LOCUS       NM_001039672            2769 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens Yip1 interacting factor homolog B, membrane
            trafficking protein (YIF1B), transcript variant 5, mRNA.
ACCESSION   NM_001039672
VERSION     NM_001039672.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2769)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 2769)
  AUTHORS   Diaz,J., Gerard,X., Emerit,M.B., Areias,J., Geny,D., Degardin,J.,
            Simonutti,M., Guerquin,M.J., Collin,T., Viollet,C., Billard,J.M.,
            Metin,C., Hubert,L., Larti,F., Kahrizi,K., Jobling,R., Agolini,E.,
            Shaheen,R., Zigler,A., Rouiller-Fabre,V., Rozet,J.M., Picaud,S.,
            Novelli,A., Alameer,S., Najmabadi,H., Cohn,R., Munnich,A.,
            Barth,M., Lugli,L., Alkuraya,F.S., Blaser,S., Gashlan,M.,
            Besmond,C., Darmon,M. and Masson,J.
  TITLE     YIF1B mutations cause a post-natal neurodevelopmental syndrome
            associated with Golgi and primary cilium alterations
  JOURNAL   Brain 143 (10), 2911-2928 (2020)
   PUBMED   33103737
  REMARK    GeneRIF: YIF1B mutations cause a post-natal neurodevelopmental
            syndrome associated with Golgi and primary cilium alterations.
            Erratum:[Brain. 2021 May 7;144(4):e40. doi: 10.1093/brain/awaa449..
            PMID: 33438001]
REFERENCE   3  (bases 1 to 2769)
  AUTHORS   Liu,J., Chen,Z., Zhao,P. and Li,W.
  TITLE     Prognostic and immune regulating roles of YIF1B in Pan-Cancer: a
            potential target for both survival and therapy response evaluation
  JOURNAL   Biosci Rep 40 (7) (2020)
   PUBMED   32648580
  REMARK    GeneRIF: Prognostic and immune regulating roles of YIF1B in
            Pan-Cancer: a potential target for both survival and therapy
            response evaluation.
REFERENCE   4  (bases 1 to 2769)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 2769)
  AUTHORS   AlMuhaizea,M., AlMass,R., AlHargan,A., AlBader,A., Medico
            Salsench,E., Howaidi,J., Ihinger,J., Karachunski,P., Begtrup,A.,
            Segura Castell,M., Bauer,P., Bertoli-Avella,A., Kaya,I.H.,
            AlSufayan,J., AlQuait,L., Chedrawi,A., Arold,S.T., Colak,D.,
            Barakat,T.S. and Kaya,N.
  TITLE     Truncating mutations in YIF1B cause a progressive encephalopathy
            with various degrees of mixed movement disorder, microcephaly, and
            epilepsy
  JOURNAL   Acta Neuropathol 139 (4), 791-794 (2020)
   PUBMED   32006098
  REMARK    GeneRIF: Truncating mutations in YIF1B cause a progressive
            encephalopathy with various degrees of mixed movement disorder,
            microcephaly, and epilepsy.
REFERENCE   6  (bases 1 to 2769)
  AUTHORS   Graab,P., Bock,C., Weiss,K., Hirth,A., Koller,N., Braner,M.,
            Jung,J., Loehr,F., Tampe,R., Behrends,C. and Abele,R.
  TITLE     Lysosomal targeting of the ABC transporter TAPL is determined by
            membrane-localized charged residues
  JOURNAL   J Biol Chem 294 (18), 7308-7323 (2019)
   PUBMED   30877195
REFERENCE   7  (bases 1 to 2769)
  AUTHORS   Sokolina,K., Kittanakom,S., Snider,J., Kotlyar,M., Maurice,P.,
            Gandia,J., Benleulmi-Chaachoua,A., Tadagaki,K., Oishi,A., Wong,V.,
            Malty,R.H., Deineko,V., Aoki,H., Amin,S., Yao,Z., Morato,X.,
            Otasek,D., Kobayashi,H., Menendez,J., Auerbach,D., Angers,S.,
            Przulj,N., Bouvier,M., Babu,M., Ciruela,F., Jockers,R., Jurisica,I.
            and Stagljar,I.
  TITLE     Systematic protein-protein interaction mapping for clinically
            relevant human GPCRs
  JOURNAL   Mol Syst Biol 13 (3), 918 (2017)
   PUBMED   28298427
  REMARK    Erratum:[Mol Syst Biol. 2025 Feb;21(2):208-209. doi:
            10.1038/s44320-024-00080-3.. PMID: 39762653]
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2769)
  AUTHORS   Alterio,J., Masson,J., Diaz,J., Chachlaki,K., Salman,H., Areias,J.,
            Al Awabdh,S., Emerit,M.B. and Darmon,M.
  TITLE     Yif1B Is Involved in the Anterograde Traffic Pathway and the Golgi
            Architecture
  JOURNAL   Traffic 16 (9), 978-993 (2015)
   PUBMED   26077767
REFERENCE   9  (bases 1 to 2769)
  AUTHORS   Carrel,D., Masson,J., Al Awabdh,S., Capra,C.B., Lenkei,Z.,
            Hamon,M., Emerit,M.B. and Darmon,M.
