LOCUS       NM_001039671            2745 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens Yip1 interacting factor homolog B, membrane
            trafficking protein (YIF1B), transcript variant 3, mRNA.
ACCESSION   NM_001039671
VERSION     NM_001039671.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2745)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 2745)
  AUTHORS   Diaz,J., Gerard,X., Emerit,M.B., Areias,J., Geny,D., Degardin,J.,
            Simonutti,M., Guerquin,M.J., Collin,T., Viollet,C., Billard,J.M.,
            Metin,C., Hubert,L., Larti,F., Kahrizi,K., Jobling,R., Agolini,E.,
            Shaheen,R., Zigler,A., Rouiller-Fabre,V., Rozet,J.M., Picaud,S.,
            Novelli,A., Alameer,S., Najmabadi,H., Cohn,R., Munnich,A.,
            Barth,M., Lugli,L., Alkuraya,F.S., Blaser,S., Gashlan,M.,
            Besmond,C., Darmon,M. and Masson,J.
  TITLE     YIF1B mutations cause a post-natal neurodevelopmental syndrome
            associated with Golgi and primary cilium alterations
  JOURNAL   Brain 143 (10), 2911-2928 (2020)
   PUBMED   33103737
  REMARK    GeneRIF: YIF1B mutations cause a post-natal neurodevelopmental
            syndrome associated with Golgi and primary cilium alterations.
            Erratum:[Brain. 2021 May 7;144(4):e40. doi: 10.1093/brain/awaa449..
            PMID: 33438001]
REFERENCE   3  (bases 1 to 2745)
  AUTHORS   Liu,J., Chen,Z., Zhao,P. and Li,W.
  TITLE     Prognostic and immune regulating roles of YIF1B in Pan-Cancer: a
            potential target for both survival and therapy response evaluation
  JOURNAL   Biosci Rep 40 (7) (2020)
   PUBMED   32648580
  REMARK    GeneRIF: Prognostic and immune regulating roles of YIF1B in
            Pan-Cancer: a potential target for both survival and therapy
            response evaluation.
REFERENCE   4  (bases 1 to 2745)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 2745)
  AUTHORS   AlMuhaizea,M., AlMass,R., AlHargan,A., AlBader,A., Medico
            Salsench,E., Howaidi,J., Ihinger,J., Karachunski,P., Begtrup,A.,
            Segura Castell,M., Bauer,P., Bertoli-Avella,A., Kaya,I.H.,
            AlSufayan,J., AlQuait,L., Chedrawi,A., Arold,S.T., Colak,D.,
            Barakat,T.S. and Kaya,N.
  TITLE     Truncating mutations in YIF1B cause a progressive encephalopathy
            with various degrees of mixed movement disorder, microcephaly, and
            epilepsy
  JOURNAL   Acta Neuropathol 139 (4), 791-794 (2020)
   PUBMED   32006098
  REMARK    GeneRIF: Truncating mutations in YIF1B cause a progressive
            encephalopathy with various degrees of mixed movement disorder,
            microcephaly, and epilepsy.
REFERENCE   6  (bases 1 to 2745)
  AUTHORS   Graab,P., Bock,C., Weiss,K., Hirth,A., Koller,N., Braner,M.,
            Jung,J., Loehr,F., Tampe,R., Behrends,C. and Abele,R.
  TITLE     Lysosomal targeting of the ABC transporter TAPL is determined by
            membrane-localized charged residues
  JOURNAL   J Biol Chem 294 (18), 7308-7323 (2019)
   PUBMED   30877195
REFERENCE   7  (bases 1 to 2745)
  AUTHORS   Sokolina,K., Kittanakom,S., Snider,J., Kotlyar,M., Maurice,P.,
            Gandia,J., Benleulmi-Chaachoua,A., Tadagaki,K., Oishi,A., Wong,V.,
            Malty,R.H., Deineko,V., Aoki,H., Amin,S., Yao,Z., Morato,X.,
            Otasek,D., Kobayashi,H., Menendez,J., Auerbach,D., Angers,S.,
            Przulj,N., Bouvier,M., Babu,M., Ciruela,F., Jockers,R., Jurisica,I.
            and Stagljar,I.
