LOCUS       NM_173834               6010 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens Yip1 domain family member 6 (YIPF6), transcript
            variant A, mRNA.
ACCESSION   NM_173834
VERSION     NM_173834.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6010)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 6010)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 6010)
  AUTHORS   Wang,L., Mazagova,M., Pan,C., Yang,S., Brandl,K., Liu,J.,
            Reilly,S.M., Wang,Y., Miao,Z., Loomba,R., Lu,N., Guo,Q., Liu,J.,
            Yu,R.T., Downes,M., Evans,R.M., Brenner,D.A., Saltiel,A.R.,
            Beutler,B. and Schnabl,B.
  TITLE     YIPF6 controls sorting of FGF21 into COPII vesicles and promotes
            obesity
  JOURNAL   Proc Natl Acad Sci U S A 116 (30), 15184-15193 (2019)
   PUBMED   31289229
  REMARK    GeneRIF: Levels of YIPF6 protein in human liver correlate with
            hepatic steatosis and correlate inversely with levels of FGF21 in
            serum from patients with nonalcoholic fatty liver disease.
REFERENCE   4  (bases 1 to 6010)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   5  (bases 1 to 6010)
  AUTHORS   Djusberg,E., Jernberg,E., Thysell,E., Golovleva,I., Lundberg,P.,
            Crnalic,S., Widmark,A., Bergh,A., Brattsand,M. and Wikstrom,P.
  TITLE     High levels of the AR-V7 Splice Variant and Co-Amplification of the
            Golgi Protein Coding YIPF6 in AR Amplified Prostate Cancer Bone
            Metastases
  JOURNAL   Prostate 77 (6), 625-638 (2017)
   PUBMED   28144969
  REMARK    GeneRIF: YIPF6 overexpression in prostate cancer tumor cell lines
            resulted in reduced cell proliferation and colony formation.
REFERENCE   6  (bases 1 to 6010)
  AUTHORS   Soonthornsit,J., Sakai,N., Sasaki,Y., Watanabe,R., Osako,S. and
            Nakamura,N.
  TITLE     YIPF1, YIPF2, and YIPF6 are medial-/trans-Golgi and trans-Golgi
            network-localized Yip domain family proteins, which play a role in
            the Golgi reassembly and glycan synthesis
  JOURNAL   Exp Cell Res 353 (2), 100-108 (2017)
   PUBMED   28286305
  REMARK    GeneRIF: Knockdown of YIPF1 and YIPF2, but not that of YIPF6, also
            reduced intracellular glycans in HT-29 cells. Thus, we confirmed
            that YIPF1, YIPF2, and YIPF6 play a significant role in supporting
            normal glycan synthesis
REFERENCE   7  (bases 1 to 6010)
  AUTHORS   Ross,M.T., Grafham,D.V., Coffey,A.J., Scherer,S., McLay,K.,
            Muzny,D., Platzer,M., Howell,G.R., Burrows,C., Bird,C.P.,
            Frankish,A., Lovell,F.L., Howe,K.L., Ashurst,J.L., Fulton,R.S.,
            Sudbrak,R., Wen,G., Jones,M.C., Hurles,M.E., Andrews,T.D.,
            Scott,C.E., Searle,S., Ramser,J., Whittaker,A., Deadman,R.,
            Carter,N.P., Hunt,S.E., Chen,R., Cree,A., Gunaratne,P., Havlak,P.,
            Hodgson,A., Metzker,M.L., Richards,S., Scott,G., Steffen,D.,
            Sodergren,E., Wheeler,D.A., Worley,K.C., Ainscough,R.,
            Ambrose,K.D., Ansari-Lari,M.A., Aradhya,S., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Ballabio,A., Banerjee,R., Barker,G.E.,
            Barlow,K.F., Barrett,I.P., Bates,K.N., Beare,D.M., Beasley,H.,
