LOCUS       NM_022828               6305 bp    mRNA    linear   PRI 11-SEP-2024
DEFINITION  Homo sapiens YTH N6-methyladenosine RNA binding protein C2
            (YTHDC2), transcript variant 1, mRNA.
ACCESSION   NM_022828
VERSION     NM_022828.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6305)
  AUTHORS   Tian,S., Faheem,M., Satti,H.S., Xiao,J., Zhang,F., Khan,T.N. and
            Liu,C.
  TITLE     A homozygous missense variant in YTHDC2 induces azoospermia in two
            siblings
  JOURNAL   Mol Genet Genomics 299 (1), 84 (2024)
   PUBMED   39223386
  REMARK    GeneRIF: A homozygous missense variant in YTHDC2 induces
            azoospermia in two siblings.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6305)
  AUTHORS   Yang,Z., Verghese,M., Yang,S., Shah,P. and He,Y.Y.
  TITLE     The m6A reader YTHDC2 regulates UVB-induced DNA damage repair and
            histone modification
  JOURNAL   Photochem Photobiol 100 (4), 1031-1040 (2024)
   PUBMED   38190286
  REMARK    GeneRIF: The m[6]A reader YTHDC2 regulates UVB-induced DNA damage
            repair and histone modification.
REFERENCE   3  (bases 1 to 6305)
  AUTHORS   Sun,Y., Liu,Y., Wang,P., Chang,L. and Huang,J.
  TITLE     The m6A Reader YTHDC2 Suppresses Lung Adenocarcinoma Tumorigenesis
            by Destabilizing MRPL12
  JOURNAL   Mol Biotechnol 66 (5), 1051-1061 (2024)
   PUBMED   38129673
  REMARK    GeneRIF: The m6A Reader YTHDC2 Suppresses Lung Adenocarcinoma
            Tumorigenesis by Destabilizing MRPL12.
REFERENCE   4  (bases 1 to 6305)
  AUTHORS   Zhou,G. and Wang,S.
  TITLE     YTHDC2 Retards Cell Proliferation and Triggers Apoptosis in
            Papillary Thyroid Cancer by Regulating CYLD-Mediated Inactivation
            of Akt Signaling
  JOURNAL   Appl Biochem Biotechnol 196 (1), 588-603 (2024)
   PUBMED   37162682
  REMARK    GeneRIF: YTHDC2 Retards Cell Proliferation and Triggers Apoptosis
            in Papillary Thyroid Cancer by Regulating CYLD-Mediated
            Inactivation of Akt Signaling.
REFERENCE   5  (bases 1 to 6305)
  AUTHORS   Sun,T., Xu,Y., Xiang,Y., Ou,J., Soderblom,E.J. and Diao,Y.
  TITLE     Crosstalk between RNA m6A and DNA methylation regulates
            transposable element chromatin activation and cell fate in human
            pluripotent stem cells
  JOURNAL   Nat Genet 55 (8), 1324-1335 (2023)
   PUBMED   37474847
  REMARK    GeneRIF: Crosstalk between RNA m[6]A and DNA methylation regulates
            transposable element chromatin activation and cell fate in human
            pluripotent stem cells.
REFERENCE   6  (bases 1 to 6305)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   7  (bases 1 to 6305)
  AUTHORS   Li,S., Wang,L., Berman,M., Kong,Y.Y. and Dorf,M.E.
  TITLE     Mapping a dynamic innate immunity protein interaction network
            regulating type I interferon production
  JOURNAL   Immunity 35 (3), 426-440 (2011)
   PUBMED   21903422
  REMARK    Erratum:[Immunity. 2011 Oct 28;35(4):647-8]
REFERENCE   8  (bases 1 to 6305)
  AUTHORS   Morohashi,K., Sahara,H., Watashi,K., Iwabata,K., Sunoki,T.,
            Kuramochi,K., Takakusagi,K., Miyashita,H., Sato,N., Tanabe,A.,
            Shimotohno,K., Kobayashi,S., Sakaguchi,K. and Sugawara,F.
  TITLE     Cyclosporin A associated helicase-like protein facilitates the
            association of hepatitis C virus RNA polymerase with its cellular
            cyclophilin B
  JOURNAL   PLoS One 6 (4), e18285 (2011)
   PUBMED   21559518
  REMARK    GeneRIF: CAHL is a CsA associated helicase-like protein, which
            would form trimer complex with cyclophilin B and NS5B of HCV.
