LOCUS       NM_012479               3705 bp    mRNA    linear   PRI 15-MAR-2025
DEFINITION  Homo sapiens tyrosine 3-monooxygenase/tryptophan 5-monooxygenase
            activation protein gamma (YWHAG), mRNA.
ACCESSION   NM_012479
VERSION     NM_012479.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3705)
  AUTHORS   Khoroshkin,M., Buyan,A., Dodel,M., Navickas,A., Yu,J., Trejo,F.,
            Doty,A., Baratam,R., Zhou,S., Lee,S.B., Joshi,T., Garcia,K.,
            Choi,B., Miglani,S., Subramanyam,V., Modi,H., Carpenter,C.,
            Markett,D., Corces,M.R., Mardakheh,F.K., Kulakovskiy,I.V. and
            Goodarzi,H.
  TITLE     Systematic identification of post-transcriptional regulatory
            modules
  JOURNAL   Nat Commun 15 (1), 7872 (2024)
   PUBMED   39251607
  REMARK    Erratum:[Nat Commun. 2024 Oct 28;15(1):9277. doi:
            10.1038/s41467-024-52903-4. PMID: 39468017]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3705)
  AUTHORS   Wang,Y., Cao,Y., Chen,Y., Cheng,H., Liu,Z., Wang,M., Feng,Y.,
            Fei,B., Cui,K. and Huang,Z.
  TITLE     YWHAG promotes colorectal cancer progression by regulating the
            CTTN-Wnt/beta-catenin signaling axis
  JOURNAL   Med Oncol 41 (5), 100 (2024)
   PUBMED   38538804
  REMARK    GeneRIF: YWHAG promotes colorectal cancer progression by regulating
            the CTTN-Wnt/beta-catenin signaling axis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3705)
  AUTHORS   He,C., Xing,X., Chen,H.Y., Gao,M., Shi,J., Xiang,B., Xiao,X.,
            Sun,Y., Yu,H., Xu,G., Yao,Y., Xie,Z., Xing,Y., Budiarto,B.R.,
            Chen,S.Y., Gao,Y., Lee,Y.R. and Zhang,J.
  TITLE     UFL1 ablation in T cells suppresses PD-1 UFMylation to enhance
            anti-tumor immunity
  JOURNAL   Mol Cell 84 (6), 1120-1138 (2024)
   PUBMED   38377992
REFERENCE   4  (bases 1 to 3705)
  AUTHORS   Lee,J.X.T., Tan,W.R., Low,Z.S., Lee,J.Q., Chua,D., Yeo,W.D.C.,
            See,B., Vos,M.I.G., Yasuda,T., Nomura,S., Cheng,H.S. and Tan,N.S.
  TITLE     YWHAG Deficiency Disrupts the EMT-Associated Network to Induce
            Oxidative Cell Death and Prevent Metastasis
  JOURNAL   Adv Sci (Weinh) 10 (31), e2301714 (2023)
   PUBMED   37759388
  REMARK    GeneRIF: YWHAG Deficiency Disrupts the EMT-Associated Network to
            Induce Oxidative Cell Death and Prevent Metastasis.
REFERENCE   5  (bases 1 to 3705)
  AUTHORS   Iglesias-Martinez,L.F., Rauch,N., Wynne,K., McCann,B., Kolch,W. and
            Rauch,J.
  TITLE     Interactome dynamics of RAF1-BRAF kinase monomers and dimers
  JOURNAL   Sci Data 10 (1), 203 (2023)
   PUBMED   37045861
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3705)
  AUTHORS   Vincenz,C. and Dixit,V.M.
  TITLE     14-3-3 proteins associate with A20 in an isoform-specific manner
            and function both as chaperone and adapter molecules
  JOURNAL   J Biol Chem 271 (33), 20029-20034 (1996)
   PUBMED   8702721
REFERENCE   7  (bases 1 to 3705)
  AUTHORS   Golsteyn,R.M., Mundt,K.E., Fry,A.M. and Nigg,E.A.
