LOCUS       NM_016258               2744 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens YTH N6-methyladenosine RNA binding protein F2
            (YTHDF2), transcript variant 1, mRNA.
ACCESSION   NM_016258
VERSION     NM_016258.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2744)
  AUTHORS   Jiao,Y.Y., Song,N., Fang,X.Y., Lu,X.T., Sun,N., Jin,H.X., Chen,L.,
            Huang,X.J., Wen,S., Wu,Z.T., Wang,X.P., Cheng,T.T., Yao,G.D. and
            Song,W.Y.
  TITLE     YTHDF2 regulates MSS51 expression contributing to mitochondria
            dysfunction of granulosa cells in polycystic ovarian syndrome
            patients
  JOURNAL   Mol Cell Endocrinol 592, 112292 (2024)
   PUBMED   38830447
  REMARK    GeneRIF: YTHDF2 regulates MSS51 expression contributing to
            mitochondria dysfunction of granulosa cells in polycystic ovarian
            syndrome patients.
REFERENCE   2  (bases 1 to 2744)
  AUTHORS   Wang,J., Shen,Y., Zhang,Y., Lin,D., Wang,Q., Sun,X., Wei,D.,
            Shen,B., Chen,J., Ji,Y., Fulton,D., Yu,Y., Chen,F. and Hu,L.
  TITLE     Smooth Muscle Ythdf2 Abrogation Ameliorates Pulmonary Vascular
            Remodeling by Regulating Myadm Transcript Stability
  JOURNAL   Hypertension 81 (8), 1785-1798 (2024)
   PUBMED   38832511
  REMARK    GeneRIF: Smooth Muscle Ythdf2 Abrogation Ameliorates Pulmonary
            Vascular Remodeling by Regulating Myadm Transcript Stability.
REFERENCE   3  (bases 1 to 2744)
  AUTHORS   Yang,Z., Zhang,X., Zhang,X., Liu,Y., Zhang,J. and Yuan,X.
  TITLE     [Porphyromonas gingivalis infection facilitates immune escape of
            esophageal cancer by enhancing YTHDF2-mediated Fas degradation]
  JOURNAL   Nan Fang Yi Ke Da Xue Xue Bao 44 (6), 1159-1165 (2024)
   PUBMED   38977346
  REMARK    GeneRIF: [Porphyromonas gingivalis infection facilitates immune
            escape of esophageal cancer by enhancing YTHDF2-mediated Fas
            degradation].
REFERENCE   4  (bases 1 to 2744)
  AUTHORS   Zhang,P., Zhang,W., Wang,X., Li,L., Lin,Y., Wu,N., Mao,R., Lin,J.,
            Kang,M. and Ding,C.
  TITLE     BCLAF1 drives esophageal squamous cell carcinoma progression
            through regulation of YTHDF2-dependent SIX1 mRNA degradation
  JOURNAL   Cancer Lett 591, 216874 (2024)
   PUBMED   38636894
  REMARK    GeneRIF: BCLAF1 drives esophageal squamous cell carcinoma
            progression through regulation of YTHDF2-dependent SIX1 mRNA
            degradation.
REFERENCE   5  (bases 1 to 2744)
  AUTHORS   Xiao,S., Ma,S., Sun,B., Pu,W., Duan,S., Han,J., Hong,Y., Zhang,J.,
            Peng,Y., He,C., Yi,P., Caligiuri,M.A. and Yu,J.
  TITLE     The tumor-intrinsic role of the m6A reader YTHDF2 in regulating
            immune evasion
  JOURNAL   Sci Immunol 9 (95), eadl2171 (2024)
   PUBMED   38820140
  REMARK    GeneRIF: The tumor-intrinsic role of the m[6]A reader YTHDF2 in
            regulating immune evasion.
REFERENCE   6  (bases 1 to 2744)
  AUTHORS   Dominissini,D., Moshitch-Moshkovitz,S., Schwartz,S.,
            Salmon-Divon,M., Ungar,L., Osenberg,S., Cesarkas,K.,
            Jacob-Hirsch,J., Amariglio,N., Kupiec,M., Sorek,R. and Rechavi,G.