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 6305)
  AUTHORS   Bhatnagar,P., Purvis,S., Barron-Casella,E., DeBaun,M.R.,
            Casella,J.F., Arking,D.E. and Keefer,J.R.
  TITLE     Genome-wide association study identifies genetic variants
            influencing F-cell levels in sickle-cell patients
  JOURNAL   J Hum Genet 56 (4), 316-323 (2011)
   PUBMED   21326311
REFERENCE   10 (bases 1 to 6305)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK096486.1, BC137285.1 and
            AC010389.8.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_022828.4.
            
            Summary: This gene encodes a member of the DEAH (Asp-Glu-Ala-His)
            subfamily of proteins, part of the DEAD (Asp-Glu-Ala-Asp) box
            family of RNA helicases. The encoded protein binds to
            N6-methyladenosine, a common modified RNA nucleotide that is
            enriched in the stop codons and 3' UTRs of eukaryotic messenger
            RNAs. Binding of proteins to this modified nucleotide may regulate
            mRNA translation and stability. This gene may be associated with
            susceptibility to pancreatic cancer in human patients, and
            knockdown of this gene resulted in reduced proliferation in a human
            liver cancer cell line. [provided by RefSeq, Sep 2016].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.118755.1,
                                           SRR1660807.231200.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000161863.9/ ENSP00000161863.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-50                AK096486.1         1-50
            51-5250             BC137285.1         1-5200
            5251-6305           AC010389.8         92637-93691         c
FEATURES             Location/Qualifiers
     source          1..6305
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q22.2"
     gene            1..6305
                     /gene="YTHDC2"
                     /gene_synonym="CAHL; hYTHDC2"
                     /note="YTH N6-methyladenosine RNA binding protein C2"
                     /db_xref="GeneID:64848"
                     /db_xref="HGNC:HGNC:24721"
                     /db_xref="MIM:616530"
     exon            1..389
                     /gene="YTHDC2"
                     /gene_synonym="CAHL; hYTHDC2"
                     /inference="alignment:Splign:2.1.0"
     CDS             203..4495
                     /gene="YTHDC2"
                     /gene_synonym="CAHL; hYTHDC2"
                     /EC_number="3.6.4.13"
                     /note="isoform 1 is encoded by transcript variant 1;
                     probable ATP-dependent RNA helicase YTHDC2; CsA-associated
                     helicase-like protein; 3'-5' RNA helicase YTHDC2; YTH
                     domain containing 2"
                     /codon_start=1
                     /product="3'-5' RNA helicase YTHDC2 isoform 1"
                     /protein_id="NP_073739.3"
                     /db_xref="CCDS:CCDS4113.1"
                     /db_xref="GeneID:64848"
                     /db_xref="HGNC:HGNC:24721"
                     /db_xref="MIM:616530"
                     /translation="MSRPSSVSPRQPAPGGGGGGGPSPCGPGGGGRAKGLKDIRIDEE
                     VKIAVNIALERFRYGDQREMEFPSSLTSTERAFIHRLSQSLGLVSKSKGKGANRYLTV
                     KKKDGSETAHAMMTCNLTHNTKHAVRSLIQRFPVTNKERTELLPKTERGNVFAVEAEN
                     REMSKTSGRLNNGIPQIPVKRGESEFDSFRQSLPVFEKQEEIVKIIKENKVVLIVGET
                     GSGKTTQIPQFLLDDCFKNGIPCRIFCTQPRRLAAIAVAERVAAERRERIGQTIGYQI
