LOCUS       NM_145690               5011 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens tyrosine 3-monooxygenase/tryptophan 5-monooxygenase
            activation protein zeta (YWHAZ), transcript variant 2, mRNA.
ACCESSION   NM_145690
VERSION     NM_145690.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5011)
  AUTHORS   Khoroshkin,M., Buyan,A., Dodel,M., Navickas,A., Yu,J., Trejo,F.,
            Doty,A., Baratam,R., Zhou,S., Lee,S.B., Joshi,T., Garcia,K.,
            Choi,B., Miglani,S., Subramanyam,V., Modi,H., Carpenter,C.,
            Markett,D., Corces,M.R., Mardakheh,F.K., Kulakovskiy,I.V. and
            Goodarzi,H.
  TITLE     Systematic identification of post-transcriptional regulatory
            modules
  JOURNAL   Nat Commun 15 (1), 7872 (2024)
   PUBMED   39251607
  REMARK    Erratum:[Nat Commun. 2024 Oct 28;15(1):9277. doi:
            10.1038/s41467-024-52903-4.. PMID: 39468017]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5011)
  AUTHORS   Lughmani,H., Patel,H. and Chakravarti,R.
  TITLE     Structural Features and Physiological Associations of Human
            14-3-3zeta Pseudogenes
  JOURNAL   Genes (Basel) 15 (4), 399 (2024)
   PUBMED   38674334
  REMARK    GeneRIF: Structural Features and Physiological Associations of
            Human 14-3-3zeta Pseudogenes.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5011)
  AUTHORS   Shi,L., Wang,X., Guo,S., Gou,H., Shang,H., Jiang,X., Wei,C.,
            Wang,J., Li,C., Wang,L., Zhao,Z., Yu,W. and Yu,J.
  TITLE     TMEM65 promotes gastric tumorigenesis by targeting YWHAZ to
            activate PI3K-Akt-mTOR pathway and is a therapeutic target
  JOURNAL   Oncogene 43 (13), 931-943 (2024)
   PUBMED   38341472
  REMARK    GeneRIF: TMEM65 promotes gastric tumorigenesis by targeting YWHAZ
            to activate PI3K-Akt-mTOR pathway and is a therapeutic target.
REFERENCE   4  (bases 1 to 5011)
  AUTHORS   Mukherjee,S., Roy,S., Mukherjee,S., Harikishore,A., Bhunia,A. and
            Mandal,A.K.
  TITLE     14-3-3 interaction with phosphodiesterase 8A sustains PKA signaling
            and downregulates the MAPK pathway
  JOURNAL   J Biol Chem 300 (3), 105725 (2024)
   PUBMED   38325743
  REMARK    GeneRIF: 14-3-3 interaction with phosphodiesterase 8A sustains PKA
            signaling and downregulates the MAPK pathway.
REFERENCE   5  (bases 1 to 5011)
  AUTHORS   Qiang,Q., Skudder-Hill,L., Toyota,T., Huang,Z., Wei,W. and
            Adachi,H.
  CONSRTM   Alzheimer's Disease Neuroimaging Initiative
  TITLE     CSF 14-3-3 zeta(zeta) isoform is associated with tau pathology and
            cognitive decline in Alzheimer's disease
  JOURNAL   J Neurol Sci 457, 122861 (2024)
   PUBMED   38194803
  REMARK    GeneRIF: CSF 14-3-3 zeta(zeta) isoform is associated with tau
            pathology and cognitive decline in Alzheimer's disease.
REFERENCE   6  (bases 1 to 5011)
  AUTHORS   Koyama,S., Williams,L.T. and Kikuchi,A.
  TITLE     Characterization of the interaction of Raf-1 with ras p21 or 14-3-3
            protein in intact cells
  JOURNAL   FEBS Lett 368 (2), 321-325 (1995)
   PUBMED   7628630
REFERENCE   7  (bases 1 to 5011)
  AUTHORS   Liu,D., Bienkowska,J., Petosa,C., Collier,R.J., Fu,H. and
            Liddington,R.
  TITLE     Crystal structure of the zeta isoform of the 14-3-3 protein
  JOURNAL   Nature 376 (6536), 191-194 (1995)
   PUBMED   7603574
REFERENCE   8  (bases 1 to 5011)
  AUTHORS   Sato,T., Irie,S., Kitada,S. and Reed,J.C.
