LOCUS       NM_013313               4297 bp    mRNA    linear   PRI 09-FEB-2024
DEFINITION  Homo sapiens yippee like 1 (YPEL1), transcript variant 1, mRNA.
ACCESSION   NM_013313
VERSION     NM_013313.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4297)
  AUTHORS   Abiatari,I., Kiladze,M., Kerkadze,V., Friess,H. and Kleeff,J.
  TITLE     Expression of YPEL1 in pancreatic cancer cell lines and tissues
  JOURNAL   Georgian Med News (175), 60-62 (2009)
   PUBMED   19893129
REFERENCE   2  (bases 1 to 4297)
  AUTHORS   Hosono,K., Sasaki,T., Minoshima,S. and Shimizu,N.
  TITLE     Identification and characterization of a novel gene family YPEL in
            a wide spectrum of eukaryotic species
  JOURNAL   Gene 340 (1), 31-43 (2004)
   PUBMED   15556292
REFERENCE   3  (bases 1 to 4297)
  AUTHORS   Farlie,P., Reid,C., Wilcox,S., Peeters,J., Reed,G. and Newgreen,D.
  TITLE     Ypel1: a novel nuclear protein that induces an epithelial-like
            morphology in fibroblasts
  JOURNAL   Genes Cells 6 (7), 619-629 (2001)
   PUBMED   11473580
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AB098734.1, AW006162.1,
            AW161786.1 and BC015229.1.
            
            On Nov 23, 2018 this sequence version replaced NM_013313.4.
            
            Summary: This gene is located in the region associated with
            DiGeorge syndrome on chromosome 22. The encoded protein localizes
            to the centrosome and nucleolus and may play a role in the
            regulation of cell division. [provided by RefSeq, Feb 2015].
            
            Transcript Variant: This variant (1) encodes the protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB098734.1, BC034486.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2151119 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000339468.8/ ENSP00000342832.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-727               AB098734.1         41-767
            728-971             AW006162.1         1-244               c
            972-1346            AW161786.1         5-379               c
            1347-4284           AB098734.1         1384-4321
            4285-4297           BC015229.1         1918-1930
FEATURES             Location/Qualifiers
     source          1..4297
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q11.21-q11.22"
     gene            1..4297
                     /gene="YPEL1"
                     /gene_synonym="FKSG3"
                     /note="yippee like 1"
                     /db_xref="GeneID:29799"
                     /db_xref="HGNC:HGNC:12845"
                     /db_xref="MIM:608082"
     exon            1..180
                     /gene="YPEL1"
                     /gene_synonym="FKSG3"
                     /inference="alignment:Splign:2.1.0"
     exon            181..461
                     /gene="YPEL1"
                     /gene_synonym="FKSG3"
                     /inference="alignment:Splign:2.1.0"
     CDS             345..704
                     /gene="YPEL1"
                     /gene_synonym="FKSG3"
                     /note="DiGeorge syndrome-related protein"
                     /codon_start=1
                     /product="protein yippee-like 1"
                     /protein_id="NP_037445.1"
                     /db_xref="CCDS:CCDS13794.1"
                     /db_xref="GeneID:29799"
