LOCUS       NM_001321439            2111 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens Yip1 domain family member 2 (YIPF2), transcript
            variant 2, mRNA.
ACCESSION   NM_001321439 XM_005260069
VERSION     NM_001321439.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2111)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 2111)
  AUTHORS   Wang,Y., Guo,S., Li,D., Tang,Y., Li,L., Su,L. and Liu,X.
  TITLE     YIPF2 promotes chemotherapeutic agent-mediated apoptosis via
            enhancing TNFRSF10B recycling to plasma membrane in non-small cell
            lung cancer cells
  JOURNAL   Cell Death Dis 11 (4), 242 (2020)
   PUBMED   32303681
  REMARK    GeneRIF: YIPF2 promotes chemotherapeutic agent-mediated apoptosis
            via enhancing TNFRSF10B recycling to plasma membrane in non-small
            cell lung cancer cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2111)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2111)
  AUTHORS   Qi,S., Su,L., Li,J., Zhao,P., Zhang,Q., Niu,X., Liu,J., Jia,G.,
            Wei,X., Tavernier,J., Jiang,J., Chen,Z. and Zhang,S.
  TITLE     YIPF2 is a novel Rab-GDF that enhances HCC malignant phenotypes by
            facilitating CD147 endocytic recycle
  JOURNAL   Cell Death Dis 10 (6), 462 (2019)
   PUBMED   31189879
  REMARK    GeneRIF: YIPF2 is a new trafficking determinant essential for CD147
            glycosylation and transport. YIPF2-controlled ER-Golgi trafficking
            signature promotes CD147-medated malignant phenotypes in
            hepatocellular carcinoma.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2111)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   6  (bases 1 to 2111)
  AUTHORS   Soonthornsit,J., Sakai,N., Sasaki,Y., Watanabe,R., Osako,S. and
            Nakamura,N.
  TITLE     YIPF1, YIPF2, and YIPF6 are medial-/trans-Golgi and trans-Golgi
            network-localized Yip domain family proteins, which play a role in
            the Golgi reassembly and glycan synthesis
  JOURNAL   Exp Cell Res 353 (2), 100-108 (2017)
   PUBMED   28286305
REFERENCE   7  (bases 1 to 2111)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            HY020827.1, BC000056.2 and AC011442.5.
            
            On Jun 3, 2019 this sequence version replaced NM_001321439.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038193.100997.1,
                                           SRR18074968.1616059.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000586748.6/ ENSP00000466055.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-53                HY020827.1         34-86
            54-1266             BC000056.2         1-1213
            1267-2111           AC011442.5         43888-44732         c
FEATURES             Location/Qualifiers
     source          1..2111
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.2"
     gene            1..2111
                     /gene="YIPF2"
                     /gene_synonym="FinGER2; Yip5C; YIPFbeta3B"
                     /note="Yip1 domain family member 2"
                     /db_xref="GeneID:78992"
                     /db_xref="HGNC:HGNC:28476"
                     /db_xref="MIM:617522"
     exon            1..129
                     /gene="YIPF2"
                     /gene_synonym="FinGER2; Yip5C; YIPFbeta3B"
                     /inference="alignment:Splign:2.1.0"
     exon            130..190
                     /gene="YIPF2"
                     /gene_synonym="FinGER2; Yip5C; YIPFbeta3B"
                     /inference="alignment:Splign:2.1.0"
     CDS             160..1110
                     /gene="YIPF2"
                     /gene_synonym="FinGER2; Yip5C; YIPFbeta3B"
                     /note="isoform 1 is encoded by transcript variant 2;
                     protein YIPF2; YIP1 family member 2"
                     /codon_start=1
                     /product="protein YIPF2 isoform 1"
                     /protein_id="NP_001308368.1"
                     /db_xref="CCDS:CCDS12251.1"
                     /db_xref="GeneID:78992"
                     /db_xref="HGNC:HGNC:28476"
                     /db_xref="MIM:617522"
                     /translation="MASADELTFHEFEEATNLLADTPDAATTSRSDQLTPQGHVAVAV
                     GSGGSYGAEDEVEEESDKAALLQEQQQQQQPGFWTFSYYQSFFDVDTSQVLDRIKGSL
                     LPRPGHNFVRHHLRNRPDLYGPFWICATLAFVLAVTGNLTLVLAQRRDPSIHYSPQFH
                     KVTVAGISIYCYAWLVPLALWGFLRWRKGVQERMGPYTFLETVCIYGYSLFVFIPMVV
                     LWLIPVPWLQWLFGALALGLSAAGLVFTLWPVVREDTRLVATVLLSVVVLLHALLAMG
                     CKLYFFQSLPPENVAPPPQITSLPSNIALSPTLPQSLAPS"
     exon            191..351
                     /gene="YIPF2"
                     /gene_synonym="FinGER2; Yip5C; YIPFbeta3B"
                     /inference="alignment:Splign:2.1.0"
     exon            352..438
                     /gene="YIPF2"