  TITLE     Targeting of the 5-HT1A serotonin receptor to neuronal dendrites is
            mediated by Yif1B
  JOURNAL   J Neurosci 28 (32), 8063-8073 (2008)
   PUBMED   18685031
REFERENCE   10 (bases 1 to 2769)
  AUTHORS   Medico-Salsench,E., Kaya,N. and Barakat,T.S.
  TITLE     YIF1B-Related Neurodevelopmental Disorder
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   39265055
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AW630507.1, BC091477.1, AC011479.7 and AK027130.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001039672.2.
            
            Transcript Variant: This variant (5) encodes the longest isoform
            (5).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.105240.1,
                                           SRR5189661.12937.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000339413.11/ ENSP00000343435.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7                 AW630507.1         20-26
            8-1206              BC091477.1         1-1199
            1207-1306           AC011479.7         14258-14357
            1307-2767           AK027130.1         1-1461
            2768-2769           AC011479.7         15819-15820
FEATURES             Location/Qualifiers
     source          1..2769
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.2"
     gene            1..2769
                     /gene="YIF1B"
                     /gene_synonym="FinGER8; KABAMAS"
                     /note="Yip1 interacting factor homolog B, membrane
                     trafficking protein"
                     /db_xref="GeneID:90522"
                     /db_xref="HGNC:HGNC:30511"
                     /db_xref="MIM:619109"
     exon            1..88
                     /gene="YIF1B"
                     /gene_synonym="FinGER8; KABAMAS"
                     /inference="alignment:Splign:2.1.0"
     CDS             31..975
                     /gene="YIF1B"
                     /gene_synonym="FinGER8; KABAMAS"
                     /note="isoform 5 is encoded by transcript variant 5;
                     protein YIF1B; YIP1-interacting factor homolog B"
                     /codon_start=1
                     /product="protein YIF1B isoform 5"
                     /protein_id="NP_001034761.1"
                     /db_xref="CCDS:CCDS33010.1"
                     /db_xref="GeneID:90522"
                     /db_xref="HGNC:HGNC:30511"
                     /db_xref="MIM:619109"
                     /translation="MHPAGLAAAAAGTPRLRKWPSKRRIPVSQPGMADPHQLFDDTSS
                     AQSRGYGAQRAPGGLSYPAASPTPHAAFLADPVSNMAMAYGSSLAAQGKELVDKNIDR
                     FIPITKLKYYFAVDTMYVGRKLGLLFFPYLHQDWEVQYQQDTPVAPRFDVNAPDLYIP
                     AMAFITYVLVAGLALGTQDRFSPDLLGLQASSALAWLTLEVLAILLSLYLVTVNTDLT
                     TIDLVAFLGYKYVGMIGGVLMGLLFGKIGYYLVLGWCCVAIFVFMIRTLRLKILADAA
                     AEGVPVRGARNQLRMYLTMAVAAAQPMLMYWLTFHLVR"
     exon            89..327
                     /gene="YIF1B"
                     /gene_synonym="FinGER8; KABAMAS"
                     /inference="alignment:Splign:2.1.0"
     exon            328..432
                     /gene="YIF1B"
                     /gene_synonym="FinGER8; KABAMAS"
                     /inference="alignment:Splign:2.1.0"
     exon            433..511
                     /gene="YIF1B"
                     /gene_synonym="FinGER8; KABAMAS"
                     /inference="alignment:Splign:2.1.0"
     exon            512..569
                     /gene="YIF1B"
                     /gene_synonym="FinGER8; KABAMAS"
                     /inference="alignment:Splign:2.1.0"
     exon            570..725
                     /gene="YIF1B"
                     /gene_synonym="FinGER8; KABAMAS"
                     /inference="alignment:Splign:2.1.0"
     exon            726..819
                     /gene="YIF1B"
                     /gene_synonym="FinGER8; KABAMAS"
                     /inference="alignment:Splign:2.1.0"
     exon            820..2769
                     /gene="YIF1B"
                     /gene_synonym="FinGER8; KABAMAS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1192..1197
                     /regulatory_class="polyA_signal_sequence"