  TITLE     FAP-1: a protein tyrosine phosphatase that associates with Fas
  JOURNAL   Science 268 (5209), 411-415 (1995)
   PUBMED   7536343
REFERENCE   9  (bases 1 to 5011)
  AUTHORS   Kawamoto,S., Shoji,M., Setoguchi,Y., Kato,M., Hashizume,S.,
            Ichikawa,A., Osada,K., Katakura,Y., Tachibana,H. and Murakami,H.
  TITLE     Molecular cloning of the 31 kDa cytosolic phospholipase A2, as an
            antigen recognized by the lung cancer-specific human monoclonal
            antibody, AE6F4
  JOURNAL   Cytotechnology 17 (2), 103-108 (1995)
   PUBMED   7547034
REFERENCE   10 (bases 1 to 5011)
  AUTHORS   Zupan,L.A., Steffens,D.L., Berry,C.A., Landt,M. and Gross,R.W.
  TITLE     Cloning and expression of a human 14-3-3 protein mediating
            phospholipolysis. Identification of an arachidonoyl-enzyme
            intermediate during catalysis
  JOURNAL   J Biol Chem 267 (13), 8707-8710 (1992)
   PUBMED   1577711
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC072426.1, BM783874.1 and
            AC027373.11.
            
            On Nov 23, 2018 this sequence version replaced NM_145690.2.
            
            Summary: This gene product belongs to the 14-3-3 family of proteins
            which mediate signal transduction by binding to
            phosphoserine-containing proteins. This highly conserved protein
            family is found in both plants and mammals, and this protein is 99%
            identical to the mouse, rat and sheep orthologs. The encoded
            protein interacts with IRS1 protein, suggesting a role in
            regulating insulin sensitivity. Several transcript variants that
            differ in the 5' UTR but that encode the same protein have been
            identified for this gene. [provided by RefSeq, Oct 2008].
            
            Transcript Variant: This variant (2) represents the longest
            transcript. All six transcripts encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.267178.1,
                                           SRR1660803.129561.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMEA2155770
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000395958.6/ ENSP00000379288.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2851              BC072426.1         5-2855
            2852-2958           BM783874.1         221-327
            2959-5011           AC027373.11        9751-11803
FEATURES             Location/Qualifiers
     source          1..5011
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q22.3"
     gene            1..5011
                     /gene="YWHAZ"
                     /gene_synonym="14-3-3-zeta; HEL-S-3; HEL-S-93; HEL4;
                     KCIP-1; POPCHAS; YWHAD"
                     /note="tyrosine 3-monooxygenase/tryptophan 5-monooxygenase
                     activation protein zeta"
                     /db_xref="GeneID:7534"
                     /db_xref="HGNC:HGNC:12855"
                     /db_xref="MIM:601288"
     exon            1..92
                     /gene="YWHAZ"
                     /gene_synonym="14-3-3-zeta; HEL-S-3; HEL-S-93; HEL4;
                     KCIP-1; POPCHAS; YWHAD"
                     /inference="alignment:Splign:2.1.0"
     exon            93..397
                     /gene="YWHAZ"
                     /gene_synonym="14-3-3-zeta; HEL-S-3; HEL-S-93; HEL4;
                     KCIP-1; POPCHAS; YWHAD"
                     /inference="alignment:Splign:2.1.0"
     CDS             104..841
                     /gene="YWHAZ"
                     /gene_synonym="14-3-3-zeta; HEL-S-3; HEL-S-93; HEL4;
                     KCIP-1; POPCHAS; YWHAD"
                     /note="14-3-3 delta; tyrosine 3-monooxygenase/tryptophan
