LOCUS       NM_018023               6526 bp    mRNA    linear   PRI 23-JUL-2024
DEFINITION  Homo sapiens YEATS domain containing 2 (YEATS2), transcript variant
            3, mRNA.
ACCESSION   NM_018023
VERSION     NM_018023.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6526)
  AUTHORS   Wu,Q., Zheng,Q., Yuan,L., Gao,D., Hu,Y., Jiang,X., Zhai,Q., Liu,M.,
            Xu,L., Xu,H., Ye,J. and Zhang,F.
  TITLE     Repression of YEATS2 induces cellular senescence in hepatocellular
            carcinoma and inhibits tumor growth
  JOURNAL   Cell Cycle 23 (4), 478-494 (2024)
   PUBMED   38619971
  REMARK    GeneRIF: Repression of YEATS2 induces cellular senescence in
            hepatocellular carcinoma and inhibits tumor growth.
REFERENCE   2  (bases 1 to 6526)
  AUTHORS   Sheng,H., Zheng,F., Lan,T., Chen,H.F., Xu,C.Y., Wang,S.W.,
            Weng,Y.Y., Xu,L.F. and Zhang,F.
  TITLE     YEATS2 regulates the activation of TAK1/NF-kappaB pathway and is
            critical for pancreatic ductal adenocarcinoma cell survival
  JOURNAL   Cell Biol Toxicol 39 (3), 1-16 (2023)
   PUBMED   34686948
  REMARK    GeneRIF: YEATS2 regulates the activation of TAK1/NF-kappaB pathway
            and is critical for pancreatic ductal adenocarcinoma cell survival.
REFERENCE   3  (bases 1 to 6526)
  AUTHORS   Sha,T., Li,J., Sun,S., Li,J., Zhao,X., Li,Z. and Cui,Z.
  TITLE     YEATS domain-containing 2 (YEATS2), targeted by microRNA
            miR-378a-5p, regulates growth and metastasis in head and neck
            squamous cell carcinoma
  JOURNAL   Bioengineered 12 (1), 7286-7296 (2021)
   PUBMED   34587874
  REMARK    GeneRIF: YEATS domain-containing 2 (YEATS2), targeted by microRNA
            miR-378a-5p, regulates growth and metastasis in head and neck
            squamous cell carcinoma.
REFERENCE   4  (bases 1 to 6526)
  AUTHORS   Zeng,Z., Lei,S., He,Z., Chen,T. and Jiang,J.
  TITLE     YEATS2 is a target of HIF1alpha and promotes pancreatic cancer cell
            proliferation and migration
  JOURNAL   J Cell Physiol 236 (3), 2087-2098 (2021)
   PUBMED   32749678
  REMARK    GeneRIF: YEATS2 is a target of HIF1alpha and promotes pancreatic
            cancer cell proliferation and migration.
REFERENCE   5  (bases 1 to 6526)
  AUTHORS   Yeetong,P., Pongpanich,M., Srichomthong,C., Assawapitaksakul,A.,
            Shotelersuk,V., Tantirukdham,N., Chunharas,C., Suphapeetiporn,K.
            and Shotelersuk,V.
  TITLE     TTTCA repeat insertions in an intron of YEATS2 in benign adult
            familial myoclonic epilepsy type 4
  JOURNAL   Brain 142 (11), 3360-3366 (2019)
   PUBMED   31539032
  REMARK    GeneRIF: our findings suggest that benign adult familial myoclonic
            epilepsy type 4 is caused by the insertions of the intronic TTTCA
            repeats in YEATS2
REFERENCE   6  (bases 1 to 6526)
  AUTHORS   Nagy,Z., Riss,A., Fujiyama,S., Krebs,A., Orpinell,M., Jansen,P.,
            Cohen,A., Stunnenberg,H.G., Kato,S. and Tora,L.
