LOCUS       NM_001031732            6233 bp    mRNA    linear   PRI 24-OCT-2024
DEFINITION  Homo sapiens YTH N6-methyladenosine RNA binding protein C1
            (YTHDC1), transcript variant 1, mRNA.
ACCESSION   NM_001031732
VERSION     NM_001031732.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6233)
  AUTHORS   Yu,Z., Xia,Y., Li,J., Jiang,J., Li,Y., Li,Y. and Wang,L.
  TITLE     METTL3 mediates m6A modification of lncRNA CRNDE to promote ATG10
            expression and improve brain ischemia/reperfusion injury through
            YTHDC1
  JOURNAL   Biol Direct 19 (1), 92 (2024)
   PUBMED   39407279
  REMARK    GeneRIF: METTL3 mediates m6A modification of lncRNA CRNDE to
            promote ATG10 expression and improve brain ischemia/reperfusion
            injury through YTHDC1.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6233)
  AUTHORS   Shen,X., Zhong,J., Yu,P., Liu,F., Peng,H. and Chen,N.
  TITLE     YTHDC1-dependent m6A modification modulated FOXM1 promotes
            glycolysis and tumor progression through CENPA in triple-negative
            breast cancer
  JOURNAL   Cancer Sci 115 (6), 1881-1895 (2024)
   PUBMED   38566554
  REMARK    GeneRIF: YTHDC1-dependent m6A modification modulated FOXM1 promotes
            glycolysis and tumor progression through CENPA in triple-negative
            breast cancer.
REFERENCE   3  (bases 1 to 6233)
  AUTHORS   Picavet,L.W., van Vroonhoven,E.C.N., Scholman,R.C., Smits,Y.T.H.,
            Banerjee,R., Besteman,S.B., Viveen,M.C., van der Vlist,M.M.,
            Tanenbaum,M.E., Lebbink,R.J., Vastert,S.J. and van Loosdregt,J.
  TITLE     m6A Reader YTHDC1 Impairs Respiratory Syncytial Virus Infection by
            Downregulating Membrane CX3CR1 Expression
  JOURNAL   Viruses 16 (5), 778 (2024)
   PUBMED   38793659
  REMARK    GeneRIF: m[6]A Reader YTHDC1 Impairs Respiratory Syncytial Virus
            Infection by Downregulating Membrane CX3CR1 Expression.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6233)
  AUTHORS   Yang,Y., Zhang,Y., Chen,G., Sun,B., Luo,F., Gao,Y., Feng,H. and
            Li,Y.
  TITLE     KAP1 stabilizes MYCN mRNA and promotes neuroblastoma tumorigenicity
            by protecting the RNA m6A reader YTHDC1 protein degradation
  JOURNAL   J Exp Clin Cancer Res 43 (1), 141 (2024)
   PUBMED   38745192
  REMARK    GeneRIF: KAP1 stabilizes MYCN mRNA and promotes neuroblastoma
            tumorigenicity by protecting the RNA m[6]A reader YTHDC1 protein
            degradation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6233)
  AUTHORS   Dong,D., Wei,J., Wang,W., Zhou,H., Hong,L., Ji,G. and Yang,X.
  TITLE     YTHDC1 promotes the malignant progression of gastric cancer by
            promoting ROD1 translocation to the nucleus
  JOURNAL   Cell Biol Toxicol 40 (1), 19 (2024)
   PUBMED   38573528
  REMARK    GeneRIF: YTHDC1 promotes the malignant progression of gastric
            cancer by promoting ROD1 translocation to the nucleus.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6233)
  AUTHORS   Rafalska,I., Zhang,Z., Benderska,N., Wolff,H., Hartmann,A.M.,
            Brack-Werner,R. and Stamm,S.
  TITLE     The intranuclear localization and function of YT521-B is regulated
            by tyrosine phosphorylation
  JOURNAL   Hum Mol Genet 13 (15), 1535-1549 (2004)
   PUBMED   15175272
  REMARK    GeneRIF: phosphorylation causes sequestration of YT521-B in an
            insoluble nuclear form, which is unable to change splice sites
REFERENCE   7  (bases 1 to 6233)
  AUTHORS   Wilkinson,F.L., Holaska,J.M., Zhang,Z., Sharma,A., Manilal,S.,
            Holt,I., Stamm,S., Wilson,K.L. and Morris,G.E.
