LOCUS       NM_005433               4605 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens YES proto-oncogene 1, Src family tyrosine kinase
            (YES1), mRNA.
ACCESSION   NM_005433
VERSION     NM_005433.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4605)
  AUTHORS   Barros,P., Matos,A.M., Matos,P. and Jordan,P.
  TITLE     YES1 Kinase Mediates the Membrane Removal of Rescued F508del-CFTR
            in Airway Cells by Promoting MAPK Pathway Activation via SHC1
  JOURNAL   Biomolecules 13 (6), 949 (2023)
   PUBMED   37371529
  REMARK    GeneRIF: YES1 Kinase Mediates the Membrane Removal of Rescued
            F508del-CFTR in Airway Cells by Promoting MAPK Pathway Activation
            via SHC1.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4605)
  AUTHORS   Jin,M., Wang,Y., Zhou,D., Liu,W., Han,R. and Chi,Y.
  TITLE     Downregulation of circ-YES1 suppresses NSCLC migration and
            proliferation through the miR-142-3p-HMGB1 axis
  JOURNAL   Respir Res 24 (1), 100 (2023)
   PUBMED   37009887
  REMARK    GeneRIF: Downregulation of circ-YES1 suppresses NSCLC migration and
            proliferation through the miR-142-3p-HMGB1 axis.
            Erratum:[Respir Res. 2023 Jul 10;24(1):181. doi:
            10.1186/s12931-023-02468-5.. PMID: 37424028]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4605)
  AUTHORS   Redin,E., Garrido-Martin,E.M., Valencia,K., Redrado,M.,
            Solorzano,J.L., Carias,R., Echepare,M., Exposito,F., Serrano,D.,
            Ferrer,I., Nunez-Buiza,A., Garmendia,I., Garcia-Pedrero,J.M.,
            Gurpide,A., Paz-Ares,L., Politi,K., Montuenga,L.M. and Calvo,A.
  TITLE     YES1 Is a Druggable Oncogenic Target in SCLC
  JOURNAL   J Thorac Oncol 17 (12), 1387-1403 (2022)
   PUBMED   35988891
  REMARK    GeneRIF: YES1 Is a Druggable Oncogenic Target in SCLC.
REFERENCE   4  (bases 1 to 4605)
  AUTHORS   Murphy,R., Irnaten,M., Hopkins,A., O'Callaghan,J., Stamer,W.D.,
            Clark,A.F., Wallace,D. and O'Brien,C.J.
  TITLE     Matrix Mechanotransduction via Yes-Associated Protein in Human
            Lamina Cribrosa Cells in Glaucoma
  JOURNAL   Invest Ophthalmol Vis Sci 63 (1), 16 (2022)
   PUBMED   35015027
  REMARK    GeneRIF: Matrix Mechanotransduction via Yes-Associated Protein in
            Human Lamina Cribrosa Cells in Glaucoma.
REFERENCE   5  (bases 1 to 4605)
  AUTHORS   Benz,C., Ali,M., Krystkowiak,I., Simonetti,L., Sayadi,A.,
            Mihalic,F., Kliche,J., Andersson,E., Jemth,P., Davey,N.E. and
            Ivarsson,Y.
  TITLE     Proteome-scale mapping of binding sites in the unstructured regions
            of the human proteome
  JOURNAL   Mol Syst Biol 18 (1), e10584 (2022)
   PUBMED   35044719
REFERENCE   6  (bases 1 to 4605)
  AUTHORS   Alai,M., Mui,A.L., Cutler,R.L., Bustelo,X.R., Barbacid,M. and
            Krystal,G.
  TITLE     Steel factor stimulates the tyrosine phosphorylation of the
            proto-oncogene product, p95vav, in human hemopoietic cells
  JOURNAL   J Biol Chem 267 (25), 18021-18025 (1992)
   PUBMED   1381360
REFERENCE   7  (bases 1 to 4605)
  AUTHORS   Cichowski,K., McCormick,F. and Brugge,J.S.
