LOCUS       NM_152758               5095 bp    mRNA    linear   PRI 24-SEP-2024
DEFINITION  Homo sapiens YTH N6-methyladenosine RNA binding protein F3
            (YTHDF3), transcript variant 1, mRNA.
ACCESSION   NM_152758
VERSION     NM_152758.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5095)
  AUTHORS   Duan,J., Fan,D., Chen,P., Xiang,J., Xie,X., Peng,Y., Bai,J., Li,T.,
            Li,Y., Song,H., Fu,W., Zhang,T., Xiao,Y., Qi,X., Hong,W., Zhou,J.,
            He,Y., Wu,C., Zeng,H., Bai,H., Chen,T., Yu,W. and Zhang,Q.
  TITLE     YTHDF3 Regulates the Degradation and Stability of m6A-Enriched
            Transcripts to Facilitate the Progression of Castration-Resistant
            Prostate Cancer
  JOURNAL   J Pineal Res 76 (5), e13003 (2024)
   PUBMED   39143673
  REMARK    GeneRIF: YTHDF3 Regulates the Degradation and Stability of
            m6A-Enriched Transcripts to Facilitate the Progression of
            Castration-Resistant Prostate Cancer.
REFERENCE   2  (bases 1 to 5095)
  AUTHORS   Qiu,D., Gao,L. and Yu,X.
  TITLE     Knockdown of YAP1 Reduces YTHDF3 to Stabilize SMAD7 and thus
            Inhibit Bladder Cancer Stem Cell Stemness
  JOURNAL   Discov Med 36 (186), 1486-1498 (2024)
   PUBMED   39054719
  REMARK    GeneRIF: Knockdown of YAP1 Reduces YTHDF3 to Stabilize SMAD7 and
            thus Inhibit Bladder Cancer Stem Cell Stemness.
REFERENCE   3  (bases 1 to 5095)
  AUTHORS   Zhang,H., Sun,Y., Wang,Z., Huang,X., Tang,L., Jiang,K. and Jin,X.
  TITLE     ZDHHC20-mediated S-palmitoylation of YTHDF3 stabilizes MYC mRNA to
            promote pancreatic cancer progression
  JOURNAL   Nat Commun 15 (1), 4642 (2024)
   PUBMED   38821916
  REMARK    GeneRIF: ZDHHC20-mediated S-palmitoylation of YTHDF3 stabilizes MYC
            mRNA to promote pancreatic cancer progression.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5095)
  AUTHORS   Zhong,S., Guo,Q., Chen,X., Luo,X., Long,Y., Chong,T., Ye,M., He,H.,
            Lu,A., Ao,K., Yin,M., Xu,A., Li,X., Hao,Y. and Guo,X.
  TITLE     The inhibition of YTHDF3/m6A/LRP6 reprograms fatty acid metabolism
            and suppresses lymph node metastasis in cervical cancer
  JOURNAL   Int J Biol Sci 20 (3), 916-936 (2024)
   PUBMED   38250152
  REMARK    GeneRIF: The inhibition of YTHDF3/m[6]A/LRP6 reprograms fatty acid
            metabolism and suppresses lymph node metastasis in cervical cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5095)
  AUTHORS   Lee,H.H., Hsieh,C.C., Chang,C.C., Liao,W.T. and Chi,H.C.
  TITLE     YTHDF3 Modulates EGFR/ATK/ERK/p21 Signaling Axis to Promote Cancer
            Progression and Osimertinib Resistance of Glioblastoma Cells
  JOURNAL   Anticancer Res 43 (12), 5485-5498 (2023)
   PUBMED   38030188
  REMARK    GeneRIF: YTHDF3 Modulates EGFR/ATK/ERK/p21 Signaling Axis to
            Promote Cancer Progression and Osimertinib Resistance of
            Glioblastoma Cells.
REFERENCE   6  (bases 1 to 5095)
  AUTHORS   Varade,J., Comabella,M., Ortiz,M.A., Arroyo,R., Fernandez,O.,
            Pinto-Medel,M.J., Fedetz,M., Izquierdo,G., Lucas,M., Gomez,C.L.,
            Rabasa,A.C., Alcina,A., Matesanz,F., Alloza,I., Antiguedad,A.,
            Garcia-Barcina,M., Otaegui,D., Olascoaga,J., Saiz,A., Blanco,Y.,
            Montalban,X., Vandenbroeck,K. and Urcelay,E.