            Beasley,O., Beck,A., Bethel,G., Blechschmidt,K., Brady,N.,
            Bray-Allen,S., Bridgeman,A.M., Brown,A.J., Brown,M.J., Bonnin,D.,
            Bruford,E.A., Buhay,C., Burch,P., Burford,D., Burgess,J.,
            Burrill,W., Burton,J., Bye,J.M., Carder,C., Carrel,L., Chako,J.,
            Chapman,J.C., Chavez,D., Chen,E., Chen,G., Chen,Y., Chen,Z.,
            Chinault,C., Ciccodicola,A., Clark,S.Y., Clarke,G., Clee,C.M.,
            Clegg,S., Clerc-Blankenburg,K., Clifford,K., Cobley,V., Cole,C.G.,
            Conquer,J.S., Corby,N., Connor,R.E., David,R., Davies,J., Davis,C.,
            Davis,J., Delgado,O., Deshazo,D., Dhami,P., Ding,Y., Dinh,H.,
            Dodsworth,S., Draper,H., Dugan-Rocha,S., Dunham,A., Dunn,M.,
            Durbin,K.J., Dutta,I., Eades,T., Ellwood,M., Emery-Cohen,A.,
            Errington,H., Evans,K.L., Faulkner,L., Francis,F., Frankland,J.,
            Fraser,A.E., Galgoczy,P., Gilbert,J., Gill,R., Glockner,G.,
            Gregory,S.G., Gribble,S., Griffiths,C., Grocock,R., Gu,Y.,
            Gwilliam,R., Hamilton,C., Hart,E.A., Hawes,A., Heath,P.D.,
            Heitmann,K., Hennig,S., Hernandez,J., Hinzmann,B., Ho,S., Hoffs,M.,
            Howden,P.J., Huckle,E.J., Hume,J., Hunt,P.J., Hunt,A.R.,
            Isherwood,J., Jacob,L., Johnson,D., Jones,S., de Jong,P.J.,
            Joseph,S.S., Keenan,S., Kelly,S., Kershaw,J.K., Khan,Z.,
            Kioschis,P., Klages,S., Knights,A.J., Kosiura,A., Kovar-Smith,C.,
            Laird,G.K., Langford,C., Lawlor,S., Leversha,M., Lewis,L., Liu,W.,
            Lloyd,C., Lloyd,D.M., Loulseged,H., Loveland,J.E., Lovell,J.D.,
            Lozado,R., Lu,J., Lyne,R., Ma,J., Maheshwari,M., Matthews,L.H.,
            McDowall,J., McLaren,S., McMurray,A., Meidl,P., Meitinger,T.,
            Milne,S., Miner,G., Mistry,S.L., Morgan,M., Morris,S., Muller,I.,
            Mullikin,J.C., Nguyen,N., Nordsiek,G., Nyakatura,G., O'Dell,C.N.,
            Okwuonu,G., Palmer,S., Pandian,R., Parker,D., Parrish,J.,
            Pasternak,S., Patel,D., Pearce,A.V., Pearson,D.M., Pelan,S.E.,
            Perez,L., Porter,K.M., Ramsey,Y., Reichwald,K., Rhodes,S.,
            Ridler,K.A., Schlessinger,D., Schueler,M.G., Sehra,H.K.,
            Shaw-Smith,C., Shen,H., Sheridan,E.M., Shownkeen,R., Skuce,C.D.,
            Smith,M.L., Sotheran,E.C., Steingruber,H.E., Steward,C.A.,
            Storey,R., Swann,R.M., Swarbreck,D., Tabor,P.E., Taudien,S.,
            Taylor,T., Teague,B., Thomas,K., Thorpe,A., Timms,K., Tracey,A.,
            Trevanion,S., Tromans,A.C., d'Urso,M., Verduzco,D., Villasana,D.,
            Waldron,L., Wall,M., Wang,Q., Warren,J., Warry,G.L., Wei,X.,
            West,A., Whitehead,S.L., Whiteley,M.N., Wilkinson,J.E.,
            Willey,D.L., Williams,G., Williams,L., Williamson,A.,
            Williamson,H., Wilming,L., Woodmansey,R.L., Wray,P.W., Yen,J.,
            Zhang,J., Zhou,J., Zoghbi,H., Zorilla,S., Buck,D., Reinhardt,R.,
            Poustka,A., Rosenthal,A., Lehrach,H., Meindl,A., Minx,P.J.,
            Hillier,L.W., Willard,H.F., Wilson,R.K., Waterston,R.H., Rice,C.M.,
            Vaudin,M., Coulson,A., Nelson,D.L., Weinstock,G., Sulston,J.E.,
            Durbin,R., Hubbard,T., Gibbs,R.A., Beck,S., Rogers,J. and
            Bentley,D.R.
