LOCUS       NM_006530               1468 bp    mRNA    linear   PRI 01-AUG-2024
DEFINITION  Homo sapiens YEATS domain containing 4 (YEATS4), transcript variant
            1, mRNA.
ACCESSION   NM_006530
VERSION     NM_006530.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1468)
  AUTHORS   Han,S., Cao,C., Liu,R., Yuan,Y., Pan,L., Xu,M., Hu,C., Zhang,X.,
            Li,M. and Zhang,X.
  TITLE     GAS41 mediates proliferation and GEM chemoresistance via H2A.Z.2
            and Notch1 in pancreatic cancer
  JOURNAL   Cell Oncol (Dordr) 45 (3), 429-446 (2022)
   PUBMED   35503594
  REMARK    GeneRIF: GAS41 mediates proliferation and GEM chemoresistance via
            H2A.Z.2 and Notch1 in pancreatic cancer.
REFERENCE   2  (bases 1 to 1468)
  AUTHORS   Buljan,M., Ciuffa,R., van Drogen,A., Vichalkovski,A., Mehnert,M.,
            Rosenberger,G., Lee,S., Varjosalo,M., Pernas,L.E., Spegg,V.,
            Snijder,B., Aebersold,R. and Gstaiger,M.
  TITLE     Kinase Interaction Network Expands Functional and Disease Roles of
            Human Kinases
  JOURNAL   Mol Cell 79 (3), 504-520 (2020)
   PUBMED   32707033
REFERENCE   3  (bases 1 to 1468)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1468)
  AUTHORS   Cho,H.J., Li,H., Linhares,B.M., Kim,E., Ndoj,J., Miao,H.,
            Grembecka,J. and Cierpicki,T.
  TITLE     GAS41 Recognizes Diacetylated Histone H3 through a Bivalent Binding
            Mode
  JOURNAL   ACS Chem Biol 13 (9), 2739-2746 (2018)
   PUBMED   30071723
  REMARK    GeneRIF: This study determined the crystal structure of the GAS41
            YEATS domain with H3K23acK27ac to visualize the molecular basis of
            diacetylated histone binding. The results suggest a unique binding
            mode in which full-length GAS41 is a reader of diacetylated
            histones.
REFERENCE   5  (bases 1 to 1468)
  AUTHORS   Wang,Y., Jin,J., Chung,M.W.H., Feng,L., Sun,H. and Hao,Q.
  TITLE     Identification of the YEATS domain of GAS41 as a pH-dependent
            reader of histone succinylation
  JOURNAL   Proc Natl Acad Sci U S A 115 (10), 2365-2370 (2018)
   PUBMED   29463709
  REMARK    GeneRIF: Cellular and structural studies revealed that GAS41 is a
            histone lysine succinylation reader owing to a protonated histidine
            residue located inside the pocket.
REFERENCE   6  (bases 1 to 1468)
  AUTHORS   Debernardi,S., Bassini,A., Jones,L.K., Chaplin,T., Linder,B., de
            Bruijn,D.R., Meese,E. and Young,B.D.
  TITLE     The MLL fusion partner AF10 binds GAS41, a protein that interacts
            with the human SWI/SNF complex
  JOURNAL   Blood 99 (1), 275-281 (2002)
   PUBMED   11756182
REFERENCE   7  (bases 1 to 1468)
  AUTHORS   Munnia,A., Schutz,N., Romeike,B.F., Maldener,E., Glass,B., Maas,R.,
            Nastainczyk,W., Feiden,W., Fischer,U. and Meese,E.
  TITLE     Expression, cellular distribution and protein binding of the glioma
            amplified sequence (GAS41), a highly conserved putative
            transcription factor
  JOURNAL   Oncogene 20 (35), 4853-4863 (2001)
   PUBMED   11521196
REFERENCE   8  (bases 1 to 1468)
  AUTHORS   Harborth,J., Weber,K. and Osborn,M.
  TITLE     GAS41, a highly conserved protein in eukaryotic nuclei, binds to
            NuMA
  JOURNAL   J Biol Chem 275 (41), 31979-31985 (2000)
   PUBMED   10913114
REFERENCE   9  (bases 1 to 1468)
  AUTHORS   Fischer,U., Heckel,D., Michel,A., Janka,M., Hulsebos,T. and
            Meese,E.