                     RLESRVSPKTLLTFCTNGVLLRTLMAGDSTLSTVTHVIVDEVHERDRFSDFLLTKLRD
                     LLQKHPTLKLILSSAALDVNLFIRYFGSCPVIYIQGRPFEVKEMFLEDILRTTGYTNK
                     EMLKYKKEKQQEEKQQTTLTEWYSAQENSFKPESQRQRTVLNVTDEYDLLDDGGDAVF
                     SQLTEKDVNCLEPWLIKEMDACLSDIWLHKDIDAFAQVFHLILTENVSVDYRHSETSA
                     TALMVAAGRGFASQVEQLISMGANVHSKASNGWMALDWAKHFGQTEIVDLLESYSATL
                     EFGNLDESSLVQTNGSDLSAEDRELLKAYHHSFDDEKVDLDLIMHLLYNICHSCDAGA
                     VLIFLPGYDEIVGLRDRILFDDKRFADSTHRYQVFMLHSNMQTSDQKKVLKNPPAGVR
                     KIILSTNIAETSITVNDVVFVIDSGKVKEKSFDALNFVTMLKMVWISKASAIQRKGRA
                     GRCRPGICFRLFSRLRFQNMLEFQTPELLRMPLQELCLHTKLLAPVNCPIADFLMKAP
                     EPPPALIVRNAVQMLKTIDAMDTWEDLTELGYHLADLPVEPHLGKMVLCAVVLKCLDP
                     ILTIACTLAYRDPFVLPTQASQKRAAMLCRKRFTAGAFSDHMALLRAFQAWQKARSDG
                     WERAFCEKNFLSQATMEIIIGMRTQLLGQLRASGFVRARGGGDIRDVNTNSENWAVVK
                     AALVAGMYPNLVHVDRENLVLTGPKEKKVRFHPASVLSQPQYKKIPPANGQAAAIKAL
                     PTDWLIYDEMTRAHRIANIRCCSAVTPVTILVFCGPARLASNALQEPSSFRVDGIPND
                     SSDSEMEDKTTANLAALKLDEWLHFTLEPEAASLLLQLRQKWHSLFLRRMRAPSKPWS
                     QVDEATIRAIIAVLSTEEQSAGLQQPSGIGQRPRPMSSEELPLASSWRSNNSRKSSAD
                     TEFSDECTTAERVLMKSPSPALHPPQKYKDRGILHPKRGTEDRSDQSSLKSTDSSSYP
                     SPCASPSPPSSGKGSKSPSPRPNMPVRYFIMKSSNLRNLEISQQKGIWSTTPSNERKL
                     NRAFWESSIVYLVFSVQGSGHFQGFSRMSSEIGREKSQDWGSAGLGGVFKVEWIRKES
                     LPFQFAHHLLNPWNDNKKVQISRDGQELEPLVGEQLLQLWERLPLGEKNTTD"
     exon            390..480
                     /gene="YTHDC2"
                     /gene_synonym="CAHL; hYTHDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            481..677
                     /gene="YTHDC2"
                     /gene_synonym="CAHL; hYTHDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            678..877
                     /gene="YTHDC2"
                     /gene_synonym="CAHL; hYTHDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            878..1044
                     /gene="YTHDC2"
                     /gene_synonym="CAHL; hYTHDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1045..1147
                     /gene="YTHDC2"
                     /gene_synonym="CAHL; hYTHDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1148..1304
                     /gene="YTHDC2"
                     /gene_synonym="CAHL; hYTHDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1305..1412
                     /gene="YTHDC2"
                     /gene_synonym="CAHL; hYTHDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1413..1561
                     /gene="YTHDC2"
                     /gene_synonym="CAHL; hYTHDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1562..1697
                     /gene="YTHDC2"
                     /gene_synonym="CAHL; hYTHDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1698..1824
                     /gene="YTHDC2"
                     /gene_synonym="CAHL; hYTHDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1825..1890
                     /gene="YTHDC2"
                     /gene_synonym="CAHL; hYTHDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1891..2069
                     /gene="YTHDC2"
                     /gene_synonym="CAHL; hYTHDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2070..2166
                     /gene="YTHDC2"
                     /gene_synonym="CAHL; hYTHDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2167..2254
                     /gene="YTHDC2"
