca tttattcaaa gtgcaaacat actgtgtgtc tttctgtttt gtgtatgctt
     3001 gactgcaaga taaatgacaa actagctaat atccgagatt tatttacaaa tggccaggga
     3061 ccccatcagg tgaaacacat agcccattgt cttagagctt ctccatcggt cctgtacagg
     3121 aggattggtg acctactaac agtgaccctg tggctctgtg gaattttgaa gtgccttttg
     3181 tgaatcatga atgaaacatt taacttgaga ccctttaaaa aattcatcca gaatctgtta
     3241 ccccttgggt agtttgatgg aactgagtta agcagaagac cccagctgtt ttctgggtaa
     3301 gccaggcttt gctgtatctg gcagtcagga gagaggtcag cccatggtgg aggtcttcag
     3361 tgccgagggc tcggatgaga acgtgtagtt ctttgacttg gacctgggca gcgtcttcta
     3421 tggatgcctg ccttgtgagc acccacacct tccctcccca ctgtcgggtt gagtagcccc
     3481 agcgtggctg tgttaggagt cctttgccca acattgtgct gcactggagc ctggccctgg
     3541 cactgtcctc aggaccctgc ccaagggccc accgcagagc acacctatgc tatggggagc
     3601 cctgctggca gccccgagag ccatgccatg gcctgcagga gccaggctcc tgtgtggatg
     3661 aagtccctct tcctctgtgc cttgatccct tgggggtgcc tttggtcatc tcttctgtcc
     3721 tttcctgtct ctgaaatagt catcactccc cttgactctc tctgttcacg tcttctcagt
     3781 ctgcagagtt aacttctgta aggagtttaa tctggggttc caagaaaaca agttccttgt
     3841 taacatagca ctgactttgc aacaatagaa aactaacaaa tgagcaacaa tataaagagt
     3901 agaggtagtt ctcattgggt gtaacttcaa cccattctgc ttgtggttag aatttataat
     3961 tttgctaacg atgtaattta ctaaggtttg aaatggtatt ctaacagtga gtccattgtc
     4021 ttgaggatta atctgattta taagtaatac tgatagacat attttcgtac atctgagcag
     4081 aaataaatgc atgtttctag catatgtaat ataaaaactc cagaggataa gtttacactt
     4141 aacaagatgt tgttttctat ttttgaattt cttattattt cccccttttt ggtagtggag
     4201 ttgagagggg gagcatacta tttgtataaa gaactgtcac cccagagtga catttatttt
     4261 ccaagatgac cctgaactca tgctgttggt ttcatatggt gtttgtgtgc tttgcctaga
     4321 ttcaaggcct gaggatttga ggaaaatcgg gatttttttt ttcctatttg gttttcatgt
     4381 aaaagttcta aatgtcactt attttgctaa ataagaccct ttcacaggat agtgtgcgca
     4441 atacctgtcc gtgtttccaa gcagagttca agttcatgtc ttcacaagta gatgagagtc
     4501 acttccagtc gggggaagcc cgcctgagca gtgttttgag agtgcgtaca ttggaggact
     4561 gccccacgtc cgtttgcact ctgccttgca aaacttactg tggagacgtg tcccagactg
     4621 gtctcagacc agagtttgtg gcacaggaaa acctggcccc ctaaaaagaa gttttggaat
     4681 tggaagcctg ataatttcgg gaggctgagg caggagaacg gcgtgaaccc gggaggcgga
     4741 gcttgcagtg agccgagatc gcaccactgc actccagcct gggtgacaga gcaagactcc
     4801 gtctcccaaa aaaaaaaaaa aaaaaaaaaa aaaggaaacc tgacaattct acccacctcc
     4861 ccccaccccc gactataggc aaagagagtt gatcacttcc agggtctctg acttctgtga
     4921 cctggaaatc agcctggctt gggaaattca tgttgttgat ctttaattat ttaattattc
     4981 tttaataatc cttctatttt cttgacatct gacccccagc aagagtaagg atcccagagg
     5041 tcaaaacagt ggtgagagcc aagctgctca cagacaccca cttgatgcca cagccatgcc
     5101 atgaggcttc ctcccagctg ctctgctggc ttgctgaagc cagctctgag tcacagggtt
     5161 gccttggacc ctcggctgta gggggcacct gtctggctcc gggccctttg tcctggatac
     5221 actgacagta atgtgagcgc agcacttcag agttcaggcc cagcaggtcc tggcaagtgc
     5281 attccacccg aacttttaac ccaagcggtg gggaaggaag ccaaaactcc aagctgcact
     5341 ttcttggggt tctggccatg cacttcttag ccttctctct gactttacag gacaaaaggt
     5401 accccacgcc ttcagaatca tgcttacctg cacggcagca tctgactgga tggctggcta
     5461 ggtctcatcc accccaaatt actgaccctt gatttatgtt gttactgctc aggttatgct
     5521 cagatgccct ggttgcctga agatggttta agtgcaggcc cttcagacaa gtcacgtcag
     5581 gcaagagagg gctggcctct gacccacaag agggcagatt tgtggccaag aggcttcctg
     5641 gcatccaccc ccaggcccaa gggatcagtg tggtgccaga gaggatcttt aagctgggac
     5701 tgtactgagg cttgatggga agtatgggca gcatgtactt gacacgttat cacccagtcc
     5761 ccttgtaaaa tctggaatgg agcgtttaag ctgagcgtta gcatcaggtc agcaggcaaa
     5821 gcaaacctcc cacaaactgg gtgccgtaag gtgggaggtg acacatggag agcttcgtcc
     5881 tggccgagca ggcacccagc cccatgtccc ccgccagcat tctggatgtc agaggagggt
     5941 gcgtgtgatg gcgtcacatt catctgaagc acactgattg attttccaca aggtggcaag
     6001 tttgatcaaa ttgaccgctt ttcatgagac acccagatgc tgtaaaaaaa aaaaacagca
     6061 ctgggatgtg ttgaggaggg ggcagtttgc tgtgctctgt tctgtctgct gctctctctg
     6121 ggggccgcac aatgtccgca cacatcacgg aggggagaaa ggcatcagta ccaaacggaa
     6181 caacctcttt tttctacatt gtccataccc ggacatgtga ggctctatta tcaacaggtg
     6241 gtgagaaaaa ttatgttttt attcgctttc tggtaacttc tgtaggccct ggctcaagga
     6301 cttagcattt cgtctcatgt acatcttttt cttaagtgtt ctttgccatt tctggaattg
     6361 tccttggttt ttccttagct cataggtcat agatgcagaa atatagtatt taaggcatcc
     6421 gcatccagca tcagatggct ttgcatccag aaaaacattg ataactcagt ttgaagcacc
     6481 aagcatgtgt aatatggctc tatacaatat aataaatgca taatgttaag cttt
//
