LOCUS       NM_006761               2052 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens tyrosine 3-monooxygenase/tryptophan 5-monooxygenase
            activation protein epsilon (YWHAE), transcript variant 1, mRNA.
ACCESSION   NM_006761 XM_935509
VERSION     NM_006761.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2052)
  AUTHORS   Hu,Y., Zhang,C., Wang,S., Xiong,H., Xie,W., Zeng,Z., Cai,H.,
            Wang,Q.K. and Lu,Z.
  TITLE     14-3-3epsilon/YWHAE regulates the transcriptional expression of
            cardiac sodium channel NaV1.5
  JOURNAL   Heart Rhythm 21 (11), 2320-2329 (2024)
   PUBMED   38750908
  REMARK    GeneRIF: 14-3-3epsilon/YWHAE regulates the transcriptional
            expression of cardiac sodium channel NaV1.5.
REFERENCE   2  (bases 1 to 2052)
  AUTHORS   Khoroshkin,M., Buyan,A., Dodel,M., Navickas,A., Yu,J., Trejo,F.,
            Doty,A., Baratam,R., Zhou,S., Lee,S.B., Joshi,T., Garcia,K.,
            Choi,B., Miglani,S., Subramanyam,V., Modi,H., Carpenter,C.,
            Markett,D., Corces,M.R., Mardakheh,F.K., Kulakovskiy,I.V. and
            Goodarzi,H.
  TITLE     Systematic identification of post-transcriptional regulatory
            modules
  JOURNAL   Nat Commun 15 (1), 7872 (2024)
   PUBMED   39251607
  REMARK    Erratum:[Nat Commun. 2024 Oct 28;15(1):9277. doi:
            10.1038/s41467-024-52903-4.. PMID: 39468017]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2052)
  AUTHORS   Ye,N., Shi,X., Gao,J., Dong,R., Wang,G., Wang,J., Luo,L. and
            Zhang,T.
  TITLE     Exosomes from Intrahepatic Cholestasis of Pregnancy Induce Cell
            Apoptosis Through the miRNA-6891-5p/YWHAE Pathway
  JOURNAL   Dig Dis Sci 69 (4), 1253-1262 (2024)
   PUBMED   38361148
  REMARK    GeneRIF: Exosomes from Intrahepatic Cholestasis of Pregnancy Induce
            Cell Apoptosis Through the miRNA-6891-5p/YWHAE Pathway.
REFERENCE   4  (bases 1 to 2052)
  AUTHORS   Li,Z., Liu,J., Wang,P., Zhang,B., He,G. and Yang,L.
  TITLE     The novel miR-873-5p-YWHAE-PI3K/AKT axis is involved in non-small
            cell lung cancer progression and chemoresistance by mediating
            autophagy
  JOURNAL   Funct Integr Genomics 24 (2), 33 (2024)
   PUBMED   38363382
  REMARK    GeneRIF: The novel miR-873-5p-YWHAE-PI3K/AKT axis is involved in
            non-small cell lung cancer progression and chemoresistance by
            mediating autophagy.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2052)
  AUTHORS   Zhang,Y., Yan,M., Yu,Y., Wang,J., Jiao,Y., Zheng,M. and Zhang,S.
  TITLE     14-3-3epsilon: a protein with complex physiology function but
            promising therapeutic potential in cancer
  JOURNAL   Cell Commun Signal 22 (1), 72 (2024)
   PUBMED   38279176
  REMARK    GeneRIF: 14-3-3epsilon: a protein with complex physiology function
            but promising therapeutic potential in cancer.
            Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2052)
  AUTHORS   Jin,D.Y., Lyu,M.S., Kozak,C.A. and Jeang,K.T.
  TITLE     Function of 14-3-3 proteins
  JOURNAL   Nature 382 (6589), 308 (1996)
   PUBMED   8684458
REFERENCE   7  (bases 1 to 2052)
  AUTHORS   Conklin,D.S., Galaktionov,K. and Beach,D.
  TITLE     14-3-3 proteins associate with cdc25 phosphatases
  JOURNAL   Proc Natl Acad Sci U S A 92 (17), 7892-7896 (1995)
   PUBMED   7644510
REFERENCE   8  (bases 1 to 2052)
  AUTHORS   Jones,D.H., Ley,S. and Aitken,A.
  TITLE     Isoforms of 14-3-3 protein can form homo- and heterodimers in vivo
            and in vitro: implications for function as adapter proteins
  JOURNAL   FEBS Lett 368 (1), 55-58 (1995)
   PUBMED   7615088
REFERENCE   9  (bases 1 to 2052)
  AUTHORS   Golsteyn,R.M., Mundt,K.E., Fry,A.M. and Nigg,E.A.
  TITLE     Cell cycle regulation of the activity and subcellular localization
            of Plk1, a human protein kinase implicated in mitotic spindle
            function
  JOURNAL   J Cell Biol 129 (6), 1617-1628 (1995)
   PUBMED   7790358
REFERENCE   10 (bases 1 to 2052)
  AUTHORS   Detlav,I.E.