  TITLE     The metazoan ATAC and SAGA coactivator HAT complexes regulate
            different sets of inducible target genes
  JOURNAL   Cell Mol Life Sci 67 (4), 611-628 (2010)
   PUBMED   19936620
REFERENCE   7  (bases 1 to 6526)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   8  (bases 1 to 6526)
  AUTHORS   Guelman,S., Kozuka,K., Mao,Y., Pham,V., Solloway,M.J., Wang,J.,
            Wu,J., Lill,J.R. and Zha,J.
  TITLE     The double-histone-acetyltransferase complex ATAC is essential for
            mammalian development
  JOURNAL   Mol Cell Biol 29 (5), 1176-1188 (2009)
   PUBMED   19103755
REFERENCE   9  (bases 1 to 6526)
  AUTHORS   Wang,Y.L., Faiola,F., Xu,M., Pan,S. and Martinez,E.
  TITLE     Human ATAC Is a GCN5/PCAF-containing acetylase complex with a novel
            NC2-like histone fold module that interacts with the TATA-binding
            protein
  JOURNAL   J Biol Chem 283 (49), 33808-33815 (2008)
   PUBMED   18838386
REFERENCE   10 (bases 1 to 6526)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC068769.19, BC150273.1,
            BC082270.1 and CA416892.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 24, 2018 this sequence version replaced NM_018023.4.
            
            Summary: Summary: The protein encoded by this gene is a scaffolding
            subunit of the ATAC complex, which is a complex with
            acetyltransferase activity on histones H3 and H4. Alternative
            splicing results in multiple transcript variants encoding different
            isoforms. [provided by RefSeq, May 2017].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC150273.1, AB033023.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000305135.10/ ENSP00000306983.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                AC068769.19        95835-95855         c
            22-3962             BC150273.1         1-3941
            3963-4555           BC082270.1         1247-1839
            4556-6522           BC150273.1         4535-6501
            6523-6526           CA416892.1         20-23               c
FEATURES             Location/Qualifiers
     source          1..6526
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q27.1"
     gene            1..6526
                     /gene="YEATS2"
                     /gene_synonym="FAME4"
                     /note="YEATS domain containing 2"
                     /db_xref="GeneID:55689"
                     /db_xref="HGNC:HGNC:25489"
                     /db_xref="MIM:613373"
     exon            1..197
                     /gene="YEATS2"
                     /gene_synonym="FAME4"
                     /inference="alignment:Splign:2.1.0"
     exon            198..316
                     /gene="YEATS2"
                     /gene_synonym="FAME4"
                     /inference="alignment:Splign:2.1.0"
     CDS             217..4485
                     /gene="YEATS2"
                     /gene_synonym="FAME4"
                     /note="isoform 3 is encoded by transcript variant 3; YEATS
                     domain-containing protein 2"
                     /codon_start=1
