LOCUS       NM_015388               1507 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens Yip1 domain family member 3 (YIPF3), mRNA.
ACCESSION   NM_015388
VERSION     NM_015388.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1507)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1507)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1507)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   4  (bases 1 to 1507)
  AUTHORS   Soonthornsit,J., Sakai,N., Sasaki,Y., Watanabe,R., Osako,S. and
            Nakamura,N.
  TITLE     YIPF1, YIPF2, and YIPF6 are medial-/trans-Golgi and trans-Golgi
            network-localized Yip domain family proteins, which play a role in
            the Golgi reassembly and glycan synthesis
  JOURNAL   Exp Cell Res 353 (2), 100-108 (2017)
   PUBMED   28286305
  REMARK    GeneRIF: Knockdown of YIPF1 and YIPF2, but not that of YIPF6, also
            reduced intracellular glycans in HT-29 cells. Thus, we confirmed
            that YIPF1, YIPF2, and YIPF6 play a significant role in supporting
            normal glycan synthesis
REFERENCE   5  (bases 1 to 1507)
  AUTHORS   Kranjc,T., Dempsey,E., Cagney,G., Nakamura,N., Shields,D.C. and
            Simpson,J.C.
  TITLE     Functional characterisation of the YIPF protein family in mammalian
            cells
  JOURNAL   Histochem Cell Biol 147 (4), 439-451 (2017)
   PUBMED   27999994
  REMARK    GeneRIF: The significance of YIPF3 protein for the maintenance of
            the morphology of the Golgi was tested by RNA interference,
            revealing a number of specific morphological changes to this
            organelle on their depletion.
REFERENCE   6  (bases 1 to 1507)
  AUTHORS   Tanimoto,K., Suzuki,K., Jokitalo,E., Sakai,N., Sakaguchi,T.,
            Tamura,D., Fujii,G., Aoki,K., Takada,S., Ishida,R., Tanabe,M.,
            Itoh,H., Yoneda,Y., Sohda,M., Misumi,Y. and Nakamura,N.
  TITLE     Characterization of YIPF3 and YIPF4, cis-Golgi Localizing Yip
            domain family proteins
  JOURNAL   Cell Struct Funct 36 (2), 171-185 (2011)
   PUBMED   21757827
  REMARK    GeneRIF: YIPF3 is synthesized in the ER as a N-glycosylated form
            (40 kDa), is then O-glycosylated in the Golgi apparatus to become a
            lower mobility form (46 kDa) and finally becomes a higher mobility
            form cleaved at its C-terminal luminal domain (36 kDa).
REFERENCE   7  (bases 1 to 1507)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC019297.1.
            
            On Nov 22, 2018 this sequence version replaced NM_015388.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC019297.1, SRR1660803.123200.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2151119 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000372422.7/ ENSP00000361499.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1507              BC019297.1         14-1520
FEATURES             Location/Qualifiers
     source          1..1507
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.1"
     gene            1..1507
                     /gene="YIPF3"
                     /gene_synonym="C6orf109; dJ337H4.3; FinGER3; KLIP1; Yip5b;
                     YIPFbeta2"
                     /note="Yip1 domain family member 3"
                     /db_xref="GeneID:25844"
                     /db_xref="HGNC:HGNC:21023"
                     /db_xref="MIM:609775"
     exon            1..200
                     /gene="YIPF3"
                     /gene_synonym="C6orf109; dJ337H4.3; FinGER3; KLIP1; Yip5b;
                     YIPFbeta2"
                     /inference="alignment:Splign:2.1.0"
     CDS             120..1172
                     /gene="YIPF3"
                     /gene_synonym="C6orf109; dJ337H4.3; FinGER3; KLIP1; Yip5b;
                     YIPFbeta2"
                     /note="killer lineage protein 1; natural killer
                     cell-specific antigen KLIP1"
                     /codon_start=1
                     /product="protein YIPF3"
                     /protein_id="NP_056203.2"
                     /db_xref="CCDS:CCDS4899.1"
                     /db_xref="GeneID:25844"
                     /db_xref="HGNC:HGNC:21023"
                     /db_xref="MIM:609775"
                     /translation="MATTAAPAGGARNGAGPEWGGFEENIQGGGSAVIDMENMDDTSG
                     SSFEDMGELHQRLREEEVDADAADAAAAEEEDGEFLGMKGFKGQLSRQVADQMWQAGK
                     RQASRAFSLYANIDILRPYFDVEPAQVRSRLLESMIPIKMVNFPQKIAGELYGPLMLV
                     FTLVAILLHGMKTSDTIIREGTLMGTAIGTCFGYWLGVSSFIYFLAYLCNAQITMLQM