  TITLE     Emerin interacts in vitro with the splicing-associated factor,
            YT521-B
  JOURNAL   Eur J Biochem 270 (11), 2459-2466 (2003)
   PUBMED   12755701
  REMARK    GeneRIF: YT521-B has a role in a gene expression in the
            pathogenesis of Emery-Dreifuss muscular dystrophy
REFERENCE   8  (bases 1 to 6233)
  AUTHORS   Stoilov,P., Rafalska,I. and Stamm,S.
  TITLE     YTH: a new domain in nuclear proteins
  JOURNAL   Trends Biochem Sci 27 (10), 495-497 (2002)
   PUBMED   12368078
  REMARK    Review article
REFERENCE   9  (bases 1 to 6233)
  AUTHORS   Nayler,O., Hartmann,A.M. and Stamm,S.
  TITLE     The ER repeat protein YT521-B localizes to a novel subnuclear
            compartment
  JOURNAL   J Cell Biol 150 (5), 949-962 (2000)
   PUBMED   10973987
REFERENCE   10 (bases 1 to 6233)
  AUTHORS   Hartmann,A.M., Nayler,O., Schwaiger,F.W., Obermeier,A. and Stamm,S.
  TITLE     The interaction and colocalization of Sam68 with the
            splicing-associated factor YT521-B in nuclear dots is regulated by
            the Src family kinase p59(fyn)
  JOURNAL   Mol Biol Cell 10 (11), 3909-3926 (1999)
   PUBMED   10564280
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC074378.4.
            
            On Jun 2, 2019 this sequence version replaced NM_001031732.3.
            
            Transcript Variant: This variant (1) encodes isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC041119.1, SRR14038192.782194.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000344157.9/ ENSP00000339245.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-365               AC074378.4         45366-45730         c
            366-467             AC074378.4         33923-34024         c
            468-796             AC074378.4         33212-33540         c
            797-1220            AC074378.4         32667-33090         c
            1221-1310           AC074378.4         28948-29037         c
            1311-1364           AC074378.4         28434-28487         c
            1365-1459           AC074378.4         27743-27837         c
            1460-1568           AC074378.4         25842-25950         c
            1569-1686           AC074378.4         25642-25759         c
            1687-1771           AC074378.4         19779-19863         c
            1772-1938           AC074378.4         18389-18555         c
            1939-2021           AC074378.4         15763-15845         c
            2022-2058           AC074378.4         14466-14502         c
            2059-2098           AC074378.4         14330-14369         c
            2099-2161           AC074378.4         14159-14221         c
            2162-2296           AC074378.4         11954-12088         c
            2297-6233           AC074378.4         6027-9963           c
FEATURES             Location/Qualifiers
     source          1..6233
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q13.2"
     gene            1..6233
                     /gene="YTHDC1"
                     /gene_synonym="YT521; YT521-B"
                     /note="YTH N6-methyladenosine RNA binding protein C1"
                     /db_xref="GeneID:91746"
                     /db_xref="HGNC:HGNC:30626"
                     /db_xref="MIM:617283"
     exon            1..365
                     /gene="YTHDC1"
                     /gene_synonym="YT521; YT521-B"
                     /inference="alignment:Splign:2.1.0"
     CDS             338..2521
                     /gene="YTHDC1"