  TITLE     Cell cycle regulation of the activity and subcellular localization
            of Plk1, a human protein kinase implicated in mitotic spindle
            function
  JOURNAL   J Cell Biol 129 (6), 1617-1628 (1995)
   PUBMED   7790358
REFERENCE   8  (bases 1 to 3705)
  AUTHORS   Morrison,D.
  TITLE     14-3-3: modulators of signaling proteins?
  JOURNAL   Science 266 (5182), 56-57 (1994)
   PUBMED   7939645
  REMARK    Review article
REFERENCE   9  (bases 1 to 3705)
  AUTHORS   Robertson,N.G., Khetarpal,U., Gutierrez-Espeleta,G.A., Bieber,F.R.
            and Morton,C.C.
  TITLE     Isolation of novel and known genes from a human fetal cochlear cDNA
            library using subtractive hybridization and differential screening
  JOURNAL   Genomics 23 (1), 42-50 (1994)
   PUBMED   7829101
REFERENCE   10 (bases 1 to 3705)
  AUTHORS   Roth,D., Morgan,A., Martin,H., Jones,D., Martens,G.J., Aitken,A.
            and Burgoyne,R.D.
  TITLE     Characterization of 14-3-3 proteins in adrenal chromaffin cells and
            demonstration of isoform-specific phospholipid binding
  JOURNAL   Biochem J 301 (Pt 1) (Pt 1), 305-310 (1994)
   PUBMED   8037685
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC020963.2, AB024334.1,
            AC006388.3 and BI495132.1.
            
            On Nov 22, 2018 this sequence version replaced NM_012479.3.
            
            Summary: This gene product belongs to the 14-3-3 family of proteins
            which mediate signal transduction by binding to
            phosphoserine-containing proteins. This highly conserved protein
            family is found in both plants and mammals, and this protein is
            100% identical to the rat ortholog. It is induced by growth factors
            in human vascular smooth muscle cells, and is also highly expressed
            in skeletal and heart muscles, suggesting an important role for
            this protein in muscle tissue. It has been shown to interact with
            RAF1 and protein kinase C, proteins involved in various signal
            transduction pathways. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC020963.2, AK024230.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000307630.5/ ENSP00000306330.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-632               BC020963.2         9-640
            633-1677            AB024334.1         619-1663
            1678-3223           AC006388.3         22951-24496
            3224-3705           BI495132.1         8-489
FEATURES             Location/Qualifiers
     source          1..3705
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q11.23"
     gene            1..3705
                     /gene="YWHAG"
                     /gene_synonym="14-3-3GAMMA; DEE56; EIEE56; PPP1R170"
                     /note="tyrosine 3-monooxygenase/tryptophan 5-monooxygenase
                     activation protein gamma"
                     /db_xref="GeneID:7532"
                     /db_xref="HGNC:HGNC:12852"
                     /db_xref="MIM:605356"
     exon            1..270
                     /gene="YWHAG"
                     /gene_synonym="14-3-3GAMMA; DEE56; EIEE56; PPP1R170"