  TITLE     p21rasGAP association with Fyn, Lyn, and Yes in thrombin-activated
            platelets
  JOURNAL   J Biol Chem 267 (8), 5025-5028 (1992)
   PUBMED   1544885
REFERENCE   8  (bases 1 to 4605)
  AUTHORS   Brickell,P.M.
  TITLE     The p60c-src family of protein-tyrosine kinases: structure,
            regulation, and function
  JOURNAL   Crit Rev Oncog 3 (4), 401-446 (1992)
   PUBMED   1384720
  REMARK    Review article
REFERENCE   9  (bases 1 to 4605)
  AUTHORS   Holtrich,U., Brauninger,A., Strebhardt,K. and Rubsamen-Waigmann,H.
  TITLE     Two additional protein-tyrosine kinases expressed in human lung:
            fourth member of the fibroblast growth factor receptor family and
            an intracellular protein-tyrosine kinase
  JOURNAL   Proc Natl Acad Sci U S A 88 (23), 10411-10415 (1991)
   PUBMED   1720539
REFERENCE   10 (bases 1 to 4605)
  AUTHORS   Huang,M.M., Bolen,J.B., Barnwell,J.W., Shattil,S.J. and Brugge,J.S.
  TITLE     Membrane glycoprotein IV (CD36) is physically associated with the
            Fyn, Lyn, and Yes protein-tyrosine kinases in human platelets
  JOURNAL   Proc Natl Acad Sci U S A 88 (17), 7844-7848 (1991)
   PUBMED   1715582
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP000894.6, AP001020.4 and
            AP001178.4.
            
            On Nov 23, 2018 this sequence version replaced NM_005433.3.
            
            Summary: This gene is the cellular homolog of the Yamaguchi sarcoma
            virus oncogene. The encoded protein has tyrosine kinase activity
            and belongs to the src family of proteins. This gene lies in close
            proximity to thymidylate synthase gene on chromosome 18, and a
            corresponding pseudogene has been found on chromosome 22. [provided
            by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.64204.1, BC048960.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000314574.5/ ENSP00000324740.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-129               AP000894.6         16918-17046         c
            130-408             AP001020.4         34227-34505         c
            409-508             AP001020.4         29375-29474         c
            509-607             AP001020.4         25590-25688         c
            608-711             AP001020.4         23618-23721         c
            712-861             AP001020.4         23378-23527         c
            862-1017            AP001020.4         20930-21085         c
            1018-1197           AP001020.4         20588-20767         c
            1198-1274           AP001020.4         17405-17481         c
            1275-1428           AP001020.4         14478-14631         c
            1429-1560           AP001020.4         10504-10635         c
            1561-4605           AP001178.4         149274-152318       c
FEATURES             Location/Qualifiers
     source          1..4605
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18p11.32"
     gene            1..4605
                     /gene="YES1"
                     /gene_synonym="c-yes; HsT441; P61-YES; Yes"
                     /note="YES proto-oncogene 1, Src family tyrosine kinase"
                     /db_xref="GeneID:7525"
                     /db_xref="HGNC:HGNC:12841"
                     /db_xref="MIM:164880"
     exon            1..129
                     /gene="YES1"
                     /gene_synonym="c-yes; HsT441; P61-YES; Yes"