                     5-monooxygenase activation protein, delta polypeptide;
                     14-3-3 zeta; phospholipase A2; protein kinase C inhibitor
                     protein-1; tyrosine 3/tryptophan 5 -monooxygenase
                     activation protein, zeta polypeptide; 14-3-3
                     protein/cytosolic phospholipase A2; epididymis secretory
                     protein Li 93; tyrosine 3-monooxygenase/tryptophan
                     5-monooxygenase activation protein, zeta polypeptide;
                     epididymis secretory protein Li 3; epididymis luminal
                     protein 4"
                     /codon_start=1
                     /product="14-3-3 protein zeta/delta"
                     /protein_id="NP_663723.1"
                     /db_xref="CCDS:CCDS6290.1"
                     /db_xref="GeneID:7534"
                     /db_xref="HGNC:HGNC:12855"
                     /db_xref="MIM:601288"
                     /translation="MDKNELVQKAKLAEQAERYDDMAACMKSVTEQGAELSNEERNLL
                     SVAYKNVVGARRSSWRVVSSIEQKTEGAEKKQQMAREYREKIETELRDICNDVLSLLE
                     KFLIPNASQAESKVFYLKMKGDYYRYLAEVAAGDDKKGIVDQSQQAYQEAFEISKKEM
                     QPTHPIRLGLALNFSVFYYEILNSPEKACSLAKTAFDEAIAELDTLSEESYKDSTLIM
                     QLLRDNLTLWTSDTQGDEAEAGEGGEN"
     exon            398..521
                     /gene="YWHAZ"
                     /gene_synonym="14-3-3-zeta; HEL-S-3; HEL-S-93; HEL4;
                     KCIP-1; POPCHAS; YWHAD"
                     /inference="alignment:Splign:2.1.0"
     exon            522..685
                     /gene="YWHAZ"
                     /gene_synonym="14-3-3-zeta; HEL-S-3; HEL-S-93; HEL4;
                     KCIP-1; POPCHAS; YWHAD"
                     /inference="alignment:Splign:2.1.0"
     exon            686..781
                     /gene="YWHAZ"
                     /gene_synonym="14-3-3-zeta; HEL-S-3; HEL-S-93; HEL4;
                     KCIP-1; POPCHAS; YWHAD"
                     /inference="alignment:Splign:2.1.0"
     exon            782..5011
                     /gene="YWHAZ"
                     /gene_synonym="14-3-3-zeta; HEL-S-3; HEL-S-93; HEL4;
                     KCIP-1; POPCHAS; YWHAD"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2788..2793
                     /regulatory_class="polyA_signal_sequence"
                     /gene="YWHAZ"
                     /gene_synonym="14-3-3-zeta; HEL-S-3; HEL-S-93; HEL4;
                     KCIP-1; POPCHAS; YWHAD"
                     /note="hexamer: AATAAA"
     polyA_site      2807
                     /gene="YWHAZ"
                     /gene_synonym="14-3-3-zeta; HEL-S-3; HEL-S-93; HEL4;
                     KCIP-1; POPCHAS; YWHAD"
     polyA_site      2851
                     /gene="YWHAZ"
                     /gene_synonym="14-3-3-zeta; HEL-S-3; HEL-S-93; HEL4;
                     KCIP-1; POPCHAS; YWHAD"
                     /note="major polyA site"
     regulatory      2886..2891
                     /regulatory_class="polyA_signal_sequence"
                     /gene="YWHAZ"
                     /gene_synonym="14-3-3-zeta; HEL-S-3; HEL-S-93; HEL4;
                     KCIP-1; POPCHAS; YWHAD"
                     /note="hexamer: ATTAAA"
     polyA_site      2915
                     /gene="YWHAZ"
                     /gene_synonym="14-3-3-zeta; HEL-S-3; HEL-S-93; HEL4;
                     KCIP-1; POPCHAS; YWHAD"
     regulatory      2940..2945
                     /regulatory_class="polyA_signal_sequence"
                     /gene="YWHAZ"
                     /gene_synonym="14-3-3-zeta; HEL-S-3; HEL-S-93; HEL4;
                     KCIP-1; POPCHAS; YWHAD"