                     /inference="alignment:Splign:2.1.0"
     CDS             184..927
                     /gene="YWHAG"
                     /gene_synonym="14-3-3GAMMA; DEE56; EIEE56; PPP1R170"
                     /note="KCIP-1; protein kinase C inhibitor protein 1;
                     tyrosine 3-monooxygenase/tryptophan 5-monooxygenase
                     activation protein, gamma polypeptide; protein phosphatase
                     1, regulatory subunit 170"
                     /codon_start=1
                     /product="14-3-3 protein gamma"
                     /protein_id="NP_036611.2"
                     /db_xref="CCDS:CCDS5584.1"
                     /db_xref="GeneID:7532"
                     /db_xref="HGNC:HGNC:12852"
                     /db_xref="MIM:605356"
                     /translation="MVDREQLVQKARLAEQAERYDDMAAAMKNVTELNEPLSNEERNL
                     LSVAYKNVVGARRSSWRVISSIEQKTSADGNEKKIEMVRAYREKIEKELEAVCQDVLS
                     LLDNYLIKNCSETQYESKVFYLKMKGDYYRYLAEVATGEKRATVVESSEKAYSEAHEI
                     SKEHMQPTHPIRLGLALNYSVFYYEIQNAPEQACHLAKTAFDDAIAELDTLNEDSYKD
                     STLIMQLLRDNLTLWTSDQQDDDGGEGNN"
     exon            271..3705
                     /gene="YWHAG"
                     /gene_synonym="14-3-3GAMMA; DEE56; EIEE56; PPP1R170"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3687..3692
                     /regulatory_class="polyA_signal_sequence"
                     /gene="YWHAG"
                     /gene_synonym="14-3-3GAMMA; DEE56; EIEE56; PPP1R170"
                     /note="hexamer: AATAAA"
     polyA_site      3705
                     /gene="YWHAG"
                     /gene_synonym="14-3-3GAMMA; DEE56; EIEE56; PPP1R170"
                     /note="major polyA site"
ORIGIN      
        1 gcagccgcct cgcgcccggt cccgcggtcg cagctccagc cgcctcctcc gcgcagccgc
       61 cgcctcagct gctcgctctg tgggtcggtc ctctccggca cttgggctcc agtcgcgccc
      121 tccaagccct tcaggccgcc ccagtgtcct cctccttctc cggccagacc cagccccgcg
      181 aagatggtgg accgcgagca actggtgcag aaagcccggc tggccgagca ggcggagcgc
      241 tacgacgaca tggccgcggc catgaagaac gtgacagagc tgaatgagcc actgtcgaat
      301 gaggaacgaa accttctgtc tgtggcctac aagaacgttg tgggggcacg ccgctcttcc
      361 tggagggtca tcagtagcat tgagcagaag acatctgcag acggcaatga gaagaagatt
      421 gagatggtcc gtgcgtaccg ggagaagata gagaaggagt tggaggctgt gtgccaggat
      481 gtgctgagcc tgctggataa ctacctgatc aagaattgca gcgagaccca gtacgagagc
      541 aaagtgttct acctgaagat gaaaggggac tactaccgct acctggctga agtggccacc
      601 ggagagaaaa gggcgacggt ggtggagtcc tccgagaagg cctacagcga agcccacgag
      661 atcagcaaag agcacatgca gcccacccac cccatccgat taggcctggc tcttaactac
      721 tccgtcttct actatgagat ccagaacgcc ccagagcaag cgtgccactt ggccaagacc
      781 gcgttcgacg acgccatcgc cgagcttgac accctcaacg aggactccta caaggactcc
      841 acgctcatca tgcagctcct ccgcgacaac ctcacgctct ggacgagcga ccagcaggac
      901 gacgatggcg gcgaaggcaa caattaaggc cccaggggaa ctggcagcgc acgcggatgc
      961 tactactgca gtctttattt ttttcccatg agttgggggt cgggtggggg agggaaaggg
     1021 agggatgacc ttcccaggga gaaacccacg acctgtcctg tctttgatcg cctctttgac
     1081 atttttgcca aaataccact agtggaaagt caggctagct gtgctggtat tggaatagca
