LOCUS       NM_016061               2136 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens yippee like 5 (YPEL5), transcript variant 4, mRNA.
ACCESSION   NM_016061
VERSION     NM_016061.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2136)
  AUTHORS   Zhou,D., Tang,W., Xu,Y., Xu,Y., Xu,B., Fu,S., Wang,Y., Chen,F.,
            Chen,Y., Han,Y. and Wang,G.
  TITLE     METTL3/YTHDF2 m6A axis accelerates colorectal carcinogenesis
            through epigenetically suppressing YPEL5
  JOURNAL   Mol Oncol 15 (8), 2172-2184 (2021)
   PUBMED   33411363
  REMARK    GeneRIF: METTL3/YTHDF2 m6A axis accelerates colorectal
            carcinogenesis through epigenetically suppressing YPEL5.
REFERENCE   2  (bases 1 to 2136)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2136)
  AUTHORS   Lampert,F., Stafa,D., Goga,A., Soste,M.V., Gilberto,S., Olieric,N.,
            Picotti,P., Stoffel,M. and Peter,M.
  TITLE     The multi-subunit GID/CTLH E3 ubiquitin ligase promotes cell
            proliferation and targets the transcription factor Hbp1 for
            degradation
  JOURNAL   Elife 7, e35528 (2018)
   PUBMED   29911972
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2136)
  AUTHORS   Lee,J.Y., Jun,D.Y., Park,J.E., Kwon,G.H., Kim,J.S. and Kim,Y.H.
  TITLE     Pro-Apoptotic Role of the Human YPEL5 Gene Identified by Functional
            Complementation of a Yeast moh1Delta Mutation
  JOURNAL   J Microbiol Biotechnol 27 (3), 633-643 (2017)
   PUBMED   28173693
  REMARK    GeneRIF: results demonstrate the functional conservation between
            yeast Moh1 and human YPEL5, and their involvement in
            mitochondria-dependent apoptosis induced by DNA damage
REFERENCE   5  (bases 1 to 2136)
  AUTHORS   Jeidane,S., Scott-Boyer,M.P., Tremblay,N., Cardin,S., Picard,S.,
            Baril,M., Lamarre,D. and Deschepper,C.F.
  TITLE     Association of a Network of Interferon-Stimulated Genes with a
            Locus Encoding a Negative Regulator of Non-conventional IKK Kinases
            and IFNB1
  JOURNAL   Cell Rep 17 (2), 425-435 (2016)
   PUBMED   27705791
  REMARK    GeneRIF: YPEL5 silencing enhanced the induction of IFNB1 by pattern
            recognition receptors and phosphorylation of TBK1/IKBKE kinases,
            whereas co-immunoprecipitation experiments revealed that YPEL5
            interacted physically with IKBKE.
REFERENCE   6  (bases 1 to 2136)
  AUTHORS   Velusamy,T., Palanisamy,N., Kalyana-Sundaram,S.,
            Sahasrabuddhe,A.A., Maher,C.A., Robinson,D.R., Bahler,D.W.,
            Cornell,T.T., Wilson,T.E., Lim,M.S., Chinnaiyan,A.M. and
            Elenitoba-Johnson,K.S.
  TITLE     Recurrent reciprocal RNA chimera involving YPEL5 and PPP1CB in
            chronic lymphocytic leukemia
  JOURNAL   Proc Natl Acad Sci U S A 110 (8), 3035-3040 (2013)
   PUBMED   23382248
  REMARK    GeneRIF: results indicate that SCN-iPS cells provide a useful
            disease model for SCN, and the activation of the Wnt3a/beta-catenin
            pathway may offer a novel therapy for SCN with ELANE mutation
REFERENCE   7  (bases 1 to 2136)
  AUTHORS   Olson,J.E., Wang,X., Pankratz,V.S., Fredericksen,Z.S., Vachon,C.M.,
            Vierkant,R.A., Cerhan,J.R. and Couch,F.J.
  TITLE     Centrosome-related genes, genetic variation, and risk of breast
            cancer
  JOURNAL   Breast Cancer Res Treat 125 (1), 221-228 (2011)
   PUBMED   20508983
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 2136)
  AUTHORS   Hosono,K., Noda,S., Shimizu,A., Nakanishi,N., Ohtsubo,M.,
            Shimizu,N. and Minoshima,S.