  TITLE     Systematic protein-protein interaction mapping for clinically
            relevant human GPCRs
  JOURNAL   Mol Syst Biol 13 (3), 918 (2017)
   PUBMED   28298427
  REMARK    Erratum:[Mol Syst Biol. 2025 Feb;21(2):208-209. doi:
            10.1038/s44320-024-00080-3.. PMID: 39762653]
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2745)
  AUTHORS   Alterio,J., Masson,J., Diaz,J., Chachlaki,K., Salman,H., Areias,J.,
            Al Awabdh,S., Emerit,M.B. and Darmon,M.
  TITLE     Yif1B Is Involved in the Anterograde Traffic Pathway and the Golgi
            Architecture
  JOURNAL   Traffic 16 (9), 978-993 (2015)
   PUBMED   26077767
REFERENCE   9  (bases 1 to 2745)
  AUTHORS   Carrel,D., Masson,J., Al Awabdh,S., Capra,C.B., Lenkei,Z.,
            Hamon,M., Emerit,M.B. and Darmon,M.
  TITLE     Targeting of the 5-HT1A serotonin receptor to neuronal dendrites is
            mediated by Yif1B
  JOURNAL   J Neurosci 28 (32), 8063-8073 (2008)
   PUBMED   18685031
REFERENCE   10 (bases 1 to 2745)
  AUTHORS   Medico-Salsench,E., Kaya,N. and Barakat,T.S.
  TITLE     YIF1B-Related Neurodevelopmental Disorder
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   39265055
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BM703847.1, BE877226.1, BX379501.2, CA487891.1, AC011479.7 and
            AK027130.1.
            
            On May 31, 2019 this sequence version replaced NM_001039671.2.
            
            Transcript Variant: This variant (3) contains an alternate 5'
            terminal exon, and it thus differs in the 5' UTR and 5' coding
            region, compared to variant 5. The resulting isoform (3) has a
            shorter and distinct N-terminus, compared to isoform 5.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853560.14541.1,
                                           SRR11853567.15543.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                BM703847.1         26-54
            30-511              BE877226.1         1-482
            512-776             BX379501.2         473-737
            777-820             CA487891.1         755-798
            821-1282            AC011479.7         13896-14357
            1283-2743           AK027130.1         1-1461
            2744-2745           AC011479.7         15819-15820
FEATURES             Location/Qualifiers
     source          1..2745
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.2"
     gene            1..2745
                     /gene="YIF1B"
                     /gene_synonym="FinGER8; KABAMAS"
                     /note="Yip1 interacting factor homolog B, membrane
                     trafficking protein"
                     /db_xref="GeneID:90522"
                     /db_xref="HGNC:HGNC:30511"
                     /db_xref="MIM:619109"
     exon            1..64
                     /gene="YIF1B"
                     /gene_synonym="FinGER8; KABAMAS"
                     /inference="alignment:Splign:2.1.0"
     CDS             52..951
                     /gene="YIF1B"
                     /gene_synonym="FinGER8; KABAMAS"
                     /note="isoform 3 is encoded by transcript variant 3;