                     /product="YEATS domain-containing protein 2 isoform 3"
                     /protein_id="NP_060493.3"
                     /db_xref="CCDS:CCDS43175.1"
                     /db_xref="GeneID:55689"
                     /db_xref="HGNC:HGNC:25489"
                     /db_xref="MIM:613373"
                     /translation="MSGIKRTIKETDPDYEDVSVALPNKRHKAIENSARDAAVQKIET
                     IIKEQFALEMKNKEHEIEVIDQRLIEARRMMDKLRACIVANYYASAGLLKVSEGSKTC
                     DTMVFNHPAIKKFLESPSRSSSPANQRAETPSANHSESDSLSQHNDFLSDKDNNSNMD
                     IEERLSNNMEQRPSRNTGRDTSRITGSHKTEQRNADLTDETSRLFVKKTIVVGNVSKY
                     IPPDKREENDQSTHKWMVYVRGSRREPSINHFVKKVWFFLHPSYKPNDLVEVREPPFH
                     LTRRGWGEFPVRVQVHFKDSQNKRIDIIHNLKLDRTYTGLQTLGAETVVDVELHRHSL
                     GEDCIYPQSSESDISDAPPSLPLTIPAPVKASSPIKQSHEPVPDTSVEKGFPASTEAE
                     RHTPFYALPSSLERTPTKMTTSQKVTFCSHGNSAFQPIASSCKIVPQSQVPNPESPGK
                     SFQPITMSCKIVSGSPISTPSPSPLPRTPTSTPVHVKQGTAGSVINNPYVIMDKQPGQ
                     VIGATTPSTGSPTNKISTASQVSQGTGSPVPKIHGSSFVTSTVKQEDSLFASMPPLCP
                     IGSHPKVQSPKPITGGLGAFTKVIIKQEPGEAPHVPATGAASQSPLPQYVTVKGGHMI
                     AVSPQKQVITPGEGIAQSAKVQPSKVVGVPVGSALPSTVKQAVAISGGQILVAKASSS
                     VSKAVGPKQVVTQGVAKAIVSGGGGTIVAQPVQTLTKAQVTAAGPQKSGSQGSVMATL
                     QLPATNLANLANLPPGTKLYLTTNSKNPSGKGKLLLIPQGAILRATNNANLQSGSAAS
                     GGSGAGGGGGGGGGGGSGSGGGGSTGGGGGTAGGGTQSTAGPGGISQHLTYTSYILKQ
                     TPQGTFLVGQPSPQTSGKQLTTGSVVQGTLGVSTSSAQGQQTLKVISGQKTTLFTQAA
                     HGGQASLMKISDSTLKTVPATSQLSKPGTTMLRVAGGVITTATSPAVALSANGPAQQS
                     EGMAPVSSSTVSSVTKTSGQQQVCVSQATVGTCKAATPTVVSATSLVPTPNPISGKAT
                     VSGLLKIHSSQSSPQQAVLTIPSQLKPLSVNTSGGVQTILMPVNKVVQSFSTSKPPAI
                     LPVAAPTPVVPSSAPAAVAKVKTEPETPGPSCLSQEGQTAVKTEESSELGNYVIKIDH
                     LETIQQLLTAVVKKIPLITAKSEDASCFSAKSVEQYYGWNIGKRRAAEWQRAMTMRKV
                     LQEILEKNPRFHHLTPLKTKHIAHWCRCHGYTPPDPESLRNDGDSIEDVLTQIDSEPE
                     CPSSFSSADNLCRKLEDLQQFQKREPENEEEVDILSLSEPVKINIKKEQEEKQEEVKF
                     YLPPTPGSEFIGDVTQKIGITLQPVALHRNVYASVVEDMILKATEQLVNDILRQALAV
                     GYQTASHNRIPKEITVSNIHQAICNIPFLDFLTNKHMGILNEDQ"
     exon            317..414
                     /gene="YEATS2"
                     /gene_synonym="FAME4"
                     /inference="alignment:Splign:2.1.0"
     exon            415..507
                     /gene="YEATS2"
                     /gene_synonym="FAME4"
                     /inference="alignment:Splign:2.1.0"
     exon            508..753
                     /gene="YEATS2"
                     /gene_synonym="FAME4"
                     /inference="alignment:Splign:2.1.0"
     exon            754..866
                     /gene="YEATS2"
                     /gene_synonym="FAME4"
                     /inference="alignment:Splign:2.1.0"
     exon            867..1028
                     /gene="YEATS2"
                     /gene_synonym="FAME4"
                     /inference="alignment:Splign:2.1.0"
     exon            1029..1140