                     LALLGYGLFGHCIVLFITYNIHLHALFYLFWLLVGGLSTLRMVAVLVSRTVGPTQRLL
                     LCGTLAALHMLFLLYLHFAYHKVVEGILDTLEGPNIPPIQRVPRDIPAMLPAARLPTT
                     VLNATAKAVAVTLQSH"
     exon            201..407
                     /gene="YIPF3"
                     /gene_synonym="C6orf109; dJ337H4.3; FinGER3; KLIP1; Yip5b;
                     YIPFbeta2"
                     /inference="alignment:Splign:2.1.0"
     exon            408..514
                     /gene="YIPF3"
                     /gene_synonym="C6orf109; dJ337H4.3; FinGER3; KLIP1; Yip5b;
                     YIPFbeta2"
                     /inference="alignment:Splign:2.1.0"
     exon            515..560
                     /gene="YIPF3"
                     /gene_synonym="C6orf109; dJ337H4.3; FinGER3; KLIP1; Yip5b;
                     YIPFbeta2"
                     /inference="alignment:Splign:2.1.0"
     exon            561..653
                     /gene="YIPF3"
                     /gene_synonym="C6orf109; dJ337H4.3; FinGER3; KLIP1; Yip5b;
                     YIPFbeta2"
                     /inference="alignment:Splign:2.1.0"
     exon            654..785
                     /gene="YIPF3"
                     /gene_synonym="C6orf109; dJ337H4.3; FinGER3; KLIP1; Yip5b;
                     YIPFbeta2"
                     /inference="alignment:Splign:2.1.0"
     exon            786..899
                     /gene="YIPF3"
                     /gene_synonym="C6orf109; dJ337H4.3; FinGER3; KLIP1; Yip5b;
                     YIPFbeta2"
                     /inference="alignment:Splign:2.1.0"
     exon            900..1023
                     /gene="YIPF3"
                     /gene_synonym="C6orf109; dJ337H4.3; FinGER3; KLIP1; Yip5b;
                     YIPFbeta2"
                     /inference="alignment:Splign:2.1.0"
     exon            1024..1507
                     /gene="YIPF3"
                     /gene_synonym="C6orf109; dJ337H4.3; FinGER3; KLIP1; Yip5b;
                     YIPFbeta2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1482..1487
                     /regulatory_class="polyA_signal_sequence"
                     /gene="YIPF3"
                     /gene_synonym="C6orf109; dJ337H4.3; FinGER3; KLIP1; Yip5b;
                     YIPFbeta2"
                     /note="hexamer: ATTAAA"
     polyA_site      1507
                     /gene="YIPF3"
                     /gene_synonym="C6orf109; dJ337H4.3; FinGER3; KLIP1; Yip5b;
                     YIPFbeta2"
                     /note="major polyA site"
ORIGIN      
        1 gtgttccggc cgatcccacc tctcctcgac cctggacgtc taccttccgg aggcccacat
       61 cttgcccact ccgcgcgcgg ggctagcgcg ggtttcagcg acgggagccc tcaagggaca
      121 tggcaactac agcggcgccg gcgggcggcg cccgaaatgg agctggcccg gaatggggag
      181 ggttcgaaga aaacatccag ggcggaggct cagctgtgat tgacatggag aacatggatg
      241 atacctcagg ctctagcttc gaggatatgg gtgagctgca tcagcgcctg cgcgaggaag
      301 aagtagacgc tgatgcagct gatgcagctg ctgctgaaga ggaggatgga gagttcctgg
      361 gcatgaaggg ctttaaggga cagctgagcc ggcaggtggc agatcagatg tggcaggctg
      421 ggaaaagaca agcctccagg gccttcagct tgtacgccaa catcgacatc ctcagaccct
      481 actttgatgt ggagcctgct caggtgcgaa gcaggctcct ggagtccatg atccctatca
      541 agatggtcaa cttcccccag aaaattgcag gtgaactcta tggacctctc atgctggtct
      601 tcactctggt tgctatccta ctccatggga tgaagacgtc tgacactatt atccgggagg
      661 gcaccctgat gggcacagcc attggcacct gcttcggcta ctggctggga gtctcatcct
      721 tcatttactt ccttgcctac ctgtgcaacg cccagatcac catgctgcag atgttggcac
      781 tgctgggcta tggcctcttt gggcattgca ttgtcctgtt catcacctat aatatccacc
      841 tccacgccct cttctacctc ttctggctgt tggtgggtgg actgtccaca ctgcgcatgg
      901 tagcagtgtt ggtgtctcgg accgtgggcc ccacacagcg gctgctcctc tgtggcaccc
      961 tggctgccct acacatgctc ttcctgctct atctgcattt tgcctaccac aaagtggtag
     1021 aggggatcct ggacacactg gagggcccca acatcccgcc catccagagg gtccccagag
     1081 acatccctgc catgctccct gctgctcggc ttcccaccac cgtcctcaac gccacagcca
     1141 aagctgttgc ggtgaccctg cagtcacact gaccccacct gaaattcttg gccagtcctc
     1201 tttcccgcag ctgcagagag gaggaagact attaaaggac agtcctgatg acatgtttcg
     1261 tagatggggt ttgcagctgc cactgagctg tagctgcgta agtacctcct tgatgcctgt
     1321 cggcacttct gaaaggcaca aggccaagaa ctcctggcca ggactgcaag gctctgcagc
     1381 caatgcagaa aatgggtcag ctcctttgag aacccctccc cacctacccc ttccttcctc
     1441 tttatctctc ccacattgtc ttgctaaata tagacttggt aattaaaatg ttgattgaag
     1501 tctggaa
//
