LOCUS       NM_020470               1097 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens Yip1 interacting factor homolog A, membrane
            trafficking protein (YIF1A), transcript variant 1, mRNA.
ACCESSION   NM_020470
VERSION     NM_020470.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1097)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 1097)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 1097)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1097)
  AUTHORS   Sokolina,K., Kittanakom,S., Snider,J., Kotlyar,M., Maurice,P.,
            Gandia,J., Benleulmi-Chaachoua,A., Tadagaki,K., Oishi,A., Wong,V.,
            Malty,R.H., Deineko,V., Aoki,H., Amin,S., Yao,Z., Morato,X.,
            Otasek,D., Kobayashi,H., Menendez,J., Auerbach,D., Angers,S.,
            Przulj,N., Bouvier,M., Babu,M., Ciruela,F., Jockers,R., Jurisica,I.
            and Stagljar,I.
  TITLE     Systematic protein-protein interaction mapping for clinically
            relevant human GPCRs
  JOURNAL   Mol Syst Biol 13 (3), 918 (2017)
   PUBMED   28298427
  REMARK    Erratum:[Mol Syst Biol. 2025 Feb;21(2):208-209. doi:
            10.1038/s44320-024-00080-3.. PMID: 39762653]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1097)
  AUTHORS   Gupta,G.D., Coyaud,E., Goncalves,J., Mojarad,B.A., Liu,Y., Wu,Q.,
            Gheiratmand,L., Comartin,D., Tkach,J.M., Cheung,S.W., Bashkurov,M.,
            Hasegan,M., Knight,J.D., Lin,Z.Y., Schueler,M., Hildebrandt,F.,
            Moffat,J., Gingras,A.C., Raught,B. and Pelletier,L.
  TITLE     A Dynamic Protein Interaction Landscape of the Human
            Centrosome-Cilium Interface
  JOURNAL   Cell 163 (6), 1484-1499 (2015)
   PUBMED   26638075
REFERENCE   6  (bases 1 to 1097)
  AUTHORS   Breuza,L., Halbeisen,R., Jeno,P., Otte,S., Barlowe,C., Hong,W. and
            Hauri,H.P.
  TITLE     Proteomics of endoplasmic reticulum-Golgi intermediate compartment
            (ERGIC) membranes from brefeldin A-treated HepG2 cells identifies
            ERGIC-32, a new cycling protein that interacts with human Erv46
  JOURNAL   J Biol Chem 279 (45), 47242-47253 (2004)
   PUBMED   15308636
REFERENCE   7  (bases 1 to 1097)
  AUTHORS   Calero,M., Winand,N.J. and Collins,R.N.
  TITLE     Identification of the novel proteins Yip4p and Yip5p as Rab GTPase
            interacting factors
  JOURNAL   FEBS Lett 515 (1-3), 89-98 (2002)
   PUBMED   11943201
REFERENCE   8  (bases 1 to 1097)
  AUTHORS   Gisler,S.M., Stagljar,I., Traebert,M., Bacic,D., Biber,J. and
            Murer,H.
  TITLE     Interaction of the type IIa Na/Pi cotransporter with PDZ proteins
  JOURNAL   J Biol Chem 276 (12), 9206-9213 (2001)
   PUBMED   11099500
REFERENCE   9  (bases 1 to 1097)
  AUTHORS   Matern,H., Yang,X., Andrulis,E., Sternglanz,R., Trepte,H.H. and
            Gallwitz,D.
  TITLE     A novel Golgi membrane protein is part of a GTPase-binding protein
            complex involved in vesicle targeting
  JOURNAL   EMBO J 19 (17), 4485-4492 (2000)
   PUBMED   10970842
REFERENCE   10 (bases 1 to 1097)
  AUTHORS   Vitale,G., Alexandrov,K., Ullrich,O., Horiuchi,H., Giner,A.,
            Dobson,C., Baykova,O., Gournier,H., Stenmark,H. and Zerial,M.
  TITLE     The GDP/GTP cycle of Rab5 in the regulation of endocytotic membrane
            traffic
  JOURNAL   Cold Spring Harb Symp Quant Biol 60, 211-220 (1995)
   PUBMED   8824393
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK291124.1, BC001299.1 and BC009892.2.