                     /gene_synonym="CAHL; hYTHDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2255..2335
                     /gene="YTHDC2"
                     /gene_synonym="CAHL; hYTHDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2336..2418
                     /gene="YTHDC2"
                     /gene_synonym="CAHL; hYTHDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2419..2524
                     /gene="YTHDC2"
                     /gene_synonym="CAHL; hYTHDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2525..2644
                     /gene="YTHDC2"
                     /gene_synonym="CAHL; hYTHDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2645..2917
                     /gene="YTHDC2"
                     /gene_synonym="CAHL; hYTHDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2918..3044
                     /gene="YTHDC2"
                     /gene_synonym="CAHL; hYTHDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            3045..3250
                     /gene="YTHDC2"
                     /gene_synonym="CAHL; hYTHDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            3251..3446
                     /gene="YTHDC2"
                     /gene_synonym="CAHL; hYTHDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            3447..3556
                     /gene="YTHDC2"
                     /gene_synonym="CAHL; hYTHDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            3557..3849
                     /gene="YTHDC2"
                     /gene_synonym="CAHL; hYTHDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            3850..4027
                     /gene="YTHDC2"
                     /gene_synonym="CAHL; hYTHDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            4028..4231
                     /gene="YTHDC2"
                     /gene_synonym="CAHL; hYTHDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            4232..4414
                     /gene="YTHDC2"
                     /gene_synonym="CAHL; hYTHDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            4415..4502
                     /gene="YTHDC2"
                     /gene_synonym="CAHL; hYTHDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            4503..6305
                     /gene="YTHDC2"
                     /gene_synonym="CAHL; hYTHDC2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6285..6290
                     /regulatory_class="polyA_signal_sequence"
                     /gene="YTHDC2"
                     /gene_synonym="CAHL; hYTHDC2"
                     /note="hexamer: ATTAAA"
     polyA_site      6305
                     /gene="YTHDC2"
                     /gene_synonym="CAHL; hYTHDC2"
                     /note="major polyA site"
ORIGIN      
        1 gctcctcgcc tggccgtgat atcaatggcg caggcttcac ttctgctgtg gcggtgactg
       61 aggcctttct ggtgacctca gcccaacaca ggccgtctcc ggagcttccc ggtagtggcc
      121 ccggattccc acggtctttg tcattggctg tcagctagca ggcctggccg ctcccgtgcg
      181 gagagaccat ctcttcaggg caatgtccag gccgagcagc gtctccccgc ggcagccggc
      241 tcctggcggt ggcggaggcg gcggcccctc gccttgtggc cctgggggcg gcggccgggc
      301 caaggggctg aaggacattc gcattgatga ggaggtgaag atcgcagtca atatcgcgct
      361 ggagcgcttc cgatacgggg accagagaga aatggaattt ccttcttctt tgaccagtac
      421 tgaaagagcc tttattcatc gactcagtca gtctcttggt ttggtctcta aaagtaaagg
      481 aaagggagca aatagatacc taactgtgaa gaagaaagat ggatcagaaa cagctcatgc
      541 aatgatgacc tgtaatttga ctcataatac aaaacatgct gttaggagcc taattcaaag
      601 atttcctgtc accaataaag agcgtacaga acttctgcct aaaacagaaa gaggaaatgt