  TITLE     YPEL5 protein of the YPEL gene family is involved in the cell cycle
            progression by interacting with two distinct proteins RanBPM and
            RanBP10
  JOURNAL   Genomics 96 (2), 102-111 (2010)
   PUBMED   20580816
  REMARK    GeneRIF: YPEL5 protein of the YPEL gene family is involved in the
            cell cycle progression by interacting with two distinct proteins
            RanBPM and RanBP10.
REFERENCE   9  (bases 1 to 2136)
  AUTHORS   Hosono,K., Sasaki,T., Minoshima,S. and Shimizu,N.
  TITLE     Identification and characterization of a novel gene family YPEL in
            a wide spectrum of eukaryotic species
  JOURNAL   Gene 340 (1), 31-43 (2004)
   PUBMED   15556292
REFERENCE   10 (bases 1 to 2136)
  AUTHORS   Roxstrom-Lindquist,K. and Faye,I.
  TITLE     The Drosophila gene Yippee reveals a novel family of putative zinc
            binding proteins highly conserved among eukaryotes
  JOURNAL   Insect Mol Biol 10 (1), 77-86 (2001)
   PUBMED   11240639
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF172940.1, AC016907.6 and AK025730.1.
            
            On Nov 23, 2018 this sequence version replaced NM_016061.2.
            
            Transcript Variant: This variant (4) lacks two alternate exons,
            compared to variant 1. Variants 1, 2, 3, and 4 encode the same
            protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF151885.1, SRR1660805.257778.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000261353.9/ ENSP00000261353.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-384               AF172940.1         48-431
            385-2123            AC016907.6         158216-159954
            2124-2136           AK025730.1         2183-2195
FEATURES             Location/Qualifiers
     source          1..2136
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p23.1"
     gene            1..2136
                     /gene="YPEL5"
                     /gene_synonym="CGI-127"
                     /note="yippee like 5"
                     /db_xref="GeneID:51646"
                     /db_xref="HGNC:HGNC:18329"
                     /db_xref="MIM:609726"
     exon            1..56
                     /gene="YPEL5"
                     /gene_synonym="CGI-127"
                     /inference="alignment:Splign:2.1.0"
     exon            57..221
                     /gene="YPEL5"
                     /gene_synonym="CGI-127"
                     /inference="alignment:Splign:2.1.0"
     CDS             81..446
                     /gene="YPEL5"
                     /gene_synonym="CGI-127"
                     /EC_number="1.5.8.4"
                     /codon_start=1
                     /product="protein yippee-like 5"
                     /protein_id="NP_057145.1"
                     /db_xref="CCDS:CCDS1771.1"
                     /db_xref="GeneID:51646"
                     /db_xref="HGNC:HGNC:18329"
                     /db_xref="MIM:609726"
                     /translation="MGRIFLDHIGGTRLFSCANCDTILTNRSELISTRFTGATGRAFL
                     FNKVVNLQYSEVQDRVMLTGRHMVRDVSCKNCNSKLGWIYEFATEDSQRYKEGRVILE
                     RALVRESEGFEEHVPSDNS"
     exon            222..2136
                     /gene="YPEL5"
                     /gene_synonym="CGI-127"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1137..1142
                     /regulatory_class="polyA_signal_sequence"
                     /gene="YPEL5"
                     /gene_synonym="CGI-127"
                     /note="hexamer: AATAAA"
     polyA_site      1154