  TITLE     Replication study of 10 genes showing evidence for association with
            multiple sclerosis: validation of TMEM39A, IL12B and CBLB
            [correction of CLBL] genes
  JOURNAL   Mult Scler 18 (7), 959-965 (2012)
   PUBMED   22194214
REFERENCE   7  (bases 1 to 5095)
  AUTHORS   Dominissini,D., Moshitch-Moshkovitz,S., Schwartz,S.,
            Salmon-Divon,M., Ungar,L., Osenberg,S., Cesarkas,K.,
            Jacob-Hirsch,J., Amariglio,N., Kupiec,M., Sorek,R. and Rechavi,G.
  TITLE     Topology of the human and mouse m6A RNA methylomes revealed by
            m6A-seq
  JOURNAL   Nature 485 (7397), 201-206 (2012)
   PUBMED   22575960
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 5095)
  AUTHORS   Jager,S., Cimermancic,P., Gulbahce,N., Johnson,J.R., McGovern,K.E.,
            Clarke,S.C., Shales,M., Mercenne,G., Pache,L., Li,K., Hernandez,H.,
            Jang,G.M., Roth,S.L., Akiva,E., Marlett,J., Stephens,M., D'Orso,I.,
            Fernandes,J., Fahey,M., Mahon,C., O'Donoghue,A.J., Todorovic,A.,
            Morris,J.H., Maltby,D.A., Alber,T., Cagney,G., Bushman,F.D.,
            Young,J.A., Chanda,S.K., Sundquist,W.I., Kortemme,T.,
            Hernandez,R.D., Craik,C.S., Burlingame,A., Sali,A., Frankel,A.D.
            and Krogan,N.J.
  TITLE     Global landscape of HIV-human protein complexes
  JOURNAL   Nature 481 (7381), 365-370 (2011)
   PUBMED   22190034
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 5095)
  AUTHORS   Sundstrom,G., Dreborg,S. and Larhammar,D.
  TITLE     Concomitant duplications of opioid peptide and receptor genes
            before the origin of jawed vertebrates
  JOURNAL   PLoS One 5 (5), e10512 (2010)
   PUBMED   20463905
  REMARK    GeneRIF: Includes a multi-species analysis of YTHDF family members.
            Publication Status: Online-Only
REFERENCE   10 (bases 1 to 5095)
  AUTHORS   Stoilov,P., Rafalska,I. and Stamm,S.
  TITLE     YTH: a new domain in nuclear proteins
  JOURNAL   Trends Biochem Sci 27 (10), 495-497 (2002)
   PUBMED   12368078
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK127574.1 and AL832335.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_152758.5.
            
            Summary: This gene encodes a member of the YTH (YT521-B homology)
            domain protein family. The YTH domain is common in eukaryotes, is
            often found in the middle of the protein sequence, and may function
            in binding to RNA. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Apr 2013].