                     /gene="YIF1B"
                     /gene_synonym="FinGER8; KABAMAS"
                     /note="hexamer: AATAAA"
     polyA_site      1213
                     /gene="YIF1B"
                     /gene_synonym="FinGER8; KABAMAS"
                     /note="major polyA site"
     regulatory      2741..2746
                     /regulatory_class="polyA_signal_sequence"
                     /gene="YIF1B"
                     /gene_synonym="FinGER8; KABAMAS"
                     /note="hexamer: AATAAA"
     polyA_site      2769
                     /gene="YIF1B"
                     /gene_synonym="FinGER8; KABAMAS"
ORIGIN      
        1 gaaccgcggc ttaggtggcg gcggcgaagg atgcacccgg caggcttggc ggcggcggct
       61 gcggggacgc cccggctgcg taagtggccc tcgaagcgga ggatccctgt gtcccagccg
      121 ggcatggccg acccccacca gcttttcgat gacacaagtt cagcccagag ccggggctat
      181 ggggcccagc gggcacctgg tggcctgagt tatcctgcag cctctcccac gccccatgca
      241 gccttcctgg ctgacccggt gtccaacatg gccatggcct atgggagcag cctggccgcg
      301 cagggcaagg agctggtgga taagaacatc gaccgcttca tccccatcac caagctcaag
      361 tattactttg ctgtggacac catgtatgtg ggcagaaagc tgggcctgct gttcttcccc
      421 tacctacacc aggactggga agtgcagtac caacaggaca ccccggtggc cccccgcttt
      481 gacgtcaatg ccccggacct ctacattcca gcaatggctt tcatcaccta cgttttggtg
      541 gctggtcttg cgctggggac ccaggatagg ttctccccag acctcctggg gctgcaagcg
      601 agctcagccc tggcctggct gaccctggag gtgctggcca tcctgctcag cctctatctg
      661 gtcactgtca acaccgacct caccaccatc gacctggtgg ccttcttggg ctacaaatat
      721 gtcgggatga ttggcggggt cctcatgggc ctgctcttcg ggaagattgg ctactacctg
      781 gtgctgggct ggtgctgcgt agccatcttt gtgttcatga tccggacgct gcggctgaag
      841 atcttggcag acgcagcagc tgagggggtc ccggtgcgtg gggcccggaa ccagctgcgc
      901 atgtacctga ccatggcggt ggcggcggcg cagcctatgc tcatgtactg gctcaccttc
      961 cacctggtgc ggtgagcgcg cccgctgaac ctcccgctgc tgctgctgct gctgggggcc
     1021 actgtggccg ccgaactcat ctcctgcctg caggccccaa ggtccaccct gtctggccac
     1081 aggcaccgcc tccatcccat gtcccgccca gccccgcccc caacccaagg tgctgagaga
     1141 tctccagctg cacaggccac cgccccaggg cgtggccgct gttacagaaa caataaaccc
     1201 tgatgggcat ggcgtggaca gcctctcctt ggcctcgcgc acgaatgggc gggcccagcg
     1261 ctgggcaggg ggcagggagc tggggacggg ccagagtagg caccacgctg accagtcgca
     1321 gaaggcagag aggaaggttt aatgagccct gtccagggcc cttcagtggg gagcctcctt
     1381 cttcttgccc ttctccttct tgcccttctc cttcttcttc actttgggct tcttggcctt
     1441 gcccgggatg ctctcgtgct gcttggagcc agcagcgtgg gactgtgggg ccgagggcag
     1501 ggatgggaga gaagagatgg ttctgggctg gaagcgagac agggggacca ctccccgcac
     1561 cctccccgcc agccccagtg cggggacgcc tctctggggt gcagggcacg tgcttgggga
     1621 cgctggcgag agccccttac cttcacatcc gtgtccgaat cgctggagct gctgctggag
     1681 tcggaagagc tgtggtgtcc ttgctggatg gaggtgcggc agtgaggcgg cgccccttac
     1741 ccagccccct gaagttggag gcctaaggca ggaccctggg gtcaggggca accccagcct
     1801 tcccgcccct ccgcagccgg tgatgaggcg acttaccttt ggacccggac ctgcccctgc
     1861 ctccgaccgg ccctgaactt tgtggggact gagcttggga tctcccccgt ggcccgcccc
     1921 cacaccgggc ttctgggagg tgggctccag ggctgtggag agaagttggg tggttggtgc
     1981 aggcagcttc tgggcttgag tccggccccc tgcacctcca gtccacactc cccaggagct
     2041 cacctgctcc caggtcgaac tccatggcgg taagagaagt tgggtcctaa ggccaagggc
     2101 gcctgggccc tgcagaggag cggagcaggg ggaggagcgc tgagacctgc ccgttggagg
     2161 aatgctgaga cgccccaccc aacctctgtc ctggtcctca gccctgactc attgcccggc
     2221 accacccagg atttcctctg tgagaagtgg gggagatgga caggtgactg cttccgccag
     2281 ccttggtgcc tcaggggagg ccgactgagg ggggctctgt ggatggcatt cggggagcta
     2341 caggtttccc ccaaaagctc agatgctcgt tcttgaagag ggaggtgctg cccctgcctt
     2401 cctgcgtacc gcgacaatac agcttcctcc gcggcgcttt aacacgcagg gcgctgctgc
     2461 caggggcgtc ccgtgttcta actcgctccc acagcccctc cggcttggtg agcagcgtct
     2521 gaggggtgag gggcatagac ttggagccag cctgctgcac tagatgccag ctgtgtcact
     2581 tagcagcaag gtgacctcag caaagttgtt ttacctctgt gcctcagttt cctcatctgt
     2641 aaataacagc tacccatggg attgatgtga aagtcagagg agttaatttc ctagaatggt
     2701 gtctggcatg aagtactgat aatgtgttgg ttttttaaaa aataaaaggt aggtgtttta
     2761 ggccagtca
//