  TITLE     The DNA sequence of the human X chromosome
  JOURNAL   Nature 434 (7031), 325-337 (2005)
   PUBMED   15772651
REFERENCE   8  (bases 1 to 6010)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC012469.1 and AL928603.5.
            
            On Nov 22, 2018 this sequence version replaced NM_173834.3.
            
            Transcript Variant: This variant (A) represents the longer
            transcript and encodes the longer isoform (A).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BG570565.1, SRR1660803.232025.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000462683.6/ ENSP00000417573.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-619               BC012469.1         8-626
            620-620             AL928603.5         23765-23765
            621-1187            BC012469.1         628-1194
            1188-6010           AL928603.5         24333-29155
FEATURES             Location/Qualifiers
     source          1..6010
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq12-q13.1"
     gene            1..6010
                     /gene="YIPF6"
                     /gene_synonym="FinGER6; Yip4; YIPFalpha3"
                     /note="Yip1 domain family member 6"
                     /db_xref="GeneID:286451"
                     /db_xref="HGNC:HGNC:28304"
                     /db_xref="MIM:300996"
     exon            1..73
                     /gene="YIPF6"
                     /gene_synonym="FinGER6; Yip4; YIPFalpha3"
                     /inference="alignment:Splign:2.1.0"
     CDS             17..727
                     /gene="YIPF6"
                     /gene_synonym="FinGER6; Yip4; YIPFalpha3"
                     /note="isoform A is encoded by transcript variant A;
                     protein YIPF6; YIP1 family member 6"
                     /codon_start=1
                     /product="protein YIPF6 isoform A"
                     /protein_id="NP_776195.2"
                     /db_xref="CCDS:CCDS14389.1"
                     /db_xref="GeneID:286451"
                     /db_xref="HGNC:HGNC:28304"
                     /db_xref="MIM:300996"
                     /translation="MAEAEESPGDPGTASPRPLFAGLSDISISQDIPVEGEITIPMRS
                     RIREFDSSTLNESVRNTIMRDLKAVGKKFMHVLYPRKSNTLLRDWDLWGPLILCVTLA
                     LMLQRDSADSEKDGGPQFAEVFVIVWFGAVTITLNSKLLGGNISFFQSLCVLGYCILP
                     LTVAMLICRLVLLADPGPVNFMVRLFVVIVMFAWSIVASTAFLADSQPPNRRALAVYP
                     VFLFYFVISWMILTFTPQ"
     exon            74..202
                     /gene="YIPF6"
                     /gene_synonym="FinGER6; Yip4; YIPFalpha3"
                     /inference="alignment:Splign:2.1.0"
     exon            203..281
                     /gene="YIPF6"
                     /gene_synonym="FinGER6; Yip4; YIPFalpha3"
                     /inference="alignment:Splign:2.1.0"
     exon            282..324
                     /gene="YIPF6"
                     /gene_synonym="FinGER6; Yip4; YIPFalpha3"
                     /inference="alignment:Splign:2.1.0"
     exon            325..450
                     /gene="YIPF6"
