LOCUS       NM_031477               1601 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens yippee like 3 (YPEL3), transcript variant 1, mRNA.
ACCESSION   NM_031477
VERSION     NM_031477.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1601)
  AUTHORS   Baek,H.S., Kwon,T.U., Shin,S., Kwon,Y.J. and Chun,Y.J.
  TITLE     Steroid sulfatase deficiency causes cellular senescence and
            abnormal differentiation by inducing Yippee-like 3 expression in
            human keratinocytes
  JOURNAL   Sci Rep 11 (1), 20867 (2021)
   PUBMED   34675221
  REMARK    GeneRIF: Steroid sulfatase deficiency causes cellular senescence
            and abnormal differentiation by inducing Yippee-like 3 expression
            in human keratinocytes.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1601)
  AUTHORS   Blanco-Sanchez,B., Clement,A., Stednitz,S.J., Kyle,J., Peirce,J.L.,
            McFadden,M., Wegner,J., Phillips,J.B., Macnamara,E., Huang,Y.,
            Adams,D.R., Toro,C., Gahl,W.A., Malicdan,M.C.V., Tifft,C.J.,
            Zink,E.M., Bloodsworth,K.J., Stratton,K.G., Koeller,D.M.,
            Metz,T.O., Washbourne,P. and Westerfield,M.
  CONSRTM   Undiagnosed Diseases Network
  TITLE     yippee like 3 (ypel3) is a novel gene required for myelinating and
            perineurial glia development
  JOURNAL   PLoS Genet 16 (6), e1008841 (2020)
   PUBMED   32544203
  REMARK    GeneRIF: yippee like 3 (ypel3) is a novel gene required for
            myelinating and perineurial glia development.
            Erratum:[PLoS Genet. 2020 Oct 26;16(10):e1009156. doi:
            10.1371/journal.pgen.1009156.. PMID: 33104717]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1601)
  AUTHORS   Kong,X., Li,Y. and Zhang,X.
  TITLE     Increased Expression of the YPEL3 Gene in Human Colonic
            Adenocarcinoma Tissue and the Effects on Proliferation, Migration,
            and Invasion of Colonic Adenocarcinoma Cells In Vitro via the
            Wnt/b-Catenin Signaling Pathway
  JOURNAL   Med Sci Monit 24, 4767-4775 (2018)
   PUBMED   29988027
  REMARK    GeneRIF: Expression of the YPEL3 gene was upregulated in human
            colonic adenocarcinoma tissue.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1601)
  AUTHORS   Zhang,J., Wen,X., Ren,X.Y., Li,Y.Q., Tang,X.R., Wang,Y.Q., He,Q.M.,
            Yang,X.J., Sun,Y., Liu,N. and Ma,J.
  TITLE     YPEL3 suppresses epithelial-mesenchymal transition and metastasis
            of nasopharyngeal carcinoma cells through the Wnt/beta-catenin
            signaling pathway
  JOURNAL   J Exp Clin Cancer Res 35 (1), 109 (2016)
   PUBMED   27400785
  REMARK    GeneRIF: Data show that YPEL3 is downregulated in nasopharyngeal
            carcinoma (NPC) cell lines and tissue samples and it suppresses NPC
            EMT and metastasis by suppressing the Wnt/beta-catenin signaling
            pathway.
            Erratum:[J Exp Clin Cancer Res. 2020 Oct 12;39(1):214. doi:
            10.1186/s13046-020-01710-y.. PMID: 33046124]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1601)
  CONSRTM   Schizophrenia Working Group of the Psychiatric Genomics Consortium
  TITLE     Biological insights from 108 schizophrenia-associated genetic loci
  JOURNAL   Nature 511 (7510), 421-427 (2014)
   PUBMED   25056061
REFERENCE   6  (bases 1 to 1601)
  AUTHORS   Tuttle,R., Simon,M., Hitch,D.C., Maiorano,J.N., Hellan,M.,
            Ouellette,J., Termuhlen,P. and Berberich,S.J.
  TITLE     Senescence-associated gene YPEL3 is downregulated in human colon
            tumors
  JOURNAL   Ann Surg Oncol 18 (6), 1791-1796 (2011)
   PUBMED   21267786
  REMARK    GeneRIF: YPEL3 is downregulated in colon tumors.
REFERENCE   7  (bases 1 to 1601)
  AUTHORS   Berberich,S.J., Todd,A. and Tuttle,R.
  TITLE     Why YPEL3 represents a novel tumor suppressor
  JOURNAL   Front Biosci (Landmark Ed) 16 (5), 1746-1751 (2011)
   PUBMED   21196260
  REMARK    GeneRIF: In this review we show that transcriptionally active forms
            of p73 and p63, family members of p53, can transactivate the human
            YPEL3 gene[review]
            Review article
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 1601)
  AUTHORS   Olson,J.E., Wang,X., Pankratz,V.S., Fredericksen,Z.S., Vachon,C.M.,
            Vierkant,R.A., Cerhan,J.R. and Couch,F.J.
  TITLE     Centrosome-related genes, genetic variation, and risk of breast
            cancer
  JOURNAL   Breast Cancer Res Treat 125 (1), 221-228 (2011)
   PUBMED   20508983
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 1601)
  AUTHORS   Kelley,K.D., Miller,K.R., Todd,A., Kelley,A.R., Tuttle,R. and
            Berberich,S.J.
  TITLE     YPEL3, a p53-regulated gene that induces cellular senescence
  JOURNAL   Cancer Res 70 (9), 3566-3575 (2010)
   PUBMED   20388804
  REMARK    GeneRIF: Findings point to YPEL3 being a novel tumor suppressor,
            which upon induction triggers a permanent growth arrest in human
            tumor and normal cells.
