LOCUS       NM_001363487            1882 bp    mRNA    linear   PRI 11-JUN-2024
DEFINITION  Homo sapiens yippee like 4 (YPEL4), transcript variant 1, mRNA.
ACCESSION   NM_001363487 XM_017017318
VERSION     NM_001363487.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1882)
  AUTHORS   Oki,K., Plonczynski,M.W., Gomez-Sanchez,E.P. and Gomez-Sanchez,C.E.
  TITLE     YPEL4 modulates HAC15 adrenal cell proliferation and is associated
            with tumor diameter
  JOURNAL   Mol Cell Endocrinol 434, 93-98 (2016)
   PUBMED   27333825
  REMARK    GeneRIF: Results demonstrated that YPEL4 stimulates human adrenal
            cortical cell proliferation, increasing aldosterone production.
            Also, YPEL4 expression levels are higher in human aldosterone
            producing adenoma.
REFERENCE   2  (bases 1 to 1882)
  CONSRTM   Schizophrenia Working Group of the Psychiatric Genomics Consortium
  TITLE     Biological insights from 108 schizophrenia-associated genetic loci
  JOURNAL   Nature 511 (7510), 421-427 (2014)
   PUBMED   25056061
REFERENCE   3  (bases 1 to 1882)
  AUTHORS   Olson,J.E., Wang,X., Pankratz,V.S., Fredericksen,Z.S., Vachon,C.M.,
            Vierkant,R.A., Cerhan,J.R. and Couch,F.J.
  TITLE     Centrosome-related genes, genetic variation, and risk of breast
            cancer
  JOURNAL   Breast Cancer Res Treat 125 (1), 221-228 (2011)
   PUBMED   20508983
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   4  (bases 1 to 1882)
  AUTHORS   Liang,P., Wan,Y., Yan,Y., Wang,Y., Luo,N., Deng,Y., Fan,X.,
            Zhou,J., Li,Y., Wang,Z., Yuan,W., Tang,M., Mo,X. and Wu,X.
  TITLE     MVP interacts with YPEL4 and inhibits YPEL4-mediated activities of
            the ERK signal pathway
  JOURNAL   Biochem Cell Biol 88 (3), 445-450 (2010)
   PUBMED   20555386
  REMARK    GeneRIF: Data show that major vault protein (MVP), a lung
            resistance associated protein, is a binding partner of YPEL4.
REFERENCE   5  (bases 1 to 1882)
  AUTHORS   Hosono,K., Sasaki,T., Minoshima,S. and Shimizu,N.
  TITLE     Identification and characterization of a novel gene family YPEL in
            a wide spectrum of eukaryotic species
  JOURNAL   Gene 340 (1), 31-43 (2004)
   PUBMED   15556292
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP000662.4.
            
            On Aug 13, 2020 this sequence version replaced NM_001363487.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.360692.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN03465402 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-228               AP000662.4         45165-45392         c
            229-420             AP000662.4         42953-43144         c
            421-745             AP000662.4         42447-42771         c
            746-789             AP000662.4         42231-42274         c
            790-898             AP000662.4         41777-41885         c
            899-1882            AP000662.4         40567-41550         c
FEATURES             Location/Qualifiers
     source          1..1882
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q12.1"
     gene            1..1882
                     /gene="YPEL4"
                     /note="yippee like 4"
                     /db_xref="GeneID:219539"
                     /db_xref="HGNC:HGNC:18328"
                     /db_xref="MIM:609725"
     exon            1..228
                     /gene="YPEL4"
                     /inference="alignment:Splign:2.1.0"
     exon            229..420
                     /gene="YPEL4"
                     /inference="alignment:Splign:2.1.0"
     exon            421..745
                     /gene="YPEL4"