  TITLE     Topology of the human and mouse m6A RNA methylomes revealed by
            m6A-seq
  JOURNAL   Nature 485 (7397), 201-206 (2012)
   PUBMED   22575960
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2744)
  AUTHORS   Nguyen,T.T., Ma,L.N., Slovak,M.L., Bangs,C.D., Cherry,A.M. and
            Arber,D.A.
  TITLE     Identification of novel Runx1 (AML1) translocation partner genes
            SH3D19, YTHDf2, and ZNF687 in acute myeloid leukemia
  JOURNAL   Genes Chromosomes Cancer 45 (10), 918-932 (2006)
   PUBMED   16858696
REFERENCE   8  (bases 1 to 2744)
  AUTHORS   Cardelli,M., Marchegiani,F., Cavallone,L., Olivieri,F.,
            Giovagnetti,S., Mugianesi,E., Moresi,R., Lisa,R. and Franceschi,C.
  TITLE     A polymorphism of the YTHDF2 gene (1p35) located in an Alu-rich
            genomic domain is associated with human longevity
  JOURNAL   J Gerontol A Biol Sci Med Sci 61 (6), 547-556 (2006)
   PUBMED   16799135
  REMARK    GeneRIF: YTHDF2 messenger RNA resulted to be mainly expressed in
            testis and placenta. The data suggest a possible role of this locus
            in human longevity.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 2744)
  AUTHORS   Stoilov,P., Rafalska,I. and Stamm,S.
  TITLE     YTH: a new domain in nuclear proteins
  JOURNAL   Trends Biochem Sci 27 (10), 495-497 (2002)
   PUBMED   12368078
  REMARK    Review article
REFERENCE   10 (bases 1 to 2744)
  AUTHORS   Scanlan,M.J., Gordan,J.D., Williamson,B., Stockert,E., Bander,N.H.,
            Jongeneel,V., Gure,A.O., Jager,D., Jager,E., Knuth,A., Chen,Y.T.
            and Old,L.J.
  TITLE     Antigens recognized by autologous antibody in patients with
            renal-cell carcinoma
  JOURNAL   Int J Cancer 83 (4), 456-464 (1999)
   PUBMED   10508479
  REMARK    GeneRIF: PMID:10508479 reported that AF155095 (clone REN-2) may be
            involved in signal transduction and the gene is on chromosome 14.
            It turns out that it is the pseudogene, not the real gene, is
            located on chromosome 14.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL645729.14 and AL356786.36.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_016258.2.
            
            Summary: This gene encodes a member of the YTH (YT521-B homology)
            superfamily containing YTH domain. The YTH domain is typical for
            the eukaryotes and is particularly abundant in plants. The YTH
            domain is usually located in the middle of the protein sequence and
            may function in binding to RNA. In addition to a YTH domain, this
            protein has a proline rich region which may be involved in signal
            transduction. An Alu-rich domain has been identified in one of the
            introns of this gene, which is thought to be associated with human
            longevity. In addition, reciprocal translocations between this gene
            and the Runx1 (AML1) gene on chromosome 21 has been observed in
            patients with acute myeloid leukemia. This gene was initially
            mapped to chromosome 14, which was later turned out to be a
            pseudogene. Alternatively spliced transcript variants encoding
            different isoforms have been identified in this gene. [provided by
            RefSeq, Oct 2012].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.6449.1,
                                           SRR3476690.1034250.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000373812.8/ ENSP00000362918.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-208               AL645729.14        82539-82746