                     /note="hexamer: AATAAA"
     polyA_site      2981
                     /gene="YWHAZ"
                     /gene_synonym="14-3-3-zeta; HEL-S-3; HEL-S-93; HEL4;
                     KCIP-1; POPCHAS; YWHAD"
     polyA_site      2988
                     /gene="YWHAZ"
                     /gene_synonym="14-3-3-zeta; HEL-S-3; HEL-S-93; HEL4;
                     KCIP-1; POPCHAS; YWHAD"
     regulatory      4649..4654
                     /regulatory_class="polyA_signal_sequence"
                     /gene="YWHAZ"
                     /gene_synonym="14-3-3-zeta; HEL-S-3; HEL-S-93; HEL4;
                     KCIP-1; POPCHAS; YWHAD"
                     /note="hexamer: ATTAAA"
     polyA_site      4667
                     /gene="YWHAZ"
                     /gene_synonym="14-3-3-zeta; HEL-S-3; HEL-S-93; HEL4;
                     KCIP-1; POPCHAS; YWHAD"
     polyA_site      5011
                     /gene="YWHAZ"
                     /gene_synonym="14-3-3-zeta; HEL-S-3; HEL-S-93; HEL4;
                     KCIP-1; POPCHAS; YWHAD"
ORIGIN      
        1 gacagagtct cagcctcgcc gctgctgccg ccgccgccgc ccagagactg ctgagcccgt
       61 ccgtccgccg ccaccaccca ctccggacac agaacatcca gtcatggata aaaatgagct
      121 ggttcagaag gccaaactgg ccgagcaggc tgagcgatat gatgacatgg cagcctgcat
      181 gaagtctgta actgagcaag gagctgaatt atccaatgag gagaggaatc ttctctcagt
      241 tgcttataaa aatgttgtag gagcccgtag gtcatcttgg agggtcgtct caagtattga
      301 acaaaagacg gaaggtgctg agaaaaaaca gcagatggct cgagaataca gagagaaaat
      361 tgagacggag ctaagagata tctgcaatga tgtactgtct cttttggaaa agttcttgat
      421 ccccaatgct tcacaagcag agagcaaagt cttctatttg aaaatgaaag gagattacta
      481 ccgttacttg gctgaggttg ccgctggtga tgacaagaaa gggattgtcg atcagtcaca
      541 acaagcatac caagaagctt ttgaaatcag caaaaaggaa atgcaaccaa cacatcctat
      601 cagactgggt ctggccctta acttctctgt gttctattat gagattctga actccccaga
      661 gaaagcctgc tctcttgcaa agacagcttt tgatgaagcc attgctgaac ttgatacatt
      721 aagtgaagag tcatacaaag acagcacgct aataatgcaa ttactgagag acaacttgac
      781 attgtggaca tcggataccc aaggagacga agctgaagca ggagaaggag gggaaaatta
      841 accggccttc caacttttgt ctgcctcatt ctaaaattta cacagtagac catttgtcat
      901 ccatgctgtc ccacaaatag ttttttgttt acgatttatg acaggtttat gttacttcta
      961 tttgaatttc tatatttccc atgtggtttt tatgtttaat attaggggag tagagccagt
     1021 taacatttag ggagttatct gttttcatct tgaggtggcc aatatgggga tgtggaattt
     1081 ttatacaagt tataagtgtt tggcatagta cttttggtac attgtggctt caaaagggcc
     1141 agtgtaaaac tgcttccatg tctaagcaaa gaaaactgcc tacatactgg tttgtcctgg
     1201 cggggaataa aagggatcat tggttccagt cacaggtgta gtaattgtgg gtactttaag
     1261 gtttggagca cttacaaggc tgtggtagaa tcatacccca tggataccac atattaaacc
     1321 atgtatatct gtggaatact caatgtgtac acctttgact acagctgcag aagtgttcct
     1381 ttagacaaag ttgtgaccca ttttactctg gataagggca gaaacggttc acattccatt
     1441 atttgtaaag ttacctgctg ttagctttca ttatttttgc tacactcatt ttatttgtat
     1501 ttaaatgttt taggcaacct aagaacaaat gtaaaagtaa agatgcagga aaaatgaatt
     1561 gcttggtatt cattacttca tgtatatcaa gcacagcagt aaaacaaaaa cccatgtatt
     1621 taactttttt ttaggatttt tgcttttgtg attttttttt ttttgatact tgcctaacat
     1681 gcatgtgctg taaaaatagt taacagggaa ataacttgag atgatggcta gctttgttta
     1741 atgtcttatg aaattttcat gaacaatcca agcataattg ttaagaacac gtgtattaaa
     1801 ttcatgtaag tggaataaaa gttttatgaa tggacttttc aactactttc tctacagctt
     1861 ttcatgtaaa ttagtcttgg ttctgaaact tctctaaagg aaattgtaca ttttttgaaa
     1921 tttattcctt attccctctt ggcagctaat gggctcttac caagtttaaa cacaaaattt
     1981 atcataacaa aaatactact aatataacta ctgtttccat gtcccatgat cccctctctt
     2041 cctccccacc ctgaaaaaaa tgagttccta ttttttctgg gagagggggg gattgattag
