LOCUS       NM_017798               3198 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens YTH N6-methyladenosine RNA binding protein F1
            (YTHDF1), mRNA.
ACCESSION   NM_017798
VERSION     NM_017798.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3198)
  AUTHORS   Han,Y., Pu,Y., Liu,X., Liu,Z., Chen,Y., Tang,L., Zhou,J., Song,Q.
            and Ji,Q.
  TITLE     YTHDF1 regulates GID8-mediated glutamine metabolism to promote
            colorectal cancer progression in m6A-dependent manner
  JOURNAL   Cancer Lett 601, 217186 (2024)
   PUBMED   39151722
  REMARK    GeneRIF: YTHDF1 regulates GID8-mediated glutamine metabolism to
            promote colorectal cancer progression in m6A-dependent manner.
REFERENCE   2  (bases 1 to 3198)
  AUTHORS   Zhang,L., Cai,E., Xu,Y., Liu,Z., Zheng,M., Sun,Z., Pei,D. and
            Wang,Q.
  TITLE     YTHDF1 facilitates esophageal cancer progression via augmenting
            m6A-dependent TINAGL1 translation
  JOURNAL   Cell Signal 122, 111332 (2024)
   PUBMED   39098703
  REMARK    GeneRIF: YTHDF1 facilitates esophageal cancer progression via
            augmenting m6A-dependent TINAGL1 translation.
REFERENCE   3  (bases 1 to 3198)
  AUTHORS   Chen,D., Ji,F., Zhou,Q., Cheung,H., Pan,Y., Lau,H.C., Liang,C.,
            Yang,Z., Huang,P., Wei,Q., Cheung,A.H., Kang,W., Chen,H., Yu,J. and
            Wong,C.C.
  TITLE     RUVBL1/2 Blockade Targets YTHDF1 Activity to Suppress m6A-Dependent
            Oncogenic Translation and Colorectal Tumorigenesis
  JOURNAL   Cancer Res 84 (17), 2856-2872 (2024)
   PUBMED   38900944
  REMARK    GeneRIF: RUVBL1/2 Blockade Targets YTHDF1 Activity to Suppress
            m6A-Dependent Oncogenic Translation and Colorectal Tumorigenesis.
REFERENCE   4  (bases 1 to 3198)
  AUTHORS   Wang,S., Xu,L., Wang,D., Zhao,S., Li,K., Ma,F., Yao,Q., Zhang,Y.,
            Wu,Z., Shao,Y., Song,S. and Yan,W.
  TITLE     YTHDF1 promotes the osteolytic bone metastasis of breast cancer via
            inducing EZH2 and CDH11 translation
  JOURNAL   Cancer Lett 597, 217047 (2024)
   PUBMED   38871245
  REMARK    GeneRIF: YTHDF1 promotes the osteolytic bone metastasis of breast
            cancer via inducing EZH2 and CDH11 translation.
REFERENCE   5  (bases 1 to 3198)
  AUTHORS   Wu,Y., Luo,Y., Yao,X., Shi,X., Xu,Z., Re,J., Shi,M., Li,M., Liu,J.,
            He,Y. and Du,X.
  TITLE     KIAA1429 increases FOXM1 expression through YTHDF1-mediated m6A
            modification to promote aerobic glycolysis and tumorigenesis in
            multiple myeloma
  JOURNAL   Cell Biol Toxicol 40 (1), 58 (2024)
   PUBMED   39060874
  REMARK    GeneRIF: KIAA1429 increases FOXM1 expression through
            YTHDF1-mediated m6A modification to promote aerobic glycolysis and
            tumorigenesis in multiple myeloma.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3198)
  AUTHORS   Li,L., Fridley,B.L., Kalari,K., Niu,N., Jenkins,G., Batzler,A.,
            Abo,R.P., Schaid,D. and Wang,L.
  TITLE     Discovery of genetic biomarkers contributing to variation in drug
            response of cytidine analogues using human lymphoblastoid cell
            lines
  JOURNAL   BMC Genomics 15, 93 (2014)
   PUBMED   24483146
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3198)
  AUTHORS   Wang,X., Lu,Z., Gomez,A., Hon,G.C., Yue,Y., Han,D., Fu,Y.,
            Parisien,M., Dai,Q., Jia,G., Ren,B., Pan,T. and He,C.