            
            Transcript Variant: This variant (1) encodes isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL832005.1, SRR1660803.159280.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000539294.6/ ENSP00000473496.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4505              AK127574.1         1-4505
            4506-5095           AL832335.1         4502-5091
FEATURES             Location/Qualifiers
     source          1..5095
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q12.3"
     gene            1..5095
                     /gene="YTHDF3"
                     /gene_synonym="DF3"
                     /note="YTH N6-methyladenosine RNA binding protein F3"
                     /db_xref="GeneID:253943"
                     /db_xref="HGNC:HGNC:26465"
                     /db_xref="MIM:618669"
     exon            1..281
                     /gene="YTHDF3"
                     /gene_synonym="DF3"
                     /inference="alignment:Splign:2.1.0"
     CDS             258..2015
                     /gene="YTHDF3"
                     /gene_synonym="DF3"
                     /note="isoform a is encoded by transcript variant 1; YTH
                     domain family protein 3; YTH N(6)-methyladenosine RNA
                     binding protein 3; YTH domain-containing family protein 3;
                     YTH domain family, member 3; YTH N6-methyladenosine RNA
                     binding protein 3"
                     /codon_start=1
                     /product="YTH domain-containing family protein 3 isoform
                     a"
                     /protein_id="NP_689971.4"
                     /db_xref="CCDS:CCDS75747.1"
                     /db_xref="GeneID:253943"
                     /db_xref="HGNC:HGNC:26465"
                     /db_xref="MIM:618669"
                     /translation="MSATSVDQRPKGQGNKVSVQNGSIHQKDAVNDDDFEPYLSSQTN
                     QSNSYPPMSDPYMPSYYAPSIGFPYSLGEAAWSTAGDQPMPYLTTYGQMSNGEHHYIP
                     DGVFSQPGALGNTPPFLGQHGFNFFPGNADFSTWGTSGSQGQSTQSSAYSSSYGYPPS
                     SLGRAITDGQAGFGNDTLSKVPGISSIEQGMTGLKIGGDLTAAVTKTVGTALSSSGMT
                     SIATNSVPPVSSAAPKPTSWAAIARKPAKPQPKLKPKGNVGIGGSAVPPPPIKHNMNI
                     GTWDEKGSVVKAPPTQPVLPPQTIIQQPQPLIQPPPLVQSQLPQQQPQPPQPQQQQGP
                     QPQAQPHQVQPQQQQLQNRWVAPRNRGAGFNQNNGAGSENFGLGVVPVSASPSSVEVH
                     PVLEKLKAINNYNPKDFDWNLKNGRVFIIKSYSEDDIHRSIKYSIWCSTEHGNKRLDA
                     AYRSLNGKGPLYLLFSVNGSGHFCGVAEMKSVVDYNAYAGVWSQDKWKGKFEVKWIFV
                     KDVPNNQLRHIRLENNDNKPVTNSRDTQEVPLEKAKQVLKIIATFKHTTSIFDDFAHY
                     EKRQEEEEAMRRERNRNKQ"
     exon            282..306
                     /gene="YTHDF3"
                     /gene_synonym="DF3"
                     /inference="alignment:Splign:2.1.0"
     exon            307..392
                     /gene="YTHDF3"
                     /gene_synonym="DF3"
                     /inference="alignment:Splign:2.1.0"
     exon            393..1991
                     /gene="YTHDF3"
                     /gene_synonym="DF3"
                     /inference="alignment:Splign:2.1.0"
     exon            1992..5095
                     /gene="YTHDF3"
                     /gene_synonym="DF3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5077..5082
                     /regulatory_class="polyA_signal_sequence"