                     /inference="alignment:Splign:2.1.0"
     exon            130..408
                     /gene="YES1"
                     /gene_synonym="c-yes; HsT441; P61-YES; Yes"
                     /inference="alignment:Splign:2.1.0"
     CDS             138..1769
                     /gene="YES1"
                     /gene_synonym="c-yes; HsT441; P61-YES; Yes"
                     /EC_number="2.7.10.2"
                     /note="Yamaguchi sarcoma oncogene; cellular yes-1 protein;
                     proto-oncogene tyrosine-protein kinase YES; proto-oncogene
                     c-Yes; v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1;
                     YES1 proto-oncogene, Src family tyrosine kinase"
                     /codon_start=1
                     /product="tyrosine-protein kinase Yes"
                     /protein_id="NP_005424.1"
                     /db_xref="CCDS:CCDS11824.1"
                     /db_xref="GeneID:7525"
                     /db_xref="HGNC:HGNC:12841"
                     /db_xref="MIM:164880"
                     /translation="MGCIKSKENKSPAIKYRPENTPEPVSTSVSHYGAEPTTVSPCPS
                     SSAKGTAVNFSSLSMTPFGGSSGVTPFGGASSSFSVVPSSYPAGLTGGVTIFVALYDY
                     EARTTEDLSFKKGERFQIINNTEGDWWEARSIATGKNGYIPSNYVAPADSIQAEEWYF
                     GKMGRKDAERLLLNPGNQRGIFLVRESETTKGAYSLSIRDWDEIRGDNVKHYKIRKLD
                     NGGYYITTRAQFDTLQKLVKHYTEHADGLCHKLTTVCPTVKPQTQGLAKDAWEIPRES
                     LRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVP
                     LYAVVSEEPIYIVTEFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIERMNY
                     IHRDLRAANILVGENLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFT
                     IKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHELMNLC
                     WKKDPDERPTFEYIQSFLEDYFTATEPQYQPGENL"
     exon            409..508
                     /gene="YES1"
                     /gene_synonym="c-yes; HsT441; P61-YES; Yes"
                     /inference="alignment:Splign:2.1.0"
     exon            509..607
                     /gene="YES1"
                     /gene_synonym="c-yes; HsT441; P61-YES; Yes"
                     /inference="alignment:Splign:2.1.0"
     exon            608..711
                     /gene="YES1"
                     /gene_synonym="c-yes; HsT441; P61-YES; Yes"
                     /inference="alignment:Splign:2.1.0"
     exon            712..861
                     /gene="YES1"
                     /gene_synonym="c-yes; HsT441; P61-YES; Yes"
                     /inference="alignment:Splign:2.1.0"
     exon            862..1017
                     /gene="YES1"
                     /gene_synonym="c-yes; HsT441; P61-YES; Yes"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1197
                     /gene="YES1"
                     /gene_synonym="c-yes; HsT441; P61-YES; Yes"
                     /inference="alignment:Splign:2.1.0"
     exon            1198..1274
                     /gene="YES1"
                     /gene_synonym="c-yes; HsT441; P61-YES; Yes"
                     /inference="alignment:Splign:2.1.0"
     exon            1275..1428
                     /gene="YES1"
                     /gene_synonym="c-yes; HsT441; P61-YES; Yes"
                     /inference="alignment:Splign:2.1.0"
     exon            1429..1560
                     /gene="YES1"