            209-233             AL645729.14        83257-83281
            234-313             AL645729.14        83858-83937
            314-1897            AL645729.14        88002-89585
            1898-2744           AL356786.36        20308-21154
FEATURES             Location/Qualifiers
     source          1..2744
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p35.3"
     gene            1..2744
                     /gene="YTHDF2"
                     /gene_synonym="CAHL; DF2; HGRG8; NY-REN-2"
                     /note="YTH N6-methyladenosine RNA binding protein F2"
                     /db_xref="GeneID:51441"
                     /db_xref="HGNC:HGNC:31675"
                     /db_xref="MIM:610640"
     exon            1..208
                     /gene="YTHDF2"
                     /gene_synonym="CAHL; DF2; HGRG8; NY-REN-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             182..1921
                     /gene="YTHDF2"
                     /gene_synonym="CAHL; DF2; HGRG8; NY-REN-2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     high-glucose-regulated protein 8; 9430020E02Rik;
                     CLL-associated antigen KW-14; YTH N6-methyladenosine RNA
                     binding protein 2; renal carcinoma antigen NY-REN-2; YTH
                     domain-containing family protein 2; YTH domain family,
                     member 2; YTH N(6)-methyladenosine RNA binding protein 2"
                     /codon_start=1
                     /product="YTH domain-containing family protein 2 isoform
                     1"
                     /protein_id="NP_057342.2"
                     /db_xref="CCDS:CCDS41296.1"
                     /db_xref="GeneID:51441"
                     /db_xref="HGNC:HGNC:31675"
                     /db_xref="MIM:610640"
                     /translation="MSASSLLEQRPKGQGNKVQNGSVHQKDGLNDDDFEPYLSPQARP
                     NNAYTAMSDSYLPSYYSPSIGFSYSLGEAAWSTGGDTAMPYLTSYGQLSNGEPHFLPD
                     AMFGQPGALGSTPFLGQHGFNFFPSGIDFSAWGNNSSQGQSTQSSGYSSNYAYAPSSL
                     GGAMIDGQSAFANETLNKAPGMNTIDQGMAALKLGSTEVASNVPKVVGSAVGSGSITS
                     NIVASNSLPPATIAPPKPASWADIASKPAKQQPKLKTKNGIAGSSLPPPPIKHNMDIG
                     TWDNKGPVAKAPSQALVQNIGQPTQGSPQPVGQQANNSPPVAQASVGQQTQPLPPPPP
                     QPAQLSVQQQAAQPTRWVAPRNRGSGFGHNGVDGNGVGQSQAGSGSTPSEPHPVLEKL
                     RSINNYNPKDFDWNLKHGRVFIIKSYSEDDIHRSIKYNIWCSTEHGNKRLDAAYRSMN
                     GKGPVYLLFSVNGSGHFCGVAEMKSAVDYNTCAGVWSQDKWKGRFDVRWIFVKDVPNS
                     QLRHIRLENNENKPVTNSRDTQEVPLEKAKQVLKIIASYKHTTSIFDDFSHYEKRQEE
                     EESVKKERQGRGK"
     exon            209..233
                     /gene="YTHDF2"
                     /gene_synonym="CAHL; DF2; HGRG8; NY-REN-2"
                     /inference="alignment:Splign:2.1.0"
     exon            234..313
                     /gene="YTHDF2"
                     /gene_synonym="CAHL; DF2; HGRG8; NY-REN-2"
                     /inference="alignment:Splign:2.1.0"
     exon            314..1897
                     /gene="YTHDF2"
                     /gene_synonym="CAHL; DF2; HGRG8; NY-REN-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1898..2744
                     /gene="YTHDF2"
                     /gene_synonym="CAHL; DF2; HGRG8; NY-REN-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2717..2722
                     /regulatory_class="polyA_signal_sequence"
                     /gene="YTHDF2"
                     /gene_synonym="CAHL; DF2; HGRG8; NY-REN-2"
                     /note="hexamer: AATAAA"
     polyA_site      2744