REFERENCE   10 (bases 1 to 1601)
  AUTHORS   Hosono,K., Sasaki,T., Minoshima,S. and Shimizu,N.
  TITLE     Identification and characterization of a novel gene family YPEL in
            a wide spectrum of eukaryotic species
  JOURNAL   Gene 340 (1), 31-43 (2004)
   PUBMED   15556292
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC012645.7 and BC050664.1.
            
            On May 17, 2019 this sequence version replaced NM_031477.4.
            
            Transcript Variant: This variant (1) represents a longer transcript
            and longer protein isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC050664.1, CA312571.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2144333
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000398841.6/ ENSP00000381821.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                AC012645.7         33568-33580         c
            14-427              BC050664.1         1-414
            428-962             AC012645.7         32619-33153         c
            963-1006            AC012645.7         32470-32513         c
            1007-1115           AC012645.7         32156-32264         c
            1116-1587           AC012645.7         29695-30166         c
            1588-1601           BC050664.1         1574-1587
FEATURES             Location/Qualifiers
     source          1..1601
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p11.2"
     gene            1..1601
                     /gene="YPEL3"
                     /note="yippee like 3"
                     /db_xref="GeneID:83719"
                     /db_xref="HGNC:HGNC:18327"
                     /db_xref="MIM:609724"
     exon            1..962
                     /gene="YPEL3"
                     /inference="alignment:Splign:2.1.0"
     CDS             732..1205
                     /gene="YPEL3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein yippee-like 3"
                     /codon_start=1
                     /product="protein yippee-like 3 isoform 1"
                     /protein_id="NP_113665.3"
                     /db_xref="CCDS:CCDS42147.1"
                     /db_xref="GeneID:83719"
                     /db_xref="HGNC:HGNC:18327"
                     /db_xref="MIM:609724"
                     /translation="MCVAQVLTAHLLPPRQALGSLCSPWAAPRVGPLPPAPAMVRISK
                     PKTFQAYLDDCHRRYSCAHCRAHLANHDDLISKSFQGSQGRAYLFNSVVNVGCGPAEE
                     RVLLTGLHAVADIHCENCKTTLGWKYEQAFESSQKYKEGKYIIELNHMIKDNGWD"
     exon            963..1006
                     /gene="YPEL3"
                     /inference="alignment:Splign:2.1.0"
     exon            1007..1115
                     /gene="YPEL3"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..1601
                     /gene="YPEL3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1579..1584
                     /regulatory_class="polyA_signal_sequence"
                     /gene="YPEL3"
                     /note="hexamer: AATAAA"
     polyA_site      1601
                     /gene="YPEL3"
                     /note="major polyA site"
ORIGIN      
        1 gtaaacaagt ccaggcgcct gcgaacccgg gcccgggggg gacggcgccc gccaggagcg
       61 ccccccactc ccaggccagc ccaccccggc ggaccgggcc ccgcgcgccc aggcgaggtg
      121 aggcccgcgc cgtcagggct gcgtgtcgcc ccgcgcccct gcccagcccg cgaggactgc
      181 cccctccccc ggcgcccgcc cccacccccg cgccccaggt gagccccgga gtccaggtaa
      241 ggctccgcgt tgcaggtaag agcccctgag cgtagaggag gccttggcgc ccgcaggtga
      301 gagcccctcc cctcctaggt gaccctcaac cttcacggcg aggcctccta cctcctccag
      361 gtgggggacc ctctccccga tgaaccccct aaaccaccag tgaaccccac tgctctccag
      421 atgaggtcgc aaggaccaac cagtgcctac ccgcccatgc tcccccgaaa ctgggaactg
      481 acagcccagc ccctccaaag ccccttcctc cagcttcagc tgccaggtca gcaagggtga
      541 ggccggaagc aggcgggtga ctcaccctgg gcacctccga gcctcagttt ccccatggat
      601 gcaacctgag gcctcctcac tgagtcaaaa ccgagacgcc tctggtcccc ggagaggctg
      661 ctggctctgg ggaaaggaga gagcagccca gtgtgacaga gcgagtcccc acggctctgg
      721 gagtgcctcg catgtgtgtg gcccaggtcc tgacagccca cctactccct ccccggcagg
      781 cactgggctc cctctgctcc ccgtgggccg ctccccgcgt ggggccactg cccccggccc
      841 ccgccatggt gcggatttca aagcccaaga cgtttcaggc ctacttggat gattgtcacc
      901 ggaggtatag ctgtgcccac tgccgcgctc acctggccaa ccacgacgac ctcatctcca
      961 agtccttcca gggcagtcag gggcgtgcct acctcttcaa ctcagtggtg aacgtgggct
     1021 gcgggccagc cgaggagcgg gtgctgctga ccggcctcca tgctgtcgcc gacatccact
     1081 gcgagaactg caagaccact ttgggctgga aatatgaaca ggcctttgag agcagccaga
     1141 agtacaaaga ggggaagtac atcattgaac tcaaccacat gatcaaagac aacggctggg
     1201 actgaccccc gctcccccga cgcatgtggc tccagcccgg cctggccgcc agggagcgcc
     1261 actggcttcc cgccacccga agggagctct ggaccctcag agcccctgca gaggacggat
     1321 ctagctcctg tatatatatt ttattgcatg cactgtgacc ttggggggag aacagaaggg
     1381 ggacgacgcc cccgcacctc ctgcgatctg gctggcttgg atctcgtttt taacccgttc
     1441 ctgccccacc tgccctatag ttatggcctg tgttctgctc tcctggtccc agtgcaccgt
     1501 ctgctctgtg aactcctccc accaggccct tcttacccca cgcgtgtctg tccccctcgt
     1561 tctgtagcgt ttgtacataa taaaacaatg gagtggagac a
//
