LOCUS       NM_018982               1821 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens Yip1 domain family member 1 (YIPF1), transcript
            variant 1, mRNA.
ACCESSION   NM_018982
VERSION     NM_018982.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1821)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 1821)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 1821)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1821)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   5  (bases 1 to 1821)
  AUTHORS   Soonthornsit,J., Sakai,N., Sasaki,Y., Watanabe,R., Osako,S. and
            Nakamura,N.
  TITLE     YIPF1, YIPF2, and YIPF6 are medial-/trans-Golgi and trans-Golgi
            network-localized Yip domain family proteins, which play a role in
            the Golgi reassembly and glycan synthesis
  JOURNAL   Exp Cell Res 353 (2), 100-108 (2017)
   PUBMED   28286305
  REMARK    GeneRIF: Knockdown of YIPF1 and YIPF2, but not that of YIPF6, also
            reduced intracellular glycans in HT-29 cells. Thus, we confirmed
            that YIPF1, YIPF2, and YIPF6 play a significant role in supporting
            normal glycan synthesis
REFERENCE   6  (bases 1 to 1821)
  AUTHORS   Kawaguchi,T., Sumida,Y., Umemura,A., Matsuo,K., Takahashi,M.,
            Takamura,T., Yasui,K., Saibara,T., Hashimoto,E., Kawanaka,M.,
            Watanabe,S., Kawata,S., Imai,Y., Kokubo,M., Shima,T., Park,H.,
            Tanaka,H., Tajima,K., Yamada,R., Matsuda,F. and Okanoue,T.
  CONSRTM   Japan Study Group of Nonalcoholic Fatty Liver Disease
  TITLE     Genetic polymorphisms of the human PNPLA3 gene are strongly
            associated with severity of non-alcoholic fatty liver disease in
            Japanese
  JOURNAL   PLoS One 7 (6), e38322 (2012)
   PUBMED   22719876
REFERENCE   7  (bases 1 to 1821)
  AUTHORS   Orvedahl,A., Sumpter,R. Jr., Xiao,G., Ng,A., Zou,Z., Tang,Y.,
            Narimatsu,M., Gilpin,C., Sun,Q., Roth,M., Forst,C.V., Wrana,J.L.,
            Zhang,Y.E., Luby-Phelps,K., Xavier,R.J., Xie,Y. and Levine,B.
  TITLE     Image-based genome-wide siRNA screen identifies selective autophagy
            factors
  JOURNAL   Nature 480 (7375), 113-117 (2011)
   PUBMED   22020285
REFERENCE   8  (bases 1 to 1821)
  AUTHORS   Starkuviene,V., Liebel,U., Simpson,J.C., Erfle,H., Poustka,A.,
            Wiemann,S. and Pepperkok,R.
  TITLE     High-content screening microscopy identifies novel proteins with a
            putative role in secretory membrane traffic
  JOURNAL   Genome Res 14 (10A), 1948-1956 (2004)
   PUBMED   15466293
REFERENCE   9  (bases 1 to 1821)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BI757212.1, AL031427.15, AL391003.15 and AL596480.1.
            
            On Nov 23, 2018 this sequence version replaced NM_018982.4.