                     /gene_synonym="c-yes; HsT441; P61-YES; Yes"
                     /inference="alignment:Splign:2.1.0"
     exon            1561..4605
                     /gene="YES1"
                     /gene_synonym="c-yes; HsT441; P61-YES; Yes"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4421..4426
                     /regulatory_class="polyA_signal_sequence"
                     /gene="YES1"
                     /gene_synonym="c-yes; HsT441; P61-YES; Yes"
                     /note="hexamer: AATAAA"
     polyA_site      4444
                     /gene="YES1"
                     /gene_synonym="c-yes; HsT441; P61-YES; Yes"
                     /note="major polyA site"
     regulatory      4579..4584
                     /regulatory_class="polyA_signal_sequence"
                     /gene="YES1"
                     /gene_synonym="c-yes; HsT441; P61-YES; Yes"
                     /note="hexamer: ATTAAA"
     polyA_site      4605
                     /gene="YES1"
                     /gene_synonym="c-yes; HsT441; P61-YES; Yes"
ORIGIN      
        1 gtcgttgctg ccgccgggcg ccccgggacg aggaggtgga ggagggagag ggcccgcggg
       61 cctcgcctcc gccctccgcc acctcgagct gcggtagcag cgactcatga gagcgcggcc
      121 ggaggacaga tttgataatg ggctgcatta aaagtaaaga aaacaaaagt ccagccatta
      181 aatacagacc tgaaaatact ccagagcctg tcagtacaag tgtgagccat tatggagcag
      241 aacccactac agtgtcacca tgtccgtcat cttcagcaaa gggaacagca gttaatttca
      301 gcagtctttc catgacacca tttggaggat cctcaggggt aacgcctttt ggaggtgcat
      361 cttcctcatt ttcagtggtg ccaagttcat atcctgctgg tttaacaggt ggtgttacta
      421 tatttgtggc cttatatgat tatgaagcta gaactacaga agacctttca tttaagaagg
      481 gtgaaagatt tcaaataatt aacaatacgg aaggagattg gtgggaagca agatcaatcg
      541 ctacaggaaa gaatggttat atcccgagca attatgtagc gcctgcagat tccattcagg
      601 cagaagaatg gtattttggc aaaatgggga gaaaagatgc tgaaagatta cttttgaatc
      661 ctggaaatca acgaggtatt ttcttagtaa gagagagtga aacaactaaa ggtgcttatt
      721 ccctttctat tcgtgattgg gatgagataa ggggtgacaa tgtgaaacac tacaaaatta
      781 ggaaacttga caatggtgga tactatatca caaccagagc acaatttgat actctgcaga
      841 aattggtgaa acactacaca gaacatgctg atggtttatg ccacaagttg acaactgtgt
      901 gtccaactgt gaaacctcag actcaaggtc tagcaaaaga tgcttgggaa atccctcgag
      961 aatctttgcg actagaggtt aaactaggac aaggatgttt cggcgaagtg tggatgggaa
     1021 catggaatgg aaccacgaaa gtagcaatca aaacactaaa accaggtaca atgatgccag
     1081 aagctttcct tcaagaagct cagataatga aaaaattaag acatgataaa cttgttccac
     1141 tatatgctgt tgtttctgaa gaaccaattt acattgtcac tgaatttatg tcaaaaggaa
     1201 gcttattaga tttccttaag gaaggagatg gaaagtattt gaagcttcca cagctggttg
     1261 atatggctgc tcagattgct gatggtatgg catatattga aagaatgaac tatattcacc
     1321 gagatcttcg ggctgctaat attcttgtag gagaaaatct tgtgtgcaaa atagcagact
     1381 ttggtttagc aaggttaatt gaagacaatg aatacacagc aagacaaggt gcaaaatttc
     1441 caatcaaatg gacagctcct gaagctgcac tgtatggtcg gtttacaata aagtctgatg
     1501 tctggtcatt tggaattctg caaacagaac tagtaacaaa gggccgagtg ccatatccag
     1561 gtatggtgaa ccgtgaagta ttagaacaag tggagcgagg atacaggatg ccgtgccctc
     1621 agggctgtcc agaatccctc catgaattga tgaatctgtg ttggaagaag gaccctgatg
     1681 aaagaccaac atttgaatat attcagtcct tcttggaaga ctacttcact gctacagagc
     1741 cacagtacca gccaggagaa aatttataat tcaagtagcc tattttatat gcacaaatct
     1801 gccaaaatat aaagaacttg tgtagatttt ctacaggaat caaaagaaga aaatcttctt
     1861 tactctgcat gtttttaatg gtaaactgga atcccagata tggttgcaca aaaccacttt
