LOCUS       NM_182592               1170 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens Yip1 domain family member 7 (YIPF7), transcript
            variant 1, mRNA.
ACCESSION   NM_182592
VERSION     NM_182592.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1170)
  AUTHORS   Kim,S.W., Jung,Y.S., Ahn,J.B., Shin,E.S., Jang,H.W., Lee,H.J., Il
            Kim,T., Kim,D.Y., Bang,D., Kim,W.H. and Cheon,J.H.
  TITLE     Identification of genetic susceptibility loci for intestinal
            Behcet's disease
  JOURNAL   Sci Rep 7, 39850 (2017)
   PUBMED   28045058
  REMARK    GeneRIF: GWAS showed intestinal Behcet's disease-specific
            associations with an NAALADL2 rs3914501.  Down-regulation of
            NAALADL2 expression was associated with exacerbating intestinal
            inflammatory responses both in vitro and in vivo.
            Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC103996.1, AK096895.1, DB299886.1 and AC093852.3.
            
            On Oct 2, 2020 this sequence version replaced NM_182592.2.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA2158800,
                              SAMEA2159607 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000415895.9/
                                                ENSP00000412696.4
            RefSeq Select criteria           :: based on conservation,
                                                expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-161               BC103996.1         17-177
            162-412             AK096895.1         178-428
            413-921             DB299886.1         1-509               c
            922-1170            AC093852.3         142417-142665       c
FEATURES             Location/Qualifiers
     source          1..1170
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p12"
     gene            1..1170
                     /gene="YIPF7"
                     /gene_synonym="FinGER9; Yip1b; YIPFalpha1b"
                     /note="Yip1 domain family member 7"
                     /db_xref="GeneID:285525"
                     /db_xref="HGNC:HGNC:26825"
                     /db_xref="MIM:619754"
     exon            1..72
                     /gene="YIPF7"
                     /gene_synonym="FinGER9; Yip1b; YIPFalpha1b"
                     /inference="alignment:Splign:2.1.0"
     exon            73..189
                     /gene="YIPF7"
                     /gene_synonym="FinGER9; Yip1b; YIPFalpha1b"
                     /inference="alignment:Splign:2.1.0"
     CDS             74..844
                     /gene="YIPF7"
                     /gene_synonym="FinGER9; Yip1b; YIPFalpha1b"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein YIPF7; YIP1 family member 7; five-pass
                     transmembrane protein localizing in the Golgi apparatus
                     and the endoplasmic reticulum 9"
                     /codon_start=1
                     /product="protein YIPF7 isoform 1"
                     /protein_id="NP_872398.3"
                     /db_xref="CCDS:CCDS54766.2"
                     /db_xref="GeneID:285525"
                     /db_xref="HGNC:HGNC:26825"
                     /db_xref="MIM:619754"
                     /translation="MSNLAQFDSDFYQSNFTIDNQEQSGNDSNAYGNLYGSRKQQAGE
                     QPQPASFVPSEMLMSSGYAGQFFQPASNSDYYSQSPYIDSFDEEPPLLEELGIHFDHI
                     WQKTLTVLNPMKPVDGSIMNETDLTGPILFCVALGATLLLAGKVQFGYVYGMSAIGCL
                     VIHALLNLMSSSGVSYGCVASVLGYCLLPMVILSGCAMFFSLQGIFGIMSSLVIIGWC
                     SLSASKIFIAALHMEGQQLLVAYPCAILYGLFALLTIF"
     exon            190..353
                     /gene="YIPF7"
                     /gene_synonym="FinGER9; Yip1b; YIPFalpha1b"
                     /inference="alignment:Splign:2.1.0"
     exon            354..499
                     /gene="YIPF7"
                     /gene_synonym="FinGER9; Yip1b; YIPFalpha1b"
                     /inference="alignment:Splign:2.1.0"
     exon            500..681
                     /gene="YIPF7"
                     /gene_synonym="FinGER9; Yip1b; YIPFalpha1b"
                     /inference="alignment:Splign:2.1.0"
     exon            682..1170
                     /gene="YIPF7"
                     /gene_synonym="FinGER9; Yip1b; YIPFalpha1b"
                     /inference="alignment:Splign:2.1.0"
     regulatory      899..904
                     /regulatory_class="polyA_signal_sequence"
                     /gene="YIPF7"
                     /gene_synonym="FinGER9; Yip1b; YIPFalpha1b"
                     /note="hexamer: AATATA"
     polyA_site      924
                     /gene="YIPF7"
                     /gene_synonym="FinGER9; Yip1b; YIPFalpha1b"
                     /note="major polyA site"
     regulatory      1043..1048
                     /regulatory_class="polyA_signal_sequence"
                     /gene="YIPF7"
                     /gene_synonym="FinGER9; Yip1b; YIPFalpha1b"
                     /note="hexamer: ATTAAA"
     polyA_site      1074
                     /gene="YIPF7"
                     /gene_synonym="FinGER9; Yip1b; YIPFalpha1b"
     regulatory      1142..1147
                     /regulatory_class="polyA_signal_sequence"
                     /gene="YIPF7"
                     /gene_synonym="FinGER9; Yip1b; YIPFalpha1b"
                     /note="hexamer: AATAAA"
     polyA_site      1170
                     /gene="YIPF7"
                     /gene_synonym="FinGER9; Yip1b; YIPFalpha1b"
                     /note="major polyA site"
ORIGIN      
        1 aatggatttg cttaaaattt ctcacacaaa gctacattta ctggaggatc tttctataaa
       61 aaataaacag aggatgtcaa acttggcaca atttgactct gatttttacc aatctaattt
      121 tactattgat aaccaggagc agagtggtaa tgactctaat gcctatggaa atctttatgg
      181 atctagaaaa caacaagctg gtgagcagcc tcagcctgcc tcctttgttc catcagagat
      241 gctcatgtca tcgggttacg caggacaatt ttttcagcca gcatccaact cagattatta
      301 ttcacaatct ccttacattg acagttttga tgaagagcct cctttgctag aagaacttgg
      361 aatccatttt gatcacatat ggcaaaaaac tttgacagtg ttaaacccaa tgaagccagt
      421 agatggcagc attatgaatg aaacggacct cactggaccc attctttttt gcgtagccct
      481 gggagccacc ttgcttctgg caggaaaagt tcagtttggt tatgtgtatg gcatgagtgc
      541 cattggctgc cttgtgattc atgccttgct gaacctgatg agctcttcag gggtgtcgta
      601 cggctgtgtg gccagcgtgc tgggttactg cctgctcccc atggtcatcc tgtctggttg
      661 cgccatgttc ttttcactgc agggcatctt tggaatcatg tcatccctgg tcatcattgg
      721 ctggtgtagt ctctcagctt ccaagatctt cattgcagcc ttgcacatgg aaggacagca
      781 gcttcttgtt gcctaccctt gtgccatact ttatggactt tttgccctcc taacaatttt
      841 ctaaagaatg tttgagatgg catttcaaga ctctgtttgc tgtccagatt attttggaaa
      901 tatattaaca ttcaaatttg gtgatatgat ttctgtttta ttgcttttga gagagtaata
      961 agcagagaga caaagcagca cttaagggtg gtgctctaat agcctgttgg tttgaatgat
     1021 gttttgcttt tgagtttggt gcattaaaac atttcaaaat acttaaaatc aaaagggata
     1081 cagttgctgt actgatcaac cctgcttttc tcaatagagg tatttctgag aaaagtaagt
     1141 aaataaactc atatgtttac taaaaggaaa
//