                     /gene_synonym="YT521; YT521-B"
                     /note="isoform 1 is encoded by transcript variant 1; YTH
                     domain-containing protein 1; splicing factor YT521-B;
                     putative splicing factor YT521; YTH domain containing 1"
                     /codon_start=1
                     /product="YTH domain-containing protein 1 isoform 1"
                     /protein_id="NP_001026902.1"
                     /db_xref="CCDS:CCDS33992.1"
                     /db_xref="GeneID:91746"
                     /db_xref="HGNC:HGNC:30626"
                     /db_xref="MIM:617283"
                     /translation="MAADSREEKDGELNVLDDILTEVPEQDDELYNPESEQDKNEKKG
                     SKRKSDRMESTDTKRQKPSVHSRQLVSKPLSSSVSNNKRIVSTKGKSATEYKNEEYQR
                     SERNKRLDADRKIRLSSSASREPYKNQPEKTCVRKRDPERRAKSPTPDGSERIGLEVD
                     RRASRSSQSSKEEVNSEEYGSDHETGSSGSSDEQGNNTENEEEGVEEDVEEDEEVEED
                     AEEDEEVDEDGEEEEEEEEEEEEEEEEEEEEYEQDERDQKEEGNDYDTRSEASDSGSE
                     SVSFTDGSVRSGSGTDGSDEKKKERKRARGISPIVFDRSGSSASESYAGSEKKHEKLS
                     SSVRAVRKDQTSKLKYVLQDARFFLIKSNNHENVSLAKAKGVWSTLPVNEKKLNLAFR
                     SARSVILIFSVRESGKFQGFARLSSESHHGGSPIHWVLPAGMSAKMLGGVFKIDWICR
                     RELPFTKSAHLTNPWNEHKPVKIGRDGQEIELECGTQLCLLFPPDESIDLYQVIHKMR
                     HKRRMHSQPRSRGRPSRREPVRDVGRRRPEDYDIHNSRKKPRIDYPPEFHQRPGYLKD
                     PRYQEVDRRFSGVRRDVFLNGSYNDYVREFHNMGPPPPWQGMPPYPGMEQPPHHPYYQ
                     HHAPPPQAHPPYSGHHPVPHEARYRDKRVHDYDMRVDDFLRRTQAVVSGRRSRPRERD
                     RERERDRPRDNRRDRERDRGRDRERERERLCDRDRDRGERGRYRR"
     exon            366..467
                     /gene="YTHDC1"
                     /gene_synonym="YT521; YT521-B"
                     /inference="alignment:Splign:2.1.0"
     exon            468..796
                     /gene="YTHDC1"
                     /gene_synonym="YT521; YT521-B"
                     /inference="alignment:Splign:2.1.0"
     exon            797..1220
                     /gene="YTHDC1"
                     /gene_synonym="YT521; YT521-B"
                     /inference="alignment:Splign:2.1.0"
     exon            1221..1310
                     /gene="YTHDC1"
                     /gene_synonym="YT521; YT521-B"
                     /inference="alignment:Splign:2.1.0"
     exon            1311..1364
                     /gene="YTHDC1"
                     /gene_synonym="YT521; YT521-B"
                     /inference="alignment:Splign:2.1.0"
     exon            1365..1459
                     /gene="YTHDC1"
                     /gene_synonym="YT521; YT521-B"
                     /inference="alignment:Splign:2.1.0"
     exon            1460..1568
                     /gene="YTHDC1"
                     /gene_synonym="YT521; YT521-B"
                     /inference="alignment:Splign:2.1.0"
     exon            1569..1686
                     /gene="YTHDC1"
                     /gene_synonym="YT521; YT521-B"
                     /inference="alignment:Splign:2.1.0"
     exon            1687..1771
                     /gene="YTHDC1"
                     /gene_synonym="YT521; YT521-B"
                     /inference="alignment:Splign:2.1.0"
     exon            1772..1938
                     /gene="YTHDC1"
                     /gene_synonym="YT521; YT521-B"
                     /inference="alignment:Splign:2.1.0"
     exon            1939..2021
                     /gene="YTHDC1"
                     /gene_synonym="YT521; YT521-B"
