LOCUS       NM_145008               1690 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens yippee like 4 (YPEL4), transcript variant 2, mRNA.
ACCESSION   NM_145008
VERSION     NM_145008.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1690)
  AUTHORS   Oki,K., Plonczynski,M.W., Gomez-Sanchez,E.P. and Gomez-Sanchez,C.E.
  TITLE     YPEL4 modulates HAC15 adrenal cell proliferation and is associated
            with tumor diameter
  JOURNAL   Mol Cell Endocrinol 434, 93-98 (2016)
   PUBMED   27333825
  REMARK    GeneRIF: Results demonstrated that YPEL4 stimulates human adrenal
            cortical cell proliferation, increasing aldosterone production.
            Also, YPEL4 expression levels are higher in human aldosterone
            producing adenoma.
REFERENCE   2  (bases 1 to 1690)
  CONSRTM   Schizophrenia Working Group of the Psychiatric Genomics Consortium
  TITLE     Biological insights from 108 schizophrenia-associated genetic loci
  JOURNAL   Nature 511 (7510), 421-427 (2014)
   PUBMED   25056061
REFERENCE   3  (bases 1 to 1690)
  AUTHORS   Olson,J.E., Wang,X., Pankratz,V.S., Fredericksen,Z.S., Vachon,C.M.,
            Vierkant,R.A., Cerhan,J.R. and Couch,F.J.
  TITLE     Centrosome-related genes, genetic variation, and risk of breast
            cancer
  JOURNAL   Breast Cancer Res Treat 125 (1), 221-228 (2011)
   PUBMED   20508983
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   4  (bases 1 to 1690)
  AUTHORS   Liang,P., Wan,Y., Yan,Y., Wang,Y., Luo,N., Deng,Y., Fan,X.,
            Zhou,J., Li,Y., Wang,Z., Yuan,W., Tang,M., Mo,X. and Wu,X.
  TITLE     MVP interacts with YPEL4 and inhibits YPEL4-mediated activities of
            the ERK signal pathway
  JOURNAL   Biochem Cell Biol 88 (3), 445-450 (2010)
   PUBMED   20555386
  REMARK    GeneRIF: Data show that major vault protein (MVP), a lung
            resistance associated protein, is a binding partner of YPEL4.
REFERENCE   5  (bases 1 to 1690)
  AUTHORS   Hosono,K., Sasaki,T., Minoshima,S. and Shimizu,N.
  TITLE     Identification and characterization of a novel gene family YPEL in
            a wide spectrum of eukaryotic species
  JOURNAL   Gene 340 (1), 31-43 (2004)
   PUBMED   15556292
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AB098738.1.
            
            On Nov 22, 2018 this sequence version replaced NM_145008.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB098738.1, SRR3476690.433653.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000300022.8/ ENSP00000300022.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1690              AB098738.1         33-1722
FEATURES             Location/Qualifiers
     source          1..1690
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q12.1"
     gene            1..1690
                     /gene="YPEL4"
                     /note="yippee like 4"
                     /db_xref="GeneID:219539"
                     /db_xref="HGNC:HGNC:18328"
                     /db_xref="MIM:609725"
     exon            1..228
                     /gene="YPEL4"
                     /inference="alignment:Splign:2.1.0"
     exon            229..553
                     /gene="YPEL4"
                     /inference="alignment:Splign:2.1.0"
     CDS             413..796
                     /gene="YPEL4"