      661 gtttgcagtt gaagctgaaa accgggaaat gagcaagaca agtgggcgac tcaacaatgg
      721 catacctcag attccagtga aaagaggaga atccgaattt gattctttta ggcagtcttt
      781 accagtgttt gagaaacagg aagaaattgt taaaataatt aaggaaaata aagtagtttt
      841 gattgtagga gaaactgggt ctggaaagac cacacagatt cctcagttcc ttttagatga
      901 ttgctttaaa aatggtatcc cctgccgtat attttgtact caaccaagac gattggcagc
      961 tatcgctgtg gctgaaagag ttgccgcaga gagacgggaa aggattggtc aaacaattgg
     1021 ttatcagatc cgattagaaa gcagggtttc tccaaagaca cttctgacat tttgtactaa
     1081 tggggtattg cttcgtacat tgatggcagg agatagtacg ttgtcgactg tgacacatgt
     1141 tatcgtggat gaagtgcatg aaagggatcg atttagtgat tttttactta caaagttaag
     1201 agatttgttg caaaagcacc caactttgaa actaattctt tctagtgctg ccttggatgt
     1261 aaatctcttt ataagatatt ttggaagttg tccagtgata tatatacagg gaagaccatt
     1321 tgaagtaaaa gaaatgtttc tggaagatat tttaagaaca actggatata caaacaaaga
     1381 aatgttaaaa tataaaaagg aaaaacagca agaagagaaa caacaaacca cacttacaga
     1441 atggtactca gctcaagaaa atagtttcaa gcctgaatct cagaggcaga gaactgttct
     1501 aaatgtgact gatgagtatg acttactgga tgatggtggt gatgctgtct tcagtcagct
     1561 gactgaaaaa gatgtgaatt gccttgaacc atggttaata aaggaaatgg atgcttgcct
     1621 ttctgatata tggctacata aagatattga tgcctttgct caggtctttc atctcatttt
     1681 aactgaaaat gttagtgttg attacagaca tagtgaaacc agtgcaacag ctctgatggt
     1741 tgctgcagga cgtggctttg caagtcaagt agaacagtta atcagtatgg gagccaatgt
     1801 ccatagtaaa gcatcaaatg gctggatggc attggattgg gctaaacact ttgggcagac
     1861 tgaaattgtg gatcttctag aatcttacag tgctacactg gaatttggaa atctagatga
     1921 aagttctctg gttcaaacaa atggaagtga cctcagtgct gaagacagag agctcctgaa
     1981 agcttatcat catagtttcg atgatgaaaa agtagacttg gatttgatca tgcatcttct
     2041 atacaatatc tgccatagtt gtgatgctgg tgcagtacta atttttctgc ctggatatga
     2101 cgaaattgtt ggactgagag atcgcatcct gtttgatgac aagcggtttg ctgacagtac
     2161 acatagatac caagtcttta tgcttcattc aaatatgcaa acatccgatc aaaagaaagt
     2221 attaaaaaac ccacctgcag gtgttcgaaa aataattctt tccaccaata ttgctgaaac
     2281 cagcatcaca gtcaatgatg ttgtctttgt tattgattct ggtaaggtga aagagaaatc
     2341 ctttgatgct ctgaattttg ttacaatgtt aaaaatggta tggatttcca aagctagtgc
     2401 catacagcgg aaaggcaggg cagggcgatg tagacctgga atttgttttc gtctgttcag
     2461 tagactccga ttccagaata tgttggaatt tcagactccg gaacttttga gaatgccatt
     2521 acaggaactt tgcttacata ccaagctgtt agccccagtt aattgtccca ttgctgattt
     2581 tcttatgaaa gctcctgaac ctccaccagc tttaattgta agaaatgctg tacaaatgct
     2641 taagacaata gatgcaatgg atacatggga agatctgact gaacttgggt atcatttggc
     2701 tgacttgcca gtagaaccac atcttggtaa aatggtcttg tgtgctgttg ttttaaagtg
     2761 tctggacccc atccttacaa ttgcttgcac actagcttat cgagatcctt ttgtactacc
     2821 tactcaggcc tctcaaaaac gtgcagctat gctttgtagg aaacgtttta ctgcaggagc
     2881 tttcagtgac catatggcac ttctcagagc attccaggcc tggcaaaaag cacgaagtga
     2941 tgggtgggag cgagcctttt gtgaaaagaa ttttctttca caggctacta tggaaataat
     3001 cataggcatg agaacacagt tgcttggtca acttagagca tcaggttttg ttagagcacg
     3061 aggtggtggt gacattcggg acgttaacac aaactctgag aattgggctg tcgttaaagc
     3121 tgcattggtg gcaggcatgt atcctaattt agtccacgtg gacagagaga atctagtgtt
     3181 gacagggcca aaggagaaaa aagtacgatt tcatcctgct tcagttctca gtcagcctca
     3241 atataaaaag attcctccag ccaatggtca agctgcagca attaaggcac tgcccacaga
     3301 ttggcttatt tatgatgaaa tgaccagagc ccatagaata gctaatatta gatgttgttc
     3361 agcagtgacg cctgtcacta tattggtatt ctgtggacca gctagattgg caagtaatgc
     3421 tcttcaggaa ccttcatcct ttagagtgga tggcattccc aatgacagta gtgatagtga
