LOCUS       NM_139323               3020 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens tyrosine 3-monooxygenase/tryptophan 5-monooxygenase
            activation protein beta (YWHAB), transcript variant 2, mRNA.
ACCESSION   NM_139323
VERSION     NM_139323.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3020)
  AUTHORS   Khoroshkin,M., Buyan,A., Dodel,M., Navickas,A., Yu,J., Trejo,F.,
            Doty,A., Baratam,R., Zhou,S., Lee,S.B., Joshi,T., Garcia,K.,
            Choi,B., Miglani,S., Subramanyam,V., Modi,H., Carpenter,C.,
            Markett,D., Corces,M.R., Mardakheh,F.K., Kulakovskiy,I.V. and
            Goodarzi,H.
  TITLE     Systematic identification of post-transcriptional regulatory
            modules
  JOURNAL   Nat Commun 15 (1), 7872 (2024)
   PUBMED   39251607
  REMARK    Erratum:[Nat Commun. 2024 Oct 28;15(1):9277. doi:
            10.1038/s41467-024-52903-4.. PMID: 39468017]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3020)
  AUTHORS   Nan,L., Kaisi,F., Mengzhen,Z., Yang,Y., Jiaming,Y., Huirong,Y.,
            Xinwei,H., Chen,W., Liucheng,Y. and Kai,W.
  TITLE     miR-375-3p targets YWHAB to attenuate intestine injury in neonatal
            necrotizing enterocolitis
  JOURNAL   Pediatr Surg Int 40 (1), 63 (2024)
   PUBMED   38431920
  REMARK    GeneRIF: miR-375-3p targets YWHAB to attenuate intestine injury in
            neonatal necrotizing enterocolitis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3020)
  AUTHORS   Iglesias-Martinez,L.F., Rauch,N., Wynne,K., McCann,B., Kolch,W. and
            Rauch,J.
  TITLE     Interactome dynamics of RAF1-BRAF kinase monomers and dimers
  JOURNAL   Sci Data 10 (1), 203 (2023)
   PUBMED   37045861
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3020)
  AUTHORS   Segal,D., Maier,S., Mastromarco,G.J., Qian,W.W., Nabeel-Shah,S.,
            Lee,H., Moore,G., Lacoste,J., Larsen,B., Lin,Z.Y.,
            Selvabaskaran,A., Liu,K., Smibert,C., Zhang,Z., Greenblatt,J.,
            Peng,J., Lee,H.O., Gingras,A.C. and Taipale,M.
  TITLE     A central chaperone-like role for 14-3-3 proteins in human cells
  JOURNAL   Mol Cell 83 (6), 974-993 (2023)
   PUBMED   36931259
REFERENCE   5  (bases 1 to 3020)
  AUTHORS   Cogo,S., Tomkins,J.E., Vavouraki,N., Giusti,V., Forcellato,F.,
            Franchin,C., Tessari,I., Arrigoni,G., Cendron,L., Manzoni,C.,
            Civiero,L., Lewis,P.A. and Greggio,E.
  TITLE     Cytosolic sequestration of spatacsin by Protein Kinase A and 14-3-3
            proteins
  JOURNAL   Neurobiol Dis 174, 105858 (2022)
   PUBMED   36096339
REFERENCE   6  (bases 1 to 3020)
  AUTHORS   Conklin,D.S., Galaktionov,K. and Beach,D.
  TITLE     14-3-3 proteins associate with cdc25 phosphatases
  JOURNAL   Proc Natl Acad Sci U S A 92 (17), 7892-7896 (1995)
   PUBMED   7644510
REFERENCE   7  (bases 1 to 3020)
  AUTHORS   Aitken,A., Howell,S., Jones,D., Madrazo,J. and Patel,Y.
  TITLE     14-3-3 alpha and delta are the phosphorylated forms of
            raf-activating 14-3-3 beta and zeta. In vivo stoichiometric
            phosphorylation in brain at a Ser-Pro-Glu-Lys MOTIF
  JOURNAL   J Biol Chem 270 (11), 5706-5709 (1995)
   PUBMED   7890696
REFERENCE   8  (bases 1 to 3020)
  AUTHORS   Li,S., Janosch,P., Tanji,M., Rosenfeld,G.C., Waymire,J.C.,
            Mischak,H., Kolch,W. and Sedivy,J.M.