                     /gene_synonym="FinGER6; Yip4; YIPFalpha3"
                     /inference="alignment:Splign:2.1.0"
     exon            451..608
                     /gene="YIPF6"
                     /gene_synonym="FinGER6; Yip4; YIPFalpha3"
                     /inference="alignment:Splign:2.1.0"
     exon            609..6010
                     /gene="YIPF6"
                     /gene_synonym="FinGER6; Yip4; YIPFalpha3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3382..3387
                     /regulatory_class="polyA_signal_sequence"
                     /gene="YIPF6"
                     /gene_synonym="FinGER6; Yip4; YIPFalpha3"
                     /note="hexamer: AATAAA"
     polyA_site      3411
                     /gene="YIPF6"
                     /gene_synonym="FinGER6; Yip4; YIPFalpha3"
                     /note="major polyA site"
     regulatory      5942..5947
                     /regulatory_class="polyA_signal_sequence"
                     /gene="YIPF6"
                     /gene_synonym="FinGER6; Yip4; YIPFalpha3"
                     /note="hexamer: AATAAA"
     polyA_site      5968
                     /gene="YIPF6"
                     /gene_synonym="FinGER6; Yip4; YIPFalpha3"
                     /note="major polyA site"
     regulatory      5992..5997
                     /regulatory_class="polyA_signal_sequence"
                     /gene="YIPF6"
                     /gene_synonym="FinGER6; Yip4; YIPFalpha3"
                     /note="hexamer: ACTAAA"
     polyA_site      6010
                     /gene="YIPF6"
                     /gene_synonym="FinGER6; Yip4; YIPFalpha3"
                     /note="major polyA site"
ORIGIN      
        1 gagaaggagg gccaagatgg cggaagcgga ggagtctcca ggagacccgg ggacagcatc
       61 gcccaggccc ctgtttgcag gcctttcaga tatatccatc tcacaagaca tccccgtaga
      121 aggagaaatc accattccta tgagatctcg catccgggag tttgacagct ccacattaaa
      181 tgaatctgtt cgcaatacca tcatgcgtga tctaaaagct gttgggaaaa aattcatgca
      241 tgttttgtac ccaaggaaaa gtaatactct tttgagagat tgggatttgt ggggcccttt
      301 gatcctttgt gtgacactcg cattaatgct gcaaagagac tctgcagata gtgaaaaaga
      361 tggagggccc caatttgcag aggtgtttgt cattgtctgg tttggtgcag ttaccatcac
      421 cctcaactca aaacttcttg gagggaacat atcttttttt cagagcctct gtgtgctggg
      481 ttactgtata cttcccttga cagtagcaat gctgatttgc cggctggtac ttttggctga
      541 tccaggacct gtaaacttca tggttcggct ttttgtggtg attgtgatgt ttgcctggtc
      601 tatagttgcc tccacagctt tccttgctga tagccagcct ccaaaccgca gagccctagc
      661 tgtttatcct gttttcctgt tttactttgt catcagttgg atgattctca cctttactcc
      721 tcagtaaatc aggaatggga aattaaaaac cagtgaattg aaagcacatc tgaaagatgc
      781 aattcaccat ggagctttgt ctctggccct tatttgtcta attttggagg tatttgataa
      841 ctgagtaggt gaggagatta aaagggagcc atatagcact gtcacccctt atttgaggaa
      901 ctgatgtttg aaaggctgtt cttttctctc ttaatgtcat ttctttaaaa atacatgtgc
      961 atactacaca cagtatataa tgcctcctta aggcatgatg gagtcaccgt ggtccatttg
     1021 ggtgacaacc agtgacttgg gaagcacata gatacatctt acaagttgaa tagagttgat
     1081 aactattttc agttttgaga ataccagttc aggtgcagct cttaaacaca ttgccttatg