  TITLE     [Anti-brain antibodies in serum and cerebrospinal fluid following
            cranio-cerebral trauma]
  JOURNAL   Zh Nevropatol Psikhiatr Im S S Korsakova 76 (3), 344-348 (1976)
   PUBMED   1266503
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC365395.1, AY883089.1 and
            AC032044.28.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_006761.4.
            
            Summary: This gene product belongs to the 14-3-3 family of proteins
            which mediate signal transduction by binding to
            phosphoserine-containing proteins. This highly conserved protein
            family is found in both plants and mammals, and this protein is
            100% identical to the mouse ortholog. It interacts with CDC25
            phosphatases, RAF1 and IRS1 proteins, suggesting its role in
            diverse biochemical activities related to signal transduction, such
            as cell division and regulation of insulin sensitivity. It has also
            been implicated in the pathogenesis of small cell lung cancer. Two
            transcript variants, one protein-coding and the other
            non-protein-coding, have been found for this gene. [provided by
            RefSeq, Aug 2008].
            
            Transcript Variant: This variant (1) represents the protein-coding
            transcript.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.552827.1,
                                           SRR3476690.305381.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000264335.13/ ENSP00000264335.8
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-508               DC365395.1         42-549
            509-1787            AY883089.1         509-1787
            1788-2052           AC032044.28        104793-105057
FEATURES             Location/Qualifiers
     source          1..2052
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.3"
     gene            1..2052
                     /gene="YWHAE"
                     /gene_synonym="14-3-3E; HEL2; KCIP-1; MDCR; MDS"
                     /note="tyrosine 3-monooxygenase/tryptophan 5-monooxygenase
                     activation protein epsilon"
                     /db_xref="GeneID:7531"
                     /db_xref="HGNC:HGNC:12851"
                     /db_xref="MIM:605066"
     exon            1..176
                     /gene="YWHAE"
                     /gene_synonym="14-3-3E; HEL2; KCIP-1; MDCR; MDS"
                     /inference="alignment:Splign:2.1.0"
     CDS             113..880
                     /gene="YWHAE"
                     /gene_synonym="14-3-3E; HEL2; KCIP-1; MDCR; MDS"
                     /note="mitochondrial import stimulation factor L subunit;
                     protein kinase C inhibitor protein-1; tyrosine
                     3/tryptophan 5 -monooxygenase activation protein, epsilon
                     polypeptide; 14-3-3 epsilon; tyrosine
                     3-monooxygenase/tryptophan 5-monooxygenase activation
                     protein, epsilon polypeptide; epididymis luminal protein
                     2"
                     /codon_start=1
                     /product="14-3-3 protein epsilon"
                     /protein_id="NP_006752.1"
                     /db_xref="CCDS:CCDS11001.1"
                     /db_xref="GeneID:7531"
                     /db_xref="HGNC:HGNC:12851"
                     /db_xref="MIM:605066"
                     /translation="MDDREDLVYQAKLAEQAERYDEMVESMKKVAGMDVELTVEERNL
                     LSVAYKNVIGARRASWRIISSIEQKEENKGGEDKLKMIREYRQMVETELKLICCDILD
                     VLDKHLIPAANTGESKVFYYKMKGDYHRYLAEFATGNDRKEAAENSLVAYKAASDIAM
                     TELPPTHPIRLGLALNFSVFYYEILNSPDRACRLAKAAFDDAIAELDTLSEESYKDST
                     LIMQLLRDNLTLWTSDMQGDGEEQNKEALQDVEDENQ"
     exon            177..376
                     /gene="YWHAE"
                     /gene_synonym="14-3-3E; HEL2; KCIP-1; MDCR; MDS"
                     /inference="alignment:Splign:2.1.0"
     exon            377..483
                     /gene="YWHAE"
                     /gene_synonym="14-3-3E; HEL2; KCIP-1; MDCR; MDS"
                     /inference="alignment:Splign:2.1.0"
     exon            484..690
                     /gene="YWHAE"
                     /gene_synonym="14-3-3E; HEL2; KCIP-1; MDCR; MDS"
                     /inference="alignment:Splign:2.1.0"
     exon            691..827
                     /gene="YWHAE"
