LOCUS       NM_003405               1751 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens tyrosine 3-monooxygenase/tryptophan 5-monooxygenase
            activation protein eta (YWHAH), mRNA.
ACCESSION   NM_003405
VERSION     NM_003405.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1751)
  AUTHORS   Diao,S., Han,X., Ye,W.L., Zhang,C., Yang,D.M., Fan,Z.P. and
            Wang,S.L.
  TITLE     GREM1 Negatively Regulates Osteo-/Dentinogenic Differentiation of
            Dental Pulp Stem Cells via Association with YWHAH
  JOURNAL   Chin J Dent Res 27 (3), 203-213 (2024)
   PUBMED   39221981
  REMARK    GeneRIF: GREM1 Negatively Regulates Osteo-/Dentinogenic
            Differentiation of Dental Pulp Stem Cells via Association with
            YWHAH.
REFERENCE   2  (bases 1 to 1751)
  AUTHORS   Chan,Y.J., Liu,N.T., Hsin,F., Lu,J.Y., Lin,J.Y. and Liu,H.M.
  TITLE     Temporal regulation of MDA5 inactivation by Caspase-3 dependent
            cleavage of 14-3-3eta
  JOURNAL   PLoS Pathog 20 (6), e1012287 (2024)
   PUBMED   38843304
  REMARK    GeneRIF: Temporal regulation of MDA5 inactivation by Caspase-3
            dependent cleavage of 14-3-3eta.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1751)
  AUTHORS   Zhou,H., Sun,X., Dai,Y., Wang,X., Dai,Z. and Li,X.
  TITLE     14-3-3-eta interacts with BCL-2 to protect human endothelial
            progenitor cells from ox-LDL-triggered damage
  JOURNAL   Cell Biol Int 48 (3), 290-299 (2024)
   PUBMED   38100125
  REMARK    GeneRIF: 14-3-3-eta interacts with BCL-2 to protect human
            endothelial progenitor cells from ox-LDL-triggered damage.
REFERENCE   4  (bases 1 to 1751)
  AUTHORS   Liu,Y.Q., Xu,Y.C. and Shuai,Z.W.
  TITLE     Mir-142-3P regulates MAPK protein family by inhibiting 14-3-3eta to
            enhance bone marrow mesenchymal stem cells osteogenesis
  JOURNAL   Sci Rep 13 (1), 22862 (2023)
   PUBMED   38129425
  REMARK    GeneRIF: Mir-142-3P regulates MAPK protein family by inhibiting
            14-3-3eta to enhance bone marrow mesenchymal stem cells
            osteogenesis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1751)
  AUTHORS   Pierga,A., Matusiak,R., Cauhape,M., Branchu,J., Danglot,L.,
            Boutry,M. and Darios,F.
  TITLE     Spatacsin regulates directionality of lysosome trafficking by
            promoting the degradation of its partner AP5Z1
  JOURNAL   PLoS Biol 21 (10), e3002337 (2023)
   PUBMED   37871017
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1751)
  AUTHORS   Ichimura,T., Uchiyama,J., Kunihiro,O., Ito,M., Horigome,T.,
            Omata,S., Shinkai,F., Kaji,H. and Isobe,T.
  TITLE     Identification of the site of interaction of the 14-3-3 protein
            with phosphorylated tryptophan hydroxylase
  JOURNAL   J Biol Chem 270 (48), 28515-28518 (1995)
   PUBMED   7499362
REFERENCE   7  (bases 1 to 1751)
  AUTHORS   Jones,D.H., Ley,S. and Aitken,A.
  TITLE     Isoforms of 14-3-3 protein can form homo- and heterodimers in vivo
            and in vitro: implications for function as adapter proteins
  JOURNAL   FEBS Lett 368 (1), 55-58 (1995)
   PUBMED   7615088
REFERENCE   8  (bases 1 to 1751)
  AUTHORS   Wu,C., Friedlander,P., Lamoureux,C., Zannis-Hadjopoulos,M. and
            Price,G.B.