            
            On Nov 22, 2018 this sequence version replaced NM_020470.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK226003.1, AK291124.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000376901.9/ ENSP00000366098.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-320               AK291124.1         3-322
            321-1096            BC001299.1         296-1071
            1097-1097           BC009892.2         548-548
FEATURES             Location/Qualifiers
     source          1..1097
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.2"
     gene            1..1097
                     /gene="YIF1A"
                     /gene_synonym="54TM; FinGER7; YIF1; YIF1P"
                     /note="Yip1 interacting factor homolog A, membrane
                     trafficking protein"
                     /db_xref="GeneID:10897"
                     /db_xref="HGNC:HGNC:16688"
                     /db_xref="MIM:611484"
     exon            1..189
                     /gene="YIF1A"
                     /gene_synonym="54TM; FinGER7; YIF1; YIF1P"
                     /inference="alignment:Splign:2.1.0"
     CDS             159..1040
                     /gene="YIF1A"
                     /gene_synonym="54TM; FinGER7; YIF1; YIF1P"
                     /note="isoform 1 is encoded by transcript variant 1;
                     Yip1p-interacting factor; protein YIF1A; putative
                     Rab5-interacting protein; putative transmembrane protein
                     54TMp; YIP1-interacting factor homolog A"
                     /codon_start=1
                     /product="protein YIF1A isoform 1"
                     /protein_id="NP_065203.2"
                     /db_xref="CCDS:CCDS8132.1"
                     /db_xref="GeneID:10897"
                     /db_xref="HGNC:HGNC:16688"
                     /db_xref="MIM:611484"
                     /translation="MAYHSGYGAHGSKHRARAAPDPPPLFDDTSGGYSSQPGGYPATG
                     ADVAFSVNHLLGDPMANVAMAYGSSIASHGKDMVHKELHRFVSVSKLKYFFAVDTAYV
                     AKKLGLLVFPYTHQNWEVQYSRDAPLPPRQDLNAPDLYIPTMAFITYVLLAGMALGIQ
                     KRFSPEVLGLCASTALVWVVMEVLALLLGLYLATVRSDLSTFHLLAYSGYKYVGMILS
                     VLTGLLFGSDGYYVALAWTSSALMYFIVRSLRTAALGPDSMGGPVPRQRLQLYLTLGA
                     AAFQPLIIYWLTFHLVR"
     exon            190..401
                     /gene="YIF1A"
                     /gene_synonym="54TM; FinGER7; YIF1; YIF1P"
                     /inference="alignment:Splign:2.1.0"
     exon            402..506
                     /gene="YIF1A"
                     /gene_synonym="54TM; FinGER7; YIF1; YIF1P"
                     /inference="alignment:Splign:2.1.0"
     exon            507..585
                     /gene="YIF1A"
                     /gene_synonym="54TM; FinGER7; YIF1; YIF1P"
                     /inference="alignment:Splign:2.1.0"
     exon            586..643
                     /gene="YIF1A"
                     /gene_synonym="54TM; FinGER7; YIF1; YIF1P"
                     /inference="alignment:Splign:2.1.0"
     exon            644..799
                     /gene="YIF1A"
                     /gene_synonym="54TM; FinGER7; YIF1; YIF1P"
                     /inference="alignment:Splign:2.1.0"
     exon            800..893
                     /gene="YIF1A"
                     /gene_synonym="54TM; FinGER7; YIF1; YIF1P"
                     /inference="alignment:Splign:2.1.0"
     exon            894..1097
                     /gene="YIF1A"
                     /gene_synonym="54TM; FinGER7; YIF1; YIF1P"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1097
                     /gene="YIF1A"
                     /gene_synonym="54TM; FinGER7; YIF1; YIF1P"
                     /note="major polyA site"
ORIGIN      
        1 gacgccacgg acatggtggc cgagaccggc ggggtggggg acgtgtcgcg cggccgggtg
       61 gcctcggtcg gtaccctggg cgcggagcag ctgcctcatt agtattcgta cccacgaggc
      121 ggcgcagcgg gccctcgggg acagcgagcg tcgcggccat ggcttatcac tcgggctacg
      181 gagcccacgg ctccaagcac agggcccggg cagccccgga tccccctccc ctcttcgatg
      241 acacaagcgg tggttattcc agccagcccg ggggataccc agccacagga gcagacgtgg
      301 ccttcagtgt caaccacttg cttggggacc caatggccaa tgtggctatg gcctatggca
      361 gctccatcgc atcccatggg aaggacatgg tgcacaagga gctgcaccgt tttgtgtctg
      421 tgagcaaact caagtatttt tttgctgtgg acacagccta cgtggccaag aagctagggc
      481 tgctggtctt cccctacaca caccagaact gggaagtgca gtacagtcgt gatgctcctc
      541 tgcccccccg gcaagacctc aacgcccctg acctctatat ccccacgatg gccttcatta
      601 cttacgtgct cctggctggg atggcactgg gcattcagaa aaggttctcc ccggaggtgc
      661 tgggcctgtg tgcaagcaca gcgctggtgt gggtggtgat ggaggtgctg gccctgctcc
      721 tgggcctcta cctggccacc gtgcgcagtg acctgagcac ctttcacctg ctggcctaca
      781 gtggctacaa atacgtggga atgatcctca gtgtgctcac ggggctgctg ttcggcagcg
      841 atggctacta cgtggcgctg gcctggacct catcggcgct catgtacttc attgtgcgct
      901 ctttgcggac agcagccctg ggccccgaca gcatgggggg ccccgtcccc cggcagcgtc
      961 tccagctcta cctgactctg ggagctgcag ccttccagcc cctcatcata tactggctga
     1021 ctttccacct ggtccggtga ccccctggcc ccagatggca ctgagttttt cattcattga
     1081 agatttgatt tccttga
//