                     /gene_synonym="14-3-3E; HEL2; KCIP-1; MDCR; MDS"
                     /inference="alignment:Splign:2.1.0"
     exon            828..2052
                     /gene="YWHAE"
                     /gene_synonym="14-3-3E; HEL2; KCIP-1; MDCR; MDS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1748..1753
                     /regulatory_class="polyA_signal_sequence"
                     /gene="YWHAE"
                     /gene_synonym="14-3-3E; HEL2; KCIP-1; MDCR; MDS"
                     /note="hexamer: ATTAAA"
     polyA_site      1769
                     /gene="YWHAE"
                     /gene_synonym="14-3-3E; HEL2; KCIP-1; MDCR; MDS"
     regulatory      1774..1779
                     /regulatory_class="polyA_signal_sequence"
                     /gene="YWHAE"
                     /gene_synonym="14-3-3E; HEL2; KCIP-1; MDCR; MDS"
                     /note="hexamer: ATTAAA"
     polyA_site      1788
                     /gene="YWHAE"
                     /gene_synonym="14-3-3E; HEL2; KCIP-1; MDCR; MDS"
                     /note="major polyA site"
     regulatory      1818..1823
                     /regulatory_class="polyA_signal_sequence"
                     /gene="YWHAE"
                     /gene_synonym="14-3-3E; HEL2; KCIP-1; MDCR; MDS"
                     /note="hexamer: AATAAA"
     polyA_site      1841
                     /gene="YWHAE"
                     /gene_synonym="14-3-3E; HEL2; KCIP-1; MDCR; MDS"
     regulatory      2030..2035
                     /regulatory_class="polyA_signal_sequence"
                     /gene="YWHAE"
                     /gene_synonym="14-3-3E; HEL2; KCIP-1; MDCR; MDS"
                     /note="hexamer: ATTAAA"
     polyA_site      2052
                     /gene="YWHAE"
                     /gene_synonym="14-3-3E; HEL2; KCIP-1; MDCR; MDS"
ORIGIN      
        1 ggattgaggc gccgccattt ttgctgcccg gacgcggagc gagaggctga gagagtcgga
       61 gacactatcc gcttccatcc gtcgcgcaga ccctgccgga gccgctgccg ctatggatga
      121 tcgagaggat ctggtgtacc aggcgaagct ggccgagcag gctgagcgat acgacgaaat
      181 ggtggagtca atgaagaaag tagcagggat ggatgtggag ctgacagttg aagaaagaaa
      241 cctcctatct gttgcatata agaatgtgat tggagctaga agagcctcct ggagaataat
      301 cagcagcatt gaacagaaag aagaaaacaa gggaggagaa gacaagctaa aaatgattcg
      361 ggaatatcgg caaatggttg agactgagct aaagttaatc tgttgtgaca ttctggatgt
      421 actggacaaa cacctcattc cagcagctaa cactggcgag tccaaggttt tctattataa
      481 aatgaaaggg gactaccaca ggtatctggc agaatttgcc acaggaaacg acaggaagga
      541 ggctgcggag aacagcctag tggcttataa agctgctagt gatattgcaa tgacagaact
      601 tccaccaacg catcctattc gcttaggtct tgctctcaat ttttccgtat tctactacga
      661 aattcttaat tcccctgacc gtgcctgcag gttggcaaaa gcagcttttg atgatgcaat
      721 tgcagaactg gatacgctga gtgaagaaag ctataaggac tctacactta tcatgcagtt
      781 gttacgtgat aatctgacac tatggacttc agacatgcag ggtgacggtg aagagcagaa
      841 taaagaagcg ctgcaggacg tggaagacga aaatcagtga gacataagcc aacaagagaa
      901 accatctctg accaccccct cctccccatc ccaccctttg gaaactcccc attgtcactg
      961 agaaccacca aatctgactt ttacatttgg tctcagaatt taggttcctg ccctgttggt
     1021 tttttttttt tttttttaaa cagttttcaa aagttcttaa aggcaagagt gaatttctgt
     1081 ggattttact ggtcccagct tttaggttct ttaagacact aacaggacta catagaggct
     1141 ttttcagcat tactgtgtcg tctccgtgcc agatgtggca agatcaccat tagcaaatgg
     1201 aaattacatt tgaaagccat tagacttata ggtgatgcaa gcatctaaga gagaggttaa
     1261 tcacactata gaggcataag tggtatcagt tttcattttt ctaattgttt aaactgtgtt
     1321 ttataccagt gtttgcaagt aattgggtgt tagcttgaga tggttaaagg tggtttgggg
     1381 agggacttcg ttgtaatggt tttgctgtaa aaaatgtttc caactccgct gaaatgttgc
     1441 tgaaaagcat ggtgctggta acagttcaac aatccgtggc tgctcattct tgcctacttt
     1501 actctcccac tgaagcaggt tagcgttgaa ggtggtatgg aaaagcctgc atgcctgttc
     1561 aattcttttg tttcttctcc ttccccctcc ccctacctcc ttcccctcac tcctcccctc
     1621 cttcgctcgc tcaacctctt ttgttcagta tgtgtaactt gaagctaatt tgtactactg
     1681 gatatctgac tggagccaca gatacagaat ctgtattgtt cttactgaaa cacagcatgg
     1741 aattaacatt aaacttaaat aaaacaaacc taaattaaaa atgccaaata tcgcgcctcc
     1801 atcctttata cttctaaaat aaaatctcta gtccaaacac actgacagta ttatgtttgc
     1861 ctgaatgtga aacattcctc cttttttctt ccataaataa tttgtttgct tcccaaagat
     1921 gtatgttttg gaaaaaaatt gcctgtagtc tggttgtgaa gaacactgag tcagttgatg
     1981 gtgtgtcttg tcctccagac caggcagcaa catggtattt attttaatca ttaaagtaca
     2041 acatgagtag ta
//