                     /gene="YEATS2"
                     /gene_synonym="FAME4"
                     /inference="alignment:Splign:2.1.0"
     exon            1141..1185
                     /gene="YEATS2"
                     /gene_synonym="FAME4"
                     /inference="alignment:Splign:2.1.0"
     exon            1186..1366
                     /gene="YEATS2"
                     /gene_synonym="FAME4"
                     /inference="alignment:Splign:2.1.0"
     exon            1367..1606
                     /gene="YEATS2"
                     /gene_synonym="FAME4"
                     /inference="alignment:Splign:2.1.0"
     exon            1607..1768
                     /gene="YEATS2"
                     /gene_synonym="FAME4"
                     /inference="alignment:Splign:2.1.0"
     exon            1769..1872
                     /gene="YEATS2"
                     /gene_synonym="FAME4"
                     /inference="alignment:Splign:2.1.0"
     exon            1873..1980
                     /gene="YEATS2"
                     /gene_synonym="FAME4"
                     /inference="alignment:Splign:2.1.0"
     exon            1981..2163
                     /gene="YEATS2"
                     /gene_synonym="FAME4"
                     /inference="alignment:Splign:2.1.0"
     exon            2164..2422
                     /gene="YEATS2"
                     /gene_synonym="FAME4"
                     /inference="alignment:Splign:2.1.0"
     exon            2423..2584
                     /gene="YEATS2"
                     /gene_synonym="FAME4"
                     /inference="alignment:Splign:2.1.0"
     exon            2585..2793
                     /gene="YEATS2"
                     /gene_synonym="FAME4"
                     /inference="alignment:Splign:2.1.0"
     exon            2794..2952
                     /gene="YEATS2"
                     /gene_synonym="FAME4"
                     /inference="alignment:Splign:2.1.0"
     exon            2953..3129
                     /gene="YEATS2"
                     /gene_synonym="FAME4"
                     /inference="alignment:Splign:2.1.0"
     exon            3130..3313
                     /gene="YEATS2"
                     /gene_synonym="FAME4"
                     /inference="alignment:Splign:2.1.0"
     exon            3314..3442
                     /gene="YEATS2"
                     /gene_synonym="FAME4"
                     /inference="alignment:Splign:2.1.0"
     exon            3443..3541
                     /gene="YEATS2"
                     /gene_synonym="FAME4"
                     /inference="alignment:Splign:2.1.0"
     exon            3542..3644
                     /gene="YEATS2"
                     /gene_synonym="FAME4"
                     /inference="alignment:Splign:2.1.0"
     exon            3645..3718
                     /gene="YEATS2"
                     /gene_synonym="FAME4"
                     /inference="alignment:Splign:2.1.0"
     exon            3719..3798
                     /gene="YEATS2"
                     /gene_synonym="FAME4"
                     /inference="alignment:Splign:2.1.0"