  TITLE     N6-methyladenosine-dependent regulation of messenger RNA stability
  JOURNAL   Nature 505 (7481), 117-120 (2014)
   PUBMED   24284625
REFERENCE   8  (bases 1 to 3198)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   9  (bases 1 to 3198)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   10 (bases 1 to 3198)
  AUTHORS   Deloukas,P., Matthews,L.H., Ashurst,J., Burton,J., Gilbert,J.G.,
            Jones,M., Stavrides,G., Almeida,J.P., Babbage,A.K., Bagguley,C.L.,
            Bailey,J., Barlow,K.F., Bates,K.N., Beard,L.M., Beare,D.M.,
            Beasley,O.P., Bird,C.P., Blakey,S.E., Bridgeman,A.M., Brown,A.J.,
            Buck,D., Burrill,W., Butler,A.P., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M., Clark,G., Clark,L.N., Clark,S.Y.,
            Clee,C.M., Clegg,S., Cobley,V.E., Collier,R.E., Connor,R.,
            Corby,N.R., Coulson,A., Coville,G.J., Deadman,R., Dhami,P.,
            Dunn,M., Ellington,A.G., Frankland,J.A., Fraser,A., French,L.,
            Garner,P., Grafham,D.V., Griffiths,C., Griffiths,M.N., Gwilliam,R.,
            Hall,R.E., Hammond,S., Harley,J.L., Heath,P.D., Ho,S., Holden,J.L.,
            Howden,P.J., Huckle,E., Hunt,A.R., Hunt,S.E., Jekosch,K.,
            Johnson,C.M., Johnson,D., Kay,M.P., Kimberley,A.M., King,A.,
            Knights,A., Laird,G.K., Lawlor,S., Lehvaslaiho,M.H., Leversha,M.,
            Lloyd,C., Lloyd,D.M., Lovell,J.D., Marsh,V.L., Martin,S.L.,
            McConnachie,L.J., McLay,K., McMurray,A.A., Milne,S., Mistry,D.,
            Moore,M.J., Mullikin,J.C., Nickerson,T., Oliver,K., Parker,A.,
            Patel,R., Pearce,T.A., Peck,A.I., Phillimore,B.J.,
            Prathalingam,S.R., Plumb,R.W., Ramsay,H., Rice,C.M., Ross,M.T.,
            Scott,C.E., Sehra,H.K., Shownkeen,R., Sims,S., Skuce,C.D.,
            Smith,M.L., Soderlund,C., Steward,C.A., Sulston,J.E., Swann,M.,
            Sycamore,N., Taylor,R., Tee,L., Thomas,D.W., Thorpe,A., Tracey,A.,
            Tromans,A.C., Vaudin,M., Wall,M., Wallis,J.M., Whitehead,S.L.,
            Whittaker,P., Willey,D.L., Williams,L., Williams,S.A., Wilming,L.,
            Wray,P.W., Hubbard,T., Durbin,R.M., Bentley,D.R., Beck,S. and
            Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 20
  JOURNAL   Nature 414 (6866), 865-871 (2001)
   PUBMED   11780052
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC050284.1 and BC003681.1.
            
            On Nov 23, 2018 this sequence version replaced NM_017798.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC050284.1, AK095795.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000370339.8/ ENSP00000359364.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2499              BC050284.1         56-2554
            2500-3198           BC003681.1         2230-2928
FEATURES             Location/Qualifiers
     source          1..3198
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.33"
     gene            1..3198
                     /gene="YTHDF1"
                     /gene_synonym="C20orf21; DF1"
                     /note="YTH N6-methyladenosine RNA binding protein F1"
                     /db_xref="GeneID:54915"
                     /db_xref="HGNC:HGNC:15867"
                     /db_xref="MIM:616529"
     exon            1..266
                     /gene="YTHDF1"
                     /gene_synonym="C20orf21; DF1"