     1921 tttttcccca agtattaaac tctaatgtac caatgatgaa tttatcagcg tatttcaggg
     1981 tccaaacaaa atagagctaa gatactgatg acagtgtggg tgacagcatg gtaatgaagg
     2041 acagtgaggc tcctgcttat ttataaatca tttcctttct ttttttcccc aaagtcagaa
     2101 ttgctcaaag aaaattattt attgttacag ataaaacttg agagataaaa agctatacca
     2161 taataaaatc taaaattaag gaatatcatg ggaccaaata attccattcc agttttttaa
     2221 agtttcttgc atttattatt ctcaaaagtt ttttctaagt taaacagtca gtatgcaatc
     2281 ttaatatatg ctttcttttg catggacatg ggccaggttt ttcaaaagga atataaacag
     2341 gatctcaaac ttgattaaat gttagaccac agaagtggaa tttgaaagta taatgcagta
     2401 cattaatatt catgttcatg gaactgaaag aataagaact ttttcacttc agtccttttc
     2461 tgaagagttt gacttagaat aatgaaggta actagaaagt gagttaatct tgtatgaggt
     2521 tgcattgatt ttttaaggca atatataatt gaaactactg tccaatcaaa ggggaaatgt
     2581 tttgatcttt agatagcatg caaagtaaga cccagcattt taaaagccct ttttaaaaac
     2641 tagacttcgt actgtgagta ttgcttatat gtccttatgg ggatgggtgc cacaaataga
     2701 aaatatgacc agatcaggga cttgaatgca cttttgctca tggtgaatat agatgaacag
     2761 agaggaaaat gtatttaaaa gaaatacgag aaaagaaagt gaaagtttta caagttagag
     2821 ggatggaagg taatgtttaa tgttgatgtc atggagtgac agaatggctt tgctggcact
     2881 cagagctcct cacttagcta tattctgaga ctttgaagag ttataaagta taactataaa
     2941 actaattttt cttacacact aaatgggtat ttgttcaaaa taatgaagtt atggcttcac
     3001 attcattgca gtgggatatg gtttttatgt aaaacatttt tagaactcca gttttcaaat
     3061 catgtttgaa tctacattca cttttttttg ttttcttttt tgagacggag tctcgctctg
     3121 tcgcccaggc tggagtgcag tggcgcgatc tcggctcact gcaagctctg cctcccaggt
     3181 tcacaccatt ctcctgcctc agcctcccga gtagctggga ctacaggtgc ccaccaccac
     3241 gcctggctag ttttttgtat ttttagtaga gacgcagttt caccgtgtta gccaggatag
     3301 tctcgatctc ctgaccttgt gatctgcccg cctcggcctc ccaaagtgct gggattacag
     3361 gcgtgagcca ccgcgcccag cctacattca cttctaaagt ctatgtaatg gtggtcattt
     3421 tttccctttt agaatacatt aaatggttga tttggggagg aaaacttatt ctgaatatta
     3481 acggtggtga aaaggggaca gtttttaccc taaagtgcaa aagtgaaaca tacaaaataa
     3541 gactaatttt taagagtaac tcagtaattt caaaatacag atttgaatag cagcattagt
     3601 ggtttgagtg tctagcaaag gaaaaattga tgaataaaat gaaggtctgg tgtatatgtt
     3661 ttaaaatact ctcatatagt cacactttaa attaagcctt atattaggcc cctctatttt
     3721 caggatataa ttcttaacta tcattattta cctgatttta atcatcagat tcgaaattct
     3781 gtgccatggc atatatgttc aaattcaaac catttttaaa atgtgaagat ggacttcatg
     3841 caagttggca gtggttctgg tactaaaaat tgtggttgtt ttttctgttt acgtaacctg
     3901 cttagtattg acactctcta ccaagagggt cttcctaaga agagtgctgt cattatttcc
     3961 tcttatcaac aacttgtgac atgagatttt ttaagggctt tatgtgaact atgatattgt
     4021 aatttttcta agcatattca aaagggtgac aaaattacgt ttatgtacta aatctaatca
     4081 ggaaagtaag gcaggaaaag ttgatggtat tcattaggtt ttaactgaat ggagcagttc
     4141 cttatataat aacaattgta tagtagggat aaaacactaa cttaatgtgt attcatttta
     4201 aattgttctg tatttttaaa ttgccaagaa aaacaacttt gtaaatttgg agatattttc
     4261 caacagcttt tcgtcttcag tgtcttaatg tggaagttaa cccttaccaa aaaaggaagt
     4321 tggcaaaaac agccttctag cacacttttt taaatgaata atggtagcct aaacttaata
     4381 tttttataaa gtattgtaat attgttttgt ggataattga aataaaaagt tctcattgaa
     4441 tgcacctatt aatcgtttta gttgctattc atattctcat tcgtttttta aaaactgata
     4501 tattctgaat ttattcttcc attgagaaaa aaatgttcag ttacttgtaa ctactgagca
     4561 gaatttaatc aatcctttat taaattcaga acattattga actca
//