                     /gene_synonym="FinGER2; Yip5C; YIPFbeta3B"
                     /inference="alignment:Splign:2.1.0"
     exon            439..526
                     /gene="YIPF2"
                     /gene_synonym="FinGER2; Yip5C; YIPFbeta3B"
                     /inference="alignment:Splign:2.1.0"
     exon            527..643
                     /gene="YIPF2"
                     /gene_synonym="FinGER2; Yip5C; YIPFbeta3B"
                     /inference="alignment:Splign:2.1.0"
     exon            644..810
                     /gene="YIPF2"
                     /gene_synonym="FinGER2; Yip5C; YIPFbeta3B"
                     /inference="alignment:Splign:2.1.0"
     exon            811..993
                     /gene="YIPF2"
                     /gene_synonym="FinGER2; Yip5C; YIPFbeta3B"
                     /inference="alignment:Splign:2.1.0"
     exon            994..1129
                     /gene="YIPF2"
                     /gene_synonym="FinGER2; Yip5C; YIPFbeta3B"
                     /inference="alignment:Splign:2.1.0"
     exon            1130..2111
                     /gene="YIPF2"
                     /gene_synonym="FinGER2; Yip5C; YIPFbeta3B"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1266
                     /gene="YIPF2"
                     /gene_synonym="FinGER2; Yip5C; YIPFbeta3B"
                     /note="major polyA site"
     regulatory      1515..1520
                     /regulatory_class="polyA_signal_sequence"
                     /gene="YIPF2"
                     /gene_synonym="FinGER2; Yip5C; YIPFbeta3B"
                     /note="hexamer: AAGAAA"
     polyA_site      1536
                     /gene="YIPF2"
                     /gene_synonym="FinGER2; Yip5C; YIPFbeta3B"
                     /note="major polyA site"
     regulatory      2093..2098
                     /regulatory_class="polyA_signal_sequence"
                     /gene="YIPF2"
                     /gene_synonym="FinGER2; Yip5C; YIPFbeta3B"
                     /note="hexamer: AATAAA"
     polyA_site      2111
                     /gene="YIPF2"
                     /gene_synonym="FinGER2; Yip5C; YIPFbeta3B"
                     /note="major polyA site"
ORIGIN      
        1 aggcgagacg cgcaggcgca gagagcccca gccacgccgg cccaggtggc ctcaggtgag
       61 ggggggcgga gcgcacctgt ggggacggga cgacgagttc aagcctccgt gggtgcagtt
      121 ggtcgccagc gagggatgcg gagacgcccc tgaacgacca tggcatcggc cgacgagctg
      181 accttccatg aattcgagga ggccactaat cttctggctg acaccccaga tgcagccacc
      241 accagcagaa gcgatcagct gaccccacaa gggcacgtgg ctgtggccgt gggctcaggt
      301 ggcagctatg gagccgagga tgaggtggag gaggagagtg acaaggccgc gctcctgcag
      361 gagcagcagc agcagcagca gccgggattc tggaccttca gctactatca gagcttcttt
      421 gacgtggaca cctcacaggt cctggaccgg atcaaaggct cactgctgcc ccggcctggc
      481 cacaactttg tgcggcacca tctgcggaat cggccggatc tgtatggccc cttctggatc
      541 tgtgccacgt tggcctttgt cctggccgtc actggcaacc tgacgctggt gctggcccag
      601 aggagggacc cctccatcca ctacagcccc cagttccaca aggtgaccgt ggcaggcatc
      661 agcatctact gctatgcgtg gctggtgccc ctggccctgt ggggcttcct gcggtggcgc
      721 aagggtgtcc aggagcgcat ggggccctac accttcctgg agactgtgtg catctacggc
      781 tactccctct ttgtcttcat ccccatggtg gtcctgtggc tcatccctgt gccttggctg
      841 cagtggctct ttggggcgct ggccctgggc ctgtcagccg ccgggctggt attcaccctc
      901 tggcccgtgg tccgtgagga caccaggctg gtggccacag tgctgctgtc cgtggtcgtg
      961 ctgctccacg ccctcctggc catgggctgt aagttgtact tcttccagtc gctgcctccg
     1021 gagaacgtgg ctcctccacc ccaaatcaca tctctgccct caaacatcgc gctgtcccct
     1081 accttgccgc agtccctggc cccctcctag gaaggcccgg gtcccacagg caacacctaa
     1141 gtggaccaac ccctctgcct gtcctgcccc ccagacgatg actgaaggct cctttgacac
     1201 cttgagatga ttctgctact ttccagactt ttcttacaaa gcaaacactt ttattttcta
     1261 tgcaaaggtg attcagagaa tttatataaa ggcgggcgag gggcagccga gcagggagct
     1321 ttgggacagg gctggggccc ccatatcccc cccgggccac ctgctttccc tcctatggct
     1381 cccctggaac aggagggaga gccaaggggg cggcccagcc tggacagcgc ccgctcctgc
     1441 ctgggtgcac acacggcggg cctgagctcc agcatctgag tttgggggta tgagaaacag
     1501 gggagcagaa ggagaagaaa actgcctgtg ctgcaacacg tttcctcatt tattttttct
     1561 ttctttttct ttttttcttt ttttggaggg agaggtccct gcaaggtccc ttcccgggca
     1621 ggggagggat ggaaatgccg tcacagtagt agggactgga gcgtctacaa ggatggaggg
     1681 gagctactca ggcctaacgt tagctacaag gaaaaaggac gccttccgtg acagatcctt
     1741 gaggtgtctg tgtctgcccc aagtggccgg cagtggcctt ccctccgggc ccaaggcctg
     1801 cagccacctg ctctaactct tgagtggggg ggcggggggg gacctgcagg ggctcgggga
     1861 caggacagca gcaagaggca ggggccgagg acggaggcct tcccgacagt ggggtgggtt
     1921 gtacattcaa gtgtgaggtg aaccctttgg tggggagggg gcccctgaag cctcggcggg
     1981 gccacccctc cccgcggcgc ctctgagtct agggagaggg gctgctggct cggcccggcc
     2041 ggcctggctt cacagagggt ctgcggattg acactggttc ttttcataaa aaaataaaat
     2101 taaaaaaagc a
//