                     protein YIF1B; YIP1-interacting factor homolog B"
                     /codon_start=1
                     /product="protein YIF1B isoform 3"
                     /protein_id="NP_001034760.1"
                     /db_xref="CCDS:CCDS46066.1"
                     /db_xref="GeneID:90522"
                     /db_xref="HGNC:HGNC:30511"
                     /db_xref="MIM:619109"
                     /translation="MPGSASKRRIPVSQPGMADPHQLFDDTSSAQSRGYGAQRAPGGL
                     SYPAASPTPHAAFLADPVSNMAMAYGSSLAAQGKELVDKNIDRFIPITKLKYYFAVDT
                     MYVGRKLGLLFFPYLHQDWEVQYQQDTPVAPRFDVNAPDLYIPAMAFITYVLVAGLAL
                     GTQDRFSPDLLGLQASSALAWLTLEVLAILLSLYLVTVNTDLTTIDLVAFLGYKYVGM
                     IGGVLMGLLFGKIGYYLVLGWCCVAIFVFMIRTLRLKILADAAAEGVPVRGARNQLRM
                     YLTMAVAAAQPMLMYWLTFHLVR"
     exon            65..303
                     /gene="YIF1B"
                     /gene_synonym="FinGER8; KABAMAS"
                     /inference="alignment:Splign:2.1.0"
     exon            304..408
                     /gene="YIF1B"
                     /gene_synonym="FinGER8; KABAMAS"
                     /inference="alignment:Splign:2.1.0"
     exon            409..487
                     /gene="YIF1B"
                     /gene_synonym="FinGER8; KABAMAS"
                     /inference="alignment:Splign:2.1.0"
     exon            488..545
                     /gene="YIF1B"
                     /gene_synonym="FinGER8; KABAMAS"
                     /inference="alignment:Splign:2.1.0"
     exon            546..701
                     /gene="YIF1B"
                     /gene_synonym="FinGER8; KABAMAS"
                     /inference="alignment:Splign:2.1.0"
     exon            702..795
                     /gene="YIF1B"
                     /gene_synonym="FinGER8; KABAMAS"
                     /inference="alignment:Splign:2.1.0"
     exon            796..2745
                     /gene="YIF1B"
                     /gene_synonym="FinGER8; KABAMAS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1168..1173
                     /regulatory_class="polyA_signal_sequence"
                     /gene="YIF1B"
                     /gene_synonym="FinGER8; KABAMAS"
                     /note="hexamer: AATAAA"
     polyA_site      1189
                     /gene="YIF1B"
                     /gene_synonym="FinGER8; KABAMAS"
                     /note="major polyA site"
     regulatory      2717..2722
                     /regulatory_class="polyA_signal_sequence"
                     /gene="YIF1B"
                     /gene_synonym="FinGER8; KABAMAS"
                     /note="hexamer: AATAAA"
     polyA_site      2745
                     /gene="YIF1B"
                     /gene_synonym="FinGER8; KABAMAS"
ORIGIN      
        1 agaggtcacg agatcaagga tctggaaccc tgaggtgtgc acagcgctgg gatgccaggt
       61 tcggcctcga agcggaggat ccctgtgtcc cagccgggca tggccgaccc ccaccagctt
      121 ttcgatgaca caagttcagc ccagagccgg ggctatgggg cccagcgggc acctggtggc
      181 ctgagttatc ctgcagcctc tcccacgccc catgcagcct tcctggctga cccggtgtcc