                     /inference="alignment:Splign:2.1.0"
     exon            2022..2058
                     /gene="YTHDC1"
                     /gene_synonym="YT521; YT521-B"
                     /inference="alignment:Splign:2.1.0"
     exon            2059..2098
                     /gene="YTHDC1"
                     /gene_synonym="YT521; YT521-B"
                     /inference="alignment:Splign:2.1.0"
     exon            2099..2161
                     /gene="YTHDC1"
                     /gene_synonym="YT521; YT521-B"
                     /inference="alignment:Splign:2.1.0"
     exon            2162..2296
                     /gene="YTHDC1"
                     /gene_synonym="YT521; YT521-B"
                     /inference="alignment:Splign:2.1.0"
     exon            2297..6233
                     /gene="YTHDC1"
                     /gene_synonym="YT521; YT521-B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3276..3281
                     /regulatory_class="polyA_signal_sequence"
                     /gene="YTHDC1"
                     /gene_synonym="YT521; YT521-B"
                     /note="hexamer: AATAAA"
     polyA_site      3301
                     /gene="YTHDC1"
                     /gene_synonym="YT521; YT521-B"
                     /note="major polyA site"
     regulatory      3637..3642
                     /regulatory_class="polyA_signal_sequence"
                     /gene="YTHDC1"
                     /gene_synonym="YT521; YT521-B"
                     /note="hexamer: CATAAA"
     polyA_site      3658
                     /gene="YTHDC1"
                     /gene_synonym="YT521; YT521-B"
     regulatory      4299..4304
                     /regulatory_class="polyA_signal_sequence"
                     /gene="YTHDC1"
                     /gene_synonym="YT521; YT521-B"
                     /note="hexamer: AATAAA"
     polyA_site      4325
                     /gene="YTHDC1"
                     /gene_synonym="YT521; YT521-B"
     regulatory      4976..4981
                     /regulatory_class="polyA_signal_sequence"
                     /gene="YTHDC1"
                     /gene_synonym="YT521; YT521-B"
                     /note="hexamer: AATAAA"
     polyA_site      5005
                     /gene="YTHDC1"
                     /gene_synonym="YT521; YT521-B"
     regulatory      6212..6217
                     /regulatory_class="polyA_signal_sequence"
                     /gene="YTHDC1"
                     /gene_synonym="YT521; YT521-B"
                     /note="hexamer: ATTAAA"
     polyA_site      6233
                     /gene="YTHDC1"
                     /gene_synonym="YT521; YT521-B"
ORIGIN      
        1 atttcgggag cgggattgtt tcgcgcagga agcaggctcc attttagcgc cgcccgccgt
       61 cgccatctgt ttcccttccc tcccccatac ctagcccgag tctgagccct aacgagaagg
      121 ctgggcctag gccgctggat gctggagtga aaggaaggga gaaagggaaa aagcgggaag
      181 agtcgagaag gctgagtgtt aagaggccaa gtgcgacgcg cgtatccggg cagacggact
      241 gacggacggg cccgtgcttc tgccgcggct gcggcgcccg cgcgagtcgc gtctaagcgg
      301 cggcggcggt ggcagcggcg gaaaccgaag gggagccatg gcggctgaca gtcgggagga
      361 gaaagatgga gaacttaatg ttctggatga tattttaact gaagtaccag aacaagatga
      421 tgaactgtat aatccagaga gtgaacaaga taaaaatgag aaaaagggat caaaaagaaa
      481 aagtgatcga atggaatcta ctgataccaa acgacaaaag ccttctgtcc attctagaca
      541 actggtttct aagccactga gctcatctgt tagcaataac aaaagaatag ttagtacaaa
      601 aggaaagtca gccacagagt ataaaaatga ggaatatcaa agatctgaaa gaaacaagcg