     exon            3799..4000
                     /gene="YEATS2"
                     /gene_synonym="FAME4"
                     /inference="alignment:Splign:2.1.0"
     exon            4001..4227
                     /gene="YEATS2"
                     /gene_synonym="FAME4"
                     /inference="alignment:Splign:2.1.0"
     exon            4228..4302
                     /gene="YEATS2"
                     /gene_synonym="FAME4"
                     /inference="alignment:Splign:2.1.0"
     exon            4303..4376
                     /gene="YEATS2"
                     /gene_synonym="FAME4"
                     /inference="alignment:Splign:2.1.0"
     exon            4377..6526
                     /gene="YEATS2"
                     /gene_synonym="FAME4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6505..6510
                     /regulatory_class="polyA_signal_sequence"
                     /gene="YEATS2"
                     /gene_synonym="FAME4"
                     /note="hexamer: AATAAA"
     polyA_site      6526
                     /gene="YEATS2"
                     /gene_synonym="FAME4"
                     /note="major polyA site"
ORIGIN      
        1 gacgcgccca gctgctgacg tgcggggcgg aacgcgccgg gcgggctcca ccgcgccgtg
       61 tgcttccgca ggttgcgggg gtcgctgggg ccttgtggcg gggcagctcc gcggggcttc
      121 gcccgctctc tcacctcgcc gtgctctctc gcggcggccg gcggggcccg cgctgcagcc
      181 ggagacccgg agaaaggtga agaactgaat gtcatcatgt ctggaatcaa gcgaaccatc
      241 aaagaaaccg accctgatta cgaggatgta tctgtggccc ttccaaataa gcggcataaa
      301 gcaattgaga attcagctcg agatgctgct gtgcagaaga ttgagactat tatcaaagaa
      361 cagtttgctc ttgaaatgaa gaataaggaa catgaaattg aagtcattga ccagcgactg
      421 attgaagcaa gaaggatgat ggataaactg cgtgcctgca ttgtagcaaa ctactatgct
      481 tctgcaggtc ttctaaaagt ttctgaggga tcaaagacat gtgatacaat ggtttttaat
      541 catcctgcta tcaagaaatt tttggaatca ccatctaggt catcatctcc tgccaatcag
      601 agagcagaaa caccatcagc caatcattca gaaagtgatt ctttatctca gcacaatgac
      661 ttcttatctg acaaagataa taacagcaat atggatatag aggaaagact ctcaaacaac
      721 atggagcaga gaccaagccg aaatactgga agggatactt ctagaattac tggctcccat
      781 aaaacagaac agcggaatgc tgatctcaca gatgagactt cacgactttt tgtaaagaaa
      841 acaatagtag tgggcaatgt gtccaagtat atacctccgg ataagaggga agaaaatgac
      901 cagtcaactc ataagtggat ggtatatgtc cgagggtccc gtagagaacc cagcattaat
      961 cattttgtca agaaggtttg gttcttcctt catcctagct ataaaccaaa tgaccttgtg
     1021 gaagttagag agcctccttt tcacctgacc agaagaggct ggggtgagtt tcccgtcaga
     1081 gttcaagttc attttaagga cagccagaac aagcggatag atatcataca taatctgaag
     1141 ctggatagaa cttatactgg cttgcagact cttggagcag agacggtagt ggatgttgaa
     1201 ctccatcgcc attctctcgg agaagactgt atctatcctc agtcctcgga gtctgacatc
     1261 tctgatgccc ctccatcttt gcctttgacc attccagccc cagtgaaagc ttcttcacca
     1321 ataaagcagt cacatgagcc agtacccgat acctctgtgg agaaaggatt cccagctagc
     1381 actgaagctg aacgacacac tccgttttat gctttgccat cttcattgga aagaacaccc
     1441 accaaaatga ctacatccca gaaagttacc ttttgttccc atggcaattc agctttccag
     1501 ccaatagcat caagctgcaa aattgttcca caaagtcagg ttcctaatcc tgagtcacct