                     /inference="alignment:Splign:2.1.0"
     CDS             605..988
                     /gene="YPEL4"
                     /codon_start=1
                     /product="protein yippee-like 4"
                     /protein_id="NP_001350416.1"
                     /db_xref="CCDS:CCDS7963.1"
                     /db_xref="GeneID:219539"
                     /db_xref="HGNC:HGNC:18328"
                     /db_xref="MIM:609725"
                     /translation="MPSCDPGPGPACLPTKTFRSYLPRCHRTYSCVHCRAHLAKHDEL
                     ISKSFQGSHGRAYLFNSVVNVGCGPAEQRLLLTGLHSVADIFCESCKTTLGWKYEQAF
                     ETSQKYKEGKYIIEMSHMVKDNGWD"
     exon            746..789
                     /gene="YPEL4"
                     /inference="alignment:Splign:2.1.0"
     exon            790..898
                     /gene="YPEL4"
                     /inference="alignment:Splign:2.1.0"
     exon            899..1882
                     /gene="YPEL4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1858..1863
                     /regulatory_class="polyA_signal_sequence"
                     /gene="YPEL4"
                     /note="hexamer: AATAAA"
     polyA_site      1882
                     /gene="YPEL4"
                     /note="major polyA site"
ORIGIN      
        1 acattcaccc acagaccgag gtacagaacg agagacaacc tctgcccccc cagcagctgg
       61 ccagctttgc agccccagtc ttgagccccc aactaccctc cccccaccca cccccatccc
      121 cttcccaatt gaaggagcgg aaagagaaga gagaagagtg agcagagaga ttgagagatt
      181 gagagagaga gagagagata gacggagatc tctggagcag acctcaagtg cctgtgcgat
      241 gcagagcctc acgaagaact gaaaaccaag gagagggcac ttgcagatga cgttgctccc
      301 atggcagcgt ctgtgcccgt gggcttctct ctgtggaaaa tggtggaggc tgcttctgcc
      361 ccaggaggga gaaacaccga ctccctggct ttggcgccag aagcctggat cggctgccag
      421 gtgacttcta tttctatctg gttctcgtct gggggggccc tggccgggca gccccccaac
      481 acttctcctg ccctgaaaca cggctctagc caacctgctc cgctgcttca cctgcgaccg
      541 tctctgcggg ggctgcacgg cgccagcccc tccagcccac cagggcattg tcctccagcc
      601 cgtcatgccc agctgtgacc ccggtccggg ccctgcctgc ctccccacca agactttccg
      661 cagctatctg ccccgctgtc accgcactta cagctgtgtc cactgccgtg cacacctggc
      721 caaacacgat gagcttattt ccaagtcctt ccaagggagc catggccgag cctacctgtt
      781 taactccgtg gtcaacgtgg gttgcgggcc agctgaacag cgcctcttgc tcacggggct
      841 ccactcggta gctgacattt tctgtgagag ctgcaaaacc acactgggct ggaaatatga
      901 gcaagctttt gagacgagcc agaagtacaa ggaagggaaa tacatcattg aaatgtcaca
      961 catggtgaag gacaacggct gggactgagg ggctcaggca gggtgtgccc ttcctccgca
     1021 tgcccctccc tccccacggc cctgccaagc agtctatacc agcatgagta ctgccccacc
     1081 cctgggggaa acctggctcc aaccaacccc tcccctgcct ccaccatatc cactaccagg
     1141 caccctttag aacaggggtc tgggggtacc ccaggggtgt taaggctcag gagtgggcag
     1201 cagtcaggga gagacagaac tgggggaaag ggatggttgt gggtctttct gttcccaaga
     1261 tcctgaacat ggaagcgatg gcagggcata gactcaggca gagaggattg tgggaggaat
     1321 ccgtttttgc tccacctctt tttgagtgaa cagaggacaa accttgggtc acagggcaag
     1381 tagatcatgg accacagaac agcagatgag aaaagacttg ggttggagtg aaattctggt
     1441 ctcagacacc aggagaccag agtctctgag gatgaagttt cctaccccta tttgtaggga
     1501 aaaggacttg agtgcaggga aaactcaaat cccaggccct gggaaatagt aaaataatca
     1561 aagggttttc catttcactc cacttgttag tttatcttgg cactgaagag gcactttcga
     1621 gtatctaact tttgccattg ggtggggtgg ggacagctgc tcgcggaaca gcccctagtc
     1681 ggctgcttcc agagtaagca gtctttatgg gctttctctg aggcccagtc actgctcctg
     1741 ggacccagtc ccctggaggg gaggtggaaa atcagtgcta cggggccagt ctttcccgtg
     1801 gctgccacca gcgaatgaaa cttttgtatg atacataaag tgcttgagtc tatttttaat
     1861 aaaaagggaa aaagcaactt ga
//
