LOCUS       NM_006826               2196 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens tyrosine 3-monooxygenase/tryptophan 5-monooxygenase
            activation protein theta (YWHAQ), mRNA.
ACCESSION   NM_006826
VERSION     NM_006826.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2196)
  AUTHORS   Khoroshkin,M., Buyan,A., Dodel,M., Navickas,A., Yu,J., Trejo,F.,
            Doty,A., Baratam,R., Zhou,S., Lee,S.B., Joshi,T., Garcia,K.,
            Choi,B., Miglani,S., Subramanyam,V., Modi,H., Carpenter,C.,
            Markett,D., Corces,M.R., Mardakheh,F.K., Kulakovskiy,I.V. and
            Goodarzi,H.
  TITLE     Systematic identification of post-transcriptional regulatory
            modules
  JOURNAL   Nat Commun 15 (1), 7872 (2024)
   PUBMED   39251607
  REMARK    Erratum:[Nat Commun. 2024 Oct 28;15(1):9277. doi:
            10.1038/s41467-024-52903-4.. PMID: 39468017]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2196)
  AUTHORS   Woo,M.S., Nilsson,J., Therriault,J., Rahmouni,N., Brinkmalm,A.,
            Benedet,A.L., Ashton,N.J., Macedo,A.C., Servaes,S., Wang,Y.T.,
            Tissot,C., Arias,J.F., Hosseini,S.A., Chamoun,M., Lussier,F.Z.,
            Karikari,T.K., Stevenson,J., Mayer,C., Ferrari-Souza,J.P.,
            Kobayashi,E., Massarweh,G., Friese,M.A., Pascoal,T.A., Gauthier,S.,
            Zetterberg,H., Blennow,K. and Rosa-Neto,P.
  TITLE     14-3-3 [Formula: see text]-reported early synaptic injury in
            Alzheimer's disease is independently mediated by sTREM2
  JOURNAL   J Neuroinflammation 20 (1), 278 (2023)
   PUBMED   38001539
  REMARK    GeneRIF: 14-3-3 [Formula: see text]-reported early synaptic injury
            in Alzheimer's disease is independently mediated by sTREM2.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2196)
  AUTHORS   Sluchanko,N.N., Kapitonova,A.A., Shulepko,M.A., Kukushkin,I.D.,
            Kulbatskii,D.S., Tugaeva,K.V., Varfolomeeva,L.A., Minyaev,M.E.,
            Boyko,K.M., Popov,V.O., Kirpichnikov,M.P. and Lyukmanova,E.N.
  TITLE     Crystal structure reveals canonical recognition of the
            phosphorylated cytoplasmic loop of human alpha7 nicotinic
            acetylcholine receptor by 14-3-3 protein
  JOURNAL   Biochem Biophys Res Commun 682, 91-96 (2023)
   PUBMED   37804592
  REMARK    GeneRIF: Crystal structure reveals canonical recognition of the
            phosphorylated cytoplasmic loop of human alpha7 nicotinic
            acetylcholine receptor by 14-3-3 protein.
REFERENCE   4  (bases 1 to 2196)
  AUTHORS   Iglesias-Martinez,L.F., Rauch,N., Wynne,K., McCann,B., Kolch,W. and
            Rauch,J.
  TITLE     Interactome dynamics of RAF1-BRAF kinase monomers and dimers
  JOURNAL   Sci Data 10 (1), 203 (2023)
   PUBMED   37045861
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2196)
  AUTHORS   Segal,D., Maier,S., Mastromarco,G.J., Qian,W.W., Nabeel-Shah,S.,
            Lee,H., Moore,G., Lacoste,J., Larsen,B., Lin,Z.Y.,
            Selvabaskaran,A., Liu,K., Smibert,C., Zhang,Z., Greenblatt,J.,
            Peng,J., Lee,H.O., Gingras,A.C. and Taipale,M.
  TITLE     A central chaperone-like role for 14-3-3 proteins in human cells
  JOURNAL   Mol Cell 83 (6), 974-993 (2023)
   PUBMED   36931259
REFERENCE   6  (bases 1 to 2196)
  AUTHORS   Bonnefoy-Berard,N., Liu,Y.C., von Willebrand,M., Sung,A., Elly,C.,
            Mustelin,T., Yoshida,H., Ishizaka,K. and Altman,A.
  TITLE     Inhibition of phosphatidylinositol 3-kinase activity by association
            with 14-3-3 proteins in T cells
  JOURNAL   Proc Natl Acad Sci U S A 92 (22), 10142-10146 (1995)
   PUBMED   7479742
REFERENCE   7  (bases 1 to 2196)
  AUTHORS   Xiao,B., Smerdon,S.J., Jones,D.H., Dodson,G.G., Soneji,Y.,
            Aitken,A. and Gamblin,S.J.
  TITLE     Structure of a 14-3-3 protein and implications for coordination of
            multiple signalling pathways
  JOURNAL   Nature 376 (6536), 188-191 (1995)
   PUBMED   7603573
REFERENCE   8  (bases 1 to 2196)
  AUTHORS   Michaud,N.R., Fabian,J.R., Mathes,K.D. and Morrison,D.K.