      661 tctagatgct gatcggaaaa ttcgtctatc aagtagtgcc tccagagaac cttataagaa
      721 tcaacctgaa aaaacctgtg tccggaaaag ggatcctgaa aggagggcca aatctcctac
      781 gccagatggt tctgagagaa ttgggcttga agtggataga cgtgcaagca gatccagcca
      841 gtcttctaag gaagaagtga actctgaaga atatggctct gaccatgaga ctggcagcag
      901 tggttcttct gatgagcaag ggaacaacac tgagaatgag gaggaaggag tggaagaaga
      961 tgtggaggaa gatgaagaag tagaagaaga tgcagaagaa gatgaagagg tggatgaaga
     1021 tggagaggag gaggaggaag aggaggagga ggaagaggag gaggaggagg aggaagaaga
     1081 agaatatgaa caggatgaga gagaccagaa agaggaggga aatgattatg acactcgaag
     1141 tgaggccagt gactctggtt ctgaatctgt ttccttcaca gatgggtctg tcagatctgg
     1201 ttcaggcaca gatggatcag atgagaaaaa gaaggaaagg aagagagcta gaggcatatc
     1261 tccaattgtt tttgatagaa gtggaagctc tgcatcagag tcatatgcag gttcagaaaa
     1321 gaagcatgag aaattatcat cttccgttcg tgctgtccga aaagatcaaa ccagtaaact
     1381 caaatatgtg cttcaagatg caagattttt cctcataaag agtaacaacc atgagaatgt
     1441 gtctcttgcc aaagcgaagg gtgtatggtc cacgctccct gtaaatgaga agaaattaaa
     1501 tcttgcattt agatctgcaa ggagtgttat cttaatattt tctgtcagag agagtggaaa
     1561 atttcaaggg tttgcaagac tttcttcaga atcacatcac ggaggatctc ctatacactg
     1621 ggtgcttcca gcaggaatga gtgctaaaat gctgggaggt gtctttaaaa ttgactggat
     1681 ttgcaggcgt gaattaccct tcactaagtc ggctcatctc accaatcctt ggaatgaaca
     1741 taaaccagta aagatcggac gtgatggaca ggaaattgaa cttgaatgtg gaacccagct
     1801 ttgtcttctg tttccccccg atgaaagtat tgacttgtat caggtcattc ataaaatgcg
     1861 tcacaagaga agaatgcatt ctcagccccg atcacgagga cgtccatccc gtcgagaacc
     1921 agtccgggat gtgggaaggc gtcgaccaga agattatgat attcataaca gcagaaagaa
     1981 accaaggatt gactatcccc ctgagtttca ccagagacca gggtatttaa aggatccacg
     2041 ataccaggaa gtggacagac gattttcagg agttcgccga gatgtgtttt taaatgggtc
     2101 ctacaatgat tatgtgaggg aatttcataa catgggacca ccaccacctt ggcaaggaat
     2161 gcccccttac ccaggaatgg aacaacctcc acaccatcct tactatcagc accatgctcc
     2221 acctcctcaa gctcatcccc cttactcagg acatcatcca gtaccacatg aagcaagata
     2281 cagagataaa cgagtacatg attatgatat gagggtggat gatttccttc gtcgcacaca
     2341 agctgttgtc agtggccgga gaagtagacc ccgtgaaaga gaccgggaac gagagcgaga
     2401 ccgccctaga gataacagac gagacagaga gcgagataga ggacgtgata gagaaagaga
     2461 aagagagcga ttatgtgatc gagacagaga ccgaggggag agaggtcgat atagaagata
     2521 atgggctttt ggaagcactg attgtttaaa gatacaaaaa atcttgtatt ttttttttgt
     2581 gtgtgtttac aagtagtaaa tttattttca gctgtctgcc tatgaagttc attgtgtaga
     2641 aggatttatt atgaccccct ttgttccaag catgcagtat cataagaact ggaaaaactc
     2701 aaatccgcca aaaatccaca gctgacagtt gaattgacac ttttattggg gcagaatgga
     2761 acagtccaag aatgtagata ctgattcttt ctccataaat gttcttatag tgtgttcatc
     2821 ctagagttat ttttttgttt gtttttttcc tttttggatc ttgattgata actgccatga
     2881 tattttgctt tgatgtgttt ctacatgtag ttgcacacgg ttcagtaaaa ataatgctgc
     2941 tatcgagtat gcaaatattg aagtatgatg gtttgactgt atggcagtgt tgtagcagcc
     3001 tcttgttttt ttccccattg cctctttttt taaaaaactt ataaagtcac tttttatttt
     3061 tcctcagtct tcaatgacga gagcaatatt aagaagacat tgctatctaa tttttaatct
     3121 ttttaaatga aaaattccta tgttcagtag cgtggttgat gctattgttt agccttcccc
     3181 tccaaattgt atacattggc ttggaatgtt cacaacttgc gtgcgtggca gcggaagacg
     3241 attcccatat tctacattgc tactgttttg tataaaataa attggtaaag attgacggtt
     3301 atcttttgta tctttttctt atccaattgc aggtttgttt tattatgcaa taatggacat
     3361 aaaagcatgc tttttgttca ggaattttag gaaccccatt tgcttttttt gaggcacact
     3421 ttagcagaaa tgattgacct aggcctgttg cattaaaagc ttacttctat ttctaacata