                     /inference="alignment:Splign:2.1.0"
     CDS             240..1919
                     /gene="YTHDF1"
                     /gene_synonym="C20orf21; DF1"
                     /note="YTH domain family 1; YTH domain family protein 1;
                     DACA-1; dermatomyositis associated with cancer putative
                     autoantigen 1; YTH domain family, member 1; YTH
                     N(6)-methyladenosine RNA binding protein 1; YTH
                     N6-methyladenosine RNA binding protein 1"
                     /codon_start=1
                     /product="YTH domain-containing family protein 1"
                     /protein_id="NP_060268.2"
                     /db_xref="CCDS:CCDS13511.1"
                     /db_xref="GeneID:54915"
                     /db_xref="HGNC:HGNC:15867"
                     /db_xref="MIM:616529"
                     /translation="MSATSVDTQRTKGQDNKVQNGSLHQKDTVHDNDFEPYLTGQSNQ
                     SNSYPSMSDPYLSSYYPPSIGFPYSLNEAPWSTAGDPPIPYLTTYGQLSNGDHHFMHD
                     AVFGQPGGLGNNIYQHRFNFFPENPAFSAWGTSGSQGQQTQSSAYGSSYTYPPSSLGG
                     TVVDGQPGFHSDTLSKAPGMNSLEQGMVGLKIGDVSSSAVKTVGSVVSSVALTGVLSG
                     NGGTNVNMPVSKPTSWAAIASKPAKPQPKMKTKSGPVMGGGLPPPPIKHNMDIGTWDN
                     KGPVPKAPVPQQAPSPQAAPQPQQVAQPLPAQPPALAQPQYQSPQQPPQTRWVAPRNR
                     NAAFGQSGGAGSDSNSPGNVQPNSAPSVESHPVLEKLKAAHSYNPKEFEWNLKSGRVF
                     IIKSYSEDDIHRSIKYSIWCSTEHGNKRLDSAFRCMSSKGPVYLLFSVNGSGHFCGVA
                     EMKSPVDYGTSAGVWSQDKWKGKFDVQWIFVKDVPNNQLRHIRLENNDNKPVTNSRDT
                     QEVPLEKAKQVLKIISSYKHTTSIFDDFAHYEKRQEEEEVVRKERQSRNKQ"
     exon            267..291
                     /gene="YTHDF1"
                     /gene_synonym="C20orf21; DF1"
                     /inference="alignment:Splign:2.1.0"
     exon            292..371
                     /gene="YTHDF1"
                     /gene_synonym="C20orf21; DF1"
                     /inference="alignment:Splign:2.1.0"
     exon            372..1892
                     /gene="YTHDF1"
                     /gene_synonym="C20orf21; DF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1893..3198
                     /gene="YTHDF1"
                     /gene_synonym="C20orf21; DF1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3176..3181
                     /regulatory_class="polyA_signal_sequence"
                     /gene="YTHDF1"
                     /gene_synonym="C20orf21; DF1"
                     /note="hexamer: AATAAA"
     polyA_site      3198
                     /gene="YTHDF1"
                     /gene_synonym="C20orf21; DF1"
                     /note="major polyA site"
ORIGIN      
        1 gtcgccgccg ccgccgccat tggagtcgac gcctcctcag tgcgtccgcg tcccgggctc
       61 accgccgctg ccgcctcgcc aggggcccgc gcgcccagca gccgccgccg ccgcccggcc
      121 ggcgcccggg gaattggcgg cggggcccgg ggccgcgcga gctagggtga caggcccggc
      181 ctctagggga ggcccgagcc ggcgggcgcc ccggccccgc gtctagttgt tcatgaagca
      241 tgtcggccac cagcgtggac acccagagaa caaaaggaca agataataaa gtacaaaatg
      301 gttcgttaca tcagaaggat acagttcatg acaatgactt tgagccctac cttactggac
      361 agtcaaatca gagtaacagt tacccctcaa tgagcgaccc ctacctgtcc agctattacc
      421 cgccgtccat tggatttcct tactccctca atgaggctcc gtggtctact gcaggggacc
      481 ctccgattcc atacctcacc acctacggac agctcagtaa cggagaccat cattttatgc