                     /gene="YTHDF3"
                     /gene_synonym="DF3"
                     /note="hexamer: AATAAA"
     polyA_site      5095
                     /gene="YTHDF3"
                     /gene_synonym="DF3"
                     /note="major polyA site"
ORIGIN      
        1 gagactaggg agtctgtccg ccattgtgga cccgagaagc agagagcgag agggggaaga
       61 ggagcgtgca agcggaaaag acgggcctct tcctccgact cccgagcgcg aggccctcat
      121 tttgggttct cagcgaacgg cggcagcggc ggcggctgga acaatcactc ggccaagggc
      181 gacagccaac tgctgtgagt gcacggggag aggcccaggc agcggcggcg gcggcggctc
      241 tcgggttgcg gtgaagaatg tcagccacta gcgtggatca gagacctaaa gggcaaggaa
      301 ataaagtttc agtacaaaac ggttcgattc atcaaaaaga tgctgtaaat gatgatgatt
      361 ttgagccata cttaagtagc cagacaaatc agagtaacag ctatccacca atgtcagatc
      421 catacatgcc tagttactat gctccatcca ttggatttcc atattctctt ggggaagcag
      481 cgtggtccac agctggagac cagcctatgc catatctgac aacctatgga caaatgagta
      541 atggagaaca tcactatata ccagatggtg tatttagtca acctggggca ttaggaaata
      601 cccctccatt tcttggtcaa catggattta acttttttcc tggtaatgct gatttctcta
      661 catgggggac aagtggatct cagggacaat caacacaaag ttctgcttat agtagcagtt
      721 atggctatcc acctagttct cttgggagag ctattactga tggacaggct ggatttggca
      781 atgatacttt gagtaaggtg cctggcatta gcagtattga gcaaggcatg actggactga
      841 aaattggtgg tgacctgaca gctgcagtga caaaaactgt aggtacagct ttgagcagca
      901 gtggtatgac tagcattgca accaatagtg tgcccccagt tagcagtgca gcacctaaac
      961 caacctcctg ggctgccatt gccagaaagc ctgccaaacc tcaaccgaaa cttaaaccca
     1021 agggcaatgt gggaattggg ggttctgctg taccaccacc tcctataaaa cacaacatga
     1081 atattggaac ttgggatgaa aaagggtcag tggtaaaggc tccaccaacc caaccagttc
     1141 tgcctcctca aactataatc cagcagcctc agccattaat tcaaccacca ccattggtgc
     1201 aaagccaact gcctcaacag cagcctcaac caccacaacc acagcagcaa caaggacctc
     1261 agccacaggc ccagcctcac caagtgcagc ctcaacagca gcagctgcag aatcgctggg
     1321 tagctcctcg taacagggga gcaggcttca accagaacaa tggagcgggc agtgaaaact
     1381 ttggtttagg tgttgtacct gtcagtgctt caccttctag tgtagaagtg catcccgtgc
     1441 tggaaaagct aaaggccata aacaactata atcccaaaga ctttgattgg aatctgaaga
     1501 atggacgtgt gtttataatt aaaagctact ctgaggatga catacatcgt tccattaaat
     1561 actctatctg gtgtagtact gagcatggta ataagcgttt ggatgcagct taccgttccc
     1621 tgaatgggaa aggcccactc tatttactct tcagtgtgaa tggcagtgga catttttgtg
     1681 gagtggctga aatgaagtct gttgtggact ataatgcgta tgctggtgtc tggtctcagg
     1741 ataagtggaa gggcaaattt gaagttaaat ggatctttgt caaagatgtt cccaataacc
     1801 aattacggca tattcgctta gaaaataatg acaacaaacc ggttaccaat tcaagggaca
     1861 ctcaagaggt acccctagaa aaagctaagc aagtgcttaa aataattgct actttcaagc
     1921 ataccacctc aatctttgat gactttgcac attatgaaaa gcgtcaagaa gaggaggaag
     1981 ccatgcgtag ggagagaaat agaaacaaac aataaccgta tgaagatgtc ctgttaaatt
     2041 tacaacacta acgatgtaga ctctggaaat gcctaataag tcaaagaaga cgtattaaag
     2101 ctcttttctg cttaaggtga catctttgaa cactttaaca caaagttgac tcttctcgta
     2161 atggttttca tcagcgcatc tgcccttata ctcttcacca aacacacttg agaactgtaa
     2221 cttcgtcaag cactttctgt cctgaagctt ttaccagtat ctgctgtctt ttgtaattat
     2281 gcatcctagc taaggcacag aagactgaat gaatgcaagg attcattaac tctttgaatt
     2341 tgttaaatac taacagttaa ccattagaag tggttcaatg atgtaagagt cacactgctt