     3481 agatacacag agttatgtta ataatttggt taagtattta tacacctgat aacattttga
     3541 gtctactctg atcacagaat cgtttattta ggttttctat ttgttgtttt agtcttctgt
     3601 aagtgaacga ctttgtacat gctttctact ttacttcata aatggacttt taaccctctt
     3661 gtattagttc tgtattttaa gttaactgtc cagttctccc agtggtaacc aactataaca
     3721 tagaaataga gccgctcaag aaaacagttt atgaaataat ttttttgaat tttttcttga
     3781 gttacacctg gagttttggc ctttggaatt tggcctttat aaacattagg aatatttgaa
     3841 tgtttgattt ttttatagta tcaacagttg tactgtgtac cagatcacat agtacagttt
     3901 tacatttaat ctatattggc ctgaaaagaa caacacaggc actttactct taaaggatat
     3961 aataaactat agttatactg cattcatatt cataccagca tgtagtatct ttccctgcat
     4021 tcacagaagt tttatttaca atgacaaaac taaagcctga ggatttgttt taaatctgca
     4081 ttgtggtaga gaggaaaaag tacttttaag gaaacctggg ttctagtttt gtcattgtct
     4141 ttaattaaac cggttagtga tacatggtaa gtcacttcat tggcattttg tgtattcatc
     4201 agtaagctag acaagatgat agctacagtt taagaatttc tgtaaccatt atacaaaact
     4261 ggtaggtaat attaaaggta ttttcctgaa ataataggaa taaatactga gcactttgta
     4321 tgcaatagag actttgtgct tttatataca gactcattta aatgggctca gagaggctag
     4381 taaacttgcc caagattaga aaggtagtaa ttgatgggcc aagattttac ccatgttttt
     4441 atttggtgtt tctaaaccac ctcatcactt ttgaaaaaac agtatataaa ttaataaatg
     4501 ttttggagat ggagtctgtc gcccaggtgg agggcagtgg catgatcttg gctcactgca
     4561 acctcctgcc tcagcctccc gaatggctgg gactacaggc acccaccacc acaccccgct
     4621 aatttttgta attttagtag agatggggtt ccaacatgtt ggccaggctg gtctcaaact
     4681 cgacctcaag tgacctcacc tgcctcagcc tcctaaagtg ttgggattac aggcgtgagc
     4741 cactgcacct ggcctgagat ttttaaacat taacatttcc ttcaggctta agcagaggat
     4801 ttttctaaag tgccatccaa ttagatgtta agttatgctt tgtatgttga gcttagtatt
     4861 gagtcgatct attttaaaaa gccaacatta agtttttacc aagtatctgg cactattcta
     4921 aacaattctg ttggctcaca taatcatcac tgttttctcc tttcctaatt tttaaaataa
     4981 acttaccgga acattgtata aaaaatgcaa gatttttttc tgtacagaag agtcagtata
     5041 taaaaatcag tatgttttat ttaatattcg tacacatgac agcttttgtc actgtgagaa
     5101 gacatggttt ctttcgtgta ctccactgtg ctgtgattct aacaatctac attagtatga
     5161 tgtgttcaga tgaaaaacag aaaattcagt cattccgagt ttagaaatcc ggtcagggat
     5221 tttattggct ggagtaatag ttcaaaggag tgaaaattca agcatgtaat ttttggattt
     5281 gatttcctcc ataatgattt cctccataat ggcttttttt caagcatggt ctaatttttc
     5341 agaaaatggc cattatctcc aagcttccat tgtccatgta gtttcagtgg caggagagag
     5401 actattttcc tcccagtgtc catgtcagtt ccccaaaagg actgaatagc catgttggtt
     5461 ttggagccag ccgtaatcca atctgtattt ccaaggaaat ggggttcttt gtctcccagc
     5521 attgggaagc aagagaggca catgttatgg tcacctctgt gaggattaca tcaggaagga
     5581 cagtctccaa aagacatgga cagaggaaat ttagcagatg tccattaaat caggatctca
     5641 tacaagttat aacacctgaa tgtttgactt ttcagagtat tttgccatca caggtgtggc
     5701 atcttgccct tggatatatc tacattctgc tgtagaatgt cgtggtcttt ctgagggtca
     5761 catacatcct gtcttgtcat aatgttaacc attaagagtc ctcaggggca tggaattgaa
     5821 gaaggaactg ttgccagcag ttaactgacc aagctagagt tccctgaccc aacgtaaggg
     5881 tgactgtgac acacatggat aattttagct tcatgtttaa gattttgtta tttgggtagg
     5941 aaacattcca aatgcagttt gaaacacata ttaaaattga ggcacacagg aaagaactgg
     6001 ctcaagttta gtccccaagt tccttatagt aggaatagga atccttagag tataagcaat
     6061 ccatgcatag tattctgtta tctatcatgt agatcattta atctctaatt ttttggggtg
     6121 gggattctct tgtttctaaa tcttacactt tcagtttctt ctgtgtctta aatatagatt
     6181 attgactatt gtcttaaata ctaataaata cattaaatgt atcttaaata cta
//