                     /gene="YTHDF2"
                     /gene_synonym="CAHL; DF2; HGRG8; NY-REN-2"
                     /note="major polyA site"
ORIGIN      
        1 agagcgtcgc cgagtcggag ccggagcctg agccgcgcgc tgtgtctccg ctgcgtccgc
       61 cgaggccccc gagtgtcagg gacaaaagcc tccgcctgct cccgcagacg gggctcatct
      121 gccgccgccg ccgcgctgag gagagttcgc cgccgtcgcc gcccgtgagg atctgagagc
      181 catgtcggcc agcagcctct tggagcagag accaaaaggt caaggaaaca aagtacaaaa
      241 tggatctgta catcaaaagg atggattaaa cgatgatgat tttgaacctt acttgagtcc
      301 acaggcaagg cccaataatg catatactgc catgtcagat tcctacttac ccagttacta
      361 cagtccctcc attggcttct cctattcttt gggtgaagct gcttggtcta cggggggtga
      421 cacagccatg ccctacttaa cttcttatgg acagctgagc aacggagagc cccacttcct
      481 accagatgca atgtttgggc aaccaggagc cctaggtagc actccatttc ttggtcagca
      541 tggttttaat ttctttccca gtgggattga cttctcagca tggggaaata acagttctca
      601 gggacagtct actcagagct ctggatatag tagcaattat gcttatgcac ctagctcctt
      661 aggtggagcc atgattgatg gacagtcagc ttttgccaat gagaccctca ataaggctcc
      721 tggcatgaat actatagacc aagggatggc agcactgaag ttgggtagca cagaagttgc
      781 aagcaatgtt ccaaaagttg taggttctgc tgttggtagc gggtccatta ctagtaacat
      841 cgtggcttcc aatagtttgc ctccagccac cattgctcct ccaaaaccag catcttgggc
      901 tgatattgct agcaagcctg caaaacagca acctaaactg aagaccaaga atggcattgc
      961 agggtcaagt cttccgccac ccccgataaa gcataacatg gatattggaa cttgggataa
     1021 caagggtccc gttgcaaaag ccccctcaca ggctttggtt cagaatatag gtcagccaac
     1081 ccaggggtct cctcagcctg taggtcagca ggctaacaat agcccaccag tggctcaggc
     1141 atcagtaggg caacagacac agccattgcc tccacctcca ccacagcctg cccagctttc
     1201 agtccagcaa caggcagctc agccaacccg ctgggtagca cctcggaacc gtggcagtgg
     1261 gttcggtcat aatggggtgg atggtaatgg agtaggacag tctcaggctg gttctggatc
     1321 tactccttca gaaccccacc cagtgttgga gaagcttcgg tccattaata actataaccc
     1381 caaagatttt gactggaatc tgaaacatgg ccgggttttc atcattaaga gctactctga
     1441 ggacgatatt caccgttcca ttaagtataa tatttggtgc agcacagagc atggtaacaa
     1501 gagactggat gctgcttatc gttccatgaa cgggaaaggc cccgtttact tacttttcag
     1561 tgtcaacggc agtggacact tctgtggcgt ggcagaaatg aaatctgctg tggactacaa
     1621 cacatgtgca ggtgtgtggt cccaggacaa atggaagggt cgttttgatg tcaggtggat
     1681 ttttgtgaag gacgttccca atagccaact gcgacacatt cgcctagaga acaacgagaa
     1741 taaaccagtg accaactcta gggacactca ggaagtgcct ctggaaaagg ctaagcaggt
     1801 gttgaaaatt atagccagct acaagcacac cacttccatt tttgatgact tctcacacta
     1861 tgagaaacgc caagaggaag aagaaagtgt taaaaaggaa cgtcaaggtc gtgggaaata
     1921 aaaggcagtt ctacacagac tgcagcaacg gttgcatctg catatcctaa gaggaaaaaa
     1981 tgaccttcaa gagaattagg acttttttct taatttcact gacttcagag acgattgcag
     2041 acttgcagtt taagtattgg aatttcacaa aagacatagg acttaactgg aaaatgaaaa
     2101 aaaaaagaaa aagaaaaaac taaacaaaaa atccctctag gtagtttagg tgaaaaatgt
     2161 cccttttatt ttggctttgg ttgtgatttc agagcataat gctatgtttt tttgtctttt
     2221 tactatgttt ttcggatttt taagtccgta agtgcataca gttttctcta atttttaaac
     2281 cctttcctcc tcccattttg acatttgcac ttggagaaca cttgagttgt gaaggttttg
     2341 ggcatccacc ccagaaagtg ggaatttgat tttatccttc cgaactggaa gaacattttt
     2401 atgaagaatt tttgtctagg agaatataac agtgttaccc aaggttgtgt ctttaagggt
     2461 ggttcatttt ctctgacctt ttgttactca aagtaaagta ctaggagtcc taagaaatgt
     2521 tctgttcttg tacattatac tgattaagtc aggattaatt tgatttcaaa gctgagaaca
     2581 gtggtaaaaa ctcgtttaca gaaatgcatt ttggaagaga aaaatactgt aaaacgtgtc
     2641 gtgaatgttt cttcagtttc ttgttcagcc aatgaggaaa gggcattgcc tttcttttta
     2701 ccattaatca cttctcaata aacgtgagat cctgttgagc atca
//