  TITLE     Cloning of a novel transcription factor-like gene amplified in
            human glioma including astrocytoma grade I
  JOURNAL   Hum Mol Genet 6 (11), 1817-1822 (1997)
   PUBMED   9302258
REFERENCE   10 (bases 1 to 1468)
  AUTHORS   Gracia,E., Fischer,U., elKahloun,A., Trent,J.M., Meese,E. and
            Meltzer,P.S.
  TITLE     Isolation of genes amplified in human cancers by microdissection
            mediated cDNA capture
  JOURNAL   Hum Mol Genet 5 (5), 595-600 (1996)
   PUBMED   8733125
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DN915967.1, U61384.1,
            AC117502.4 and CK820576.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_006530.3.
            
            Summary: The protein encoded by this gene is found in the nucleoli.
            It has high sequence homology to human MLLT1, and yeast and human
            MLLT3 proteins. Both MLLT1 and MLLT3 proteins belong to a class of
            transcription factors, indicating that the encoded protein might
            also represent a transcription factor. This protein is thought to
            be required for RNA transcription. This gene has been shown to be
            amplified in tumors. Alternative splicing results in multiple
            transcript variants encoding different isoforms. [provided by
            RefSeq, Jul 2014].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.203888.1,
                                           SRR3476690.836038.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000247843.7/ ENSP00000247843.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-72                DN915967.1         35-106
            73-119              U61384.1           64-110
            120-120             AC117502.4         6967-6967
            121-1394            U61384.1           112-1385
            1395-1468           CK820576.1         9-82                c
FEATURES             Location/Qualifiers
     source          1..1468
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q15"
     gene            1..1468
                     /gene="YEATS4"
                     /gene_synonym="4930573H17Rik; B230215M10Rik; GAS41;
                     NUBI-1; YAF9"
                     /note="YEATS domain containing 4"
                     /db_xref="GeneID:8089"
                     /db_xref="HGNC:HGNC:24859"
                     /db_xref="MIM:602116"
     exon            1..281
                     /gene="YEATS4"
                     /gene_synonym="4930573H17Rik; B230215M10Rik; GAS41;
                     NUBI-1; YAF9"
                     /inference="alignment:Splign:2.1.0"
     CDS             231..914
                     /gene="YEATS4"
                     /gene_synonym="4930573H17Rik; B230215M10Rik; GAS41;
                     NUBI-1; YAF9"
                     /note="isoform 1 is encoded by transcript variant 1; NuMA
                     binding protein 1; nuBI1; glioma-amplified sequence 41"
                     /codon_start=1
                     /product="YEATS domain-containing protein 4 isoform 1"
                     /protein_id="NP_006521.1"
                     /db_xref="CCDS:CCDS8990.1"
                     /db_xref="GeneID:8089"
                     /db_xref="HGNC:HGNC:24859"
                     /db_xref="MIM:602116"
                     /translation="MFKRMAEFGPDSGGRVKGVTIVKPIVYGNVARYFGKKREEDGHT
                     HQWTVYVKPYRNEDMSAYVKKIQFKLHESYGNPLRVVTKPPYEITETGWGEFEIIIKI
                     FFIDPNERPVTLYHLLKLFQSDTNAMLGKKTVVSEFYDEMIFQDPTAMMQQLLTTSRQ
                     LTLGAYKHETEFAELEVKTREKLEAAKKKTSFEIAELKERLKASRETINCLKNEIRKL
                     EEDDQAKDI"
     exon            282..401
                     /gene="YEATS4"
                     /gene_synonym="4930573H17Rik; B230215M10Rik; GAS41;
                     NUBI-1; YAF9"
                     /inference="alignment:Splign:2.1.0"
     exon            402..468