  TITLE     cDNA clones contain autonomous replication activity
  JOURNAL   Biochim Biophys Acta 1174 (3), 241-257 (1993)
   PUBMED   7690594
REFERENCE   9  (bases 1 to 1751)
  AUTHORS   Ichimura-Ohshima,Y., Morii,K., Ichimura,T., Araki,K., Takahashi,Y.,
            Isobe,T., Minoshima,S., Fukuyama,R., Shimizu,N. and Kuwano,R.
  TITLE     cDNA cloning and chromosome assignment of the gene for human brain
            14-3-3 protein eta chain
  JOURNAL   J Neurosci Res 31 (4), 600-605 (1992)
   PUBMED   1578511
REFERENCE   10 (bases 1 to 1751)
  AUTHORS   Ichimura,T., Isobe,T., Okuyama,T., Takahashi,N., Araki,K.,
            Kuwano,R. and Takahashi,Y.
  TITLE     Molecular cloning of cDNA coding for brain-specific 14-3-3 protein,
            a protein kinase-dependent activator of tyrosine and tryptophan
            hydroxylases
  JOURNAL   Proc Natl Acad Sci U S A 85 (19), 7084-7088 (1988)
   PUBMED   2902623
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from Z82248.1, BC003047.1 and
            AY007132.1.
            
            On Nov 23, 2018 this sequence version replaced NM_003405.3.
            
            Summary: This gene product belongs to the 14-3-3 family of proteins
            which mediate signal transduction by binding to
            phosphoserine-containing proteins. This highly conserved protein
            family is found in both plants and mammals, and this protein is 99%
            identical to the mouse, rat and bovine orthologs. This gene
            contains a 7 bp repeat sequence in its 5' UTR, and changes in the
            number of this repeat have been associated with early-onset
            schizophrenia and psychotic bipolar disorder. [provided by RefSeq,
            Jun 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163658.310288.1,
                                           SRR3476690.534567.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000248975.6/ ENSP00000248975.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-70                Z82248.1           24220-24289
            71-371              BC003047.1         48-348
            372-1751            AY007132.1         1-1380
FEATURES             Location/Qualifiers
     source          1..1751
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q12.3"
     gene            1..1751
                     /gene="YWHAH"
                     /gene_synonym="YWHA1"
                     /note="tyrosine 3-monooxygenase/tryptophan 5-monooxygenase
                     activation protein eta"
                     /db_xref="GeneID:7533"
                     /db_xref="HGNC:HGNC:12853"
                     /db_xref="MIM:113508"
     exon            1..286
                     /gene="YWHAH"
                     /gene_synonym="YWHA1"
                     /inference="alignment:Splign:2.1.0"
     CDS             200..940
                     /gene="YWHAH"
                     /gene_synonym="YWHA1"
                     /note="14-3-3 eta; tyrosine 3-monooxygenase/tryptophan
                     5-monooxygenase activation protein, eta polypeptide"
                     /codon_start=1
                     /product="14-3-3 protein eta"
                     /protein_id="NP_003396.1"
                     /db_xref="CCDS:CCDS13901.1"