                     /db_xref="HGNC:HGNC:12845"
                     /db_xref="MIM:608082"
                     /translation="MVKMTKSKTFQAYLPNCHRTYSCIHCRAHLANHDELISKSFQGS
                     QGRAYLFNSVVNVGCGPAEERVLLTGLHAVADIYCENCKTTLGWKYEHAFESSQKYKE
                     GKFIIELAHMIKDNGWE"
     exon            462..505
                     /gene="YPEL1"
                     /gene_synonym="FKSG3"
                     /inference="alignment:Splign:2.1.0"
     exon            506..614
                     /gene="YPEL1"
                     /gene_synonym="FKSG3"
                     /inference="alignment:Splign:2.1.0"
     exon            615..4297
                     /gene="YPEL1"
                     /gene_synonym="FKSG3"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      972
                     /gene="YPEL1"
                     /gene_synonym="FKSG3"
                     /note="major polyA site"
     regulatory      4269..4274
                     /regulatory_class="polyA_signal_sequence"
                     /gene="YPEL1"
                     /gene_synonym="FKSG3"
                     /note="hexamer: AATAAA"
     polyA_site      4297
                     /gene="YPEL1"
                     /gene_synonym="FKSG3"
ORIGIN      
        1 caaaacaaag ggcaggcggc ccgcggggcg gcggcgggag gatgcctcgc gccctgccta
       61 ggcgttaacg gcctcagcgc gtcccgggcc gcgccgggaa cgcctgagag ccgagcccgc
      121 gctgaccggg gcccgggccg gatgggcgct gcgggccggg gcgcggaccg cggagcggcc
      181 gttacgtttt tctctcgtcc cagctgtgtg gacagtgcca cacgccctcc tggacaacga
      241 cggctcttgc gtgcattttc cagtgttgct tttgtcagag aggccagcag agccacggtt
      301 cttccagaac cagccctgag ctgagtgagg agtgcccagg agagatggtg aaaatgacaa
      361 agtccaaaac tttccaagcg tatctgccga actgtcaccg aacgtacagc tgtatccact
      421 gcagagcaca cctggccaat catgacgagc tcatctccaa gtcctttcag gggagccagg
      481 gacgcgccta cctcttcaat tccgtggtga acgtgggctg cggccctgca gaggagaggg
      541 tccttctcac cgggctgcat gcggttgccg acatctactg cgagaactgc aagaccacgc
      601 tcgggtggaa atacgagcat gcctttgaga gcagtcagaa atataaggaa ggaaaattca
      661 tcattgagct tgctcatatg atcaaagaca atggctggga gtaatgtgcg aactttccct
      721 tctcctttga atgctgtttt gtgaaagaaa ctgtgaatgt aatggaaacg taggagcatc
      781 tggtgacagc ctttcttgcc ctctgacctc aaaggctagc tgcgcatagc tcttgacact
      841 ctcggccatc tctgtgggta aggtgtccct cggatctgtc ctcttcgtgt acacagttgt
      901 ttctgaaaat tttcaatgag ctttttctaa cttctcaagt tctagagaaa gaattaacca
      961 actgatgact tacctgccta gttaatatct tcctttcacc tttgtcttca atatagttgg
     1021 gctctgcttt tttaaggttc agttgaaaac caaactgggg ccgggtgcgg tggctcacgc
     1081 ctgtaatccc agcactttgg gaggccaaga tgggtggatc acctgaggtc aggagttcta
     1141 gatcagcctg gccaacatgg tgaaacccca tctctactaa aaatacgaaa attagccggg
     1201 catggtggcg agtgcctgta atcttagcta ctcaggaggc taaggcagga gaatcacttg
     1261 aacctgggac acggaggttg cagtgagcta agatcatgcc atcgcactcc agcctggggg
     1321 acaaaagtga gacatcgtct caaaaaaaaa aaaaaaagct gggtatggtg gcgcatgcct
     1381 ttaatcccag ctactcggga ggctgaggca cgagaatcac ttgaacccag gaggcggagg
     1441 ttgcagtgag ccaagatcgc gccactgcac tccagcctgg caatagggcg agactccgtc
     1501 tcaatttaaa acaagagaga accagactga gtctctgaag accacaggga cagggtctct
     1561 ttagatagca agtctcacca ttcccttttt tagagaaaag gtattgtagc ccaccctcca
     1621 ccccgctgtt tttcttaaat ttgcagaact tcaaattggc tattcctctt gcaaatgaac