                     /gene="YPEL5"
                     /gene_synonym="CGI-127"
                     /note="major polyA site"
     regulatory      1662..1667
                     /regulatory_class="polyA_signal_sequence"
                     /gene="YPEL5"
                     /gene_synonym="CGI-127"
                     /note="hexamer: ATTAAA"
     polyA_site      1690
                     /gene="YPEL5"
                     /gene_synonym="CGI-127"
     regulatory      2114..2119
                     /regulatory_class="polyA_signal_sequence"
                     /gene="YPEL5"
                     /gene_synonym="CGI-127"
                     /note="hexamer: AATAAA"
     polyA_site      2136
                     /gene="YPEL5"
                     /gene_synonym="CGI-127"
                     /note="major polyA site"
ORIGIN      
        1 ataccagctg aagagcgaca agccgctggc agccgcggat ctcaccgccg ctcagggttt
       61 ttagaacttc agccataaaa atgggcagaa ttttccttga tcatatcggt ggtacccgtc
      121 tgttttcttg tgcaaactgt gatacgatcc tgaccaaccg ctcagaactc atctccactc
      181 gtttcacagg cgccactggc agagcatttc tttttaacaa ggtagttaac ctgcagtaca
      241 gtgaagttca agatcgggtc atgctcactg gccgccacat ggttcgagat gtgagctgca
      301 aaaactgcaa tagcaaactg ggatggatct atgagtttgc cactgaagac agccagcgat
      361 ataaggaagg ccgcgtgatc ctggaacgtg ctctagttcg agagagtgag ggctttgagg
      421 agcatgtacc atctgataac tcttgaagat acagagagaa atccatcttt tcccaggtct
      481 ccttcactga aaacaaaaat ctacttacat acactgtcac cttagcatca gagtcggatt
      541 aatgaactgc ggaacaagag gttgtgagaa tctaagatgg aacctttctt tctttctttc
      601 ttttttttta aattttgtat tttccatcca acagcagtgt gtagagagaa tattatgcag
      661 atgccgttaa ttttttaccc tatgtttaca tcttgaggca gcagagtctg tctgcagcta
      721 tgtggtgagc tatgtaagga aaaaaatctg ggctgttaga gtgaaaaagt gtgttttatg
      781 tcaattgtga aaggaaaatg ttaggagtat ggtttttaaa cttgggcttc attttaaact
      841 ttttttttta aacccagtta tttcacttga tttgctagct tcagagaaga gatccgaatc
      901 tgtgcccagc gctaaaggct cagtgttagc atggcttgtg ctggccggtg tgccatattc
      961 ttgttggaga tgaaccgtag caccagagcc cattcttcct tgtcagtctt ggcccaaaga
     1021 tgtcaccatt cctagttatt tgtcaccaca taattggtgt tgattggaaa ctttttctga
     1081 gatgggacag aactgctggg ttgtcttttt ccatgtaact taagcatagt aatataaata
     1141 aagtaatagt tggatgcttt tggtcctgtg ttgcttttaa aaacacctta taaaagagga
     1201 gagtatttga taagcaattt tcatagtagt aaagtttttt ttcatctctt aaactaaatt
     1261 gaccatgcat ataatattct ttgtttaaat gaaagcatac tgttgaaacc cgcagtgttg
     1321 catttagaaa acagttgaac agaatgtcaa tgtgcattca tgcaaaaaaa catttaatct
     1381 gcatctgttt tagaaaaggg ggaaatgaag caacttgtct aaaaatactg ctttacaaag
     1441 catttcagcc tttccccctc agttttgcat tgattttttg acaagtctgt agagcctaat
     1501 agtttccatc aaaggcctag atctcttatt tagcattttt ttcagctctt ctctcagaag
     1561 ttcagctgtt gaaacgaaaa ctgtactttg taccctcaca tacaaaggga tcaaatttga
     1621 cctggtgtta ttttagcccc aaatttatga cattacacaa tattaaaatg taaatgtttc
     1681 tttacccaaa ctacttctag atattctagt atttgcttct ggtggaatta aatgacggta
     1741 aaattggcta attatttgaa tgaatgaatg gatggatgtt ttgcatgctc aatttctagg
     1801 tcctttgtct agaaaggaaa tttgcctcag ttgaattagt gaaatatttc tgtcgttgat
     1861 attaaaagtg acttctgagt acagttaagt tcctcctatt tgccactggg ctgttggtta
     1921 gaagcatagg taactgatta agtaggtatg atactgcatt tgaaataagt ggacacaaac
     1981 tatcctttct ccaccatgga ctcaatctga gaacaacagc attcatttcc attcatttcc
     2041 atactggctt ttgattatat gcagattcct agtagcatgc cttacctaca gcactatgtg
     2101 catttgctgt cacaataaag tatattttgt cttgca
//