     2401 caactttttc tttgttgtag tttttaaatt gtcgattttt agctatttga cagattaaaa
     2461 gcaaaataat catgccatat ttagtcctgg agttcaagtc taaatgttga tgtgaaaaat
     2521 tattgtagta aacttttaat atggcaaagc aaccttaagc tctattttag ccaaatgaaa
     2581 cataatctga aattatatta gaacatttcc cttgtcttca aactgtttgg tgtaacagaa
     2641 tattgatatg cagcttggtg gatttcacca gttaatgcac attcttcttc cctcctcccc
     2701 ccattaatat gtatactgaa aaatgtgcat ttgtctgagg aattattttg tttgctacca
     2761 cttaatgaat ctcaaaattt tgagtaaatg tacctcagtc taatcagact ttttatgacc
     2821 tttataacta catttaaaac ccttaattcc tatttctggg tgtttgcgag cctgattgct
     2881 atcatgaagt aaaaatttat tactctaggt attcactagc taaataaaca tagttcttgt
     2941 ttagcaagca tatgttgttc ctcagctctt ttctccagct tttgcagtgt cctggcatcc
     3001 ttaaaatact ttgaaaatat ggccttgatc catggattaa atcagtatct aagtgaatgt
     3061 gttgatgttt tattgatcag atctatataa gtgggaatac agcatatatc tggatattct
     3121 tatagttatc tttttaacat cttatttttt tcattaatta catatcaaca ttaattttgt
     3181 atcttgaagc aaattgattt tgtataatta aatgtgtcaa gcatctgtat taattgattt
     3241 gatggcataa ggttatgaaa ataatgtact gccccatgta ttactgttcc aaaaggagaa
     3301 agctatgtag aaagatacat taagggtgaa aatagcaata cagtagattt gaataccttg
     3361 atgttttgca ttacttcatt tatgtttaca tcatgtttag aaatgttttc atttactgtg
     3421 gtctttggtc acttcagctc aaagacctag tgatggatat ttctttgagg ctttcattta
     3481 tataatttta ttttgtacaa tgtttttttt aaatgtgcaa atactgtatt caagtgaaaa
     3541 aaatacagta tttgtagata accatagcta ctacacagtt cttcggtagt cccagtgtag
     3601 ttatatcagt gtttactgaa gggaacatca aaatattaat ggtatattat aaaataaaga
     3661 ctttcttaaa ggaaaattgc acctatttta cctttttaag agtaagccat gaaatcttgt
     3721 aacatgtctc ttaactattt ataatgaaaa gtggcatttg ggtatagtca ccacagcaat
     3781 gttctacatc cctaagatta tctaggtagg acatgtcaaa gatgactgtt gtcattctgg
     3841 aggtcctatt agagaatatt ataaaagggt gaccttgtag gaaggatctg agtcctcccc
     3901 ctgaggttct ctttttcttg gtgctttatt agcaactctg gatattttta taaaactagt
     3961 tacattataa acggtttcaa acatgtttaa tttacattag gtttttatgt aagagtgtca
     4021 tggaagcact cagcaagcag gctgattgca atagactcag acatgcgaat aaatgtaatt
     4081 gagagtctat tcatggtgag gagtacatcc cagtgccttt aacctggatt tctaatctta
     4141 agtgaaatgg gtgcagcatt cctttggaaa aaaaaatctt tttattttca agtgataatt
     4201 ttgtgttttt ctcatataag ttttctccag agcacccacc ttctcttcct tcttggtctg
     4261 tcattatatt gcaaaatatt tttcctctga atgaaattat cacaggttgt ctcaagcaca
     4321 accaactgaa tgtctcttaa ctgtggggac caaaagggag agagcctggg gtctacaaga
     4381 ggagacacat catcaaatgt ttgaatgatc acaaattaag acattatcag cccagtaaat
     4441 ttcttgctta atgtttttcc aagttctggc ttgaatattt cttattaaag ctatcttatg
     4501 tgggtatttt attttgaaag gtattatagt ttgtatattt aacagtaagg aggaaactgt
     4561 aaccaaaatt agtatttctc tatacgtatt ggtacttgaa gattcctttc aaaagaaatc
     4621 cagcgttttc ctaattttag tacttaattt ctctttttaa tttaagtgat ctttctaatt
     4681 cgaaagctgt gttctttttg aataccgtgc atgggggtta agctgatgtt aaaacagttt
     4741 gcaataaaaa aaaatgaatc agcttaagtc atttaatcat ttcaagtgca ttctgcatcc
     4801 tttaaaaata agtttaagaa atttaagaga attgtgtttt cattaagttt tgcatatctt
     4861 ttgttatgcc atgtaaattc cctttttcgt atgattaaag gaaggttatg ataaaatgat
     4921 tagttcattt acattcactt gtagcaatta catgagaatt tgaattttgt cgtgtttggg
     4981 tttgttcatt cctgtgaatg atggtacagt taggtgagat tttctgttat ggtacccaaa
     5041 ctcaccattt ggtcctcttt aatctttgag ggtttcaata aaaattgttc actca
//