  TITLE     14-3-3 is not essential for Raf-1 function: identification of Raf-1
            proteins that are biologically activated in a 14-3-3- and
            Ras-independent manner
  JOURNAL   Mol Cell Biol 15 (6), 3390-3397 (1995)
   PUBMED   7760835
REFERENCE   9  (bases 1 to 2196)
  AUTHORS   Leffers,H., Madsen,P., Rasmussen,H.H., Honore,B., Andersen,A.H.,
            Walbum,E., Vandekerckhove,J. and Celis,J.E.
  TITLE     Molecular cloning and expression of the transformation sensitive
            epithelial marker stratifin. A member of a protein family that has
            been involved in the protein kinase C signalling pathway
  JOURNAL   J Mol Biol 231 (4), 982-998 (1993)
   PUBMED   8515476
REFERENCE   10 (bases 1 to 2196)
  AUTHORS   Nielsen,P.J.
  TITLE     Primary structure of a human protein kinase regulator protein
  JOURNAL   Biochim Biophys Acta 1088 (3), 425-428 (1991)
   PUBMED   2015305
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC093019.1, BC050601.1 and
            AA729400.1.
            
            On Nov 24, 2018 this sequence version replaced NM_006826.3.
            
            Summary: This gene product belongs to the 14-3-3 family of proteins
            which mediate signal transduction by binding to
            phosphoserine-containing proteins. This highly conserved protein
            family is found in both plants and mammals, and this protein is 99%
            identical to the mouse and rat orthologs. This gene is upregulated
            in patients with amyotrophic lateral sclerosis. It contains in its
            5' UTR a 6 bp tandem repeat sequence which is polymorphic, however,
            there is no correlation between the repeat number and the disease.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.172956.1,
                                           SRR1803611.223311.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000238081.8/ ENSP00000238081.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1548              BC093019.1         1-1548
            1549-2186           BC050601.1         1420-2057
            2187-2196           AA729400.1         371-380
FEATURES             Location/Qualifiers
     source          1..2196
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p25.1"
     gene            1..2196
                     /gene="YWHAQ"
                     /gene_synonym="14-3-3; 1C5; HS1"
                     /note="tyrosine 3-monooxygenase/tryptophan 5-monooxygenase
                     activation protein theta"
                     /db_xref="GeneID:10971"
                     /db_xref="HGNC:HGNC:12854"
                     /db_xref="MIM:609009"
     exon            1..57
                     /gene="YWHAQ"
                     /gene_synonym="14-3-3; 1C5; HS1"
                     /inference="alignment:Splign:2.1.0"
     exon            58..433
                     /gene="YWHAQ"
                     /gene_synonym="14-3-3; 1C5; HS1"
                     /inference="alignment:Splign:2.1.0"
     CDS             140..877
                     /gene="YWHAQ"
                     /gene_synonym="14-3-3; 1C5; HS1"
                     /note="14-3-3 protein tau; 14-3-3 protein T-cell; tyrosine
                     3-monooxygenase/tryptophan 5-monooxygenase activation
                     protein, theta polypeptide; 14-3-3 theta"
                     /codon_start=1
                     /product="14-3-3 protein theta"
                     /protein_id="NP_006817.1"
                     /db_xref="CCDS:CCDS1666.1"
                     /db_xref="GeneID:10971"
                     /db_xref="HGNC:HGNC:12854"
                     /db_xref="MIM:609009"
                     /translation="MEKTELIQKAKLAEQAERYDDMATCMKAVTEQGAELSNEERNLL
                     SVAYKNVVGGRRSAWRVISSIEQKTDTSDKKLQLIKDYREKVESELRSICTTVLELLD
                     KYLIANATNPESKVFYLKMKGDYFRYLAEVACGDDRKQTIDNSQGAYQEAFDISKKEM
                     QPTHPIRLGLALNFSVFYYEILNNPELACTLAKTAFDEAIAELDTLNEDSYKDSTLIM
                     QLLRDNLTLWTSDSAGEECDAAEGAEN"
     exon            434..557
                     /gene="YWHAQ"
                     /gene_synonym="14-3-3; 1C5; HS1"
                     /inference="alignment:Splign:2.1.0"
     exon            558..721
                     /gene="YWHAQ"
                     /gene_synonym="14-3-3; 1C5; HS1"