     2101 aaaaaaatgt agtgtgttcc atttaaaatt ttggcatatg gcattttcta acttaggaag
     2161 ccacaatgtt cttggcccat catgacattg ggtagcatta actgtaagtt ttgtgcttcc
     2221 aaatcacttt ttggttttta agaatttctt gatactctta tagcctgcct tcaattttga
     2281 tcctttattc tttctatttg tcaggtgcac aagattacct tcctgtttta gccttctgtc
     2341 ttgtcaccaa ccattcttac ttggtggcca tgtacttgga aaaaggccgc atgatctttc
     2401 tggctccact cagtgtctaa ggcaccctgc ttcctttgct tgcatcccac agactatttc
     2461 cctcatccta tttactgcag caaatctctc cttagttgat gagactgtgt ttatctccct
     2521 ttaaaaccct acctatcctg aatggtctgt cattgtctgc ctttaaaatc cttcctcttt
     2581 cttcctcctc tattctctaa ataatgatgg ggctaagtta tacccaaagc tcactttaca
     2641 aaatatttcc tcagtacttt gcagaaaaca ccaaacaaaa atgccatttt aaaaaaggtg
     2701 tattttttct tttagaatgt aagctcctca agagcaggga caatgttttc tgtatgttct
     2761 attgtgccta gtacactgta aatgctcaat aaatattgat gatgggaggc agtgagtctt
     2821 gatgataagg gtgagaaact gaaatcccaa acactgtttt gttgcttgtt ttattatgac
     2881 ctcagattaa attgggaaat attggccctt ttgaataatt gtcccaaata ttacattcaa
     2941 ataaaagtgc aatggagacc ttggggtctt tatttccagg agaaaagata ccttctgcat
     3001 ctagggcaac aatccttttc cctcgcagct ctttctttta cctcacttac tgatttctcc
     3061 tgacccccaa gccaaggagg taaaataatt atatatatat atatatatat atatatatat
     3121 atataaagta attatatttt atagctagac tgaagaggtg ggaatttttt tgttgttttt
     3181 tttttttttg gagacaagag tcttgctctg tcacccaggc ttgagtgcag tggtgcgatc
     3241 tcggctgagt gcaacctccg cctgctgggt tcaagcgatt ctcctgcctc agcctcccaa
     3301 gtagctggga ttacaggtgc ccgccaccac acctggctaa tttttgtgtt tttagtagag
     3361 acagggtttc accatgttgt ccaggctggt cttgaattcc cgacctcagg caatccgccc
     3421 atctcaacct cccaaagtgc tgggattaca ggcataagcc accgcgccca gtagagatgt
     3481 gatattattc aagtaaataa aacctgaaac ttggcacatt tgcctattta atgtgcatca
     3541 gtcatctgaa ctaggttgat cctggaataa tgaaaacact tcactagtat taactaatgt
     3601 tttctacata gtagttccca atagattaag gaaaatttcc aacctgagat tctttgtttt
     3661 ggaatttgaa taatgtgttt gtaactattc cttgattgtc ccaaatccag gctttacgtc
     3721 tgcttttgtc aatgtaacat cctagtgcca ggaaattgga aaatccaatg actttttgtg
     3781 tgtaaagtac tggaattttt ttgttcgttt gtttttaaga cggagtgtca actctcgccc
     3841 aggctggggt gcagtggcct gatctcggct cactgcaacc ttctcctccc aggctgaagt
     3901 gattctcctg cctcagcctc gcaagtagct gggactgcag gcatgtgcca ccactcctgg
     3961 ctaattattt gtatttttag tagagagagg gtttcaccgt gttagccatg atggtctcat
     4021 tctcctgacc ttgtgatccg cccacctcgg cctcccaaag tgctgggatt acaggcgtga
     4081 gccactgtgc ccaccctggt atgttttttt taaattggcc acttaagagt tgtccttcag
     4141 aaagtggagc agcagtgtga ttagtaaaaa cgatgggctt tcctgcagct ctggcttatg
     4201 gtctttgttt ttccagttaa cagctgttac ttcatgctgt tatagggggt ggggggagaa
     4261 agagaaagaa tatgtctagt ggcttaattt tggggctcaa tttgtttatt atgtttttcc
     4321 tgcaaaagag tcaccagtct tgtcatggct caatgcatat tttaaaatga gtcaaagcca
     4381 atttggaagc tgctatctta ggttatttgt agtcaggctt caaatggaga gtgaaacttt
     4441 gactttgaaa actggtgctc tatgctcaat gatggtctta cacattcctc tagggaaagg
     4501 tcaagaaata aatttggctt gattgtattc tctcatttac catataggaa atactatggt
     4561 agaactgaaa atatgtacaa tagtaaagtg gtggctgaga ctgggcactt ggaaaataga
     4621 cttggattct tttctaagtg tgaaactaat taaatacttt tatgtgactg gtagtagtca
     4681 cagtctcctt gattgattct agttcctttt caaagtggag agacctgaat atagattgta
     4741 acaggatgtc caaccttgcc agacaagcag gcatatatgt ctctgggatg cagaagcagt
     4801 tacaagttaa tatatttaag cataatgtta gccaatccta ggtgatacca gagatgtgaa
     4861 tatttgatca tatttgagtt cattccttga aagtccaaac ctaactggtc ttaattgatt
     4921 acttcttagt attccgaatt ttagaattta aaaccctatg aattttcagt ttgtgcttac
     4981 attttctaac attggatgtt tgctttggcc a
//
