LOCUS       NM_018074               1431 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens YJU2 splicing factor homolog (YJU2), mRNA.
ACCESSION   NM_018074
VERSION     NM_018074.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1431)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 1431)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1431)
  AUTHORS   Zhan,X., Yan,C., Zhang,X., Lei,J. and Shi,Y.
  TITLE     Structure of a human catalytic step I spliceosome
  JOURNAL   Science 359 (6375), 537-545 (2018)
   PUBMED   29301961
REFERENCE   4  (bases 1 to 1431)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   5  (bases 1 to 1431)
  AUTHORS   Yachie,N., Petsalaki,E., Mellor,J.C., Weile,J., Jacob,Y., Verby,M.,
            Ozturk,S.B., Li,S., Cote,A.G., Mosca,R., Knapp,J.J., Ko,M., Yu,A.,
            Gebbia,M., Sahni,N., Yi,S., Tyagi,T., Sheykhkarimli,D., Roth,J.F.,
            Wong,C., Musa,L., Snider,J., Liu,Y.C., Yu,H., Braun,P.,
            Stagljar,I., Hao,T., Calderwood,M.A., Pelletier,L., Aloy,P.,
            Hill,D.E., Vidal,M. and Roth,F.P.
  TITLE     Pooled-matrix protein interaction screens using Barcode Fusion
            Genetics
  JOURNAL   Mol Syst Biol 12 (4), 863 (2016)
   PUBMED   27107012
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1431)
  AUTHORS   Sorrells,S., Carbonneau,S., Harrington,E., Chen,A.T., Hast,B.,
            Milash,B., Pyati,U., Major,M.B., Zhou,Y., Zon,L.I., Stewart,R.A.,
            Look,A.T. and Jette,C.
  TITLE     Ccdc94 protects cells from ionizing radiation by inhibiting the
            expression of p53
  JOURNAL   PLoS Genet 8 (8), e1002922 (2012)
   PUBMED   22952453
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC005578.1, AK001236.1 and AC008616.6.
            
            On Nov 22, 2018 this sequence version replaced NM_018074.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.378395.1,
                                           SRR3476690.506129.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000262962.12/ ENSP00000262962.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                AC005578.1         39756-39765
            11-379              AK001236.1         1-369
            380-380             AC008616.6         70853-70853         c
            381-1429            AK001236.1         371-1419
            1430-1431           AC008616.6         56162-56163         c
FEATURES             Location/Qualifiers
     source          1..1431
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..1431
                     /gene="YJU2"
                     /gene_synonym="CCDC94"
                     /note="YJU2 splicing factor homolog"
                     /db_xref="GeneID:55702"
                     /db_xref="HGNC:HGNC:25518"
     exon            1..91
                     /gene="YJU2"
                     /gene_synonym="CCDC94"
                     /inference="alignment:Splign:2.1.0"
     CDS             68..1039
                     /gene="YJU2"
                     /gene_synonym="CCDC94"
                     /note="coiled-coil domain-containing protein 94;
                     coiled-coil domain containing 94"
                     /codon_start=1
                     /product="splicing factor YJU2"
                     /protein_id="NP_060544.2"
                     /db_xref="CCDS:CCDS12124.1"
                     /db_xref="GeneID:55702"
                     /db_xref="HGNC:HGNC:25518"
                     /translation="MSERKVLNKYYPPDFDPSKIPKLKLPKDRQYVVRLMAPFNMRCK
                     TCGEYIYKGKKFNARKETVQNEVYLGLPIFRFYIKCTRCLAEITFKTDPENTDYTMEH