     1141 actattagaa tatgcctctc ttttcataaa taaaaataca tggtctatat ccattttctt
     1201 ttatttctct ctcttaagct taaaaaggca atgagagagg ttaggagtgg gttcatacac
     1261 ggagaatgag aaaacatgca ttaaccaata ttcagatttt gatcagggga aattctacac
     1321 ttgttgcaaa aaaaaaaaaa aaaaaagcaa agggcctcta aagaatcagc ctctttggtc
     1381 cctttgtgct gtcacctttt tgccatgttt aacagcatct tggttggcac tctagtctta
     1441 atcttgctcc ttaactttga atatgcagtc taaaatgtca gtagtcaaca tgtaattttc
     1501 ctttgaaatt ctgaatattc cagtgctgga acttatccaa aaagaagacc tcagaaactt
     1561 agattggtag atctctagtg catattatca tgtgggcacc ttctcttagg gtggaatgag
     1621 gcagtctgga tgcagcatag ttaaaaggag ctgtttaata ttctctgtag tctggcctct
     1681 taactagaaa gtaaagctaa atcagaagcc tgtatttaac catgtgaaca gggagggatt
     1741 tagtgttctg atggctgatt aatagaacag ctagatactt agagcatgac gtgggatggg
     1801 atgagtttac agctgctgcc ttttcatggt gagcttagca gttttctcat tagatgtgtt
     1861 tttttgggtt ggggaatagc aatttatttt attgatttta gactttatca agctaattag
     1921 ctccccttta gataagtaca tgttgcacat gtgcacctac ttgtaatctc agatatttat
     1981 gcacacaagt gtgaaggttt ttcagggagc agagcatctg ggacaggctg attctgagct
     2041 aaacagggct cctttaaggc aatatgaact gttgccttct ataaattgca cattgaggaa
     2101 ctctaataga caaagattag gtgtcaggca gaaaacactc attgtaaata tactattagt
     2161 tgataaacat aggactttct tattccccag tttttcttta tcatataatt taaatattta
     2221 ttcattttgt atttaaagac tacctacaca tagatatatg attccaaagt catactttct
     2281 ccatccccac attagccaag tgaatacagg gccaaatggg ttcttggaat gataataaca
     2341 aagcattaca aagtgggtcc ccttggttcc agccttgtcc agagtttttg gttatatatt
     2401 tctatttatt acaatttacc ttttaaattg taaaataaac ctttgtgtgg acagagccaa
     2461 tgtttcaatc ttgaatgagt aaagaaaata ctttggaact gatcctcatt ttgaaattgg
     2521 ttctaaatta ttatccattt ccaatgtctg aaattctctt acttcctgct aaaactctct
     2581 ttctgccaaa gttgtttcgt aatctgtctc aatgactata atgtaaaatt aaagaagtaa
     2641 ccatgcttct caagggggaa ttaaaagtgt ttattgaatt ttactcaggc taattgtttg
     2701 gtcagaaatt cctaaggcca cagctttggg gggttcgtgt agatgtacat ggtgggtggg
     2761 ttataaatat tgggacttaa ggcagcttgt tctatgtatt tatctttgct cttgggtgac
     2821 ttagggaatg attttatttg atttaacctt ctttctgttt gccccgagaa tactcgccag
     2881 tggcgcttgc agttgtagca tttaccccaa gataactttg cctacgaaat atttcgcttt
     2941 tattattttc acatcattct agtatatgga ctttggaaac aaaagacatt gttctattta
     3001 tagcattctt tttttttttt agtagcggta tttccattta caaaatatag taactcttga
     3061 ttactgaaaa tgtcaaatcc tagaaaacgt agcatgccta tacatgatgt taacatcatt
     3121 ctcgaacagt tgttggccga agattcattt gatgaatcca atttttttga aatagacaat
     3181 tctgatgttc tctttagaaa taactcagtt tttatctttt ttcacattga aaatcagtta
     3241 gatttgctta agcctcaaag agaatgttta tgtaaattag cgctggcaat tttttttttt
     3301 ctaaacagga aaagggttaa atgaaggttg ataaaatgga tgttcaattg tctttctgaa
     3361 agtgagtggc ttgaagggat gaataaatat tttcttaata tattcaaaaa agtgcattgc
     3421 tttctgtgat ggaagttaag acctaaatgt ctggaagttg taaccctcaa cacagctttt
     3481 cctgatttgc tgcaaaggca catagctgat tatagaagtg aagacggcaa ggacggggac