            
            Transcript Variant: This variant (1) is the protein-coding
            transcript.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.139854.1,
                                           SRR3476690.730969.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000072644.7/ ENSP00000072644.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-37                BI757212.1         15-51
            38-85               AL031427.15        35942-35989         c
            86-305              AL031427.15        35473-35692         c
            306-385             AL031427.15        35136-35215         c
            386-549             AL031427.15        29342-29505         c
            550-630             AL031427.15        24871-24951         c
            631-718             AL031427.15        24544-24631         c
            719-835             AL031427.15        17601-17717         c
            836-1002            AL031427.15        12987-13153         c
            1003-1185           AL031427.15        12429-12611         c
            1186-1283           AL031427.15        6285-6382           c
            1284-1793           AL391003.15        11751-12260         c
            1794-1821           AL596480.1         36-63               c
FEATURES             Location/Qualifiers
     source          1..1821
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p32.3"
     gene            1..1821
                     /gene="YIPF1"
                     /gene_synonym="DJ167A19.1; FinGER1; Yip5a; YIPFbeta3A"
                     /note="Yip1 domain family member 1"
                     /db_xref="GeneID:54432"
                     /db_xref="HGNC:HGNC:25231"
                     /db_xref="MIM:617521"
     exon            1..85
                     /gene="YIPF1"
                     /gene_synonym="DJ167A19.1; FinGER1; Yip5a; YIPFbeta3A"
                     /inference="alignment:Splign:2.1.0"
     exon            86..305
                     /gene="YIPF1"
                     /gene_synonym="DJ167A19.1; FinGER1; Yip5a; YIPFbeta3A"
                     /inference="alignment:Splign:2.1.0"
     exon            306..385
                     /gene="YIPF1"
                     /gene_synonym="DJ167A19.1; FinGER1; Yip5a; YIPFbeta3A"
                     /inference="alignment:Splign:2.1.0"
     CDS             355..1275
                     /gene="YIPF1"
                     /gene_synonym="DJ167A19.1; FinGER1; Yip5a; YIPFbeta3A"
                     /note="YIP1 family member 1"
                     /codon_start=1
                     /product="protein YIPF1"
                     /protein_id="NP_061855.1"
                     /db_xref="CCDS:CCDS584.1"
                     /db_xref="GeneID:54432"
                     /db_xref="HGNC:HGNC:25231"
                     /db_xref="MIM:617521"
                     /translation="MAAVDDLQFEEFGNAATSLTANPDATTVNIEDPGETPKHQPGSP
                     RGSGREEDDELLGNDDSDKTELLAGQKKSSPFWTFEYYQTFFDVDTYQVFDRIKGSLL
                     PIPGKNFVRLYIRSNPDLYGPFWICATLVFAIAISGNLSNFLIHLGEKTYHYVPEFRK
                     VSIAATIIYAYAWLVPLALWGFLMWRNSKVMNIVSYSFLEIVCVYGYSLFIYIPTAIL
                     WIIPQKAVRWILVMIALGISGSLLAMTFWPAVREDNRRVALATIVTIVLLHMLLSVGC
                     LAYFFDAPEMDHLPTTTATPNQTVAAAKSS"
     exon            386..549
                     /gene="YIPF1"
                     /gene_synonym="DJ167A19.1; FinGER1; Yip5a; YIPFbeta3A"
                     /inference="alignment:Splign:2.1.0"
     exon            550..630
                     /gene="YIPF1"
                     /gene_synonym="DJ167A19.1; FinGER1; Yip5a; YIPFbeta3A"
                     /inference="alignment:Splign:2.1.0"
     exon            631..718
                     /gene="YIPF1"
                     /gene_synonym="DJ167A19.1; FinGER1; Yip5a; YIPFbeta3A"