     1561 ggaaaatcct tccagcccat caccatgagc tgcaagattg tgtcaggttc cccaatatca
     1621 actccaagcc catcaccatt gcctcgaacc ccgacttcca ctccagtcca cgtgaagcaa
     1681 ggcactgccg gctctgttat taataatcct tatgttatca tggacaagca gccggggcag
     1741 gtgattggag ccaccactcc cagtacagga agtcctacaa acaagatctc cacggcttct
     1801 caggtctccc aaggaacagg ttcccctgtt cctaaaattc atggaagtag ttttgtaaca
     1861 tctactgtca agcaggagga ttctttgttt gcatctatgc cacctctttg cccaattggg
     1921 agtcacccta aggttcaaag ccccaaacct ataacaggag gacttggagc tttcacaaaa
     1981 gtgatcatca aacaggaacc tggtgaagcc cctcacgtgc ccgcaacagg agctgccagc
     2041 cagtcaccac tcccgcagta tgtgactgtg aaagggggtc acatgatagc tgtgtcccct
     2101 caaaaacagg tcataactcc tggagaaggg attgcccagt cagcaaaggt tcagccctcc
     2161 aaggttgtcg gggtaccagt tgggtctgct ttaccttcaa cagtgaagca ggctgtggcg
     2221 atcagtggtg gccagatcct ggtagccaag gccagctctt ctgtctccaa agcagttggg
     2281 ccaaagcaag ttgtaaccca aggagttgcc aaagcaattg tgagtggagg tggaggaacc
     2341 attgttgctc agccagtgca gaccttaacc aaggcccagg ttactgccgc tggtcctcag
     2401 aagagtggat cccagggttc agtaatggca acgttgcagc taccagccac taatttggcc
     2461 aacttggcaa atttgcctcc tggcactaaa ctctacctaa ctacaaacag caagaaccct
     2521 tcaggaaaag gaaaactgct gctgatccct caaggagcca tcctgcgagc tacgaacaat
     2581 gctaatctcc agtctggctc agctgccagt ggtgggagtg gtgccggagg aggaggagga
     2641 ggaggaggag gaggcggcag tggcagcggt ggaggcggca gcacaggagg aggaggagga
     2701 acagcaggag gaggaactca aagtactgct ggccctggag ggatatctca gcacctgact
     2761 tacacatctt acatcctcaa gcaaactccc cagggcacat ttttagttgg ccagccatca
     2821 ccccagactt ctggaaaaca actcaccact gggtcagtgg tccaaggaac actgggagtc
     2881 agcacatctt ctgcacaagg acaacaaacg ctaaaagtca tctctggaca gaaaaccaca
     2941 ttgtttacac aggcagccca tggaggacag gcatctctaa tgaaaatatc cgatagcacc
     3001 ttgaagactg tgccagccac ctcacagctc tcgaagcctg gaaccacaat gctgagagta
     3061 gcaggagggg ttatcacaac tgccacttcc cctgccgtgg ccctctcagc aaacggtcct
     3121 gcacaacagt ctgaaggaat ggctcccgtg tcttcatcta cggtcagttc tgtaacgaaa
     3181 acttctgggc agcagcaagt gtgtgtgagc caggccaccg tgggaacctg caaggctgcc
     3241 acccccaccg tcgtcagcgc cacgtccctc gtgcctacac caaaccccat ctctgggaaa
     3301 gccacagtat ccggactgtt aaagattcac tccagtcagt ccagtccgca gcaggccgtc
     3361 ctgacgattc ccagccagct caaaccactc agcgtaaaca catctggagg ggtgcagacg
     3421 atcctgatgc ctgtgaataa agtggttcag tcattttcta ccagcaagcc acctgccatt
     3481 ctgcctgtag ctgccccaac tccagttgtc cccagctctg ctccagcagc tgttgcaaaa
     3541 gtgaagactg aaccagaaac acctggaccg agttgcctct ctcaggaggg tcagacagca
     3601 gtgaaaacag aagaaagttc tgagctggga aactatgtca ttaagataga ccatttagaa
     3661 actatccagc aactcctaac tgcagtagta aagaagattc cattaatcac tgcaaaaagt
     3721 gaagatgcca gctgcttttc tgcaaagtct gtggagcagt actatggctg gaacattgga
     3781 aaaaggagag ccgctgagtg gcaaagagca atgacaatgc gaaaagtctt acaagaaatc
     3841 ctggagaaga atccgagatt tcaccacctg actcccctca aaaccaagca catcgctcac
     3901 tggtgccgct gtcatggcta caccccaccg gaccctgaga gcctgaggaa tgacggggac
     3961 tccatcgagg acgtgctgac ccagatcgac agcgagcccg agtgcccatc atcattctcc