     3541 tccaacaaag gaaaccctgt tgcaggattt gggaactttc atgcttcaga tgaaattcag
     3601 gcatgtgagc atcactgcag aatgtggtgc atcattgcca tcatgagtaa tcacttgctg
     3661 ctcctacttc tgagaccaag actcttttgt catattcttt agcaatagga cgggtaaaga
     3721 ctggatttaa ttgctgttca gagtataaaa actcaattga ttccaacata tctgaatgtg
     3781 cagtaaagtc ttaaaagtca accgttaatc attaagtctt ttgcctctaa agtcttttgc
     3841 ctctgaagag gtttattaca tgagttgatt ttcatatttt cattttggtg gggttttcct
     3901 gttgttgggc aaggtggggt cacaggacat gggactagta agcattttac tgtttactat
     3961 atttgtcttt ttataaacag tatctcccaa aatgtgatta gaaggctacc aagcctgtat
     4021 ttggacattt aattgtgtgc tttatataat gtaactacta acagtatttg gactgcctgt
     4081 tcattcctgg agacaaaaat gaaaatctgt cagttcaagt tcttgggtaa catcaagtca
     4141 ttagaattta tctaaagctt atcatgattt gataagacat ccattgcatg cagctgtttt
     4201 agctcagtgc aaaacactga aattgtgatt cttagactgt ttctgagaca tttggatgga
     4261 aataaatgta taaatgttaa ttcatgtata taaattagaa acacttttct agattctgta
     4321 ggcttttgtt aaaaatagag aatttcttgg ggtttactta ggccacagaa tggccaaata
     4381 ataataatga caatgatatt actaataata atagctaacc tttatttggc acttactgtg
     4441 tgccaggcac tattctattt ttttaagaat ttttaaaata acagctttat tgaaatacac
     4501 tttaccataa acttcacctt tttatttttt atttttatga gacagggact cacccaggct
     4561 ggagtgcagt ggagcagtca tggcacactg tagcctcgac ctccctgggc tcaagcaatc
     4621 ctcccacttc agtgtcccga gtagttggga ctacaggcat gcgtcactac acctaattgg
     4681 ctaatttttg tagtttttgt agagataggg tttcgccatg ttgcctaggc tggtcttgaa
     4741 ttcctgggct caagcgatcc acctgctttg gcctcccaaa acagtgggat tgcaggcgtg
     4801 agccaccatg cctggctgaa attcaccttt taagatgtac aattcagtgg tttttagtat
     4861 attcacacac aaaattgcac aactatcact aacatctaat tttagatcat tttgtaactt
     4921 caccaagaaa ccccaggtct gtcagcagtc agttccattc ccccttcatc ccagcctctg
     4981 gcaaccacta atctgctttc tgtcactatt gatttggcca gacactattc ttctgtgctt
     5041 ctcatgcatc tcctgtaata ccagtgctac aattctcatt ttatgtggaa aattgaggca
     5101 ctgagaggtt aagtaaattg cccacggtca cacagtaatt tgatttacaa cagtaataac
     5161 acattagatg agaacacagt aggacacaat tttgaattcc atttttatgt acctgaaatg
     5221 aatacacccc tcccccaagg tattttccct attgttagcc tttgtaccct aggtacaaat
     5281 ataggtattt tccctattgt gttatgtacc tgaaatgaat acacccttcc cccaaggtat
     5341 tttccctatt gttagccttt gtaccctaga actgactgga tgtagataac atttgttttc
     5401 agagtaatgg aacactgtat cagcagcatc tgagaacata agaacagttg gacattggaa
     5461 agaggtttgt tgccctcatc cctccttgaa cctcttttct ctcccgcttc caccaccacc
     5521 acacatatat accccttttt ctcagtctta agcatcaaac aatttctgcc tctttctttt
     5581 taattctccc agagggatgg ttaatgcatc acaatttaac ttgtctattc aggtattaat
     5641 agtcaaggga tgcatctgtt tgcttatagt accagttata ttcctaggac cttagagagc
     5701 agtagtgtga gaatagaatg cctttctatt tgggttaaac tatgtgggag gaaaaagtaa
     5761 cagagtaaag gctttgcctt aatgaagtca agtgttctgc ctggtgggaa gtggccacac
     5821 gctgcactgc gctgctcttg tttactctgt tctttcagag cctttgtact ttgccatcac
     5881 tgctagtaat ttcttggtcc ttttcaatac tccattttaa tcttgatttt tttctataaa
     5941 taataaatct gtgaaaaatc tgtaaaaaga tttgtgacta ttaaatgtgc aactaaaaac
     6001 actggaaaaa
//