                     /codon_start=1
                     /product="protein yippee-like 4"
                     /protein_id="NP_659445.1"
                     /db_xref="CCDS:CCDS7963.1"
                     /db_xref="GeneID:219539"
                     /db_xref="HGNC:HGNC:18328"
                     /db_xref="MIM:609725"
                     /translation="MPSCDPGPGPACLPTKTFRSYLPRCHRTYSCVHCRAHLAKHDEL
                     ISKSFQGSHGRAYLFNSVVNVGCGPAEQRLLLTGLHSVADIFCESCKTTLGWKYEQAF
                     ETSQKYKEGKYIIEMSHMVKDNGWD"
     exon            554..597
                     /gene="YPEL4"
                     /inference="alignment:Splign:2.1.0"
     exon            598..706
                     /gene="YPEL4"
                     /inference="alignment:Splign:2.1.0"
     exon            707..1690
                     /gene="YPEL4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1666..1671
                     /regulatory_class="polyA_signal_sequence"
                     /gene="YPEL4"
                     /note="hexamer: AATAAA"
     polyA_site      1690
                     /gene="YPEL4"
                     /note="major polyA site"
ORIGIN      
        1 acattcaccc acagaccgag gtacagaacg agagacaacc tctgcccccc cagcagctgg
       61 ccagctttgc agccccagtc ttgagccccc aactaccctc cccccaccca cccccatccc
      121 cttcccaatt gaaggagcgg aaagagaaga gagaagagtg agcagagaga ttgagagatt
      181 gagagagaga gagagagata gacggagatc tctggagcag acctcaaggt gacttctatt
      241 tctatctggt tctcgtctgg gggggccctg gccgggcagc cccccaacac ttctcctgcc
      301 ctgaaacacg gctctagcca acctgctccg ctgcttcacc tgcgaccgtc tctgcggggg
      361 ctgcacggcg ccagcccctc cagcccacca gggcattgtc ctccagcccg tcatgcccag
      421 ctgtgacccc ggtccgggcc ctgcctgcct ccccaccaag actttccgca gctatctgcc
      481 ccgctgtcac cgcacttaca gctgtgtcca ctgccgtgca cacctggcca aacacgatga
      541 gcttatttcc aagtccttcc aagggagcca tggccgagcc tacctgttta actccgtggt
      601 caacgtgggt tgcgggccag ctgaacagcg cctcttgctc acggggctcc actcggtagc
      661 tgacattttc tgtgagagct gcaaaaccac actgggctgg aaatatgagc aagcttttga
      721 gacgagccag aagtacaagg aagggaaata catcattgaa atgtcacaca tggtgaagga
      781 caacggctgg gactgagggg ctcaggcagg gtgtgccctt cctccgcatg cccctccctc
      841 cccacggccc tgccaagcag tctataccag catgagtact gccccacccc tgggggaaac
      901 ctggctccaa ccaacccctc ccctgcctcc accatatcca ctaccaggca ccctttagaa
      961 caggggtctg ggggtacccc aggggtgtta aggctcagga gtgggcagca gtcagggaga
     1021 gacagaactg ggggaaaggg atggttgtgg gtctttctgt tcccaagatc ctgaacatgg
     1081 aagcgatggc agggcataga ctcaggcaga gaggattgtg ggaggaatcc gtttttgctc
     1141 cacctctttt tgagtgaaca gaggacaaac cttgggtcac agggcaagta gatcatggac
     1201 cacagaacag cagatgagaa aagacttggg ttggagtgaa attctggtct cagacaccag
     1261 gagaccagag tctctgagga tgaagtttcc tacccctatt tgtagggaaa aggacttgag
     1321 tgcagggaaa actcaaatcc caggccctgg gaaatagtaa aataatcaaa gggttttcca
     1381 tttcactcca cttgttagtt tatcttggca ctgaagaggc actttcgagt atctaacttt
     1441 tgccattggg tggggtgggg acagctgctc gcggaacagc ccctagtcgg ctgcttccag
     1501 agtaagcagt ctttatgggc tttctctgag gcccagtcac tgctcctggg acccagtccc
     1561 ctggagggga ggtggaaaat cagtgctacg gggccagtct ttcccgtggc tgccaccagc
     1621 gaatgaaact tttgtatgat acataaagtg cttgagtcta tttttaataa aaagggaaaa
     1681 agcaacttga
//