                     /inference="alignment:Splign:2.1.0"
     exon            719..835
                     /gene="YIPF1"
                     /gene_synonym="DJ167A19.1; FinGER1; Yip5a; YIPFbeta3A"
                     /inference="alignment:Splign:2.1.0"
     exon            836..1002
                     /gene="YIPF1"
                     /gene_synonym="DJ167A19.1; FinGER1; Yip5a; YIPFbeta3A"
                     /inference="alignment:Splign:2.1.0"
     exon            1003..1185
                     /gene="YIPF1"
                     /gene_synonym="DJ167A19.1; FinGER1; Yip5a; YIPFbeta3A"
                     /inference="alignment:Splign:2.1.0"
     exon            1186..1283
                     /gene="YIPF1"
                     /gene_synonym="DJ167A19.1; FinGER1; Yip5a; YIPFbeta3A"
                     /inference="alignment:Splign:2.1.0"
     exon            1284..1821
                     /gene="YIPF1"
                     /gene_synonym="DJ167A19.1; FinGER1; Yip5a; YIPFbeta3A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1804..1809
                     /regulatory_class="polyA_signal_sequence"
                     /gene="YIPF1"
                     /gene_synonym="DJ167A19.1; FinGER1; Yip5a; YIPFbeta3A"
                     /note="hexamer: AATAAA"
     polyA_site      1821
                     /gene="YIPF1"
                     /gene_synonym="DJ167A19.1; FinGER1; Yip5a; YIPFbeta3A"
                     /note="major polyA site"
ORIGIN      
        1 ccggcaactg ggctggaccg aaaccggcgc ggagcaactg aggcccgagc cttctcggga
       61 cccgggggac gcctaacccc gcgagatgag gaaactgagg ccgcgaggag cgcgcataca
      121 gcagagaagc agcagaatcg ggaatcaaac ccagctctgt ctgaccccag agcctgtgcc
      181 tttaaccact ggctaggctg aactgccttt gttcttcact gtccccatca cctctttcaa
      241 acctcagcct ctccttcctc atcgttacat ctctaggctg cacctgctct ctaaacattc
      301 acacaaaccc tgcaaatttt cttcctcata attgggagaa gactcactgg ccgaatggca
      361 gcagtagatg acttgcaatt tgaagaattt ggcaatgcag ccacttctct gacagcaaac
      421 ccagatgcca ccacagtaaa cattgaggat cctggtgaaa ccccaaaaca tcagccagga
      481 tccccaagag gctcaggaag agaagaagat gatgagttac tgggaaatga tgactctgac
      541 aaaactgagt tacttgctgg acagaagaaa agctccccct tctggacatt tgaatactac
      601 caaacattct ttgatgtgga cacctaccag gtctttgaca gaattaaagg atctcttttg
      661 ccaatacccg ggaaaaactt tgtgaggtta tatatccgca gcaatccaga tctctatggc
      721 cccttttgga tatgtgccac gttggtcttt gccatagcaa ttagtgggaa tctttccaac
      781 ttcttgatcc atctgggaga gaagacgtac cattatgtgc ccgaattccg aaaagtgtcc
      841 atagcagcta ccatcatcta tgcctatgcc tggctggttc ctcttgcact ctggggtttc
      901 ctcatgtgga gaaacagcaa agttatgaac atcgtctcct attcatttct ggagattgtg
      961 tgtgtctatg gatattccct cttcatttat atccccaccg caatactgtg gattatcccc
     1021 cagaaagctg ttcgttggat tctagtcatg attgccctgg gcatctcagg atctctcttg
     1081 gcaatgacat tttggccagc tgttcgtgag gataaccgac gcgttgcatt ggccacaatt
     1141 gtgacaattg tgttgctcca tatgctgctt tctgtgggct gcttggcata cttttttgat
     1201 gcaccagaga tggaccatct cccaacaact acagctactc caaaccaaac agttgctgca
     1261 gccaagtcca gctaatgagg aaattctctt ttgttttttg gagcatggtt ctttgggaag
     1321 tggcatccac tgcaggaaag cagaatgagc agagccagca gaactgatgg agtggcacaa
     1381 attcccagtg tctggatggt gccacactgg cgcctaatca cccgtttaac aagcagaaat
     1441 taaatgttgc tcagcacatg tgtctttcag ctcttccttt tcacccatgg atgatcattg
     1501 cgagcatgcg ctgattggac tgaaatgcca gggaataggt taggcatgct cagtgccgtc
     1561 cctttgccac cacagtcaaa tgacatgctt cactgtggta ccttaatacc tgaaatagaa
     1621 ccatggaaaa ttctgatgtc ctctctctga attatgtaca gactacctgg gggatcctct
     1681 tctctccaaa tgttagccat cctgaagtag ccgaacagta gaaactttgg tggggattaa
     1741 ccgggagctt gaaaatttgt ctttggtaac ctgatactgg acagctgaac tgaatggctg
     1801 caaaataaat acctcacatg a
//