      241 aacatggcca tggcctatgg gagcagcctg gccgcgcagg gcaaggagct ggtggataag
      301 aacatcgacc gcttcatccc catcaccaag ctcaagtatt actttgctgt ggacaccatg
      361 tatgtgggca gaaagctggg cctgctgttc ttcccctacc tacaccagga ctgggaagtg
      421 cagtaccaac aggacacccc ggtggccccc cgctttgacg tcaatgcccc ggacctctac
      481 attccagcaa tggctttcat cacctacgtt ttggtggctg gtcttgcgct ggggacccag
      541 gataggttct ccccagacct cctggggctg caagcgagct cagccctggc ctggctgacc
      601 ctggaggtgc tggccatcct gctcagcctc tatctggtca ctgtcaacac cgacctcacc
      661 accatcgacc tggtggcctt cttgggctac aaatatgtcg ggatgattgg cggggtcctc
      721 atgggcctgc tcttcgggaa gattggctac tacctggtgc tgggctggtg ctgcgtagcc
      781 atctttgtgt tcatgatccg gacgctgcgg ctgaagatct tggcagacgc agcagctgag
      841 ggggtcccgg tgcgtggggc ccggaaccag ctgcgcatgt acctgaccat ggcggtggcg
      901 gcggcgcagc ctatgctcat gtactggctc accttccacc tggtgcggtg agcgcgcccg
      961 ctgaacctcc cgctgctgct gctgctgctg ggggccactg tggccgccga actcatctcc
     1021 tgcctgcagg ccccaaggtc caccctgtct ggccacaggc accgcctcca tcccatgtcc
     1081 cgcccagccc cgcccccaac ccaaggtgct gagagatctc cagctgcaca ggccaccgcc
     1141 ccagggcgtg gccgctgtta cagaaacaat aaaccctgat gggcatggcg tggacagcct
     1201 ctccttggcc tcgcgcacga atgggcgggc ccagcgctgg gcagggggca gggagctggg
     1261 gacgggccag agtaggcacc acgctgacca gtcgcagaag gcagagagga aggtttaatg
     1321 agccctgtcc agggcccttc agtggggagc ctccttcttc ttgcccttct ccttcttgcc
     1381 cttctccttc ttcttcactt tgggcttctt ggccttgccc gggatgctct cgtgctgctt
     1441 ggagccagca gcgtgggact gtggggccga gggcagggat gggagagaag agatggttct
     1501 gggctggaag cgagacaggg ggaccactcc ccgcaccctc cccgccagcc ccagtgcggg
     1561 gacgcctctc tggggtgcag ggcacgtgct tggggacgct ggcgagagcc ccttaccttc
     1621 acatccgtgt ccgaatcgct ggagctgctg ctggagtcgg aagagctgtg gtgtccttgc
     1681 tggatggagg tgcggcagtg aggcggcgcc ccttacccag ccccctgaag ttggaggcct
     1741 aaggcaggac cctggggtca ggggcaaccc cagccttccc gcccctccgc agccggtgat
     1801 gaggcgactt acctttggac ccggacctgc ccctgcctcc gaccggccct gaactttgtg
     1861 gggactgagc ttgggatctc ccccgtggcc cgcccccaca ccgggcttct gggaggtggg
     1921 ctccagggct gtggagagaa gttgggtggt tggtgcaggc agcttctggg cttgagtccg
     1981 gccccctgca cctccagtcc acactcccca ggagctcacc tgctcccagg tcgaactcca
     2041 tggcggtaag agaagttggg tcctaaggcc aagggcgcct gggccctgca gaggagcgga
     2101 gcagggggag gagcgctgag acctgcccgt tggaggaatg ctgagacgcc ccacccaacc
     2161 tctgtcctgg tcctcagccc tgactcattg cccggcacca cccaggattt cctctgtgag
     2221 aagtggggga gatggacagg tgactgcttc cgccagcctt ggtgcctcag gggaggccga
     2281 ctgagggggg ctctgtggat ggcattcggg gagctacagg tttcccccaa aagctcagat
     2341 gctcgttctt gaagagggag gtgctgcccc tgccttcctg cgtaccgcga caatacagct
     2401 tcctccgcgg cgctttaaca cgcagggcgc tgctgccagg ggcgtcccgt gttctaactc
     2461 gctcccacag cccctccggc ttggtgagca gcgtctgagg ggtgaggggc atagacttgg
     2521 agccagcctg ctgcactaga tgccagctgt gtcacttagc agcaaggtga cctcagcaaa
     2581 gttgttttac ctctgtgcct cagtttcctc atctgtaaat aacagctacc catgggattg
     2641 atgtgaaagt cagaggagtt aatttcctag aatggtgtct ggcatgaagt actgataatg
     2701 tgttggtttt ttaaaaaata aaaggtaggt gttttaggcc agtca
//