     4021 tctgctgaca acctctgccg caaactggag gacctgcaac agttccagaa aagggaaccc
     4081 gagaatgagg aggaggtgga catcctcagc ctctccgagc cagtgaagat aaacatcaag
     4141 aaggagcagg aagagaaaca agaggaagtc aagttctacc tgccaccaac cccagggtct
     4201 gaatttattg gggatgtcac acagaagatt gggatcaccc tgcagcccgt ggcactccac
     4261 aggaacgtgt atgcgtccgt ggtggaggac atgatcctga aggctacaga acagctggtg
     4321 aatgatatcc tgagacaggc tttggcagtt ggataccaga cagcttctca caacaggatt
     4381 cccaaagaaa ttacagtgag taatattcac caggccattt gcaacattcc ttttctggac
     4441 ttcctcacaa acaaacacat gggaatattg aatgaggacc agtgagcgga gtgaggtgcc
     4501 ctggagaagc aggctttgaa ggcacagcga agctgtaact gaggaccctg ctgctcggga
     4561 aggaggtggt ttccagtgtg actcggcatg tcatggctac ccaacctttg ccgctgcctg
     4621 ttcccacgtg tcaccagcac gctgcactcc agatgaaatc ctcctaggac aggagtttgt
     4681 ttcctgagtg tggagtgagg ctgtcagtgg atccgtgctt tgtcggccag cgtttctgca
     4741 gtctttgtaa aggccccacg agagcgggcc aggccgtgtg cctcaggccc ttctccctgg
     4801 gtgtgcttaa gggggctcct tgggcccgcc tccccaggag gtagaaaatg agtggcaggc
     4861 tagagatttc acccattttg tgggctggag ttaccagtag ctccagcagt taccctgaag
     4921 agagattggg cttcagcctt cagcaggtgg ttctctccca tgcctggcct tggtgtggag
     4981 gggctgtact ctgagcccaa gtgagtcagc tataggaaga ggccatacct agagccaaga
     5041 accatgaagg cctgagagac ggcagactga gcagaattcc ttttttgagc acgagagcat
     5101 tactagaacc attgtcaaag cagtggcaag ggacggagag gtcccaacag gagtcaggaa
     5161 gaggtttgat tataaccaag aaaactcact atgctaggaa tagactgtgt gcaccagtcc
     5221 cagacacttg gcagaagtgt agcagcgtta cacatgtgtg cgaagcagat cgcaggttcc
     5281 acgccatctg catggcctgc aggagcttct gctgctgacc ccatgctgag tggccagtgg
     5341 ggagcggcgc ccggcaggct cttctggggt cgtctgtcct atccgtggat tgtatatact
     5401 cttctctgtt aaggagtttt tcccaagaag aaaagtattt aaaagaaata ccagtgagtg
     5461 ccttaaagtt ggagaagtaa ctgcccatgc ccagaaataa ggatgccagt gcccagaagc
     5521 agtgagatta gtctgtgtcc acaagcagag gccccctcga tgggagggag tggcaggcag
     5581 gagaaggtgg cgctgccagg tgcccgggtc tattggaggc gccccatctc agacttccta
     5641 acacagcctg tgtggaaggc agaacaaaga atgcatgccc agtcagaaat ctgttctatt
     5701 ctgctccagg aaaatcggaa acctgtgagt cagagtcaga gaaacttacc caagcaacgt
     5761 aattcctgtt ttcatgggtc ctgtagatgt ttgagtcagg aaggtaaggc ggggagtgac
     5821 tgaataaact ctgcctttta aattgagcat ctgggccggg catggtggct cacgcctgta
     5881 atcccagcac tctgggaggt cgaggtgggt gggtcacctg aggttgggag ttcgagacca
     5941 gcccgaccaa catggtgaaa ccccgtctct actaaaaata cagaaaatta gctgggcatg
     6001 gtggtgtgtg cctgtaattc cagctactcg ggaggctgag gcaggaagaa tcacttgaac
     6061 ccaggaggcg gaggttgcag tgtgccaaga tcataccact gcactccagc cctggtgaca
     6121 gaggagaccc cgtctcaaaa attgattgat caattcagca tctgagggct gcaagtacag
     6181 aaggaatcta ttctcagcag ggcatagggc acgcactggc ttaacagttt agtatataag
     6241 gctcaaatag tctatacctg aactgctata agcaaggtcg atagggaagt ggatagattg
     6301 cttcagcaaa gtgaactgtg agatctccag gacagaggga gaaagatctg atccaaatga
     6361 gaacagattg gttattgcag gtatcacagc ctaaagaaat tatctttttg caaaagaaat
     6421 attaaatgat ttagcagtct ccacgtgtgt taatgtttca aacgtgtatc ataatgtgta
     6481 taattgtgta acaaaattgt ctacaataaa tcttttggta tttgtg
//