                     /inference="alignment:Splign:2.1.0"
     exon            722..817
                     /gene="YWHAQ"
                     /gene_synonym="14-3-3; 1C5; HS1"
                     /inference="alignment:Splign:2.1.0"
     exon            818..2196
                     /gene="YWHAQ"
                     /gene_synonym="14-3-3; 1C5; HS1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1526..1531
                     /regulatory_class="polyA_signal_sequence"
                     /gene="YWHAQ"
                     /gene_synonym="14-3-3; 1C5; HS1"
                     /note="hexamer: AATAAA"
     polyA_site      1548
                     /gene="YWHAQ"
                     /gene_synonym="14-3-3; 1C5; HS1"
                     /note="major polyA site"
     regulatory      1873..1878
                     /regulatory_class="polyA_signal_sequence"
                     /gene="YWHAQ"
                     /gene_synonym="14-3-3; 1C5; HS1"
                     /note="hexamer: AATAAA"
     polyA_site      1896
                     /gene="YWHAQ"
                     /gene_synonym="14-3-3; 1C5; HS1"
                     /note="major polyA site"
     regulatory      2163..2168
                     /regulatory_class="polyA_signal_sequence"
                     /gene="YWHAQ"
                     /gene_synonym="14-3-3; 1C5; HS1"
                     /note="hexamer: AATAAA"
     polyA_site      2196
                     /gene="YWHAQ"
                     /gene_synonym="14-3-3; 1C5; HS1"
ORIGIN      
        1 aaagccaaaa gcagatcaaa gtggtgggac tcgcgtcgcg gccgcggaga cgtgaagctc
       61 tcgaggctcc tcccgctgcg ggtcggcgct cgccctcgct ctcctcgccc tccgccccgg
      121 ccccggcccc gcgcccgcca tggagaagac tgagctgatc cagaaggcca agctggccga
      181 gcaggccgag cgctacgacg acatggccac ctgcatgaag gcagtgaccg agcagggcgc
      241 cgagctgtcc aacgaggagc gcaacctgct ctccgtggcc tacaagaacg tggtcggggg
      301 ccgcaggtcc gcctggaggg tcatctctag catcgagcag aagaccgaca cctccgacaa
      361 gaagttgcag ctgattaagg actatcggga gaaagtggag tccgagctga gatccatctg
      421 caccacggtg ctggaattgt tggataaata tttaatagcc aatgcaacta atccagagag
      481 taaggtcttc tatctgaaaa tgaagggtga ttacttccgg taccttgctg aagttgcgtg
      541 tggtgatgat cgaaaacaaa cgatagataa ttcccaagga gcttaccaag aggcatttga
      601 tataagcaag aaagagatgc aacccacaca cccaatccgc ctggggcttg ctcttaactt
      661 ttctgtattt tactatgaga ttcttaataa cccagagctt gcctgcacgc tggctaaaac
      721 ggcttttgat gaggccattg ctgaacttga tacactgaat gaagactcat acaaagacag
      781 caccctcatc atgcagttgc ttagagacaa cctaacactt tggacatcag acagtgcagg
      841 agaagaatgt gatgcggcag aaggggctga aaactaaatc catacagggt gtcatccttc
      901 tttccttcaa gaaacctttt tacacatctc cattccttat tccacttgga tttcctatag
      961 caaagaaacc cattcatgtg tatggaatca actgtttata gtcttttcac actgcagctt
     1021 tgggaaaact tcattccttg atttgtgttt gtcttggcct tcctggtgtg cagtactgct
     1081 gtagaaaagt attaatagct tcatttcata taaacataag taactcccaa acacttatgt
     1141 agaggactaa aaatgtatct ggtatttaag taatctgaac cagttctgca agtgactgtg
     1201 ttttgtatta ctgtgaaaat aagaaaatgt agttaattac aatttaaaga gtattccaca
     1261 taacttctta atttctacat tccctccctt actcttcggg ggtttccttt cagtaagcaa
     1321 cttttccatg ctcttaatgt attccttttt agtaggaatc cggaagtatt agattgaatg
     1381 gaaaagcact tgccatctct gtctaggggt cacaaattga aatggctcct gtatcacata
     1441 cggaggtctt gtgtatctgt ggcaacaggg agtttcctta ttcactcttt atttgctgct
     1501 gtttaagttg ccaacctccc ctcccaataa aaattcactt acacctcctg cctttgtagt
     1561 tctggtattc actttactat gtgatagaag tagcatgttg ctgccagaat acaagcattg
     1621 cttttggcaa attaaagtgc atgtcatttc ttaatacact agaaagggga aataaattaa
     1681 agtacacaag tccaagtcta aaactttagt acttttccat gcagatttgt gcacatgtga
     1741 gagggtgtcc agtttgtcta gtgattgtta tttagagagt tggaccacta ttgtgtgttg
     1801 ctaatcattg actgtagtcc caaaaaagcc ttgtgaaaat gttatgccct atgtaacagc
     1861 agagtaacat aaaataaaag tacattttat aaaccattta ctatggcttt gtaacaattg
     1921 catacccata ttttaaggga caggtgaatt tactactttc taaagtttat tgatacttcc
     1981 cttttatgta aaatgtagta gtgataccta tatttccaca ttgtgcattg tgacacactt
     2041 gtctagggat gcctggaagt gtataaaatt ggactgcatt tcttagagtg ttttactata
     2101 gatcagtctc atgggccatc tcttcctcag atgtaaatga tatctggtta agtgttatat
     2161 ggaataaagt ggacatttta aaactagcaa agttaa
//