  TITLE     Regulation of Raf-1 kinase activity by the 14-3-3 family of
            proteins
  JOURNAL   EMBO J 14 (4), 685-696 (1995)
   PUBMED   7882972
REFERENCE   9  (bases 1 to 3020)
  AUTHORS   Fantl,W.J., Muslin,A.J., Kikuchi,A., Martin,J.A., MacNicol,A.M.,
            Gross,R.W. and Williams,L.T.
  TITLE     Activation of Raf-1 by 14-3-3 proteins
  JOURNAL   Nature 371 (6498), 612-614 (1994)
   PUBMED   7935795
REFERENCE   10 (bases 1 to 3020)
  AUTHORS   Roth,D., Morgan,A., Martin,H., Jones,D., Martens,G.J., Aitken,A.
            and Burgoyne,R.D.
  TITLE     Characterization of 14-3-3 proteins in adrenal chromaffin cells and
            demonstration of isoform-specific phospholipid binding
  JOURNAL   Biochem J 301 (Pt 1) (Pt 1), 305-310 (1994)
   PUBMED   8037685
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB443535.1, BC001359.2,
            AL008725.1 and AA845374.1.
            
            On Nov 22, 2018 this sequence version replaced NM_139323.3.
            
            Summary: This gene encodes a protein belonging to the 14-3-3 family
            of proteins, members of which mediate signal transduction by
            binding to phosphoserine-containing proteins. This highly conserved
            protein family is found in both plants and mammals. The encoded
            protein has been shown to interact with RAF1 and CDC25
            phosphatases, suggesting that it may play a role in linking
            mitogenic signaling and the cell cycle machinery. Two transcript
            variants, which encode the same protein, have been identified for
            this gene. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) lacks an exon in the 5' UTR
            compared to variant 1. Variants 1 and 2 both encode the same
            protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.190139.1,
                                           SRR1803613.30355.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000353703.9/ ENSP00000300161.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 DB443535.1         161-164
            5-1010              BC001359.2         1-1006
            1011-2537           AL008725.1         61652-63178
            2538-3020           AA845374.1         11-493              c
FEATURES             Location/Qualifiers
     source          1..3020
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.12"
     gene            1..3020
                     /gene="YWHAB"
                     /gene_synonym="GW128; HEL-S-1; HS1; KCIP-1; YWHAA"
                     /note="tyrosine 3-monooxygenase/tryptophan 5-monooxygenase
                     activation protein beta"
                     /db_xref="GeneID:7529"
                     /db_xref="HGNC:HGNC:12849"
                     /db_xref="MIM:601289"
     exon            1..182
                     /gene="YWHAB"
                     /gene_synonym="GW128; HEL-S-1; HS1; KCIP-1; YWHAA"
                     /inference="alignment:Splign:2.1.0"
     exon            183..485
                     /gene="YWHAB"
                     /gene_synonym="GW128; HEL-S-1; HS1; KCIP-1; YWHAA"
                     /inference="alignment:Splign:2.1.0"
     CDS             186..926
                     /gene="YWHAB"