     1141 gcctcacact ggcgtctgga ctgttctgta gattcatgca agtggagctg tctgtctcta
     1201 atttaactta ttgctagata atagggtttt cagatgaaaa gaaaacttaa agaggaatgg
     1261 ccctcattca gtaagttctg tggttccagt aaggattttt atgtacatac gctctcgtct
     1321 ctcgttttgg gtactttcta tctcatctgt ctcggctctg catgttttcc agggtgtagc
     1381 ctacagacat ggaacagtgt aaatcccaga ctgacagact tagaacctga ggtctcattc
     1441 atccttatgg tttaggcctt gccagttttc cgaagtctct gattagttga cagtattaac
     1501 actaaattgc agtttacagt atttctacat tacagccata tgtaacatca agccatcgat
     1561 tgtgtacttt tcctttgcta gttgtttggg ctttaacatc cttattcagc cttatccagg
     1621 ttggttttgc tgttgatcgg tctcctaggc taaatgagaa tgaaagcgac ttcaggtcag
     1681 gtggctgtgg gatttttttt ttttggtcct tctttcctct taacgtaaat ccaccaccaa
     1741 aattattaat cctcttgaga gaaacgtgaa acgccacaaa aatagagaaa attcaggtct
     1801 gtatgtcatg gatcgtgttg gtattttcag agaacatccc gcttctgaag ctgctgcagc
     1861 tccctcctca gggatcacac tgccgtcacc cactctgcac tggggcgttt cctactgcgc
     1921 ctcgtgctgg cggacgcagc tgggtgcaga agctgtgggg tcggagaggc gtttggagaa
     1981 ggtctgtggt gcagtgtgtg aaaattcagg tgctagaagc ctactggtag aaaaacccaa
     2041 aaggaagagc tatatcctta accattctgt ccaatttcgg gagccttgtc agtgtgtcag
     2101 tttttcctcc ccgaagacac tccttcccca agtaattgta ggaagataaa aaaactgtta
     2161 ccagataaca aacactgaac tcctatttga ccagaacttt ttcctctcga gatagttttt
     2221 tctttttaat gaaaaaagca taggaattgg agattggctt gtctcacgca gccagtgcac
     2281 atttggaatt gacggaaaca acgttgctat ttccacccat ttgttttcgg cagccttaag
     2341 gccctcattc tcatttcggg tgaatctgtc tatctgtgaa cgtggcccgc atgtgcattc
     2401 ttttttttat atatataaag tcagtgacga ggaactcccg agacgtgtaa tgacaccaca
     2461 cttgttttct ttgtttcttt gttttattta ggcaagaaga ggtgtgagta attgaggaaa
     2521 aactgacaga tgcttttgct aataccaaaa ttgagcttac aattaggaac tgagtatgtg
     2581 taacaggata caggtgacag tgaagataga agaaccacga tgaccacaga ctcaatgtgc
     2641 tctgtaacat cgcacagttt acccagcatg actttcctta ggaggccccc tcctcacgct
     2701 agagtaaaag tcccagttaa gtgaagccta ccagaagaac tagtagaaga agctttgccg
     2761 cttttgtgcc tctcacaggc gcctaaagtc attgccatgg gaggaagacg atttgggggg
     2821 ggaggggggg gggggcaggg taggtggggc tttccctaat ttatcttcat gtccagtgag
     2881 cagtgttgcg tttttccttg tagcatttgg aaatgattta ctggaattac aaaacctatt
     2941 tttcctttaa atttcagctt tggctctggc tgctttttag aataatgcaa gataaaaatc
     3001 acacctgagg gctgaaaacg gagagggaat gggagacttg atatttaagc agcttgaatg
     3061 gtttttcttt tctttatttt taaagaaatg cacttgccta tgatactgtc tctccagtga
     3121 aatgattact cctccattac tctattgata caatattgtg catgctagtg ttgtatttct
     3181 atacagtagc ttgaaattga ttaacttata ctgtaggtgt tatgtattcc tatgacaaaa
     3241 aaaattaagt cttcaaattt tttaaaggtt tttttttttt aatttaattt ttccttttgg
     3301 gggtaaagtt tgctctacca aatagtgatt gtaacaaatt gatctgtttt ggatgttgct
     3361 atagtgacat gcagttatat attttgtttt taaaaggggg ggagcaaaag aaacaccagt
     3421 gttagcttaa tcttaatgtc tggtgtttgt catggtgaaa ttataactat tacagtgttg
     3481 gagaacaaca aatatgttct ctgaatgagc ctttgtgctt tttgtcatgt tatgcagtga
     3541 actattttta aggtctaatc agtgattatt tttccagctc cgtgtttctc taaggaatta
     3601 tttcacacac ggaccatctt tagcagtttc ctcagtgatg gaatatcatg aatgtgagtc
     3661 attatgtagc tgtcgtacat tgagcaaata aacttacaga tctga
//