     1681 ccttaaagta cagtgttatt taagaatctt ccagaggcag tcaacagact tatacactaa
     1741 gggcattttt ggtttttagc ttgttcaaaa acagaggcca gcacagatga cattttagat
     1801 acactctaaa ttgagaatgg tgtctagtgg aacatgttta tttaagccag tagattcctt
     1861 atctagaaag caggtgagct agcccttaga gaaggctgtc ccggggcccg cagaggtgcc
     1921 cttactgagg tgacagcctc acagggtctg gtaccagggg ttgtgccctc agcagtgaca
     1981 gcagcttagg tgtcaggcag ttgctgagtg gctggtccat gtctatagag taacacactg
     2041 gaccgaggaa aagtcagatt tcattttcta ccctggatgt acttgaagaa aaagaattat
     2101 ttttgcatat gaaagaggcc agaacccaca ggaaaaactt caaaacttga catttgccag
     2161 aatgtttaaa atttgttcag aaaaggttaa agcaacaagt ttagcctttg tgcatgaaga
     2221 cgcctggcct gctagacgcg ttgcccgtcc ctgcgtggtg ctgtcccatg tcacttgaac
     2281 tgatagaggg gcctgtgcaa tctcctaagg cctgtgtttc tgccatatat tttattataa
     2341 attacaatcc actcatccac ctgccctcca ccaggagtgg gcaccccata agggtttagg
     2401 ccactttgca gaggatggag gtcaaaaacc actcccagat aagtttggtt ttcaacattt
     2461 agtaacttgt ctcagggcag agggcaggca gggggaccga ggggcagcag ataggagagc
     2521 actgagcccg gatagttctc agcctggcaa gtggctctga agctgccttc agacaaggct
     2581 agtctagggg caagagtgcg agctggctga caataagaac gtggccacct gcccagcttc
     2641 acacctcccc cgacttcagc ccttcctaaa cccagacctg cggtccaggc aggcactggg
     2701 ctgtgcccac tcgagctcac tgcccacaca cagcatgcct ttgggtgcca tctctttgcc
     2761 caagcctgga agccttggca ggtgggaaat gccgctgccc tggtgggcat ggcactgaga
     2821 tgcatccact cagcaggagt gacagaggca gaagttcctt taaagcacat cttccactta
     2881 ggaaaggaag gaaatctttg tactgtcttg gaagcctcca catccggcta tggccctgca
     2941 agctgcttta tccctgcgct agtctccccc gagggtttag gctggcccag cacatcctgt
     3001 cctcctgagc tcgcgtgcag ccacccagag cgcaggggtc actgcacgct gcagggctct
     3061 tgctgccatg gtctcaagcc tgaagaggct ccgcccacaa gctggcccat gaagttagca
     3121 atgcctgtgg cttcagtcaa ttgtcttgag actgtgaaga ggctgaaaga caccttcccg
     3181 ggtggaagaa ggagttcact gaaaacttat cttaaactga cccttccctt tgagtgagtc
     3241 ttcattcctc tcccatgtgg gaacccagcc tccgatgccc cggggactag gggaaacagt
     3301 tggaggttcg tgccgtcccc agcctgccac gggtgcgagg acagccaagt cctgagtgac
     3361 tcaagatgct tcacttacat ggaagaaact tctaaaactc taccgagtgg tttttgtata
     3421 tactaaagtt ctatttagag cttttctgtt ttgggcaagt tcgctgctcc ttctatttgg
     3481 gcactttggt ttttgtactg tcttttgtga cggcattgat tgaacatttt ttactagtag
     3541 tcttatgact tttgtatttt tttttttttt tgtaatttat accaacaaca cttttatcac
     3601 tttttttttg ttgggcttct gcaaaataca agctcatttt taaaccaaat gaacagacca
     3661 tgagctggct tcaggggaag tgctattcac aggaccatat ccaccaccct cttaaattcc
     3721 taaacaatat catctaggac ttctatttaa gttatttaaa ataaatcttc cttgagagcc
     3781 ttgggaggtg atgtcagggt tataaatggc acagtgcatt tgctgtagga atgtggtttg
     3841 gcattgtttt atacacacag tattttttat accttaatgc ttattcttga tggcatctgt
     3901 cagatattag aattgaaaat aagaatcttc ccaaaatcct ttaatttacc tgatgccctc
     3961 atcaggtcgt taaaaattca aatggtttta atagctaaaa aactacaaat taagctctaa
     4021 aacaaacaaa ctacagaaat gtaaaccttc atttgccaaa ggtccttggt ggcctgtccc
     4081 ctgccctggg agcagatggc cctgaagccc ttccctcact gtgcaggcca ccgggtgagg
     4141 ctggacggtc acccatggtg gcttcactgc aaggagcagg actgccgagc tcaagcacgg
     4201 ggccttcagc ttcccctgtc ctctggccac accgccagcc cttggtcctt atctgtgtga
     4261 ggtttacaaa taaagcttct gatgtcaaat gtttaaa
//