                     /gene_synonym="GW128; HEL-S-1; HS1; KCIP-1; YWHAA"
                     /note="tyrosine 3-monooxygenase/tryptophan 5-monooxygenase
                     activation protein, alpha polypeptide; 14-3-3 alpha;
                     protein kinase C inhibitor protein-1; protein 1054;
                     tyrosine 3-monooxygenase/tryptophan 5-monooxygenase
                     activation protein, beta polypeptide; epididymis secretory
                     protein Li 1"
                     /codon_start=1
                     /product="14-3-3 protein beta/alpha"
                     /protein_id="NP_647539.1"
                     /db_xref="CCDS:CCDS13339.1"
                     /db_xref="GeneID:7529"
                     /db_xref="HGNC:HGNC:12849"
                     /db_xref="MIM:601289"
                     /translation="MTMDKSELVQKAKLAEQAERYDDMAAAMKAVTEQGHELSNEERN
                     LLSVAYKNVVGARRSSWRVISSIEQKTERNEKKQQMGKEYREKIEAELQDICNDVLEL
                     LDKYLIPNATQPESKVFYLKMKGDYFRYLSEVASGDNKQTTVSNSQQAYQEAFEISKK
                     EMQPTHPIRLGLALNFSVFYYEILNSPEKACSLAKTAFDEAIAELDTLNEESYKDSTL
                     IMQLLRDNLTLWTSENQGDEGDAGEGEN"
     exon            486..609
                     /gene="YWHAB"
                     /gene_synonym="GW128; HEL-S-1; HS1; KCIP-1; YWHAA"
                     /inference="alignment:Splign:2.1.0"
     exon            610..773
                     /gene="YWHAB"
                     /gene_synonym="GW128; HEL-S-1; HS1; KCIP-1; YWHAA"
                     /inference="alignment:Splign:2.1.0"
     exon            774..869
                     /gene="YWHAB"
                     /gene_synonym="GW128; HEL-S-1; HS1; KCIP-1; YWHAA"
                     /inference="alignment:Splign:2.1.0"
     exon            870..3020
                     /gene="YWHAB"
                     /gene_synonym="GW128; HEL-S-1; HS1; KCIP-1; YWHAA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1949..1954
                     /regulatory_class="polyA_signal_sequence"
                     /gene="YWHAB"
                     /gene_synonym="GW128; HEL-S-1; HS1; KCIP-1; YWHAA"
                     /note="hexamer: AACAAA"
     polyA_site      1965
                     /gene="YWHAB"
                     /gene_synonym="GW128; HEL-S-1; HS1; KCIP-1; YWHAA"
     regulatory      2989..2994
                     /regulatory_class="polyA_signal_sequence"
                     /gene="YWHAB"
                     /gene_synonym="GW128; HEL-S-1; HS1; KCIP-1; YWHAA"
                     /note="hexamer: AATAAA"
     polyA_site      3020
                     /gene="YWHAB"
                     /gene_synonym="GW128; HEL-S-1; HS1; KCIP-1; YWHAA"
                     /note="major polyA site"
ORIGIN      
        1 ggaagtggag ctaccgccac cgccgccgcc gattccggag ccggggtagt cgccgccgcc
       61 gccgccgctg cagccactgc aggcaccgct gccgccgcct gagtagtggg cttaggaagg
      121 aagaggtcat ctcgctcgga gcttcgctcg gaagggtctt tgttccctgc agccctccca
      181 cgggaatgac aatggataaa agtgagctgg tacagaaagc caaactcgct gagcaggctg
      241 agcgatatga tgatatggct gcagccatga aggcagtcac agaacagggg catgaactct
      301 ccaacgaaga gagaaatctg ctctctgttg cctacaagaa tgtggtaggc gcccgccgct
      361 cttcctggcg tgtcatctcc agcattgagc agaaaacaga gaggaatgag aagaagcagc