                     GATRNFQAEKLLEEEEKRVQKEREDEELNNPMKVLENRTKDSKLEMEVLENLQELKDL
                     NQRQAHVDFEAMLRQHRLSEEERRRQQQEEDEQETAALLEEARKRRLLEDSDSEDEAA
                     PSPLQPALRPNPTAILDEAPKPKRKVEVWEQSVGSLGSRPPLSRLVVVKKAKADPDCS
                     NGQPQAAPTPGAPQNRKEANPTPLTPGASSLSQLGAYLDSDDSNGSN"
     exon            92..192
                     /gene="YJU2"
                     /gene_synonym="CCDC94"
                     /inference="alignment:Splign:2.1.0"
     exon            193..337
                     /gene="YJU2"
                     /gene_synonym="CCDC94"
                     /inference="alignment:Splign:2.1.0"
     exon            338..472
                     /gene="YJU2"
                     /gene_synonym="CCDC94"
                     /inference="alignment:Splign:2.1.0"
     exon            473..654
                     /gene="YJU2"
                     /gene_synonym="CCDC94"
                     /inference="alignment:Splign:2.1.0"
     exon            655..775
                     /gene="YJU2"
                     /gene_synonym="CCDC94"
                     /inference="alignment:Splign:2.1.0"
     exon            776..926
                     /gene="YJU2"
                     /gene_synonym="CCDC94"
                     /inference="alignment:Splign:2.1.0"
     exon            927..1431
                     /gene="YJU2"
                     /gene_synonym="CCDC94"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1412..1417
                     /regulatory_class="polyA_signal_sequence"
                     /gene="YJU2"
                     /gene_synonym="CCDC94"
                     /note="hexamer: AATAAA"
     polyA_site      1431
                     /gene="YJU2"
                     /gene_synonym="CCDC94"
                     /note="major polyA site"
ORIGIN      
        1 ggaaaagctc gataattacc cagcctaacc atttctcagg tgcttgcgag gtgatcagaa
       61 ggcaaagatg tcggagcgaa aagtattaaa caaatactac ccgccggact ttgacccatc
      121 aaagatcccc aaactcaagc tccccaaaga ccggcagtac gtggtgcggc tgatggcccc
      181 cttcaacatg aggtgtaaga cgtgcggaga atacatctac aaggggaaga aattcaatgc
      241 tcggaaggag acggtgcaga acgaggtcta cctgggcctg cccatcttcc gcttttacat
      301 caagtgcacg cgctgcctgg cagagatcac cttcaagaca gaccctgaaa acacagacta
      361 caccatggag catggagcca cgcggaattt ccaggctgag aagctcctgg aggaggagga
      421 gaagagggtg cagaaggagc gggaggacga ggagctgaac aaccccatga aggtgctgga
      481 gaaccggacc aaggactcca agctggagat ggaggtgctg gagaacctcc aggagctgaa
      541 agacctgaac cagcggcagg cgcacgtgga cttcgaggct atgctgaggc agcaccgcct
      601 gtcggaggag gagcggcgga ggcagcagca ggaggaggac gagcaggaga ccgcggccct
      661 gttggaggaa gccagaaagc gaagactgct ggaggactcc gactcagagg atgaggctgc
      721 tccctcgccc ctgcagccag cccttcggcc caaccccacc gccatcctgg atgaggcccc
      781 aaagcccaag aggaaggtgg aggtctggga gcagagcgtt ggcagcctgg gcagccggcc
      841 cccgctgtcg aggctggtcg tggtgaagaa ggcaaaggcc gacccggact gcagcaacgg
      901 gcagcctcag gcggccccca ccccaggagc cccgcagaac aggaaggagg ccaaccctac
      961 acccctgacg cctggcgcgt cctccctgag ccaactgggt gcatacctgg acagtgacga
     1021 cagcaacggc agcaactgag ccctcccagg accccctcac ggggtcaaag tcacacgtcc
     1081 agcttcagcc acattgaggc cagcattgct ggtggtcagg gcaggaggcc ttggcgtgac
     1141 tggaggccgg acagacaagc gccagcgtgc tccaacacat agggccacca ggggcctcag
     1201 ccccaggagg tcccttctct gtgccctcac cagcctctca acacctcggg gacccctgct
     1261 gctcctgccc ccacctgtca ctgtgcttag ggctgcaaca tccctggagc agcttccaac
     1321 actacttcag ggtggcagtg tttggggcac tgggcgagcc tgccggcctc tagatggcct
     1381 catctcttcc ttccacaaac tgtctagaac caataaaagg aaacctgcca a
//