      541 acgatgctgt ttttgggcag cctgggggcc tggggaacaa catctatcag cacaggttca
      601 attttttccc tgaaaaccct gcgttctcag catgggggac aagtgggtct caaggtcagc
      661 agacccagag ctccgcgtat gggagcagct acacctaccc cccgagctcc ctgggtggca
      721 cggtggttga tgggcagcca ggctttcaca gcgacaccct cagcaaggcc cccgggatga
      781 acagcctgga gcagggcatg gttggcctga agattgggga cgtcagctcc tccgccgtca
      841 agacggtggg ctctgtcgtc agcagcgtgg cactgactgg tgtcctttct ggcaacggtg
      901 ggacaaatgt gaacatgcca gtttcaaagc cgacctcgtg ggctgccatt gccagcaagc
      961 ctgcaaaacc acagcctaaa atgaaaacaa agagcgggcc tgtcatgggg ggtgggctgc
     1021 cccctccacc cataaagcat aacatggaca ttggcacctg ggataacaag gggcctgtgc
     1081 cgaaggcccc agtcccccag caggcaccct ctccacaggc tgccccacag ccccagcagg
     1141 tggctcagcc tctcccagca cagcccccag ctttggctca accgcagtat cagagccctc
     1201 agcagccacc ccagacccgc tgggttgccc cacgcaacag aaacgcggcg tttgggcaga
     1261 gcggaggggc tggcagcgat agcaactctc ctggaaacgt ccagcctaat tctgccccca
     1321 gcgtcgaatc ccaccccgtc cttgaaaaac tgaaggctgc tcacagctac aacccgaaag
     1381 agtttgagtg gaatctgaaa agcgggcgtg tgttcatcat caagagctac tctgaggacg
     1441 acatccaccg ctccattaag tactccatct ggtgtagcac agagcacggc aacaagcgcc
     1501 tggacagcgc cttccgctgc atgagcagca aggggcccgt ctacctgctc ttcagcgtca
     1561 atgggagtgg gcatttttgt ggggtggccg agatgaagtc ccccgtggac tacggcacca
     1621 gtgccggggt ctggtctcag gacaagtgga aggggaagtt tgatgtccag tggatttttg
     1681 ttaaggatgt acccaataac cagctccggc acatcaggct ggagaataac gacaacaaac
     1741 cggtcacaaa ctcccgggac acccaggagg tgcccttaga aaaagccaag caagtgctga
     1801 aaattatcag ttcctacaag cacacaacct ccatcttcga cgactttgct cactacgaga
     1861 agcgccagga ggaggaggag gtggtgcgca aggaacggca gagtcgaaac aaacaatgag
     1921 ggcgaaccag tttcttacat gttctaacgt ttgactttga aaacagttta aaacacgtgt
     1981 gcttggtcag ctccagtgtg tcgtcccgtg cgggggttga gtgttgcatc tttgcctttc
     2041 ttgtcgttga tttttgccca gatggatctg catttatttg tactttttct atgtattata
     2101 atcctgtaga agtcactaat aaaggagtat tttttttgtc agcttatcaa tcagactgat
     2161 ctaatgtgaa atgtaagtat ccttaaaaac aaagcatcta ttttggcaga aattgtgttc
     2221 ttaaattcag tcatttgata ttctgtgaga cttcatattt ctcatccctt tattgctttt
     2281 tagcaaacat aagaaaccat gagtcatttt gtcatttaga gtattctgat aaaatctctt
     2341 gaaaatactg aaatcaaaag gttaatgatt ttttgttcat tctgatttgt cattttatta
     2401 tctgttatcg gtctaaagtg ctaatttacc catttgattt ttctgctaga cagataactt
     2461 ttaatttttc aaatttggca gacacttttt tttttttttt gaaaatcttt ccttccagat
     2521 ctgttgccca ctgaacagcc acccgtccct cactgtcctg gtgtccgatt gggctggatg
     2581 gtgttggggc atgatgtgtg gaggaactgg aaggtgcttt aggtctggtt cagggtcggg
     2641 cattctttgt tgtttgcaca tctttttaaa ttttacacct tttcttaaga attctaatgc
     2701 cgtcttaagt ttttatacca ataatgctga gctttaagtg taggatctgg tagtacagac
     2761 agtgtgatgg atgatgctgc tggttgtaaa tttcatcgtg tgtgtctaat tttttttcct
     2821 gttgaatggg taaaaacaaa acaaaacttt ttttagaaga tgaatttgct gtcatgtttt
     2881 gtggaatgag ggaccgttga gctcactacc acctggagtt tgagttgaag catgaaaatg
     2941 gtgcccatgc ctgacgctcc agcgcctgga tctgcacgtg cccttgtaga ggatccttac
     3001 cgtcctagag agcagacgct ttctgaaaac tacttgctcc aaaagaccct ctgagttaac
     3061 gtttcagctg tatcattaga cttgtattta gagcgtgtca cttcctctga actgttactg
     3121 cctgaatgga gtcctggacg acattgggtt tttcctctag gagaatacaa gccttaataa
     3181 acaatactat ttagcaaa
//