      421 agatgggcaa agagtaccgt gagaagatag aggcagaact gcaggacatc tgcaatgatg
      481 ttctggagct gttggacaaa tatcttattc ccaatgctac acaaccagaa agtaaggtgt
      541 tctacttgaa aatgaaagga gattatttta ggtatctttc tgaagtggca tctggagaca
      601 acaaacaaac cactgtgtcg aactcccagc aggcttacca ggaagcattt gaaattagta
      661 agaaagaaat gcagcctaca cacccaattc gtcttggtct ggcactaaat ttctcagtct
      721 tttactatga gattctaaac tctcctgaaa aggcctgtag cctggcaaaa acggcatttg
      781 atgaagcaat tgctgaattg gatacgctga atgaagagtc ttataaagac agcactctga
      841 tcatgcagtt acttagggac aatctcactc tgtggacatc ggaaaaccag ggagacgaag
      901 gagacgctgg ggagggagag aactaatgtt tctcgtgctt tgtgatctgt tcagtgtcac
      961 tctgtaccct caacatatat cccttgtgcg ataaaaaaaa aaaaaaaaaa aaaaagagaa
     1021 tcgtacgtcg actttcgatt tttcacagcc tcagcctagg aaaaatggtt catgggataa
     1081 acagctggta tttgtatcta aaactcagat tggtcacata aatgccacgg cattccgaag
     1141 ttttgatttt gattaacatt gacaggatta ctgtgtgttt aattttttaa aaactgaaca
     1201 ctgtgattat ggggttttgt aatttagcag aactcttact ggtagaaaaa atagacctga
     1261 attatgtgta actttttgga aggtttaatc tgatatcaaa ataatcattg aaatacaatt
     1321 ccattgtaaa gttgtacaga aagttataga gattatattg tgatgctgga acttggagtg
     1381 agacacacat catttggcat ttgagttgaa tggtaattca cagtaatgct gccgttgttc
     1441 gggacttaaa gacacttgac ctgtttgggc tgttgccact taaaagttca tgaccacaaa
     1501 tgtccacagt gtcttcctct gaggaaactc gaatcctgaa atggaaattc tttgtggcag
     1561 ataactggct tatgacacct tgaaaagttc aagtgctcat ataacacacc acactgaacc
     1621 ccctttccta cagcaatatg ttcactatgt taccaatttg caacttgtgc ttcaatagtg
     1681 gaatctactt tcattgttaa cactgagcta aagaaaaaaa gccgtgtgtt ttatgaatga
     1741 ccttatctgt ttcctggata atacctttaa gaataatgtc ctgagtcagg cgtggtggtg
     1801 cgtgcatcta gtcccaacta tttgggaggc tgaggcagga ggatcgcttg agcccaggag
     1861 tttaaagctg cagtgccctg tggttgcacc tgtgaataac tgcactccag cctgggcaac
     1921 atagcgagac ctcatctcca aaaaagaaaa caaaaaacaa aaaaaggaat gatgttctgt
     1981 agagatggcc tttcacttga ggagtactca gttttcaggt tcttcctagc tcggggcttt
     2041 taaattttga aatctaaaca ttctttccca ccatcctttt tgactgttga ccttggtttt
     2101 ctcttctaag tttctgtccc tctgcttcct tacttttttt cctttttgaa ttctatcttt
     2161 atctgtcttt tgttcacttt ttaatgctat atatgggcag gggtgagaga cattactgag
     2221 caccttggtg agcaagcctg gctttaaaga ttggagaaga gcttctggca ccagaaccct
     2281 gtcttcctcc agttctcaac acggtgttgc tcttcagtca taccggaatc tgaatcaaaa
     2341 aagtattttt aaatatccat gatttctccc tgtattgagg ctagccctga tcatgctttt
     2401 tgtgcctgtc accaggtctc ccaagtgcac tcatccaggt cagtgctcag atgtgtttaa
     2461 ggagacccta tattcaggga agttgcgtga acactgcagt ggggagaatt gagaatagtc
     2521 aggcctatca gtctcacaga atcacccctc tacctttgat attccactta gctgtagagt
     2581 ccatctgttt gtccatctgc tgaaatgaga aaagaaaaat ttatgcactg atttaaaaca
     2641 aaccaaaaaa aaagaaaaaa acaaaaaaaa aaatccctcc tttctagctg aacaaaaatg
     2701 tgcagttaat acttggcgct tgaaaatgca gtagtgaatg tggaaccaag cctgtctgta
     2761 tatctggtag ctcttttctt gctttgtttt ttcttaccag tattctgcct aacgtttgct
     2821 tctgtgatgg ttatattgcc tagcaagcac acccgtggtt gtgaaaatag tatagcaaaa
     2881 aagaaaaatc cccggttatt gatgtactag atttgtgtat gtcttttaaa cagttctagt
     2941 ttcaccttac acagaataat caggaaaagt gtaaaaattc aaaagtgaaa taaaaatttt
     3001 atcagttagt tgcctgtgaa
//