     3481 aatggaggac aaaactacag ctaatttggc agccttgaaa cttgatgagt ggctccattt
     3541 cacactggag ccagaggcag ctagtttatt gctgcagctc agacagaagt ggcatagctt
     3601 atttttacgc cgaatgagag ctccatctaa accttggtct caagttgatg aagctaccat
     3661 aagagcaatt atagctgttt taagcactga agaacagtct gcaggtttac aacaaccatc
     3721 tgggattggc caaaggccaa ggcctatgtc ttcagaagag cttcctttgg cctcatcttg
     3781 gaggtcaaat aatagtagga aaagttcagc agatactgaa ttttctgatg agtgtactac
     3841 tgcagaaaga gtactgatga aatctccatc tccagcatta cacccacctc agaagtacaa
     3901 agatagagga attttacatc ctaaacgagg tactgaggac cgatcagatc agtcttctct
     3961 gaaatctaca gacagcagta gttacccaag tccttgtgct agtccttctc ctccatcctc
     4021 aggaaagggc tcaaaatctc cttcgccaag accaaacatg cctgttcgat acttcataat
     4081 gaagagtagc aatttgagaa accttgaaat ttctcaacag aagggtatct ggtctacaac
     4141 tcctagtaat gaacggaagc taaatcgagc cttttgggaa agcagcatag tttacttggt
     4201 attttctgtt caaggatctg gacatttcca gggattttct aggatgtctt ctgagattgg
     4261 aagggaaaag agtcaggact ggggctctgc tggactagga ggagtattta aggtggagtg
     4321 gatacgaaaa gaaagccttc cctttcaatt tgcacaccat ttactcaatc catggaatga
     4381 caacaagaaa gtgcagataa gcagggatgg gcaggaacta gaacctctgg ttggtgaaca
     4441 gttgctccag ttatgggaac gtcttccctt gggagaaaaa aacacaactg attgacactc
     4501 agaactctta gctgtggaag aacatcatgc ctatttataa ccactgaatg cactgacttt
     4561 caaaaactga ggtggggtgt gtgttacgaa tgggcttttt aacactttta gagtgttgct
     4621 ttagaactac catcttcata tacaggagaa aggaagcatt taaattttta tagtgattat
     4681 agagaatgat tatatgatgt ttgtaatgaa taaaatagta gtttcattat ttggcacaat
     4741 agcagtttat tttaaacaaa caatttgaag ttaaacattt catttttaaa aacactgaat
     4801 tacagttctt attgatgact ttttaatgca gagtaagttg tttaagaaag gcctgaatat
     4861 atcagaacat ctgagcacca ttttagaaga gtcaactctt aagattatca ttagaaaaca
     4921 aatacgtcaa cacctatgaa aagaagcggg gaaaacaaca acaaggacaa caacaaaaaa
     4981 ccagtgaaat tctacaagtg tcccttttaa aaatagtgtg tgctaactaa gggctattca
     5041 ttctgccatt tttaacttga gacacattta agaataaagt tggatgttct ttttctgtga
     5101 ttatgaaatg caataaaatc tgaataaagg gcaaagtttc ttcctgatca gattagatta
     5161 agtgcttagt tttattccta attctgcccc ttttaacctg atgtgtacct tactctttcc
     5221 tccctctctt cctcccttcc tcctctcccc gctcctttcc tgcatttctc cctccctcct
     5281 tccctcgtca catctcttat atgagcacag taattatgac ctttttgttt tggctacaac
     5341 ttgattgaaa caagttcaaa atttaaacaa gttcatacaa gtttttaaaa attctcaact
     5401 ggtagcttgc ttgctgtgcg tcttccaaac taaagcctgc aagcgccaca attctaagtg
     5461 ccgccttcca ttttttttca gtatgttttc actggcttat gttttcagat atgattttcc
     5521 tttttcgcat atatggttta ataaatgggg gataattttt tttttgtaaa tccgtgcttg
     5581 tgccaagtct catatttctt tgccatctca gaattatctt tttaccacca ctgtttataa
     5641 aatttcctta gagacttttt gaagggaaaa tagagcaaca gggaaaaatg aaagaaatgt
     5701 cttggttact gagctctaaa tagacaggtt tgatggcact tctcatgata cattttagtt
     5761 attcttataa aagcaaacag gcaaacatga gtgtaaatta aagacaaaaa gaaaactctg
     5821 gttttatatt tgagaacacg tgaaaaatca tgggtcaaca taaaatcttg agaaccttct
     5881 actttctctg ggaaagcatt atatagtggt gcattagttt agaaagtcag ctatgatttt
     5941 gcctatagtt ctagttatta gctttggggt tttcttgtac tttaagacat acctgtaaat
     6001 tgaacctatt tgaattatat tccactgtat gtgtattatg gctcttttcc tattagagca
     6061 acttgtgttt ccctgataat gtgtacattt tttaggcatg tacttaatag ttcacaatgt
     6121 tctaaatttg gaaggactta aaaaaaaaac ttgtttaaat ttccatctgt tttgtaatat
     6181 ctagctctat atgtaaatga tgggtttgtt ggtatttaaa atgaatacaa cttgaatgta
     6241 attaaagtgc tgttttttgg aagcgataaa ctttaaatat acttattaaa atgaaattct
     6301 attaa
//