                     /gene="YEATS4"
                     /gene_synonym="4930573H17Rik; B230215M10Rik; GAS41;
                     NUBI-1; YAF9"
                     /inference="alignment:Splign:2.1.0"
     exon            469..563
                     /gene="YEATS4"
                     /gene_synonym="4930573H17Rik; B230215M10Rik; GAS41;
                     NUBI-1; YAF9"
                     /inference="alignment:Splign:2.1.0"
     exon            564..656
                     /gene="YEATS4"
                     /gene_synonym="4930573H17Rik; B230215M10Rik; GAS41;
                     NUBI-1; YAF9"
                     /inference="alignment:Splign:2.1.0"
     exon            657..744
                     /gene="YEATS4"
                     /gene_synonym="4930573H17Rik; B230215M10Rik; GAS41;
                     NUBI-1; YAF9"
                     /inference="alignment:Splign:2.1.0"
     exon            745..1468
                     /gene="YEATS4"
                     /gene_synonym="4930573H17Rik; B230215M10Rik; GAS41;
                     NUBI-1; YAF9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1371..1376
                     /regulatory_class="polyA_signal_sequence"
                     /gene="YEATS4"
                     /gene_synonym="4930573H17Rik; B230215M10Rik; GAS41;
                     NUBI-1; YAF9"
                     /note="hexamer: AATAAA"
     polyA_site      1394
                     /gene="YEATS4"
                     /gene_synonym="4930573H17Rik; B230215M10Rik; GAS41;
                     NUBI-1; YAF9"
                     /note="major polyA site"
     regulatory      1448..1453
                     /regulatory_class="polyA_signal_sequence"
                     /gene="YEATS4"
                     /gene_synonym="4930573H17Rik; B230215M10Rik; GAS41;
                     NUBI-1; YAF9"
                     /note="hexamer: AATACA"
     polyA_site      1468
                     /gene="YEATS4"
                     /gene_synonym="4930573H17Rik; B230215M10Rik; GAS41;
                     NUBI-1; YAF9"
ORIGIN      
        1 ctcttttcgc ggcgttctcc acctgcgcgg gcctgaatgg ccttcaggag cacagtcggc
       61 ctgaggagtt gacggttact caccgccgtg agcccaagta actcgccctc cttcggctag
      121 aaaccctccg cctgggcccg cgcgacagga gcgcggtctc tgaggggagc ggcgaccccg
      181 ccagccccgg tctctttccc tggcggcggc ggcttcttcc gtgggacaat atgttcaaga
      241 gaatggccga atttgggcct gactccggcg ggagagtaaa gggtgttact atcgttaaac
      301 caatagttta cggtaatgtt gctcggtatt ttggaaagaa aagagaagaa gatgggcaca
      361 ctcatcagtg gacagtatat gtgaaaccat atagaaatga ggatatgtca gcatatgtga
      421 agaaaatcca gtttaaatta catgaaagct atggcaatcc tttaagagtt gttactaaac
      481 ctccatatga aattactgaa acaggatggg gtgaattcga aataatcatc aaaatatttt
      541 tcattgaccc taatgaaaga cctgtaaccc tgtatcattt gctaaagctg tttcaatcag
      601 acaccaatgc aatgctgggg aaaaagacag tggtttcaga gttctatgat gaaatgatat
      661 ttcaagaccc aacagcaatg atgcaacaat tattgacaac atctcgtcag ctaacattag
      721 gagcctataa gcatgaaaca gaatttgcag agcttgaagt gaaaaccaga gaaaaattag
      781 aagctgctaa gaaaaaaaca agctttgaga ttgcagagct taaggagaga ttaaaagcaa
      841 gtcgtgaaac tataaattgt ttaaaaaatg aaatcagaaa acttgaagaa gatgaccaag
      901 caaaagacat ataaacagtt ctcatgagaa cttggtagta agctaaactg aaaataaggt
      961 gggcttcact ggagaaatgg acttactgca aatgctgtga tgtttcttag aggaacttca
     1021 tatacagctg ttgaccatga atttcttagc aataggaatt tgtactattt aagcaatctt
     1081 taatggaaaa tatgtgtgta agaatggatg ctatataggt attttaccaa cccattttaa
     1141 gaaaattcta tgatattaag cacagttttt aaaaatgttt attgtagtat atgtatagct
     1201 tattaccctt ttgacaggca tcaaaatttc attataaagt attacttgta caaattttgt
     1261 acttctttag tggctagaat tagtgaagaa acttaatgtg tatatttaat ttcttcaagt
     1321 tcttacctgc ccccatcctt ttttgtatat gatgtgtcca gtaagtattc aataaatgta
     1381 gtttacagat cctatttctc cctcctgatg tgtttcttcc tctttgaaga ctttctggaa
     1441 ctccctcaat acagttaaag tatcttta
//