                     /db_xref="GeneID:7533"
                     /db_xref="HGNC:HGNC:12853"
                     /db_xref="MIM:113508"
                     /translation="MGDREQLLQRARLAEQAERYDDMASAMKAVTELNEPLSNEDRNL
                     LSVAYKNVVGARRSSWRVISSIEQKTMADGNEKKLEKVKAYREKIEKELETVCNDVLS
                     LLDKFLIKNCNDFQYESKVFYLKMKGDYYRYLAEVASGEKKNSVVEASEAAYKEAFEI
                     SKEQMQPTHPIRLGLALNFSVFYYEIQNAPEQACLLAKQAFDDAIAELDTLNEDSYKD
                     STLIMQLLRDNLTLWTSDQQDEEAGEGN"
     exon            287..1751
                     /gene="YWHAH"
                     /gene_synonym="YWHA1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1700..1705
                     /regulatory_class="polyA_signal_sequence"
                     /gene="YWHAH"
                     /gene_synonym="YWHA1"
                     /note="hexamer: AATAAA"
     polyA_site      1751
                     /gene="YWHAH"
                     /gene_synonym="YWHA1"
                     /note="major polyA site"
ORIGIN      
        1 acagcgcgcg gggcgagcca gcgagagggc gcgagcggcg gcgctgcctg cagcctgcag
       61 cctgcagcct ccggccggcc ggcgagccag tgcgcgtgcg cggcggcggc ctccgcagcg
      121 accggggagc ggactgaccg gcgggagggc tagcgagcca gcggtgtgag gcgcgaggcg
      181 aggccgagcc gcgagcgaca tgggggaccg ggagcagctg ctgcagcggg cgcggctggc
      241 cgagcaggcg gagcgctacg acgacatggc ctccgctatg aaggcggtga cagagctgaa
      301 tgaacctctc tccaatgaag atcgaaatct cctctctgtg gcctacaaga atgtggttgg
      361 tgccaggcga tcttcctgga gggtcattag cagcattgag cagaaaacca tggctgatgg
      421 aaacgaaaag aaattggaga aagttaaagc ttaccgggag aagattgaga aggagctgga
      481 gacagtttgc aatgatgtcc tgtctctgct tgacaagttc ctgatcaaga actgcaatga
      541 tttccagtat gagagcaagg tgttttacct gaaaatgaag ggtgattact accgctactt
      601 agcagaggtc gcttctgggg agaagaaaaa cagtgtggtc gaagcttctg aagctgccta
      661 caaggaagcc tttgaaatca gcaaagagca gatgcaaccc acgcatccca tccggctggg
      721 cctggccctc aacttctccg tgttctacta tgagatccag aatgcacctg agcaagcctg
      781 cctcttagcc aaacaagcct tcgatgatgc catagctgag ctggacacac taaacgagga
      841 ttcctataag gactccacgc tgatcatgca gttgctgcga gacaacctca ccctctggac
      901 gagcgaccag caggatgaag aagcaggaga aggcaactga agatccttca ggtcccctgg
      961 cccttccttc acccaccacc cccatcatca ccgattcttc cttgccacaa tcactaaata
     1021 tctagtgcta aacctatctg tattggcagc acagctactc agatctgcac tcctgtctct
     1081 tgggaagcag tttcagataa atcatgggca ttgctggact gatggttgct ttgagcccac
     1141 aggagctccc tttttgaatt gtgtggagaa gtgtgttctg atgaggcatt ttactatgcc
     1201 tgttgatcta tgggaaatct aggcgaaagt aatggggaag attagaaaga attagccaac
     1261 caggctacag ttgatattta aaagatccat ttaaaacaag ctgatagtgt ttcgttaagc
     1321 agtacatctt gtgcatgcaa aaatgaattc acccctccca cctctttctt caattaatgg
     1381 aaaactgtta agggaagctg atacagagag acaacttgct cctttccatc agctttataa
     1441 taaactgttt aacgtgaggt ttcagtagct ccttggtttt gcctctttaa attatgacgt
     1501 gcacaaacct tcttttcaat gcaatgcatc tgaaagtttt gatacttgta actttttttt
     1561 ttttttggtt gcaattgttt aagaatcatg gatttatttt ttgtaactct ttggctattg
     1621 tccttgtgta tcctgacagc gccatgtgtg tcagcccatg tcaatcaaga tgggtgatta
     1681 tgaaatgcca gacttctaaa ataaatgttt tggaattcaa tgggtaaata aatgctgctt
     1741 tggggatatt a
//
